Portsmouth, NH Office Spaces for Sale

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28 properties

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Updated: Dec 15, 2025

Historic Office Building

144 Washington Street, Portsmouth, NH 03801

$3,300,000

0.25 AC lot

1747 Federal‑style office property with original architectural details
0.25‑acre parcel at Hancock and Washington Streets in Portsmouth
Professional office configuration with a private third‑floor office
Views toward Strawberry Banke Historic Museum, Prescott Park, and the Piscataqua River
Off‑street parking with space identified for a garage or carriage house

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Updated: Jun 10

Medical Office Condominium

330 Borthwick Avenue, Portsmouth, NH 03801

$550,000

Medical office condominium in the Jackson Gray Medical Building
Directly across from Portsmouth Regional Hospital
On‑site parking with additional accessible parking spaces
Immediate access to I‑95 and the Portsmouth Rotary
Located just off U.S. Route 1

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Waterfront Mixed-Use Property

94 Langdon Street, Portsmouth, NH 03801

$1,000,000

0.16 AC lot

Waterfront setting with existing industrial and office improvements, public utilities, and MRB zoning.

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Ground-Floor Retail Condominium

53 Green St, Portsmouth, NH 03801

$1,195,000

2,828 sqft

Cold, dark shell offers flexibility for a custom commercial build-out.

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Renovated Office Condominium Unit

118 Maplewood Avenue, Portsmouth, NH 03801

$250,000

Two-room office condominium with a full bathroom, assigned parking, and immediate occupancy availability.

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Recently Built Office Units

1-54 Maplewood Ave, Portsmouth, NH 03801

$3,440,000

4,862 sqft

Downtown commercial space includes on-site parking and access to nearby public parking options.

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Downtown Office Condominium Suite

118 Maplewood Avenue, #C1, Portsmouth, NH 03801

$450,000

951 sqft

Versatile office condo with three private offices, conference room, restroom, kitchenette, and two dedicated parking spaces.

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Historic Downtown Office Building

40 Congress Street, Portsmouth, NH 03801

$12,500,000

22,601 sqft 0.09 AC lot

CD5 zoning supports office, commercial, and mixed-use applications.

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Downtown Office Condominium Suite

118 Maplewood Avenue, Unit C-1, Portsmouth, NH 03801

$450,000

951 sqft

Own a functional office condominium with private offices, a conference room, and dedicated on-site parking.

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Office Condominium with Private Offices

C1-118 Maplewood Ave, Portsmouth, NH 03801

$450,000

951 sqft

Professional suite includes three enclosed offices, a flexible conference room, kitchenette, storage, and a private restroom.

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Two-Building Flex Industrial Site

3601 Lafayette Road, Portsmouth, NH 03801

$1,300,000

2,615 sqft 4.50 AC lot

Two commercial buildings on 4.5 acres include offices and a rear workshop/warehouse with four drive-in doors.

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Historic Portsmouth Office Building For Sale

144 Washington Street, Portsmouth, NH 03801

$3,300,000

3,034 sqft

Landmark Federal-style building in Portsmouth's historic Puddle Dock area.

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Compact Medical Office Condo

230 Lafayette Rd Unit 11D, Portsmouth, NH 03801

$94,160

428 sqft

A private, in-suite restroom medical office suite with ample on-site parking and easy access to major routes.

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Single-Unit Office Building

330 Borthwick Avenue, Portsmouth, NH 03801

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2,132 sqft

Single-unit office property offering 2,132 SF for sale.

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Medical Office Condominium Suite

200 Griffin Rd, Portsmouth, NH 03801

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2,870 sqft

Office suite includes a waiting room, reception area, nine exam rooms, private offices, and ample on-site parking.

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Class A Office Condominium

18 Congress Street, Portsmouth, NH 03801

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2,424 sqft

Leased office condominium in a mixed-use building with elevator service and dedicated structured parking.

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Medical Office Condominium

330 Borthwick Ave Unit 210, Portsmouth, NH 03801

$550,000

Professional suite in a medical building with on-site parking and accessible spaces.

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Medical Office Condominium

210-330 Borthwick Ave, Portsmouth, NH 03801

$550,000

Condominium office space across from Portsmouth Regional Hospital with accessible on-site parking and convenient regional highway connections.

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Full-Floor Office Condominium

25 Maplewood Avenue, Portsmouth, NH 03801

$4,500,000

Finished professional office condominium with a private street entrance and dedicated underground parking.

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Waterfront Land with Buildings

98 Cornwall Street, Portsmouth, NH 03801

$1,000,000

Waterfront site with existing industrial and office improvements near downtown Portsmouth.

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Second-Floor Walk-Up Office Condo

90 Fleet Street, Unit D, Portsmouth, NH 03801

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1,571 sqft

Upper-level commercial condominium with exterior signage offers office, retail, and other commercial use potential.

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Two-Unit First-Floor Office

230 Lafayette Road, Building D, Units A and B, Portsmouth, NH 03801

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1,501 sqft

Accessible professional office condominium with free parking, fiber-optic connectivity, and multiple bathrooms.

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Bank and Office Building

40 Congress Street, Portsmouth, NH 03801

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For-sale bank and office building located at 40 Congress Street in Portsmouth, NH.

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Office Units with Flexible Layout

500 Maplewood Ave # A, Portsmouth, NH 03801

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8,202 sqft

Two-level office configuration with private rooms, collaborative areas, support spaces, and unfinished expansion capacity.

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Portsmouth, NH Office Spaces Market Trends and Statistics

Explore 72 office spaces for sale in Portsmouth, NH, showcased through 28 active listings on our real estate platform. These investment opportunities span a total of 57,921 square feet of properties for sale, with an estimated market value of $35,379,160.

Sale prices for office spaces in Portsmouth, NH start at $94,160, averaging $1,862,061, and reaching up to $12,500,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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Top Commercial Asset Segments

Commercial property segments ranked by active listings on the market

Demographics Overview

Population 23K

Population Growth (5Y) +2.9%

Median Household Income $106,520

College Educated 17.1%

High-Yield Neighborhoods for Investment

Identify Portsmouth submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

Neighborhood	Average Price
03801	$1.7M

Taxes & Financing

Tax Rate (average for all types) 1.49%

Property Tax per SF $10.47 per SF

Tax Rate vs County Average 0.23 pp below county avg

Average Loan-to-Value 65.0%

Listings Trend

New vs delisted commercial listings in Rockingham County

New Delisted

Total CRE Inventory on Market (SF)

Property Size Breakdown

The majority of commercial real estate listings in Portsmouth fall within the 100,000+ square foot range.

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