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    Sikeston, MO Office Space for Lease

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    Downtown Sikeston Commercial Property
    $4,500 / Mo
    4,273 SF

    Downtown Sikeston Commercial Property

    202 S Kingshighway St, Sikeston, MO 63801

    Versatile commercial space in downtown Sikeston ready for lease.

    • Prime downtown Sikeston location on a corner lot.
    • Large 7,638 sq ft building suitable for various business purposes.
    • Handicap accessible with ramp, parking, and restrooms.
    • Includes 15 parking spaces (2 handicap accessible).
    • Flexible layout with open spaces, offices, conference room, and break room.
    Updated: Jul 10, 2025
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    Sikeston Office Suite For Rent
    $3,625 / Mo
    2,000 SF

    Sikeston Office Suite For Rent

    912 S Main St, Sikeston, MO 63801

    Recently-built office suite with four offices, bathroom, and kitchenette.

    • High visibility location on Sikeston's busiest corridor.
    • Ready for immediate occupancy with 4 finished offices.
    • Two entrances ideal for businesses with public traffic.
    • Includes a bathroom and kitchenette with refrigerator and table/chairs.
    • Located in a recently‑built (2020) strip center.
    Updated: Sep 22, 2025
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    Based on your search, we've compiled 6 Potential Opportunities for your consideration. Besides 2 Active listings in Sikeston, MO, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities

    Explore Office space for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Office Suite in Cape Girardeau
    $5,641 / Mo
    6,770 SF

    Office Suite in Cape Girardeau

    Office suite with high visibility and traffic in Cape Girardeau.

    450 Siemers Dr, Cape Girardeau, MO 63701
    View details
    Renovated Commercial Space For Lease
    $2,500 / Mo
    2,937 SF

    Renovated Commercial Space For Lease

    Renovated commercial space with high visibility in a prime location.

    230 N Sprigg St, Cape Girardeau, MO 63701
    View details
    Downtown Mixed-Use Commercial Space
    $500 / Mo
    1,200 SF

    Downtown Mixed-Use Commercial Space

    1,200 sq ft mixed-use space in historic downtown Poplar Bluff.

    106 S Main St, Poplar Bluff, MO 63901
    View details
    Versatile Commercial Space on Highway
    $4,000 / Mo
    8,000 SF

    Versatile Commercial Space on Highway

    8,000 sq ft building for lease or sale.

    2323 Cheshire Blvd, Poplar Bluff, MO 63901
    View details

    Sikeston, MO Office space Leasing Opportunities Market Analysis

    Explore Office space leasing options in Sikeston, MO with 2 listings featured on our commercial real estate exchange. The current inventory includes 273,251,880 square feet of properties with an estimated lease value of $34 SF/Yr.

    Estimated lease rates for Office space in Sikeston, MO begin at $12 SF/Yr, with an average of $17 SF/Yr and extend to $21 SF/Yr.
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    Popular Searches in Sikeston, MO

    Most Searched ZIP Codes in Sikeston, MO

    • 63801

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