Mesa County, CO Commercial Real Estate for Lease

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239 properties
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Retail, Office, Medical Space Available
Retail, Office, Medical Space Available

561 25 Rd, Grand Junction, CO 81505

$18 SF/Yr
4,870 sqft

Versatile space suitable for retail, office, or medical use.

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Retail Building with Dock-High
Retail Building with Dock-High

2469 Highway 6&50, Grand Junction, CO 81505

$14,000/Mo
11,885 sqft

Large, very clean retail building featuring rear dock-high loading and prominent Highway 6 & 50 frontage.

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Professional Office Suite
Professional Office Suite

1601 Riverfront Drive, Grand Junction, CO 81501

$3,420/Mo
21,594 sqft

Office space in the Bonsai Building with shared conference room access and a back patio.

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Remodeled Retail Storefront Space
Remodeled Retail Storefront Space

2454 Highway 6&50, Grand Junction, CO 81501

$1,650/Mo

Smaller retail storefront in a remodeled Valley Plaza center, available 6/1/2026 with a 3–5 year lease term.

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Lease-to-Own Commercial Land Parcel
Lease-to-Own Commercial Land Parcel

Highway 6&50, Grand Junction, CO 81505

$9,565/Mo

Land parcel with CG zoning and a high-traffic intersection setting, suited to a range of commercial service and light industrial uses.

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Bonsai Building Office Space
Bonsai Building Office Space

1601 Riverfront Dr, Grand Junction, CO

$5,550/Mo
3,018 sqft

Professional office space with shared conference room and lake access.

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Industrial Warehouse with Yard
Industrial Warehouse with Yard

711 S 6th St, Grand Junction, CO 81501

Contact for pricing
17,276 sqft

17,276 SF industrial warehouse featuring six ground-level doors and yard.

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Office/Warehouse Flex Space Available
Office/Warehouse Flex Space Available

1048 Independent Ave, Grand Junction, CO 81505

$13.75 SF/Yr
3,400 sqft

3,400 SF office/warehouse unit in Grand Junction, CO.

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Neighborhood Office and Retail Units
Neighborhood Office and Retail Units

Fg-1460 North Ave, Grand Junction, CO 81501

$745/Mo

Flexible office and retail space with dedicated parking and illuminated signage options for small-business tenants.

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Modern Office Space with Views
Modern Office Space with Views

734 W Main St, Grand Junction, CO 81501

$25 SF/Yr
3,787 sqft

Modern office space with natural light and monument views.

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Retail Space in High-Density Hub
Retail Space in High-Density Hub

632 Market St, Grand Junction, CO

Contact for pricing
2,670 sqft

Retail space centrally located near Mesa Mall in Grand Junction.

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6,500 SF Warehouse For Lease
6,500 SF Warehouse For Lease

2210 Hwy 6 And 50, Grand Junction, CO 81505

$7.02 SF/Yr
6,500 sqft

Warehouse on 0.54 acres in high-traffic area for lease.

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Class A Office Space Available
Class A Office Space Available

760 Horizon Dr, Grand Junction, CO 81506

$31.71 SF/Yr

Professional office space with quality finishes and convenient location.

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Fruita Roundabout Upstairs Office Space
Fruita Roundabout Upstairs Office Space

156 S Park Square, Fruita, CO 81521

$12.92 SF/Yr
720 sqft

720 SF office space in Fruita's vibrant Roundabout.

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Professional Office Space Available
Professional Office Space Available

2520 W Pinyon Ave, Grand Junction, CO 81505

$21.88 SF/Yr

Second level office space in new professional business building.

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Turn-Key Restaurant on US 6
Turn-Key Restaurant on US 6

2464 US-6, Grand Junction, CO

Contact for pricing
1,200 sqft

Restaurant space for lease on a main thoroughfare.

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Professional Office Space Available
Professional Office Space Available

1601 Riverfront Dr, Grand Junction, CO 81501

$19 SF/Yr

Office space for lease with patio and lake access.

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Retail Space Available For Lease
Retail Space Available For Lease

2401 N Ave, Grand Junction, CO

Contact for pricing
8,000 sqft

Junior box and in-line retail spaces available for lease.

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Restaurant Space Near Mesa Mall
Restaurant Space Near Mesa Mall

2474 US-6, Grand Junction, CO

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3,348 sqft

Restaurant space for lease on US 6 near Mesa Mall.

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Office Space Available For Lease
Office Space Available For Lease

2515 Foresight Cir, Grand Junction, CO 81505

$28 SF/Yr

Office space for lease at 2515 Foresight Cir, Grand Junction.

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High-Traffic Land Lease Opportunity
High-Traffic Land Lease Opportunity

2210 Hwy 6 And 50, Grand Junction, CO 81505

Contact for pricing

0.88 acre commercial land for lease near I-70.

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Turn-Key Restaurant on US 6
Turn-Key Restaurant on US 6

2466 Hwy 6, Grand Junction, CO

Contact for pricing
5,231 sqft

Restaurant property for rent on US 6 in Grand Junction.

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Retail Building with Parking
Retail Building with Parking

1834-1838 N 12 St, Grand Junction, CO

Contact for pricing
22,116 sqft

Retail building near CMU campus with ample parking.

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Based on your search, we've compiled 496 Potential Opportunities for your consideration. Besides 239 Active listings in Mesa County, CO, we suggest exploring alternatives. Consider Similar 257 Spaces for Sales.

Similar Spaces for Sale in Mesa County, CO

Consider Similar Space for Sale. We found 257 Spaces matching your search parameters.

Warehouse with Office and Overhead Doors
Warehouse with Office and Overhead Doors

15757 57 1/2 Road, Collbran, CO 81624

$550,000
4,960 sqft 0.29 AC lot

Move-in ready shop/office with insulated bays, electric overhead doors, and a comfort-ready office wing.

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