Sign Up Successful!
You now have access to more from Realmo!
    For Lease
    • For Sale
    • For Lease
    • Recently Sold
    • Property Lookup
    • Brokers
    Space Uses
    • Retail
    • Restaurant
    • Office
    • Coworking
    • Medical Space
    • Automotive
    • Industrial
    • Warehouse
    • Flex
    Price
    Price range
    $
    $
    Size
    Property size / sq.ft.
    AI Search

    Sikeston, MO Commercial Real Estate for Lease

    6 results
    List
    Map
    Sikeston Warehouse Space Available
    $5,000 / Mo
    20,000 SF

    Sikeston Warehouse Space Available

    300 Matthews Ln, Sikeston, MO 63801

    Warehouse space for lease in Sikeston, Missouri.

    • Versatile Space: Option for two separate units (20,000 sf and 4,700 sf) or combined into one.
    • High Ceiling: Benefit from the 18' ceiling height in the 20,000 sf front unit.
    • Multiple Loading Docks: Features 2 dock doors with levelers and three 12 x 14 overhead doors.
    • Large Front Unit: 20,000 sf front unit with 25' bays and concrete floor.
    • Functional Back Unit: 4,700 sf back unit includes a shop area, 3 offices, 3 bathrooms, and lockable storage.
    Updated: Oct 24, 2025
    View details
    Sikeston Warehouse Space Available
    $1,500 / Mo
    4,700 SF

    Sikeston Warehouse Space Available

    300 Matthews Ln, Sikeston, MO 63801

    Warehouse space for rent in Sikeston, Missouri.

    • 20,000 sf front unit with 25' bays and an impressive 18' ceiling height.
    • Potential for two separate spaces or one combined unit to suit your needs.
    • Two dock doors with levelers ensure efficient loading and unloading.
    • 4,700 sf back unit features a shop area, 3 offices, and 3 bathrooms.
    • Multiple overhead doors (12 x 14) in both units.
    Updated: Oct 24, 2025
    View details
    Sikeston Office Suite For Rent
    $3,625 / Mo
    2,000 SF

    Sikeston Office Suite For Rent

    Recently-built office suite with four offices, bathroom, and kitchenette.

    912 S Main St, Sikeston, MO 63801
    View details
    Prime Retail/Office Space Available
    $1,800 / Mo
    3,000 SF

    Prime Retail/Office Space Available

    3000 sq ft retail/office space in high-traffic Sikeston location.

    335 N Main St, Sikeston, MO 63801
    View details
    Downtown Sikeston Office Space Available
    $4,500 / Mo
    4,273 SF

    Downtown Sikeston Office Space Available

    Commercial property in downtown Sikeston ready to be leased.

    202 S Kingshighway St, Sikeston, MO 63801
    View details
    Retail Space in Sikeston, MO
    $12 SF/Yr
    2,900 SF

    Retail Space in Sikeston, MO

    Retail space available in grocery store anchored shopping center.

    925-1077 Malone Ave, Sikeston, MO 63801
    View details
    Based on your search, we've compiled 26 Potential Opportunities for your consideration. Besides 6 Active listings in Sikeston, MO, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 16 Properties for Sales.

    Explore Commercial Real Estate for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Charleston Retail Space - Main Street
    Contact for pricing
    8,351 SF

    Charleston Retail Space - Main Street

    High-traffic retail space, 8,351 sq ft.

    601 Main St, Charleston, MO 63834
    View details
    Commercial Building Near Charleston, MO
    $1,200 / Mo
    746 SF

    Commercial Building Near Charleston, MO

    Versatile commercial building suitable for office, retail, or medical use.

    2806 State Hwy, Charleston, MO 63834
    View details
    Office Suite in Cape Girardeau
    $5,641 / Mo
    6,770 SF

    Office Suite in Cape Girardeau

    Office suite with high visibility and traffic in Cape Girardeau.

    450 Siemers Dr, Cape Girardeau, MO 63701
    View details
    Retail Space Near Interstate 55
    Contact for pricing
    10,800 SF

    Retail Space Near Interstate 55

    Retail space in regional shopping hub with interstate access.

    258 Siemers Dr, Cape Girardeau, MO 63701
    View details

    Explore Similar Spaces for Sale in Sikeston, MO

    Consider Similar Space for Sale. We found 16 Spaces in Nearby Locations matching your search parameters.

    Sikeston Commercial Property For Sale
    $600,000
    1.30 Acres

    Sikeston Commercial Property For Sale

    Income-producing property with commercial spaces and storage units.

