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    Salem County, VA Mixed-use Properties for Sale

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    Updated Mixed-Use Building
    Updated: May 28
    Updated Mixed-Use Building

    4310 Brandon Ave SW, Roanoke, VA 24018

    $299,999
    0.59 AC lot
    C‑2‑zoned mixed‑use property with retail, office, or studio use potential
    0.59‑acre site at 4310 Brandon Ave SW, Roanoke, VA 24018
    Recent roof, water heater, A/C heat pump, and flooring updates
    Full bathroom and storage area within the building
    Concrete construction with marble flooring
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    Two-Unit Mixed-Use Building
    Updated: Nov 13, 2025
    Two-Unit Mixed-Use Building

    22 Campbell Ave SE, Roanoke, VA 24011

    $799,000
    0.05 AC lot
    4,400 SF two‑unit building with retail and residential components
    Second‑floor 2bd/2bth residence renovated in 2021
    Glass‑front street‑level retail space
    1902 brick construction with full sprinkler system and freight elevator
    D‑Downtown zoning on a 0.05‑acre lot
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    Mixed-Use Property with Multiple Structures
    Mixed-Use Property with Multiple Structures

    5851&5877 Cloverdale Rd, Roanoke, VA 24019

    $650,000
    2.30 AC lot

    Two commercial buildings and a house are offered in their existing condition on a 2.3-acre property.

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    Turn a Listing Into an Investment Snapshot Cap Rate, Potential NOI, Demand score for every listing. Go To Analytics Center
    Seven-Story Office Building
    Seven-Story Office Building

    30 - 38 Church Ave, Roanoke, VA 24011

    $3,200,000
    48,638 sqft

    Downtown office property with large floor plates, two passenger elevators, and Opportunity Zone Downtown zoning.

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    Mixed-Use Retail and Office Building
    Mixed-Use Retail and Office Building

    2302 Winthrop Ave Sw, Roanoke, VA 24015

    $495,000
    1,964 sqft

    One-story, handicap-accessible mixed-use building with 2 bathrooms, new roof, and a tankless water heater.

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    Historic Mixed-Use Property
    Historic Mixed-Use Property

    1307 Maple Ave SW, Roanoke, VA 24016

    Contact for pricing
    2,268 sqft

    MX-zoned property supporting residential, commercial, or combined live-work use in Roanoke’s Old Southwest area.

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    Roanoke Executive Park Investment Opportunity
    Roanoke Executive Park Investment Opportunity

    5306 Peters Creek Rd, Roanoke, VA 24019

    Contact for pricing
    54,000 sqft 5.10 AC lot

    Six-building commercial campus with flexible zoning and high visibility.

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    Mixed-Use Property with Corner Land
    Mixed-Use Property with Corner Land

    3312 Cove Rd Nw, Roanoke, VA 24017

    $850,000

    Multi-tenant improvements and an adjoining parcel accommodate current occupancy, expansion, or redevelopment plans.

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    Mixed-Use Corner Building
    Mixed-Use Corner Building

    628 S Colorado St, Salem, VA 24153

    Contact for pricing
    1,316 sqft

    Versatile corner property with flexible interior rooms, porch entry, and ample parking plus a detached garage with utilities.

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    Mixed-Use Building with Medical Offices
    Mixed-Use Building with Medical Offices

    1602 Grandin Rd Sw, Roanoke, VA 24015

    $549,000
    3,013 sqft

    CN-zoned property combines professional workspace with a separately accessed residential unit.

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    Mixed-Use Building with Leased Units
    Mixed-Use Building with Leased Units

    1011 2nd St Sw, Roanoke, VA 24016

    $415,000
    3,294 sqft

    Mixed-use building with office space and two leased apartments.

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    Mixed-Use Corner Property
    Mixed-Use Corner Property

    901 S Colorado St, Salem, VA 24153

    $475,000

    Two completely remodeled commercial buildings offer retail/office space and fully leased residential units on a corner lot.

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    Mixed-Use Retail/Office Condo
    Mixed-Use Retail/Office Condo

    5325 Peters Creek Road, Roanoke, VA 24019

    Contact for pricing

    Commercial condominium unit with display windows, a large sales floor, and access suited to office or retail occupancy.

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    Prime Commercial Development Opportunity
    Prime Commercial Development Opportunity

    4402 Old Rocky Mt Rd, Roanoke, VA 24014

    Contact for pricing
    4.36 AC lot

    4.36 acres of mixed-use land for commercial development.

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    Green Ridge Center For Sale
    Green Ridge Center For Sale

    2350 Peters Crk Rd NW, Roanoke, VA 24017

    Contact for pricing
    13,908 sqft

    Mixed-use property with retail and office spaces available for sale.

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    Mixed-Use Building with Event Space
    Mixed-Use Building with Event Space

    929 Murray Ave SE, Roanoke, VA 24013

    Contact for pricing

    Lower-level banquet space accommodates seating for up to 400 people.

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    Based on your search, we've compiled 20 Potential Opportunities for your consideration. Besides 16 Active listings in Salem County, VA, we suggest exploring several alternatives: plus 4 Land Listings that present a potential for development.

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Commercial Land with VDOT-Approved Entrance
    Commercial Land with VDOT-Approved Entrance

    Booker T Washington Hwy lot: 3, Hardy, VA 24101

    $2,200,000
    7.75 AC lot

    7.75 acres with a VDOT-approved entrance off Route 122, paved access, and water available at the site.

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    Commercial Land with Graded Pad
    Commercial Land with Graded Pad

    LOT C-26 Booker T. Washington Highway, Moneta, VA 24121

    $225,000
    1.37 AC lot

    PCD-zoned commercial land with water and gravity sewer serving a graded development pad.

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    Commercial Land with Road Frontage
    Commercial Land with Road Frontage

    15093 A Moneta Rd, Moneta, VA 24121

    $2,499,000
    56.00 AC lot

    56-acre tract with mixed-use zoning potential and utilities available, offering strong exposure along Route 122.

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    Eastlake Area Mixed-Use Land
    Eastlake Area Mixed-Use Land

    15093 Moneta Road, Moneta, VA 24121

    $2,499,000
    60.60 AC lot

    60.60 acres in Eastlake with commercial and residential potential.

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    Salem County, VA Mixed-Use Properties Market Trends and Statistics

    Explore 16 mixed-use properties for sale in Salem County, VA, showcased through 16 active listings on our real estate platform. These investment opportunities span a total of 128,401 square feet of properties for sale, with an estimated market value of $7,732,999.

    Sale prices for multi use buildings in Salem County, VA start at $299,999, averaging $859,222, and reaching up to $3,200,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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