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    Chillicothe, OH
    Office Units

    Chillicothe, OH Office Units for Sale

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    Mount Vernon, OH Kingston, OH South Salem, OH Londonderry, OH Laurelville, OH Waverly, OH Circleville, OH Ray, OH
    Main Street Retail-Office Building
    Updated: Nov 27, 2025
    Main Street Retail-Office Building

    945 E Main St, Chillicothe, OH 45601

    $159,900
    1,496 sqft
    Commercial storefront building on East Main Street in Chillicothe
    Large glass storefront for signage and display visibility
    Large open‑concept layout with a blank‑canvas interior
    Versatile use as an office, retail shop, or studio
    Numerous off‑street parking spaces for staff and customers
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    Historic Live-Work Building with Parking
    Updated: Apr 11
    Historic Live-Work Building with Parking

    192 S. Paint St., Chillicothe, OH 45601

    Contact for pricing
    4,500 sqft
    Over 4,500 sq ft of multi‑level commercial/live‑work space for an office or retailer
    Main level includes up to 7 office spaces, 2 bathrooms, and a kitchen space
    Second level offers 3 bedrooms, 2 full baths, and a kitchen with potential for additional office space or rental income
    Partially finished 3rd level provides extra living space or storage
    Updated with upgraded electrical and a new roof (about 4 years old)
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    Second-Floor Office Suites
    Second-Floor Office Suites

    50 W Main St, Chillicothe, OH 45601

    Contact for pricing

    Two second-floor office spaces are available in the historic Gazette Building with utilities included.

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    Turn Any Listing Into an Investment Snapshot Owner equity, real caprate, demand score for every listing. Go To Analytics Center
    Based on your search, we've compiled 7 Potential Opportunities for your consideration. Besides 3 Active listings in Chillicothe, OH, we suggest exploring several alternatives: 4 properties in Nearby Cities

    Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Corner Auto Repair and Retail Building
    Corner Auto Repair and Retail Building

    2758 State Route 41, Bainbridge, OH 45612

    $240,000
    8,752 sqft 0.79 AC lot

    Freestanding corner commercial building with office, two restrooms, and divided back storage for auto sales, repair, retail, or warehouse use.

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    Versatile Commercial Space on State Route
    Versatile Commercial Space on State Route

    2758 State Route 41 S, Bainbridge, OH 45612

    $240,000
    8,752 sqft 0.79 AC lot

    Corner lot commercial building suitable for warehouse, retail, or office.

    View details
    Industrial Warehouse with Office
    Industrial Warehouse with Office

    15500 Beaver Pike, Jackson, OH 45640

    $499,000
    12.00 AC lot

    Functional warehouse with attached office and concrete pad built to accommodate semis and heavy equipment.

    View details
    Professional Office Building with Parking
    Professional Office Building with Parking

    317 Broadway St, Jackson, OH 45640

    $949,000
    0.23 AC lot

    Professional office building with individual mini offices, conference rooms, reception area, and parking plus an additional lot.

    View details

    Chillicothe, OH Office Units Market Trends and Statistics

    Explore 3 office units for sale in Chillicothe, OH, showcased through 3 active listings on our real estate platform. These investment opportunities span a total of 5,996 square feet of properties for sale, with an estimated market value of $159,900.

    Sale prices for office units in Chillicothe, OH average $159,900 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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    Top Commercial Asset Segments

    Commercial property segments ranked by active listings on the market

    Office Units 3
    Medical Office Space 1
    Office buildings 1

    Demographics Overview

    Population 56K
    Population Growth (5Y) -0.5%
    Median Household Income $57,430
    College Educated 24.4%

    Taxes & Financing

    Average Loan-to-Value 65.0%

    Listings Trend

    New vs delisted commercial listings in Ross County

    New Delisted

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