    2008 N Main St, Sikeston, MO 63801
    View details
    Downtown Sikeston Commercial Office Building
    $279,000
    4,273 SF

    Downtown Sikeston Commercial Office Building

    Commercial property with endless business opportunities in downtown Sikeston.

    202 S Kingshighway St, Sikeston, MO 63801
    View details
    Sikeston Retail Property For Sale
    $550,000
    1,150 SF

    Sikeston Retail Property For Sale

    Established family-owned business with high visibility for over 30 years.

    1018 Linn St, Sikeston, MO 63801
    View details
    Sikeston Warehouse with Highway Access
    $1,100,000
    24,700 SF

    Sikeston Warehouse with Highway Access

    Large warehouse with easy access to I-55 and I-57.

    300 Matthews Ln, Sikeston, MO 63801
    View details
    Sikeston Commercial Property with Duplex
    $320,000
    4,244 SF

    Sikeston Commercial Property with Duplex

    Commercial building, duplex, and storage on a large lot.

    101-103 Donald Fulton Dr, Sikeston, MO 63801
    View details
    Sikeston Multifamily Investment Opportunity
    Pending
    $350,000
    10,272 SF

    Sikeston Multifamily Investment Opportunity

    Multifamily property for sale in Sikeston, Missouri.

    417 Lake St, Sikeston, MO 63801
    View details
    Sikeston Multifamily Investment Opportunity
    $375,000
    0.26 Acres

    Sikeston Multifamily Investment Opportunity

    Four-unit property with recent roof, financials available upon request.

    416 Lake St, Sikeston, MO 63801
    View details
    Sikeston Flex Space: Prime Industrial
    $460,000
    19,498 SF

    Sikeston Flex Space: Prime Industrial

    19,498 SF Flex Building, 1.8 Acres

    205 New Madrid St, Sikeston, MO 63801
    View details
    Sikeston Industrial Warehouse For Sale
    Contact for pricing
    0.31 Acres

    Sikeston Industrial Warehouse For Sale

    Prime Missouri Warehouse, High Visibility

    1240 Main St, Sikeston, MO 63801
    View details
    Sikeston Commercial Building - Huge Potential
    $460,000
    1.80 Acres

    Sikeston Commercial Building - Huge Potential

    Versatile facility, ample parking, leaseback option.

    205 New Madrid St, Sikeston, MO 63801
    View details
    Sikeston Commercial Building For Sale
    $239,000

    Sikeston Commercial Building For Sale

    Prime Sikeston location, great investment opportunity.

    1637 Malone Ave, Sikeston, MO 63801
    View details
    Sikeston Commercial Property - High Income Potential
    $565,000
    1.28 Acres

    Sikeston Commercial Property - High Income Potential

    Versatile Commercial Building w/ Apartment & Billboard Income

    475 Western Dr, Sikeston, MO 63801
    View details
    Sikeston Commercial Property: Prime Location
    $450,000
    1.24 Acres

    Sikeston Commercial Property: Prime Location

    Historic Church & Multi-Purpose Building

    306 Kingshighway St, Sikeston, MO 63801
    View details
    Sikeston Commercial Property - 5 Acres
    $485,000
    5.00 Acres

    Sikeston Commercial Property - 5 Acres

    Prime 5-acre commercial lot, versatile building.

    714 State Highway H, Sikeston, MO 63801
    View details
    Sikeston Commercial Building - High Traffic!
    $400,000
    0.74 Acres

    Sikeston Commercial Building - High Traffic!

    7100 sq ft, Multi-Suite, High Traffic Area

    1218 Linn St, Sikeston, MO 63801
    View details

    Sikeston, MO Commercial Real Estate Leasing Opportunities Market Analysis

    Explore Commercial Real Estate leasing options in Sikeston, MO with 22 listings featured on our commercial real estate exchange. The current inventory includes 1,606,187,880 square feet of properties with an estimated lease value of $135 SF/Yr.

    Estimated lease rates for Commercial Real Estate in Sikeston, MO begin at $6 SF/Yr, with an average of $22 SF/Yr and extend to $48 SF/Yr.

    In Sikeston, MO, current lease rates show:

    • Office Properties & Spaces positioned at $12
    • Retail properties measuring $12
    • Individual retail properties assessed at $16
    • Industrial properties calculated at $42
    List
    Map

    Popular Searches in Sikeston, MO

    Most Searched ZIP Codes in Sikeston, MO

    • 63801
    • 65501

    Select Neighborhood

    Google sign-in failed. Please try again or use another login method.
    Create New Password
    • At least 8 characters
    • Contains both letters and numbers
    • Contains uppercase and lowercase letters
    • At most 32 characters
    • Password required
    • Password reset link has expired. Please request a new one.