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    Oconee County, SC Commercial Real Estate for Lease

    18 results
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    Office Space Near Clemson
    $4,000 / Mo
    26,136 SF

    Office Space Near Clemson

    865 Old Clemson Hwy, Seneca, SC 29678

    Two-level office building suitable for various businesses, near Clemson.

    • Close proximity to Clemson and Seneca
    • Suitable for various business types and offices
    • Potential conversion to medical or dental office
    • Two levels with separate entrances
    • Multiple offices and restrooms on each level
    Updated: Aug 7, 2025
    View details
    Office Space in Seneca, SC
    $2,500 / Mo
    26,136 SF

    Office Space in Seneca, SC

    865 Old Clemson Hwy, Seneca, SC 29678

    Commercial office space available for lease in Seneca, South Carolina.

    • Central heating for those chilly nights.
    • Electric heating available as well.
    • Central air to keep you cool and comfortable.
    • Enjoy electric cooling options.
    • Built in 1997.
    Updated: Nov 11, 2025
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    Professional Office Space in Seneca
    $2,200 / Mo
    30,056 SF

    Professional Office Space in Seneca

    Office space near downtown Seneca with utilities included.

    815 Robin Dr Unit, Seneca, SC 29678
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    Move-in Ready Office Space
    $2,200 / Mo
    15,246 SF

    Move-in Ready Office Space

    Well-maintained office space in established professional park, ready for occupancy.

    111 N Earle St, Walhalla, SC 29691
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    Seneca Office Space For Lease
    $1,500 / Mo
    26,136 SF

    Seneca Office Space For Lease

    Two-level office building suitable for various businesses, near Clemson.

    865 Old Clemson Hwy, Seneca, SC 29678
    View details
    Remodeled Restaurant Space on Main
    $2,000 / Mo
    2,614 SF

    Remodeled Restaurant Space on Main

    Prime restaurant property in a high-traffic, growing tourist area.

    100 W Main St, Walhalla, SC 29691
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    Downtown Seneca Commercial Space Available
    $2,700 / Mo

    Downtown Seneca Commercial Space Available

    Commercial space for rent in downtown Seneca with street frontage.

    104 North 1St St, Seneca, SC 29678
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    Applewood Shopping Center Opportunity
    Contact for pricing
    244,693 SF

    Applewood Shopping Center Opportunity

    High-traffic retail center near Clemson University

    201 Applewood Center Pl, Seneca, SC 29678
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    401 Oconee Ave
    Contact for pricing
    170,417 SF

    401 Oconee Ave

    Distribution properties • 170,417 SF

    401 Oconee Ave, Westminster, SC 29693
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    Seneca Office Space For Rent
    $15 SF/Yr
    2,900 SF

    Seneca Office Space For Rent

    Office space in the heart of Seneca, ample parking.

    735 N Townville St, Seneca, SC 29678
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    Retail Space Near Clemson University
    $21 SF/Yr
    43,000 SF

    Retail Space Near Clemson University

    End-cap retail space with drive-thru potential near Clemson University.

    1085 Old Clemson Hwy, Seneca, SC 29672
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    Restaurant Space Near Oconee Medical
    Contact for pricing
    16,000 SF

    Restaurant Space Near Oconee Medical

    1,600 SF 2nd Gen Restaurant Space Available For Rent.

    201-273 Applewood Center Pl, Seneca, SC 29678
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    Seneca Office/Retail Space Available
    $15 SF/Yr
    4,800 SF

    Seneca Office/Retail Space Available

    Office and retail spaces for lease in Seneca, South Carolina.

    12019 North Radio Station Rd, Seneca, SC 29678
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    Retail Space Near Oconee Medical
    Contact for pricing
    1,600 SF

    Retail Space Near Oconee Medical

    Retail space available near Oconee Medical Center and Clemson University.

    101 Applewood Center Pl, Seneca, SC 29678
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    West Union Office Space Available
    $10 SF/Yr
    4,800 SF

    West Union Office Space Available

    Office space available for rent in West Union, SC.

    153 Scenic Plaza Dr, West Union, SC 29696
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    Westminster Commercial Property For Rent
    Contact for pricing

    Westminster Commercial Property For Rent

    Commercial property available for rent in Westminster, South Carolina.

    East Main And S Piedmont St, Westminster, SC 29693
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    Retail Opportunity Near Walmart
    Contact for pricing

    Retail Opportunity Near Walmart

    Retail space available for lease, GL, or build-to-suit.

    1637 Sandifer Blvd, Seneca, SC 29678
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    Retail Opportunity Near Walmart
    Contact for pricing

    Retail Opportunity Near Walmart

    Retail space available for lease near Walmart and hospital.

    Seneca, SC 29678
    View details
    Based on your search, we've compiled 71 Potential Opportunities for your consideration. Besides 18 Active listings in Oconee County, SC, we suggest exploring alternatives. Similar 53 Properties for Sales.

    Explore Similar Spaces for Sale in Oconee County, SC

    Consider Similar Space for Sale. We found 53 Spaces in Nearby Locations matching your search parameters.

    Commercial Building on Highway 28
    $579,000
    0.77 Acres

    Commercial Building on Highway 28

    Meticulously maintained commercial building with high visibility and ample parking.

    3691 Blue Ridge Blvd, Walhalla, SC 29691
    View details
    Seneca Commercial Buildings For Sale
    $450,000
    1.02 Acres

    Seneca Commercial Buildings For Sale

    Two industrial buildings with flexible space and manufacturing potential.

    306 Byp Unit Building B And, Seneca, SC 29678
    View details
    Prime Retail Property on Main
    $869,000
    0.47 Acres

    Prime Retail Property on Main

    High-visibility retail property with income potential in growing Walhalla, SC.

    100 W Main St, Walhalla, SC 29691
    View details
    Westminster Commercial Building for Sale
    $395,000
    0.29 Acres

    Westminster Commercial Building for Sale

    Commercial building suitable for medical or business office use.

    104 W Oak Hwy, Westminster, SC 29693
    View details
    Charming Commercial Building on Highway 123
    $195,000

    Charming Commercial Building on Highway 123

    Retail or restaurant opportunity on high-traffic Highway 123 in Westminster.

    3518 Toccoa Hwy, Westminster, SC 29693
    View details
    Move-in Ready Office Space
    $349,900
    0.35 Acres

    Move-in Ready Office Space

    Well-maintained office space in established park, ideal for professionals.

    111 N Earle St, Walhalla, SC 29691
    View details

    Oconee County, SC Commercial Real Estate Leasing Opportunities Market Analysis

    Explore Commercial Real Estate leasing options in Oconee County, SC with 71 listings featured on our commercial real estate exchange. The current inventory includes 21,343,790,181 square feet of properties with an estimated lease value of $83,984.

    Estimated lease rates for Commercial Real Estate in Oconee County, SC begin at $1.15 SF/Yr, with an average of $6,998 /Mo and extend to $72,000.

    In Oconee County, SC, current lease rates show:

    • Office Properties & Spaces positioned at $1,107
    • Office space measuring $1,420
    • Retail properties assessed at $514
    • Individual retail properties calculated at $19
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