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    Sikeston, MO Commercial Real Estate for Lease

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    Downtown Sikeston Commercial Property
    $4,500 / Mo
    4,273 SF

    Downtown Sikeston Commercial Property

    202 S Kingshighway St, Sikeston, MO 63801

    Versatile commercial space in downtown Sikeston ready for lease.

    • Prime downtown Sikeston location on a corner lot.
    • Large 7,638 sq ft building suitable for various business purposes.
    • Handicap accessible with ramp, parking, and restrooms.
    • Includes 15 parking spaces (2 handicap accessible).
    • Flexible layout with open spaces, offices, conference room, and break room.
    Updated: Jul 10, 2025
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    Sikeston Warehouse Space Available
    $5,000 / Mo
    20,000 SF

    Sikeston Warehouse Space Available

    300 Matthews Ln, Sikeston, MO 63801

    Warehouse space for lease in Sikeston, Missouri.

    • Versatile Space: Option for two separate units (20,000 sf and 4,700 sf) or combined into one.
    • High Ceiling: Benefit from the 18' ceiling height in the 20,000 sf front unit.
    • Multiple Loading Docks: Features 2 dock doors with levelers and three 12 x 14 overhead doors.
    • Large Front Unit: 20,000 sf front unit with 25' bays and concrete floor.
    • Functional Back Unit: 4,700 sf back unit includes a shop area, 3 offices, 3 bathrooms, and lockable storage.
    Updated: Oct 24, 2025
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    Sikeston Warehouse Space Available
    $1,500 / Mo
    4,700 SF

    Sikeston Warehouse Space Available

    Warehouse space for rent in Sikeston, Missouri.

    300 Matthews Ln, Sikeston, MO 63801
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    Sikeston Office Suite For Rent
    $3,625 / Mo
    2,000 SF

    Sikeston Office Suite For Rent

    Recently-built office suite with four offices, bathroom, and kitchenette.

    912 S Main St, Sikeston, MO 63801
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    Retail Space in Sikeston, MO
    $12 SF/Yr
    2,900 SF

    Retail Space in Sikeston, MO

    Retail space available in grocery store anchored shopping center.

    925-1077 Malone Ave, Sikeston, MO 63801
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    Based on your search, we've compiled 29 Potential Opportunities for your consideration. Besides 5 Active listings in Sikeston, MO, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 20 Properties for Sales.

    Explore Commercial Real Estate for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Charleston Retail Space - Main Street
    Contact for pricing
    8,351 SF

    Charleston Retail Space - Main Street

    High-traffic retail space, 8,351 sq ft.

    601 Main St, Charleston, MO 63834
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    Commercial Building Near Charleston, MO
    $1,200 / Mo
    746 SF

    Commercial Building Near Charleston, MO

    Versatile commercial building suitable for office, retail, or medical use.

    2806 State Hwy, Charleston, MO 63834
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    Office Suite in Cape Girardeau
    $5,641 / Mo
    6,770 SF

    Office Suite in Cape Girardeau

    Office suite with high visibility and traffic in Cape Girardeau.

    450 Siemers Dr, Cape Girardeau, MO 63701
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    West Park Mall Medical Office Space
    Contact for pricing
    79,122 SF

    West Park Mall Medical Office Space

    Missouri medical office suites for lease

    3049 William St, Cape Girardeau, MO 63703
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    Explore Similar Spaces for Sale in Sikeston, MO

    Consider Similar Space for Sale. We found 20 Spaces in Nearby Locations matching your search parameters.

    Sikeston Commercial Property For Sale
    $600,000
    1.30 Acres

    Sikeston Commercial Property For Sale

    Income-producing property with commercial spaces and storage units.

    2008 N Main St, Sikeston, MO 63801
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    Historical Building in Downtown Sikeston
    $269,000
    6,321 SF

    Historical Building in Downtown Sikeston

    Two-story historic building in downtown Sikeston, ideal for investors.

    112 Front St, Sikeston, MO 63801
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    Downtown Sikeston Commercial Office Building
    $279,000
    4,273 SF

    Downtown Sikeston Commercial Office Building

    Commercial property with endless business opportunities in downtown Sikeston.

    202 S Kingshighway St, Sikeston, MO 63801
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    Sikeston Commercial Property For Sale
    $650,000
    1.28 Acres

    Sikeston Commercial Property For Sale

    Prime commercial location with high visibility and established business history.

