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    Columbia County, FL Medical Office Space for Sale

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    Miami, FL Tampa, FL Cape Coral, FL
    Lake City Professional Office
    $295,000
    1,208 SF
    Lake City Professional Office

    1166 SW MAIN BLVD, Lake City, FL 32025

    Commercial office building with reception, exam rooms, and bathroom.
    • Great location on Main Blvd.
    • Previously used as a dental office, suitable for similar practices.
    • Includes 4 exam rooms/offices.
    • Reception/lobby area with front desk and window.
    • Brick construction.
    Updated: Dec 22, 2025
    View details
    Based on your search, we've compiled 76 Potential Opportunities for your consideration. Besides 1 Active listings in Columbia County, FL, we suggest exploring several alternatives: similar 71 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Prime Commercial Land Opportunity
    $365,000
    2.41 Acres
    Prime Commercial Land Opportunity

    2.41 acres of commercial land with high development potential.

    702 South Marion Avenue, Lake City, FL 32025

    View details
    Keystone Heights Vacant Commercial Land
    $289,000
    Keystone Heights Vacant Commercial Land

    1.12 acre commercial land in Keystone Heights, Florida.

    COMMERCIAL Circle, Keystone Heights, FL 32656

    View details
    Commercial Land with I-295 Frontage
    $1,250,000
    85,377 SF
    Commercial Land with I-295 Frontage

    3.22 acres of commercial land with interstate frontage.

    5111 Firestone Road, Jacksonville, FL 32210

    View details
    Arlington Land Parcel For Sale
    $150,000
    0.40 Acres
    Arlington Land Parcel For Sale

    0.40 acre commercial land parcel in Jacksonville, Florida.

    949 CESERY Boulevard, Jacksonville, FL 32211

    View details

    Off-Market Properties in Columbia County, FL

    Consider similar Off-Market properties in Columbia County, FL. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    4355 American Ln
    MEDICAL BUILDING
    2,607 SF Lot: 0.46 Acres
    Value Estimation by Request

    4355 American Ln, Lake City, FL 32055-4828

    View details
    1111 Main Blvd
    MEDICAL BUILDING
    3,474 SF Lot: 0.30 Acres
    Value Estimation by Request

    1111 Main Blvd, Lake City, FL 32025-5767

    View details
    1779 Barnett Way
    MEDICAL BUILDING
    3,140 SF Lot: 0.63 Acres
    Value Estimation by Request

    1779 Barnett Way, Lake City, FL 32025-6957

    View details
    763 Main Blvd
    MEDICAL BUILDING
    8,612 SF Lot: 0.44 Acres
    Estimated value
    $875,000

    763 Main Blvd, Lake City, FL 32025-5791

    View details
    256 Professional Gln
    MEDICAL BUILDING
    8,895 SF Lot: 1.95 Acres
    Estimated value
    $2,230,000

    256 Professional Gln, Lake City, FL 32025-1104

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    3140 Medical Ctr Ln
    MEDICAL BUILDING
    22,498 SF Lot: 0.60 Acres
    Estimated value
    $795,000

    3140 Medical Ctr Ln, Lake City, FL 32055-4717

    View details
    777 Duval St
    MEDICAL BUILDING
    2,760 SF Lot: 0.20 Acres
    Value Estimation by Request

    777 Duval St, Lake City, FL 32055-5806

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    373 Country Clb Rd
    MEDICAL BUILDING
    1,516 SF Lot: 0.30 Acres
    Value Estimation by Request

    373 Country Clb Rd, Lake City, FL 32025-4987

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    1717 Newland Way
    MEDICAL BUILDING
    4,050 SF Lot: 0.51 Acres
    Value Estimation by Request

    1717 Newland Way, Lake City, FL 32025-6966

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    255 Main Blvd
    MEDICAL BUILDING
    1,736 SF Lot: 0.12 Acres
    Value Estimation by Request

    255 Main Blvd, Lake City, FL 32025-7050

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    782 Sisters Welcome Rd
    MEDICAL BUILDING
    4,294 SF Lot: 9.00 Acres
    Value Estimation by Request

    782 Sisters Welcome Rd, Lake City, FL 32025-0442

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    4520 Us Hwy 90
    MEDICAL BUILDING
    7,915 SF Lot: 1.16 Acres
    Estimated value
    $2,540,000

    4520 Us Hwy 90, Lake City, FL 32055-8341

    View details
    438 Perimeter Gln
    MEDICAL BUILDING
    5,174 SF Lot: 0.66 Acres
    Estimated value
    $865,000

    438 Perimeter Gln, Lake City, FL 32025-0497

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    289 Stonegate Ter
    MEDICAL BUILDING
    20,379 SF Lot: 2.07 Acres
    Estimated value
    $4,900,000

    289 Stonegate Ter, Lake City, FL 32024-3456

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    272 Bentley Pl
    MEDICAL BUILDING
    6,960 SF Lot: 1.04 Acres
    Estimated value
    $810,000

    272 Bentley Pl, Lake City, FL 32025-6972

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    875 State Rd 47
    MEDICAL BUILDING
    2,579 SF Lot: 0.73 Acres
    Value Estimation by Request

    875 State Rd 47, Lake City, FL 32025-0433

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    457 Perimeter Gln
    MEDICAL BUILDING
    5,172 SF Lot: 0.69 Acres
    Value Estimation by Request

    457 Perimeter Gln, Lake City, FL 32025-0498

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    4812 Us Hwy 90
    MEDICAL BUILDING
    9,280 SF Lot: 0.75 Acres
    Value Estimation by Request

    4812 Us Hwy 90, Lake City, FL 32055-5126

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    449 Baya Dr
    MEDICAL BUILDING
    4,332 SF Lot: 0.63 Acres
    Value Estimation by Request

    449 Baya Dr, Lake City, FL 32025-6022

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    4241 American Ln
    MEDICAL BUILDING
    5,566 SF Lot: 0.73 Acres
    Estimated value
    $545,000

    4241 American Ln, Lake City, FL 32055-4881

    View details
    179 Prosperity Pl
    MEDICAL BUILDING
    11,142 SF Lot: 1.54 Acres
    Estimated value
    $7,355,000

    179 Prosperity Pl, Lake City, FL 32024-0683

    View details
    1297 State Rd 47
    MEDICAL BUILDING
    1,836 SF Lot: 2.04 Acres
    Value Estimation by Request

    1297 State Rd 47, Lake City, FL 32025-0484

    View details
    2400 State Rd 47
    MEDICAL BUILDING
    1,408 SF Lot: 0.53 Acres
    Value Estimation by Request

    2400 State Rd 47, Lake City, FL 32025-9725

    View details

    Columbia County, FL Medical Office Space Investment Opportunities Market Analysis

    Explore 72 medical office space for sale in Columbia County, FL on our real estate platform. These investment opportunities span a total of 1,208 square feet of properties for sale, with an estimated market value of $295,000.

    Sale prices for medical spaces in Columbia County, FL start at $295,000, averaging $295,000, and reaching up to $295,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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