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    Salem County, VA Medical Office Space for Lease

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    Bank-Converted Office Building
    Updated: Jun 1
    Bank-Converted Office Building

    301 McClanahan Street SW, Roanoke, VA 24014

    $15 SF/Yr
    6,631 sqft
    Former Wells Fargo bank branch with ~3,300 SF on two floors (total 6,631 SF).
    Second‑floor office space was recently renovated and is ready for use.
    First floor includes office space and a drive‑thru option if desired.
    34 on‑site parking spaces for employees and visitors.
    Multiple ingress/egress points for access flexibility.
    View details
    Prime Commercial Space in Roanoke
    Updated: Jul 29, 2025
    Prime Commercial Space in Roanoke

    2727 Franklin Rd, Roanoke, VA

    $12.75 SF/Yr
    10,923 sqft
    Prime location in Roanoke's Innovation Corridor, near medical, research, and professional facilities.
    Excellent connectivity with direct access to I‑581 and U.S. 220.
    High visibility on Franklin Road with approximately 28,000 AADT.
    Ample parking for clients and employees.
    Modern and versatile space with customizable floor plans.
    View details
    Office Space Off Interstate
    Office Space Off Interstate

    1125 South Jefferson St., Roanoke, VA 24016

    $12 SF/Yr

    Office leasing opportunity with convenient access just off 581 for a range of professional uses.

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    Medical Office Suite
    Medical Office Suite

    1934 BRAEBURN DR, Salem, VA 24153

    Contact for pricing
    1,500 sqft

    Well-maintained medical office with reception, exam rooms, offices, and ample parking near LewisGale Medical Center.

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    First Floor Office Suite
    First Floor Office Suite

    5304 Indian Grave Rd, Roanoke, VA

    $16 SF/Yr
    3,000 sqft

    Office suite for rent with high visibility and ample parking.

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    Office Space in Prime Location
    Office Space in Prime Location

    3241 Electric Rd, Roanoke, VA

    $15 SF/Yr
    2,023 sqft

    Ready-to-use office suites in a demographically affluent Roanoke neighborhood.

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    Roanoke Office Space For Lease
    Roanoke Office Space For Lease

    3247 Electric Rd, Roanoke, VA

    $11 SF/Yr
    1,912 sqft

    Ready-to-use office suites in a well-located Roanoke office park.

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    Professional Office Space For Lease
    Professional Office Space For Lease

    3243 Electric Rd, Roanoke, VA

    $12 SF/Yr
    957 sqft

    Customizable office suites in affluent Roanoke neighborhood, recently renovated.

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    Medical/Professional Office Space Available
    Medical/Professional Office Space Available

    375 Hershberger Rd, Roanoke, VA

    $19 SF/Yr
    3,000 sqft

    3,000 SF medical/professional office space for lease.

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    Office or Medical Space Available
    Office or Medical Space Available

    4633 Brambleton Ave, Roanoke, VA

    $17 SF/Yr
    1,800 sqft

    Office or medical space for lease in Roanoke, Virginia.

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    Based on your search, we've compiled 24 Potential Opportunities for your consideration. Besides 10 Active listings in Salem County, VA, we suggest exploring alternatives. Similar 10 Properties for Sales.

    Similar Spaces for Sale in Salem County, VA

    Consider Similar Space for Sale. We found 10 Spaces matching your search parameters.

    Medical Office Building with Mobile Shelving
    Medical Office Building with Mobile Shelving

    2118 Rosalind Ave SW, Roanoke, VA 24014

    $1,300,000
    0.44 AC lot

    Medical office property with full build-out, two conference rooms, and paved parking for 28 vehicles.

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    Brick Office Building with Parking
    Brick Office Building with Parking

    824 Iowa St, Salem, VA 24153

    $195,000
    0.24 AC lot

    Brick building with office-ready interior, small restrooms, and on-site surface parking for a range of service or office uses.

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    Multi-Tenant Office Building For Sale
    Multi-Tenant Office Building For Sale

    1618 W Main St, Salem, VA 24153

    $1,425,000
    7,416 sqft

    7,500 SF multi-tenant office building on 1.44 acres.

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    Brick Medical Office Building
    Brick Medical Office Building

    824 Iowa St, Salem, VA 24153

    $195,000
    1,000 sqft

    Brick building formerly used as a dental lab, with multiple sinks, built-in cabinets, and on-site parking.

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    Medical/Office Building Near Valley View
    Medical/Office Building Near Valley View

    4910 Valley View Boulevard Northwest, Roanoke, VA 24012

    Contact for pricing
    60,055 sqft

    60,055 RSF medical/office building adjacent to Valley View Mall.

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    Renovated Office Suites in Office Park
    Renovated Office Suites in Office Park

    3243 Electric Road, Roanoke, VA 24018

    $685,000

    Flexible office suites with recent exterior renovations, offered for sale in a quiet office park setting.

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    Storefront with New Roof
    Storefront with New Roof

    1217 Salem Ave Sw, Roanoke, VA 24016

    $105,000

    Blank-canvas storefront suited for retail, health services, or repair use, with a new roof installed in 2024.

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    South Roanoke Office/Medical Opportunity
    South Roanoke Office/Medical Opportunity

    301 McClanahan St - SW, Roanoke, VA

    $1,750,000
    6,631 sqft 0.72 AC lot

    Office or medical building near Carilion Roanoke Memorial Hospital.

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    Medical Office Building For Rent
    Medical Office Building For Rent

    5100-5104 Bernard Dr, Roanoke, VA

    $1,150,000
    3,391 sqft 0.36 AC lot

    Southwest County medical office building with two suites available.

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    Roanoke Office Building with Views
    Roanoke Office Building with Views

    7851-7857 Enon Dr, Roanoke, VA

    $1,350,000
    10,129 sqft 3.10 AC lot

    10,129 SF office building with valley views for sale.

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    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Prime Development Opportunity in Greenville
    Prime Development Opportunity in Greenville

    39 Airpark Ct, Greenville, SC 29607

    Contact for pricing

    1.27 acre interstate-visible land for ground lease or build-to-suit.

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    Commercial Land Parcel with Utilities
    Commercial Land Parcel with Utilities

    2585 Maple Lane, Pittsburgh, PA 15241

    $50,000/Mo

    Level, fully serviced commercial parcel with approvals in place and signage permitted up to 20 sq ft.

    View details
    Prime Lexington Outlot Opportunity
    Prime Lexington Outlot Opportunity

    3330 Partner Place, Lexington, KY 40503

    Contact for pricing

    Outlot for ground lease or build-to-suit in South Lexington.

    View details
    Corner Lot on Highway 72
    Corner Lot on Highway 72

    30472 Highway 72, Madison, AL 35756

    $5,000/Mo
    1,875 sqft

    1.7 acre corner lot zoned for commercial, medical, residential.

    View details

    Salem County, VA Medical Office Space Market Trends and Statistics

    Explore Medical Office Space leasing options in Salem County, VA with 10 listings featured on our commercial real estate exchange. The current inventory includes 30,246 square feet of properties with an estimated lease value of $117.75 SF/Yr.

    Estimated lease rates for Medical Office Space in Salem County, VA begin at $11 SF/Yr, with an average of $14.72 SF/Yr and extend to $19 SF/Yr.
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