    1105 S Main St, Sikeston, MO 63801
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    Historic Downtown Sikeston Retail Opportunity
    $299,000
    14,642 SF

    Historic Downtown Sikeston Retail Opportunity

    Two-story retail space in historic downtown Sikeston, Missouri.

    124 E Front St, Sikeston, MO 63801
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    Sikeston Retail Property For Sale
    $550,000
    1,150 SF

    Sikeston Retail Property For Sale

    Established family-owned business with high visibility for over 30 years.

    1018 Linn St, Sikeston, MO 63801
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    Sikeston Car Wash with Expansion Potential
    $1,000,000
    40,511 SF

    Sikeston Car Wash with Expansion Potential

    Turnkey car wash with expansion potential in high-demand market.

    531 N Main St, Sikeston, MO 63780
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    Sikeston Warehouse with Highway Access
    $1,100,000
    24,700 SF

    Sikeston Warehouse with Highway Access

    Large warehouse with easy access to I-55 and I-57.

    300 Matthews Ln, Sikeston, MO 63801
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    Sikeston Fourplex with Income Potential
    $360,000
    0.26 Acres

    Sikeston Fourplex with Income Potential

    Fourplex in Sikeston, MO with long-term tenants and income potential.

    416 Lake St, Sikeston, MO 63801
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    Sikeston Carwash with High Visibility
    $1,250,000
    40,946 SF

    Sikeston Carwash with High Visibility

    Turnkey carwash with high traffic, visibility, and recurring revenue.

    900 S Main St, Sikeston, MO 63801
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    Sikeston Commercial Property with Duplex
    $320,000
    4,244 SF

    Sikeston Commercial Property with Duplex

    Commercial building, duplex, and storage on a large lot.

    101-103 Donald Fulton Dr, Sikeston, MO 63801
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    Sikeston Flex Space: Prime Industrial
    $460,000
    19,498 SF

    Sikeston Flex Space: Prime Industrial

    19,498 SF Flex Building, 1.8 Acres

    205 New Madrid St, Sikeston, MO 63801
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    Sikeston Industrial Warehouse For Sale
    Contact for pricing
    0.31 Acres

    Sikeston Industrial Warehouse For Sale

    Prime Missouri Warehouse, High Visibility

    1240 Main St, Sikeston, MO 63801
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    Sikeston Commercial Building - Huge Potential
    $460,000
    1.80 Acres

    Sikeston Commercial Building - Huge Potential

    Versatile facility, ample parking, leaseback option.

    205 New Madrid St, Sikeston, MO 63801
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    Sikeston Commercial Building For Sale
    $239,000

    Sikeston Commercial Building For Sale

    Prime Sikeston location, great investment opportunity.

    1637 Malone Ave, Sikeston, MO 63801
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    Sikeston Commercial Property - High Income Potential
    $565,000
    1.28 Acres

    Sikeston Commercial Property - High Income Potential

    Versatile Commercial Building w/ Apartment & Billboard Income

    475 Western Dr, Sikeston, MO 63801
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    Sikeston Commercial Property: Prime Location
    $450,000
    1.24 Acres

    Sikeston Commercial Property: Prime Location

    Historic Church & Multi-Purpose Building

    306 Kingshighway St, Sikeston, MO 63801
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    Sikeston Commercial Property - 5 Acres
    $485,000
    5.00 Acres

    Sikeston Commercial Property - 5 Acres

    Prime 5-acre commercial lot, versatile building.

    714 State Highway H, Sikeston, MO 63801
    View details

    Sikeston, MO Commercial Real Estate Leasing Opportunities Market Analysis

    Explore Commercial Real Estate leasing options in Sikeston, MO with 25 listings featured on our commercial real estate exchange. The current inventory includes 1,475,507,880 square feet of properties with an estimated lease value of $53 SF/Yr.

    Estimated lease rates for Commercial Real Estate in Sikeston, MO begin at $3 SF/Yr, with an average of $10 SF/Yr and extend to $21 SF/Yr.

    In Sikeston, MO, current lease rates show:

    • Industrial properties positioned at $3
    • Office Properties & Spaces measuring $17
    • Office space assessed at $17
    • Other warehouses calculated at $3
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    Popular Searches in Sikeston, MO

    Most Searched ZIP Codes in Sikeston, MO

    • 63801
    • 65501

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