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    Columbia County, FL Commercial Real Estate for Sale

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    Miami, FL Cape Coral, FL Tampa, FL
    125 results
    Highway Frontage Commercial Property
    $610,000
    3,168 SF
    Highway Frontage Commercial Property

    2832 SW MAIN BLVD., Lake City, FL 32025

    3,168 sq ft commercial property on 1.501 acres.
    • Prime highway frontage on Hwy 41 with convenient access to Interstate 75 offers excellent visibility and accessibility.
    • Zoned Commercial Intensive, allowing for a wide range of permitted business uses.
    • Spacious garage with three roll‑up doors provides ample room for storage.
    • 3,168 sq. ft. building (over 4,000 sq. ft. total) on a large 1.501‑acre lot provides ample space.
    • Mostly fenced property offers added security.
    Updated: Apr 2
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    Commercial Property in Lake City
    $795,000
    0.39 Acres
    Commercial Property in Lake City

    535 SW MAIN BLVD, Lake City, FL 32024

    Commercial property suitable for various uses, formerly a restaurant.
    • Versatile property suitable for various uses, formerly a restaurant.
    • Durable concrete and stucco construction.
    • Central heating and air conditioning.
    • Multiple flooring types including tile and linoleum.
    • Located within city limits.
    Updated: May 6
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    Lake City Office Space Available
    $198,654
    1,529 SF
    Lake City Office Space Available

    Professional office space with multiple offices, conference room, and kitchen.

    654 BAYA DR, Lake City, FL 32025

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    Lake City Commercial Aviation Land
    $300,000
    1.70 Acres
    Lake City Commercial Aviation Land

    Commercial land in North Florida Airpark community, easy I-75 access.

    TBD 5 & 6 POBEREZNY GLN, Lake City, FL 32025

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    Lake City Industrial Property
    $699,000
    15,000 SF
    Lake City Industrial Property

    15,000 SF industrial property on 1.72 acres in Lake City.

    3887 E US HIGHWAY 90, Lake City, FL 32055

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    Recreational Property Bordering National Forest
    $869,000
    1,322 SF
    Recreational Property Bordering National Forest

    105-acre recreational property near Lake City, Florida.

    1317 Northeast Drew Road, Lake City, FL 32055

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    Lake City Commercial Aviation Lot
    $150,000
    0.50 Acres
    Lake City Commercial Aviation Lot

    Commercial lot suitable for aviation or other commercial businesses.

    LOT 6 SW POBEREZNY GLEN, Lake City, FL 32025

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    Lake City Professional Office
    $295,000
    1,208 SF
    Lake City Professional Office

    Commercial office building with reception, exam rooms, and bathroom.

    1166 SW MAIN BLVD, Lake City, FL 32025

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    Commercial Lot in Lake City
    $350,000
    2.13 Acres
    Commercial Lot in Lake City

    2.13-acre commercial lot suitable for various business types.

    1563 SW CENTURY GLN (LOT 2), Lake City, FL 32025

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    Lake City Commercial Lot
    $150,000
    0.50 Acres
    Lake City Commercial Lot

    Commercial lot suitable for aviation or other business.

    LOT 5 SW POBEREZNY GLEN, Lake City, FL 32025

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    Lake City Commercial Investment Property
    $870,000
    8,800 SF
    Lake City Commercial Investment Property

    8,800 sq ft building leased to daycare center.

    258 SW Columbia Avenue, Lake City, FL 32025

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    Lake City Commercial Lot
    $200,000
    2.22 Acres
    Lake City Commercial Lot

    Commercial lot in Lake City, Florida, with diverse business potential.

    1563 SW CENTURY GLN (LOT 3), Lake City, FL 32025

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    Retail Property Near Lake City Mall
    $1,800,000
    3,607 SF
    Retail Property Near Lake City Mall

    Retail space near Walmart and Lowe's, formerly a restaurant.

    3585 NW BASCOM NORRIS, Lake City, FL 32055

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    Prime Commercial Land on Highway
    $1,250,000
    3,144 SF
    Prime Commercial Land on Highway

    5.36-acre commercial land with high-visibility frontage on W US Highway.

    4967 W US HIGHWAY 90, Lake City, FL 32055

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    Lake City Commercial Lot Available
    $400,000
    2.04 Acres
    Lake City Commercial Lot Available

    Prime commercial lot in a rapidly developing area.

    TBD SW COMMERCE DR, Lake City, FL 32025

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    North Florida Ranch with Riverfront
    $4,399,000
    2,030 SF
    North Florida Ranch with Riverfront

    391-acre ranch featuring river frontage, home, barn, and workshop.

    4639 SW WILSON SPRINGS ROAD, Fort White, FL 32038

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    Commercial Lot Near I-75
    $500,000
    3.06 Acres
    Commercial Lot Near I-75

    Commercial land in a rapidly developing area near major routes.

    TBD SW COMMERCE DR, Lake City, FL 32025

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    16.48 Acre Commercial Tract
    $3,000,000
    16.68 Acres
    16.48 Acre Commercial Tract

    16.48 acre commercial tract with high visibility and traffic.

    0 W W US HWY 90, Lake City, FL 32024

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    Commercial Lot Near I-75
    $300,000
    2.04 Acres
    Commercial Lot Near I-75

    Commercial land in a rapidly developing area near major routes.

    TBD SW COMMERCE DR, Lake City, FL 32025

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    Versatile Commercial Asset with Airbnb Units
    $2,975,000
    26,000 SF
    Versatile Commercial Asset with Airbnb Units

    Multi-functional commercial property with retail, industrial, and residential income.

    1524 NW Main Boulevard, Lake City, FL 32055

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    Main Boulevard Office Building
    $350,000
    Main Boulevard Office Building

    Class B office building with expansion and investment potential.

    229 SW MAIN Blvd, Lake City, FL 32025

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    Industrial Development Land with I-75 Exposure
    $525,000
    11.30 Acres
    Industrial Development Land with I-75 Exposure

    Expansive A-1 zoned acreage with highly visible I-75 frontage and quick access to Exit 414.

    1449 SE OCTOBER ROAD, Lake City, FL 32025

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    Commercial Lot in Developing Area
    $100,000
    1.00 Acre
    Commercial Lot in Developing Area

    Commercial lot in a rapidly developing area near major routes.

    TBD SW COMMERCE DR, Lake City, FL 32025

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    Commercial Lot in Lake City
    $250,000
    1.02 Acres
    Commercial Lot in Lake City

    Prime commercial lot in a fast-developing area near I-75.

    TBD SW COMMERCE DR, Lake City, FL 32025

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    Columbia County, FL Commercial Real Estate Investment Opportunities Market Analysis

    Explore 125 commercial real estate for sale in Columbia County, FL, showcased through 125 active listings on our real estate platform. These investment opportunities span a total of 413,353 square feet of properties for sale, with an estimated market value of $51,135,213.

    Sale prices for business properties in Columbia County, FL start at $125,000, averaging $1,503,976, and reaching up to $6,105,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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