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    Sikeston, MO
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    Sikeston, MO Office Units for Lease

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    Charleston, MO New Madrid, MO Scott City, MO Dexter, MO
    Multi-Office Retail-Front Suite
    Updated: Sep 23, 2025
    Multi-Office Retail-Front Suite

    912 S Main Street, Sikeston, MO 63801

    $3,625/Mo
    Offices suite in a recently built strip center; year built 2020
    Suite includes 4 finished offices, plus a bathroom and kitchenette
    Kitchenette includes a free‑standing refrigerator, with table/chairs provided
    Two entrances for convenient access for entities with public traffic
    Central air and forced‑air heating; flat rubber roof; block and concrete construction
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    New Retail/Office Space Available
    Updated: Mar 2
    New Retail/Office Space Available

    E-600 N Main Street, Sikeston, MO 63801

    $1,950/Mo
    1,300 sqft
    Prime location on N. Main Street
    Exceptional traffic and visibility
    Brand new office/retail center
    1,300 square foot space available
    Ample off‑street parking
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    Turn a Listing Into an Investment Snapshot Cap Rate, Potential NOI, Demand score for every listing. Go To Analytics Center
    Based on your search, we've compiled 9 Potential Opportunities for your consideration. Besides 2 Active listings in Sikeston, MO, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 3 Properties for Sales.

    Office Units for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Office Suite with High Visibility
    Office Suite with High Visibility

    450 Siemers Drive, Cape Girardeau, MO 63701

    $5,642/Mo
    6,770 sqft

    Turnkey office suite in a business park with central air, forced-air gas heat, and driveway parking.

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    Ground-Floor Office Suite
    Ground-Floor Office Suite

    3065 William Street #109, Cape Girardeau, MO 63703

    $7,075/Mo
    4,273 sqft

    Ground-floor suite offers 4,273 SF with great parking and signage; utilities are included except voice and data.

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    Versatile Showroom, Office, and Shop
    Versatile Showroom, Office, and Shop

    229 Airport Rd, Scott City, MO 63780

    $12,000/Mo
    8,516 sqft

    8,516 SF building with high visibility and multiple drive-throughs.

    View details
    Charleston Retail or Office Space
    Charleston Retail or Office Space

    114 W Commercial St, Charleston, MO 63834

    $6.50 SF/Yr
    3,028 sqft

    Retail or office space with excellent visibility and parking.

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    Similar Spaces for Sale in Sikeston, MO

    Consider Similar Space for Sale. We found 3 Spaces matching your search parameters.

    Flex-Industrial Headquarters Facility
    Flex-Industrial Headquarters Facility

    205 S New Madrid St, Sikeston, MO 63801

    $449,500
    19,498 sqft 1.00 AC lot

    Multi-parcel flex facility combining office infrastructure with a full-length drive-through warehouse for operations and distribution.

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    Remodeled Professional Office Building
    Remodeled Professional Office Building

    210 S Kingshighway Street, Sikeston, MO 63801

    $775,000
    1.67 AC lot

    Remodeled office building with multiple entrances, parking on three sides, and new life-safety systems.

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    Office Building with Flexible Suite Layout
    Office Building with Flexible Suite Layout

    713 Tanner, Sikeston, MO 63801

    $250,000

    Commercial zoned office building offering a flexible layout for a single suite or up to four office suites.

    View details

    Sikeston, MO Office Units Market Trends and Statistics

    Explore Office Units leasing options in Sikeston, MO with 2 listings featured on our commercial real estate exchange. The current inventory includes 1,300 square feet of properties with an estimated lease value of $18.

    Estimated lease rates for Office Units in Sikeston, MO average $18 SF/Yr.
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