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    Salem County, VA Mixed-use Properties for Sale

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    15 properties
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    Mixed-Use Property with Detached Outbuilding
    Updated: Oct 6
    Mixed-Use Property with Detached Outbuilding

    7760 Williamson Rd, Roanoke, VA 24019

    $299,000
    0.38 AC lot
    0.38‑acre parcel with 1,931 finished and 1,028 unfinished square feet
    Three upstairs bedrooms, two bathrooms, kitchen, dining area, sunroom, den and full lower level
    Detached two‑story outbuilding with entry‑level and lower‑level space
    Circle driveway and on‑site parking for approximately 15 vehicles
    C2 zoning allows commercial or office use alongside full‑time residential occupancy under Roanoke County regulations
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    Updated Mixed-Use Building
    Updated: May 28
    Updated Mixed-Use Building

    4310 Brandon Ave SW, Roanoke, VA 24018

    $299,999
    0.59 AC lot
    C‑2 zoning supports retail and office use
    0.59‑acre property at 4310 Brandon Ave SW, Roanoke, VA 24018
    Recent roof, water heater, A/C heat pump, and flooring updates
    Concrete construction with marble flooring
    Full bath and storage room
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    Two-Unit Mixed-Use Building
    Two-Unit Mixed-Use Building

    22 Campbell Ave SE, Roanoke, VA 24011

    $799,000
    0.05 AC lot

    Street-level retail space is paired with a renovated two-bedroom residence above.

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    Realmo Analytics Monitor Off-market properties and contact owners who are ready to sell. Many signals applied to make quality leads for you. Get Leads
    Seven-Story Office Building
    Seven-Story Office Building

    30 - 38 Church Ave, Roanoke, VA 24011

    $3,200,000
    48,638 sqft

    Downtown office property with large floor plates, two passenger elevators, and Opportunity Zone Downtown zoning.

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    Renovated Mixed-Use Building
    Renovated Mixed-Use Building

    109 Campbell Ave SW, Roanoke, VA 24011

    $1,850,000
    0.05 AC lot

    Former gallery space with two upstairs residential units offers a combined commercial and residential configuration.

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    Mixed-Use Property with Multiple Structures
    Mixed-Use Property with Multiple Structures

    5851&5877 Cloverdale Rd, Roanoke, VA 24019

    $650,000
    2.30 AC lot

    Multiple existing structures on a 2.3-acre parcel with public water and sewer service.

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    Mixed-Use Retail and Office Building
    Mixed-Use Retail and Office Building

    2302 Winthrop Ave Sw, Roanoke, VA 24015

    $475,000
    1,964 sqft

    One-story, handicap-accessible mixed-use building with 2 bathrooms, new roof, and a tankless water heater.

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    Mixed-Use Property with End-Cap Space
    Mixed-Use Property with End-Cap Space

    1727 Peters Creek Rd Nw, Roanoke, VA 24017

    $875,000
    1.15 AC lot

    Eight-unit commercial property combining retail, office, and flex space with two-street access and a renovated vacant suite.

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    Historic Mixed-Use Property
    Historic Mixed-Use Property

    1307 Maple Ave SW, Roanoke, VA 24016

    Contact for pricing
    2,268 sqft

    MX-zoned property supporting residential, commercial, or combined live-work use in Roanoke’s Old Southwest area.

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    Roanoke Executive Park Investment Opportunity
    Roanoke Executive Park Investment Opportunity

    5306 Peters Creek Rd, Roanoke, VA 24019

    Contact for pricing
    54,000 sqft 5.10 AC lot

    Six-building commercial campus with flexible zoning and high visibility.

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    Eight-Unit Mixed-Use Property
    Eight-Unit Mixed-Use Property

    1727 Peters Creek Road Northwest, Roanoke, VA 24017

    Contact for pricing
    1.15 AC lot

    Renovated end-cap suite combines offices, break room, warehouse space, and a drive-in overhead door.

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    Mixed-Use Commercial Building
    Mixed-Use Commercial Building

    3746 Colonial Ave, Roanoke, VA 24018

    $499,950

    Reception, client rooms, shared workspace, and service areas provide a range of interior functions.

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    Mixed-Use Building with Medical Offices
    Mixed-Use Building with Medical Offices

    1602 Grandin Rd Sw, Roanoke, VA 24015

    $549,000
    3,013 sqft

    CN-zoned property combines professional workspace with a separately accessed residential unit.

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    Mixed-Use Corner Property
    Mixed-Use Corner Property

    901 S Colorado St, Salem, VA 24153

    $475,000

    Two completely remodeled commercial buildings offer retail/office space and fully leased residential units on a corner lot.

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    Prime Commercial Development Opportunity
    Prime Commercial Development Opportunity

    4402 Old Rocky Mt Rd, Roanoke, VA 24014

    Contact for pricing
    4.36 AC lot

    4.36 acres of mixed-use land for commercial development.

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    Based on your search, we've compiled 19 Potential Opportunities for your consideration. Besides 15 Active listings in Salem County, VA, we suggest exploring several alternatives: plus 4 Land Listings that present a potential for development.

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Commercial Land with Approved Entrance
    Commercial Land with Approved Entrance

    Booker T Washington Hwy lot: 3, Hardy, VA 24101

    $2,200,000
    7.75 AC lot

    The site offers paved road access, a VDOT-approved entrance, and identified septic options.

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    Commercial Land with Graded Pad
    Commercial Land with Graded Pad

    LOT C-26 Booker T. Washington Highway, Moneta, VA 24121

    $225,000
    1.37 AC lot

    PCD-zoned commercial land with water and gravity sewer serving a graded development pad.

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    Commercial Land with Road Frontage
    Commercial Land with Road Frontage

    15093 A Moneta Rd, Moneta, VA 24121

    $2,499,000
    56.00 AC lot

    56-acre tract with mixed-use zoning potential and utilities available, offering strong exposure along Route 122.

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    Commercial Land with Building Footprint
    Commercial Land with Building Footprint

    Mercantile St lot: 12, Moneta, VA 24121

    $510,000

    Supports a new main-level commercial building with optional residential space above.

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    Salem County, VA Mixed-Use Properties Market Trends and Statistics

    Explore 15 mixed-use properties for sale in Salem County, VA, showcased through 15 active listings on our real estate platform. These investment opportunities span a total of 109,883 square feet of properties for sale, with an estimated market value of $9,971,949.

    Sale prices for multi use buildings in Salem County, VA start at $299,000, averaging $906,540, and reaching up to $3,200,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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