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    Salem County, VA Commercial Real Estate for Sale

    224 results
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    Commercial Property on Williamson Road
    $550,000
    0.79 Acres

    Commercial Property on Williamson Road

    2211 Williamson Rd NE, Roanoke, VA 24012

    Two commercial buildings with high potential on a 0.79-acre lot.

    • Prime commercial property on busy Williamson Rd corner lot.
    • High visibility: 150 feet of road frontage.
    • Located less than two miles from downtown Roanoke.
    • Two commercial buildings included.
    • 0.7999 acre lot offers lots of potential.
    Updated: Oct 26, 2025
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    Roanoke Office and Retail Space
    $476,850
    0.32 Acres

    Roanoke Office and Retail Space

    624-626 Abney Rd, Roanoke, VA 24012

    Well-appointed, accessible office/retail space near interstate, airport, and downtown.

    • Move‑in ready office space with recent updates including new PVC flooring, updated bathrooms, and fresh paint (May 2024).
    • Highly accessible location: minutes from the interstate, airport, downtown, and Botetourt County.
    • Flexible space: multiple offices, boardroom, and potential to divide for two separate businesses.
    • ADA accessible entry and low‑maintenance brick exterior.
    • Four bathrooms (M/F on each end) and fully conditioned space (central heat and air).
    Updated: Oct 15, 2025
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    Updated Building with High-End Finishes
    $2,100,000
    0.05 Acres

    Updated Building with High-End Finishes

    Extensively updated building with high-end materials and great views.

    109 Campbell Ave SW, Roanoke, VA 24011
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    Franklin Road Office/Retail Opportunity
    $1,350,000
    1.00 Acre

    Franklin Road Office/Retail Opportunity

    Prime commercial land on Franklin Road with high traffic volume.

    4040 Franklin Rd SW, Roanoke, VA 24014
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    Retail Opportunity in North Roanoke
    $499,000
    0.56 Acres

    Retail Opportunity in North Roanoke

    Retail property with high visibility in North Roanoke, Virginia.

    5623 Williamson Rd, Roanoke, VA 24012
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    Roanoke Investment Opportunity
    $545,000
    0.31 Acres

    Roanoke Investment Opportunity

    Well-maintained commercial building leased to the Commonwealth of Virginia.

    414 9Th St SE, Roanoke, VA 24013
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    Versatile Retail and Industrial Property
    $349,000
    0.19 Acres

    Versatile Retail and Industrial Property

    Retail and industrial property in high-traffic location on Williamson Rd.

    1408 Williamson Rd NE, Roanoke, VA 24012
    View details
    Roanoke Office Building For Sale
    $750,000
    0.63 Acres

    Roanoke Office Building For Sale

    Traditional office building with on-site parking and corner location.

    4533 Brambleton Ave, Roanoke, VA 24018
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    Roanoke Office/Retail Building For Sale
    $650,000
    0.30 Acres

    Roanoke Office/Retail Building For Sale

    Office building with subdivision potential and ample parking.

    356 Campbell Ave SW, Roanoke, VA 24016
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    Retail Building on Williamson Road
    Pending
    $1,375,000
    8,772 SF

    Retail Building on Williamson Road

    NNN leased retail building with strong tenant in Roanoke, VA.

    3607 Williamson Rd, Roanoke, VA 24012
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    Historic Horton Building For Sale
    $2,875,000
    0.20 Acres

    Historic Horton Building For Sale

    Landmark Roanoke building blending early-20th-century craftsmanship and modern functionality.

    302 1St St SW, Roanoke, VA 24011
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    Downtown Roanoke Investment Opportunity
    $875,000
    0.05 Acres

    Downtown Roanoke Investment Opportunity

    Two-unit building in vibrant downtown Roanoke with retail and residential.

    22 Campbell Ave SE, Roanoke, VA 24011
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    Well-Maintained Condo Near Greenway
    $208,500

    Well-Maintained Condo Near Greenway

    2-bedroom, 2-bath condo near hospital, shopping, and Greenway.

    2513 Gatehouse Ln, Salem, VA 24153
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    Income Producing Duplex For Sale
    $195,000
    1,760 SF

    Income Producing Duplex For Sale

    Well-maintained duplex with two 2-bedroom units and off-street parking.

    3122 Garden City Blvd SE, Roanoke, VA 24014
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    Grandin Village Retail Opportunity
    $424,950
    2,900 SF

    Grandin Village Retail Opportunity

    Commercial property in Roanoke's Grandin Village, heavy traffic area.

    1911 Memorial Ave SW, Roanoke, VA 24015
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    Roanoke Office Building with Views
    $1,300,000
    10,129 SF

    Roanoke Office Building with Views

    10,129 SF office building with valley views for sale.

    7851-7857 Enon Dr, Roanoke, VA 24019
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    Multi-Tenant Office Building For Sale
    $1,425,000
    7,416 SF

    Multi-Tenant Office Building For Sale

    7,500 SF multi-tenant office building on 1.44 acres.

    1618 W Main St, Salem, VA 24153
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    High-Tech Manufacturing and Warehouse Facility
    $10,750,000
    146,852 SF

    High-Tech Manufacturing and Warehouse Facility

    Expandable manufacturing, office, and warehouse facility near I-581 and I-81.

    2797 Frontage Rd - NW, Roanoke, VA
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    Self-Service Car Wash Investment
    $235,000

    Self-Service Car Wash Investment

    Six-bay car wash with high visibility and traffic count.

    4101 Plantation Rd NE | Roanoke, Roanoke, VA 24012
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    Industrial Property with Two Buildings
    $1,295,000
    9,200 SF

    Industrial Property with Two Buildings

    Two industrial buildings totaling 9,200 SF on 1.4 acres.

    3718 Garman Rd, Salem, VA 24153
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    Office Condo in McVitty Center
    $205,000
    1,205 SF

    Office Condo in McVitty Center

    Office condo with reception, offices, restrooms, and kitchenette for sale.

    2774 Electric Rd Southwest | Roanoke, Roanoke, VA 24014
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    Multi-Tenant Professional Business Center
    $1,750,000
    12,000 SF

    Multi-Tenant Professional Business Center

    12,000 SF multi-tenant professional center with strong rental history.

    192 Summerfield Ct, Roanoke, VA 24019
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    Renovated Commercial Building in Roanoke
    $319,000
    1,200 SF

    Renovated Commercial Building in Roanoke

    Updated 1200 sq ft commercial space in Old Southwest Roanoke.

    708 5Th St SW, Roanoke, VA 24016
    View details
    Six-Story Commercial Building in Roanoke
    $2,600,000
    32,445 SF

    Six-Story Commercial Building in Roanoke

    Six-story commercial building in downtown Roanoke with redevelopment opportunities.

    302 S Jefferson St, Roanoke, VA 24011
    View details

    Salem County, VA Commercial Real Estate Investment Opportunities Market Analysis

    Explore 940 commercial real estate investment opportunities in Salem County, VA with 224 listings featured on our commercial real estate marketplace. The current inventory includes 41,042,618 square feet of properties with an estimated value of $392,236,139.

    Estimated prices for commercial real estate in Salem County, VA begin at $35,000, with an average of $592,501 and extend to $13,755,000.

    In Salem County, VA, current investment values show:

    • Other commercial real estate positioned at $480,235
    • Industrial properties measuring $833,277
    • Other industrial properties assessed at $1,035,491
    • Other warehouses calculated at $575,652
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