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Salem County, VA Mixed-use Properties for Sale

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11 results
Versatile Retail and Industrial Property
$329,000
0.19 Acres

Versatile Retail and Industrial Property

1408 Williamson Rd NE, Roanoke, VA 24012

Retail and industrial space in high-traffic Roanoke location.

  • High‑visibility, high‑traffic location on Williamson Rd.
  • Versatile property suitable for retail and industrial use.
  • 3,579 square feet of rentable space.
  • Includes a 1,238 square feet retail area currently set up as a hair salon.
  • 2,341 square feet industrial/storage component.
Updated: Oct 17, 2025
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Updated Mixed-Use Building with High-End Finishes
$2,100,000
0.05 Acres

Updated Mixed-Use Building with High-End Finishes

109 Campbell Ave SW, Roanoke, VA 24011

Extensively updated mixed-use building with high-end finishes and great views.

  • Extensively updated with extremely high‑end materials and great views, move‑in ready.
  • Two residential units, each with two bedrooms, Wolf gas stove, Cove dishwasher, and Sub‑Zero fridge.
  • Complete renovation including windows, flooring, HVAC, electrical, and plumbing.
  • Entry level suitable for art gallery with full‑size kitchen and plywood walls for easy artwork display.
  • Custom made cabinetry throughout.
Updated: Jan 5
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Downtown Roanoke Mixed-Use Building
$799,000
0.05 Acres

Downtown Roanoke Mixed-Use Building

Two-unit building with retail space and modern residence.

22 Campbell Ave SE, Roanoke, VA 24011
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Downtown Roanoke Mixed-Use Investment
$650,000
4,299 SF

Downtown Roanoke Mixed-Use Investment

Mixed-use property in downtown Roanoke with value-add potential.

23 Salem Ave SE, Roanoke, VA 24011
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Peters Creek Road Commercial Property
$1,300,000
14,600 SF

Peters Creek Road Commercial Property

Commercial property with visibility and access on 1.27 acres.

3783 Peters Creek Rd, Roanoke, VA 24018
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Roanoke Executive Park Investment Opportunity
$7,325,000
54,000 SF

Roanoke Executive Park Investment Opportunity

Six-building commercial campus with flexible zoning and high visibility.

5306 Peters Creek Rd, Roanoke, VA 24019
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Mixed-Use Building with Leased Units
$415,000
3,294 SF

Mixed-Use Building with Leased Units

Mixed-use building with office space and two leased apartments.

1011 2nd St SW, Roanoke, VA 24016
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Downtown Roanoke Mixed-Use Opportunity
$349,950
4,474 SF

Downtown Roanoke Mixed-Use Opportunity

Former florist building with live-work potential in downtown Roanoke.

21 Church Ave SW, Roanoke, VA
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Prime Commercial Development Opportunity
$980,000

Prime Commercial Development Opportunity

4.36 acres of mixed-use land for commercial development.

4402 Old Rocky Mt Rd, Roanoke, VA 24014
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Green Ridge Center For Sale
$1,649,000
13,908 SF

Green Ridge Center For Sale

Mixed-use property with retail and office spaces available for sale.

2350 Peters Crk Rd NW, Roanoke, VA 24017
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Land with Development Potential
$550,000

Land with Development Potential

Land with frontage on US 220 and Clearbrook Lane.

5403 Clearbrook Lane, Roanoke, VA 24014
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Based on your search, we've compiled 15 Potential Opportunities for your consideration. Besides 11 Active listings in Salem County, VA, we suggest exploring several alternatives: plus 4 Land Listings that present a potential for development.

Potential Development Sites for Consideration

Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

Roanoke, VA Land Opportunity
Contact for pricing
0.11 Acres

Roanoke, VA Land Opportunity

Premium lot near downtown Roanoke with water and sewer access.

Church Ave SE, Roanoke, VA 24013
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Prime Land For Development
$529,900

Prime Land For Development

Level to rolling landscape suitable for commercial development.

1 Moneta Road, Moneta, VA 24121
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Prime Land For Development
$999,900

Prime Land For Development

Level to rolling landscape suitable for commercial development.

1 Moneta Road, Moneta, VA 24121
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Commercial Land in Christiansburg, VA
$799,000
2.20 Acres

Commercial Land in Christiansburg, VA

2.15 acres of commercial land with development potential.

0 Lucas Street NE, Christiansburg, VA 24073
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Salem County, VA Mixed-Use Properties Investment Opportunities Market Analysis

Explore 11 mixed-use properties for sale in Salem County, VA, showcased through 11 active listings on our real estate platform. These investment opportunities span a total of 12,632 square feet of properties for sale, with an estimated market value of $3,228,000.

Sale prices for multi use buildings in Salem County, VA start at $329,000, averaging $1,076,000, and reaching up to $2,100,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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