Portsmouth, NH Medical Office Space for Rent & Lease

Updated: May 26, 2022

Office Unit with Tidal Flats Views

4 greenleaf woods Drive, Portsmouth, NH 03801

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Unit 6 measures 144 sf and overlooks tidal flats and a natural area
Windows on 3 sides provide natural light and exterior views
Shared professional office setting with health care practitioners and therapists
Reception, IT/storage rooms, kitchenette, and private bath with shower
On‑site parking with access just off Route 1 at the bypass

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Updated: Aug 26

Professional Office Unit with Natural Light

4 Greenleaf Woods Dr Unit 301, Portsmouth, NH 03801

$595/Mo

6,414 sqft

144‑square‑foot Unit 6 with views toward tidal flats and a natural area
7‑office layout with reception, IT/storage rooms, kitchenette, and private bath with shower
Recently upgraded unit and building with windows on three sides
Utilities and internet included
Ample on‑site parking in a campus‑style complex

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Medical Office Space Opposite Walmart

2299 Woodbury Ave, Portsmouth, NH 03801

$2,000/Mo

Professional and medical users share a building with client parking and included utilities.

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Renovated Medical Office Space

8-875 Greenland Rd, Portsmouth, NH 03801

$15 SF/Yr

Professional space with natural light, on-site parking, and convenient access to I-95.

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Office Units with On-Site Parking

4 Greenleaf Woods Drive, Portsmouth, NH 03801

$595/Mo

6,414 sqft

Updated professional offices support healthcare and therapy practices in a campus-style setting near downtown.

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Medical Office Suite with Private Bath

301-4 Greenleaf Woods Dr, Portsmouth, NH 03801

$595/Mo

Office suite includes a private bath with shower, kitchenette, and natural light from windows on three sides.

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Based on your search, we've compiled 14 Potential Opportunities for your consideration. Besides 6 Active listings in Portsmouth, NH, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 4 Properties for Sales.

Medical Office Space for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Second-Floor Office Suite

201-155 Portsmouth Ave, Stratham, NH 03885

$3,995/Mo

3,000 sqft

Flexible professional space includes private rooms, reception, conference space, and a kitchenette.

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Office Unit With Treatment Rooms

1 Bayside Rd 101, Greenland, NH 03840

$2,150/Mo

1,519 sqft

Renovated commercial suite with multiple enclosed rooms, private bath facilities, and access to a shared parking area.

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Renovated Medical Office Suite

101-1 Bayside Rd, Greenland, NH 03840

$2,150/Mo

1,519 sqft

Renovated in 2025 with treatment rooms, private bathrooms, and laundry hookups.

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Second-Floor Office Suite

155 Portsmouth Avenue, Stratham, NH 03885

Contact for pricing

Flexible professional space with private rooms, shared work areas, parking, and convenient access in a Town Center setting.

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Similar Spaces for Sale in Portsmouth, NH

Consider Similar Space for Sale. We found 4 Spaces matching your search parameters.

Renovated Medical Office Space

875 Greenland Rd C-8, Portsmouth, NH 03801

$499,000

2,178 sqft

Updated professional space offers natural light and on-site parking.

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Compact Medical Office Condo

230 Lafayette Rd Unit 11D, Portsmouth, NH 03801

$94,160

428 sqft

A private, in-suite restroom medical office suite with ample on-site parking and easy access to major routes.

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Medical Office Condominium

330 Borthwick Avenue, Portsmouth, NH 03801

$550,000

Condominium office setting across from Portsmouth Regional Hospital with on-site parking and direct regional highway access.

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Medical Office Condominium

210-330 Borthwick Ave, Portsmouth, NH 03801

$550,000

Condominium office space across from Portsmouth Regional Hospital with accessible on-site parking and convenient regional highway connections.

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Portsmouth, NH Medical Office Space Lease Rates & Market Statistics

Explore 6 Medical Office Space listings for lease in Portsmouth, NH on Realmo, a commercial real estate exchange covering the Portsmouth area. The current inventory totals 12,828 square feet of properties.

Asking lease rates for Medical Office Space in Portsmouth start at $1.11 SF/Yr, average $8.06 SF/Yr, and reach $15 SF/Yr at the top of the market. That's a 14x spread between entry-level and premium space, making side-by-side comparison of asking rents and lease terms essential. At $8.06 SF/Yr, the local average runs 52% below New Hampshire's state average of $16.87 SF/Yr.

Portsmouth accounts for 21% of the 28 medical office space listings currently available across Rockingham County, where nearby markets include Salem and Stratham. Medical Office Space listings make up 9% of the 70 Office Spaces currently for lease in Portsmouth, with asking rates averaging $8.06 SF/Yr — 57% below the citywide Office Spaces average of $18.89 SF/Yr. Also worth a look for tenants weighing alternatives: Office Units (64 listings) and Creative space (10 listings) elsewhere in the Portsmouth market.