Portsmouth, NH Office Spaces for sale

Updated: Dec 15, 2025

Historic Office Building

144 Washington Street, Portsmouth, NH 03801

$3,300,000

0.25 AC lot

1747 Federal‑style office property with original architectural details
0.25‑acre parcel at Hancock and Washington Streets in Portsmouth
Professional office configuration with a private third‑floor office
Views toward Strawberry Banke Historic Museum, Prescott Park, and the Piscataqua River
Off‑street parking with space identified for a garage or carriage house

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Updated: Jun 10

Medical Office Condominium

330 Borthwick Avenue, Portsmouth, NH 03801

$550,000

Medical office condominium in the Jackson Gray Medical Building
Directly across from Portsmouth Regional Hospital
On‑site parking with additional accessible parking spaces
Immediate access to I‑95 and the Portsmouth Rotary
Located just off U.S. Route 1

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Renovated Office Condominium Unit

118 Maplewood Avenue, Portsmouth, NH 03801

$250,000

Two-room office condominium with a full bathroom, assigned parking, and immediate occupancy availability.

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First-Floor Corner Office Suite

1 Cate St #1A, Portsmouth, NH 03801

$750,000

2,420 sqft

Character-rich workspace with brick walls, metal beams, city views, and on-site parking.

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Ground-Floor Retail Condominium

53 Green St, Portsmouth, NH 03801

$1,195,000

2,828 sqft

Cold, dark shell offers flexibility for a custom commercial build-out.

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First-Floor Corner Office Suite

1 Cate Street, Portsmouth, NH 03801

$750,000

2,420 sqft

Brick walls and metal beams add architectural character to a quiet workplace.

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Two-Building Flex Industrial Site

3601 Lafayette Road, Portsmouth, NH 03801

$1,300,000

2,615 sqft 4.50 AC lot

Two commercial buildings on 4.5 acres include offices and a rear workshop/warehouse with four drive-in doors.

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Single-Unit Office Building

330 Borthwick Ave Unit 210, Portsmouth, NH 03801

$550,000

2,132 sqft

Single-unit office property offering 2,132 SF for sale.

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Recently Built Office Units

1-54 Maplewood Ave, Portsmouth, NH 03801

$3,440,000

4,862 sqft

Downtown commercial space includes on-site parking and access to nearby public parking options.

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Renovated Medical Office Space

875 Greenland Rd C-8, Portsmouth, NH 03801

$499,000

2,178 sqft

Updated professional space offers natural light and on-site parking.

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Renovated Six-Office Condo

101-2 Greenleaf Woods Dr, Portsmouth, NH 03801

$225,000

1,418 sqft

A private kitchenette and a three-quarter bath support day-to-day office use.

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Renovated Office Condo

2 Greenleaf Woods Drive Unit: 101, Portsmouth, NH 03801

$225,000

1,418 sqft

Glass-fronted private offices, a bath, and kitchenette support a functional workplace layout.

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Renovated Office Condo Unit

2 Greenleaf Woods Drive Unit: 102, Portsmouth, NH 03801

$125,000

720 sqft

The suite combines private work areas with an open workspace and kitchenette.

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Downtown Office Condominium Suite

118 Maplewood Avenue, Unit C-1, Portsmouth, NH 03801

$415,000

951 sqft

Own a functional office condominium with private offices, a conference room, and dedicated on-site parking.

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Office Condominium with Private Offices

C1-118 Maplewood Ave, Portsmouth, NH 03801

$415,000

951 sqft

Professional suite includes three enclosed offices, a flexible conference room, kitchenette, storage, and a private restroom.

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Historic Portsmouth Office Building For Sale

144 Washington Street, Portsmouth, NH 03801

$3,300,000

3,034 sqft

Landmark Federal-style building in Portsmouth's historic Puddle Dock area.

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Compact Medical Office Condo

230 Lafayette Rd Unit 11D, Portsmouth, NH 03801

$94,160

428 sqft

A private, in-suite restroom medical office suite with ample on-site parking and easy access to major routes.

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Medical Office Condominium

210-330 Borthwick Ave, Portsmouth, NH 03801

$550,000

Condominium office space across from Portsmouth Regional Hospital with accessible on-site parking and convenient regional highway connections.

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Bank and Office Building

40 Congress St, Portsmouth, NH 03801

$10,000,000

For-sale bank and office building located at 40 Congress Street in Portsmouth, NH.

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Street-Level Corner Office Unit

51 Islington St 3, Portsmouth, NH 03801

$465,000

Large windows and a flexible interior support open work areas alongside two enclosed private offices.

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Office Unit with Private Offices

3-51 Islington St, Portsmouth, NH 03801

$465,000

An adaptable floor plan pairs open workspace with two enclosed offices.

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Renovated Office Condominium Unit

118 Maplewood Ave Unit 5, Portsmouth, NH 03801

$250,000

Two-room commercial suite with a full bathroom and immediate occupancy.

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Corner Office Condo

51 Islington St Unit 3, Portsmouth, NH 03801

$465,000

Two private offices complement an open work area that can support varied office configurations.

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Full-Floor Office Condominium

25 Maplewood Avenue, Portsmouth, NH 03801

$4,500,000

Finished professional office condominium with a private street entrance and dedicated underground parking.

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Portsmouth, NH Office Spaces Market Trends and Statistics

Explore 72 office spaces for sale in Portsmouth, NH, showcased through 28 active listings on our real estate platform. These investment opportunities span a total of 36,577 square feet of properties for sale, with an estimated market value of $34,328,160.

Sale prices for office properties in Portsmouth, NH start at $94,160, averaging $1,373,126, and reaching up to $10,000,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

Neighborhood	Average Price
03801	$1.4M

Neighborhood

Average Price

03801

$1.4M