Portsmouth, NH Commercial Real Estate for Sale

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43 properties

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Updated: Dec 15, 2025

Historic Office Building

144 Washington Street, Portsmouth, NH 03801

$3,300,000

0.25 AC lot

1747 Federal‑style office property with original architectural details
0.25‑acre parcel at Hancock and Washington Streets in Portsmouth
Professional office configuration with a private third‑floor office
Views toward Strawberry Banke Historic Museum, Prescott Park, and the Piscataqua River
Off‑street parking with space identified for a garage or carriage house

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Updated: Jun 10

Medical Office Condominium

330 Borthwick Avenue, Portsmouth, NH 03801

$550,000

Medical office condominium in the Jackson Gray Medical Building
Directly across from Portsmouth Regional Hospital
On‑site parking with additional accessible parking spaces
Immediate access to I‑95 and the Portsmouth Rotary
Located just off U.S. Route 1

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Street-Level Retail Condominium

40 Bridge Street Unit 101, Portsmouth, NH 03801

$2,350,000

Flexible commercial unit with storefront glazing, multiple entrances, and upgraded interior systems.

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Historic Storefront with Finished Basement

22 Ladd St Unit A, Portsmouth, NH 03801

$815,000

2,072 sqft

Downtown commercial unit with street-level space, lower-level utility, and brick architectural character.

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Restaurant with Dining Rooms and Bars

175 High Street, Portsmouth, NH 03801

$149,000

Includes a working kitchen, walk-in coolers, storage, and seasonal outdoor patio space.

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Renovated Office Condominium Unit

118 Maplewood Avenue, Portsmouth, NH 03801

$250,000

Two-room office condominium with a full bathroom, assigned parking, and immediate occupancy availability.

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Auto Shop with Overhead Doors

930 Route 1 Bypass, Portsmouth, NH 03801

$825,000

B-zoned commercial building with basement and public water service.

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Downtown Mixed-Use Property

84-88 Pleasant St, Portsmouth, NH 03801

$1,750,000

7,165 sqft

Existing shell offers a redevelopment opportunity for commercial space with residential use above.

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First-Floor Corner Office Suite

1 Cate St #1A, Portsmouth, NH 03801

$750,000

2,420 sqft

Character-rich workspace with brick walls, metal beams, city views, and on-site parking.

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First-Floor Corner Office Suite

1 Cate Street, Portsmouth, NH 03801

$750,000

2,420 sqft

Brick walls and metal beams add architectural character to a quiet workplace.

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Waterfront Restaurant Site with Full Bar

990 Lafayette Rd, Portsmouth, NH 03801

$3,600,000

17,900 sqft 2.80 AC lot

Owner-occupied restaurant with a full bar and seating for 214, positioned on a high-visibility US Rt 1 waterfront site.

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Ground-Floor Retail Condominium

53 Green St, Portsmouth, NH 03801

$1,195,000

2,828 sqft

Cold, dark shell offers flexibility for a custom commercial build-out.

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Retail Condominium Unit

135 Market Street, Unit G, Portsmouth, NH 03801

$715,000

994 sqft

Leased retail condo in a well-maintained building with prominent signage along Market Street.

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Retail Space with Loading Bays

720 Lafayette Rd, Portsmouth, NH 03801

$7,500,000

17,700 sqft

Occupied commercial space offers covered drive-up access and infrastructure for loading, unloading, and customer pickup.

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Single-Unit Office Building

330 Borthwick Ave Unit 210, Portsmouth, NH 03801

$550,000

2,132 sqft

Single-unit office property offering 2,132 SF for sale.

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Recently Built Office Units

1-54 Maplewood Ave, Portsmouth, NH 03801

$3,440,000

4,862 sqft

Downtown commercial space includes on-site parking and access to nearby public parking options.

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Renovated Medical Office Space

875 Greenland Rd C-8, Portsmouth, NH 03801

$499,000

2,178 sqft

Updated professional space offers natural light and on-site parking.

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Renovated Six-Office Condo

101-2 Greenleaf Woods Dr, Portsmouth, NH 03801

$225,000

1,418 sqft

A private kitchenette and a three-quarter bath support day-to-day office use.

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Renovated Office Condo

2 Greenleaf Woods Drive Unit: 101, Portsmouth, NH 03801

$225,000

1,418 sqft

Glass-fronted private offices, a bath, and kitchenette support a functional workplace layout.

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Renovated Office Condo Unit

2 Greenleaf Woods Drive Unit: 102, Portsmouth, NH 03801

$125,000

720 sqft

The suite combines private work areas with an open workspace and kitchenette.

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Downtown Office Condominium Suite

118 Maplewood Avenue, Unit C-1, Portsmouth, NH 03801

$415,000

951 sqft

Own a functional office condominium with private offices, a conference room, and dedicated on-site parking.

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Historic Storefront with Finished Lower Level

22 Ladd Street, Portsmouth, NH 03801

$815,000

2,072 sqft

Finished lower-level space expands the unit’s usable commercial area.

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Office Condominium with Private Offices

C1-118 Maplewood Ave, Portsmouth, NH 03801

$415,000

951 sqft

Professional suite includes three enclosed offices, a flexible conference room, kitchenette, storage, and a private restroom.

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Two-Building Flex Industrial Site

3601 Lafayette Road, Portsmouth, NH 03801

$1,300,000

2,615 sqft 4.50 AC lot

Two commercial buildings on 4.5 acres include offices and a rear workshop/warehouse with four drive-in doors.

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Portsmouth, NH Commercial Real Estate Market Trends and Statistics

Explore 72 commercial real estate for sale in Portsmouth, NH, showcased through 43 active listings on our real estate platform. These investment opportunities span a total of 114,933 square feet of properties for sale, with an estimated market value of $55,522,160.

Sale prices for business properties in Portsmouth, NH start at $94,160, averaging $1,500,598, and reaching up to $10,000,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

Portsmouth, NH CRE market trends — vacancy, lease rates and price per SF, updated monthly

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Demographics Overview

Population 23K

Population Growth (5Y) +2.9%

Median Household Income $106,520

College Educated 17.1%

High-Yield Neighborhoods for Investment

Identify Portsmouth submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

Neighborhood	Average Price
03801	$1.7M

Taxes & Financing

Tax Rate (average for all types) 1.49%

Property Tax per SF $10.47 per SF

Tax Rate vs County Average 0.23 pp below county avg

Average Loan-to-Value 65.0%

Listings Trend

New vs delisted commercial listings in Rockingham County

New Delisted

Total CRE Inventory on Market (SF)

Property Size Breakdown

The majority of commercial real estate listings in Portsmouth fall within the 100,000+ square foot range.

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