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    Columbia County, FL Medical Office Space for Sale

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    Lehigh Acres, FL Cape Coral, FL Port Charlotte, FL
    Lake City Professional Office
    $295,000
    1,208 SF

    Lake City Professional Office

    1166 SW MAIN BLVD, Lake City, FL 32025

    Commercial office building with reception, exam rooms, and bathroom.

    • Great location on Main Blvd.
    • Previously used as a dental office, suitable for similar practices.
    • Includes 4 exam rooms/offices.
    • Reception/lobby area with front desk and window.
    • Brick construction.
    Updated: Dec 22, 2025
    View details
    Based on your search, we've compiled 80 Potential Opportunities for your consideration. Besides 1 Active listings in Columbia County, FL, we suggest exploring several alternatives: similar 75 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Prime Commercial Land Opportunity
    $365,000

    Prime Commercial Land Opportunity

    2.41 acres of commercial land with high development potential.

    702 South Marion Avenue, Lake City, FL 32025
    View details
    Keystone Heights Vacant Commercial Land
    $289,000

    Keystone Heights Vacant Commercial Land

    1.12 acre commercial land in Keystone Heights, Florida.

    COMMERCIAL Circle, Keystone Heights, FL 32656
    View details
    Prime Commercial Lot in Fanning
    $51,000
    2.13 Acres

    Prime Commercial Lot in Fanning

    2-acre commercial lot in Fanning Springs, flexible zoning.

    Trenton, FL 32693
    View details
    Commercial Land with I-295 Frontage
    $1,250,000
    85,377 SF

    Commercial Land with I-295 Frontage

    3.22 acres of commercial land with interstate frontage.

    5111 Firestone Road, Jacksonville, FL 32210
    View details

    Explore Off-Market Properties in Columbia County, FL

    Consider similar Off-Market properties in Columbia County, FL. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    4355 American Ln

    4355 American Ln

    MEDICAL BUILDING • 2,607 SF
    Value Estimation by Request
    4355 American Ln, Lake City, FL 32055-4828
    View details
    1111 Main Blvd

    1111 Main Blvd

    MEDICAL BUILDING • 3,474 SF
    Value Estimation by Request
    1111 Main Blvd, Lake City, FL 32025-5767
    View details
    1779 Barnett Way

    1779 Barnett Way

    MEDICAL BUILDING • 3,140 SF
    Value Estimation by Request
    1779 Barnett Way, Lake City, FL 32025-6957
    View details
    763 Main Blvd

    763 Main Blvd

    MEDICAL BUILDING • 8,612 SF
    Value Estimation
    $875,000
    763 Main Blvd, Lake City, FL 32025-5791
    View details
    256 Professional Gln

    256 Professional Gln

    MEDICAL BUILDING • 8,895 SF
    Value Estimation
    $2,230,000
    256 Professional Gln, Lake City, FL 32025-1104
    View details
    3140 Medical Ctr Ln

    3140 Medical Ctr Ln

    MEDICAL BUILDING • 22,498 SF
    Value Estimation
    $795,000
    3140 Medical Ctr Ln, Lake City, FL 32055-4717
    View details
    777 Duval St

    777 Duval St

    MEDICAL BUILDING • 2,760 SF
    Value Estimation by Request
    777 Duval St, Lake City, FL 32055-5806
    View details
    373 Country Clb Rd

    373 Country Clb Rd

    MEDICAL BUILDING • 1,516 SF
    Value Estimation by Request
    373 Country Clb Rd, Lake City, FL 32025-4987
    View details
    1717 Newland Way

    1717 Newland Way

    MEDICAL BUILDING • 4,050 SF
    Value Estimation by Request
    1717 Newland Way, Lake City, FL 32025-6966
    View details
    255 Main Blvd

    255 Main Blvd

    MEDICAL BUILDING • 1,736 SF
    Value Estimation by Request
    255 Main Blvd, Lake City, FL 32025-7050
    View details
    782 Sisters Welcome Rd

    782 Sisters Welcome Rd

    MEDICAL BUILDING • 4,294 SF
    Value Estimation by Request
    782 Sisters Welcome Rd, Lake City, FL 32025-0442
    View details
    4520 Us Hwy 90

    4520 Us Hwy 90

    MEDICAL BUILDING • 7,915 SF
    Value Estimation
    $2,540,000
    4520 Us Hwy 90, Lake City, FL 32055-8341
    View details
    438 Perimeter Gln

    438 Perimeter Gln

    MEDICAL BUILDING • 5,174 SF
    Value Estimation
    $865,000
    438 Perimeter Gln, Lake City, FL 32025-0497
    View details
    289 Stonegate Ter

    289 Stonegate Ter

    MEDICAL BUILDING • 20,379 SF
    Value Estimation
    $4,900,000
    289 Stonegate Ter, Lake City, FL 32024-3456
    View details
    272 Bentley Pl

    272 Bentley Pl

    MEDICAL BUILDING • 6,960 SF
    Value Estimation
    $810,000
    272 Bentley Pl, Lake City, FL 32025-6972
    View details
    875 State Rd 47

    875 State Rd 47

    MEDICAL BUILDING • 2,579 SF
    Value Estimation by Request
    875 State Rd 47, Lake City, FL 32025-0433
    View details
    457 Perimeter Gln

    457 Perimeter Gln

    MEDICAL BUILDING • 5,172 SF
    Value Estimation by Request
    457 Perimeter Gln, Lake City, FL 32025-0498
    View details
    4812 Us Hwy 90

    4812 Us Hwy 90

    MEDICAL BUILDING • 9,280 SF
    Value Estimation by Request
    4812 Us Hwy 90, Lake City, FL 32055-5126
    View details
    449 Baya Dr

    449 Baya Dr

    MEDICAL BUILDING • 4,332 SF
    Value Estimation by Request
    449 Baya Dr, Lake City, FL 32025-6022
    View details
    4241 American Ln

    4241 American Ln

    MEDICAL BUILDING • 5,566 SF
    Value Estimation
    $545,000
    4241 American Ln, Lake City, FL 32055-4881
    View details
    179 Prosperity Pl

    179 Prosperity Pl

    MEDICAL BUILDING • 11,142 SF
    Value Estimation
    $7,355,000
    179 Prosperity Pl, Lake City, FL 32024-0683
    View details
    1297 State Rd 47

    1297 State Rd 47

    MEDICAL BUILDING • 1,836 SF
    Value Estimation by Request
    1297 State Rd 47, Lake City, FL 32025-0484
    View details
    2400 State Rd 47

    2400 State Rd 47

    MEDICAL BUILDING • 1,408 SF
    Value Estimation by Request
    2400 State Rd 47, Lake City, FL 32025-9725
    View details

    Columbia County, FL Medical Office Space Investment Opportunities Market Analysis

    Explore 76 medical office space for sale in Columbia County, FL on our real estate platform. These investment opportunities span a total of 2,375,183 square feet of properties for sale, with an estimated market value of $36,690,000.

    Sale prices for medical spaces in Columbia County, FL start at $50,000, averaging $611,500, and reaching up to $9,290,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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