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    South San Francisco, CA Commercial Real Estate for Lease

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    Belmont, CA San Bruno, CA Brisbane, CA
    113 results
    CA, South San Francisco - Spaces Oyster Point
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    Corner Office Space Available
    $2 SF/Yr
    2,621 SF
    Corner Office Space Available

    1486 Huntington Avenue, South San Francisco, CA 94080

    Prominent corner office space near transportation and shopping.
    • Excellent Location: Just off Hwy 380 and El Camino Real
    • Walking distance (0.5 miles) to San Bruno BART and Tanforan Shopping Center
    • Adjacent to new Safeway development at Discovery Station
    • Prominent corner office on the 3rd floor
    • 3 Private Offices
    Updated: Mar 25
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    South San Francisco Industrial Building
    $2 SF/Yr
    36,881 SF
    South San Francisco Industrial Building

    200 Shaw Road, South San Francisco, CA 94080

    36,881 SF industrial building with freight access and prime location.
    • Industrial Zoned/Freight Legal with 2.37 Acre Paved and Lighted Yard
    • 36,881 SF Building with Dock and Drive‑In Loading
    • Prime Location: Walk to Bart and Caltrain, 1.5 Miles to SFO
    • Direct Access to Highway 101 and Interstates 380 and 280
    • 1600 Amp/480 V Upgraded Power
    Updated: Nov 22, 2025
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    Industrial Space Near Transit Hubs
    $1.95 SF/Yr
    18,900 SF
    Industrial Space Near Transit Hubs

    Industrial property near BART, Caltrain, shopping, and life science campus.

    306 South Maple Avenue, South San Francisco, CA 94080

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    South San Francisco Warehouse Space
    $2 SF/Yr
    6,000 SF
    South San Francisco Warehouse Space

    6,000 SF office warehouse with secure yard near Hwy 101.

    150 West Harris Avenue, South San Francisco, CA 94080

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    South San Francisco Office/Lab Sublease
    Contact for pricing
    22,365 SF
    South San Francisco Office/Lab Sublease

    Full floor office/lab space available for sublease through July 2029.

    651 Gateway Boulevard, South San Francisco, CA 94080

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    Office/Warehouse Suite For Rent
    $1.75 SF/Yr
    5,180 SF
    Office/Warehouse Suite For Rent

    Office/warehouse suite featuring dock-high loading and ample parking.

    South San Francisco, CA

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    Prime Retail Space in California
    Contact for pricing
    Prime Retail Space in California

    Exceptional retail leasing opportunity in a vibrant South San Francisco location.

    200 Airport Boulevard, South San Francisco, CA 94080

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    South San Francisco Industrial Building
    Contact for pricing
    29,800 SF
    South San Francisco Industrial Building

    Freestanding industrial building with office/lab space for rent.

    250 Hillside Boulevard, South San Francisco, CA 94080

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    Oyster Point Flex/Lab Space
    Contact for pricing
    10,248 SF
    Oyster Point Flex/Lab Space

    30,140 SF flex/lab space available for lease.

    333 Oyster Point Blvd, South San Francisco, CA 94080

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    South San Francisco Industrial Space
    $19,700/Mo
    9,975 SF
    South San Francisco Industrial Space

    Industrial space for lease in South San Francisco, California.

    930 Linden Avenue, South San Francisco, CA 94080

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    Functional Lab/Office Space Available
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    8,711 SF
    Functional Lab/Office Space Available

    Prime location, functional lab/office space near transportation.

    600 Gateway Blvd, South San Francisco, CA 94080

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    South San Francisco Flex Space
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    30,491 SF
    South San Francisco Flex Space

    Flex space available for rent in South San Francisco.

    400 E Jamie Ct, South San Francisco, CA 94080

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    Class A Lab & Office
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    34,988 SF
    Class A Lab & Office

    Sublease opportunity: 34,988 SF of Class A lab & office.

    131 Oyster Point Blvd, South San Francisco, CA 94080

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    Retail Space on Airport Boulevard
    Contact for pricing
    1,977 SF
    Retail Space on Airport Boulevard

    Retail space available for lease in South San Francisco.

    200 Airport Blvd, South San Francisco, CA 94080

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    South San Francisco Warehouse Space
    $2 SF/Yr
    9,764 SF
    South San Francisco Warehouse Space

    Warehouse space for rent, convenient location near Highway 101.

    138 West Harris Avenue, South San Francisco, CA 94080

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    South San Francisco Flex Space
    $2 SF/Yr
    14,943 SF
    South San Francisco Flex Space

    Flex/industrial space available for lease in South San Francisco.

    310 Utah Avenue, South San Francisco, CA 94080

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    Industrial Space Available For Lease
    $1.75 SF/Yr
    5,180 SF
    Industrial Space Available For Lease

    Industrial property featuring 5,180 square feet available for lease.

    477 Littlefield Avenue, South San Francisco, CA 94080

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    Industrial Space Available For Lease
    $1.75 SF/Yr
    5,180 SF
    Industrial Space Available For Lease

    Industrial property featuring 5,180 square feet available for lease.

    469 Littlefield Avenue, South San Francisco, CA 94080

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    South San Francisco Industrial Space
    $1.70 SF/Yr
    10,479 SF
    South San Francisco Industrial Space

    Industrial space available for lease in South San Francisco.

    250 South Maple Avenue, South San Francisco, CA 94080

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    South San Francisco Warehouse Space
    Contact for pricing
    124,000 SF
    South San Francisco Warehouse Space

    Warehouse space with highway visibility near downtown and life science.

    720 Dubuque Avenue, South San Francisco, CA 94080

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    South San Francisco Office Space
    Contact for pricing
    14,000 SF
    South San Francisco Office Space

    14,000 sqft office space available for rent.

    1487 Huntington Ave, South San Francisco, CA 94080

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    South San Francisco Office Space
    Contact for pricing
    40,606 SF
    South San Francisco Office Space

    Office building with 40,606 square feet available for rent.

    453-467 Forbes Blvd, South San Francisco, CA 94080

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    South San Francisco Warehouse Space
    $1.50 SF/Yr
    12,104 SF
    South San Francisco Warehouse Space

    Industrial warehouse space with office, grade-level doors, and parking.

    255-263 Utah Ave, South San Francisco, CA

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    South San Francisco, CA Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in South San Francisco, CA with 113 listings featured on our commercial real estate exchange. The current inventory includes 527,349 square feet of properties with an estimated lease value of $106,306.

    Estimated lease rates for Commercial real estate in South San Francisco, CA begin at $0.55 SF/Yr, with an average of $2,657 /Mo and extend to $40,000.
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    Most Searched ZIP Codes in South San Francisco, CA

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    • 95080

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