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Lancaster County, SC Office Properties & Spaces for Sale

11 results
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Two Professional Buildings Near MUSC
$975,000
0.82 Acres

Two Professional Buildings Near MUSC

1201 Colonial Cmns Ct, Lancaster, SC 29720

Two professional office buildings near MUSC in Lancaster, South Carolina.

  • Prime location minutes from MUSC (Medical University of South Carolina).
  • Two professional office buildings on one property.
  • Zoned "PO" Professional Office by the City of Lancaster.
  • Building 1 features a medical office layout with 14 rooms and a wired X‑ray room.
  • New flooring and new roof installed in Building 1.
Updated: Dec 1, 2025
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Medical Office Buildings Near MUSC
$975,000

Medical Office Buildings Near MUSC

1201 Colonial Commons Ct, Lancaster, SC 29720

Two professional buildings suitable for medical or office use.

  • Prime location minutes from MUSC.
  • Two professional office buildings on one property.
  • Building 1 is set up as a medical office with 14 rooms and wired for an X‑ray room.
  • Zoned "PO" Professional Office by the City of Lancaster.
  • New flooring and roof in Building 1.
Updated: Dec 1, 2025
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Mixed-Use Commercial Property For Sale
$450,000

Mixed-Use Commercial Property For Sale

Four buildings with six potential rental opportunities on 1.6 acres.

2415 Pineview Dr, Lancaster, SC 29720
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Lancaster Light Industrial Facility
$299,000

Lancaster Light Industrial Facility

3,400 SF facility on 2 acres near Rock Hill.

1537 Lynwood Dr, Lancaster, SC 29720
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Commercial Property for Sale
Contact for pricing
1,248 SF

Commercial Property for Sale

Commercial property suitable for office, retail, or salon.

2836 Lynwood Dr, Lancaster, SC 29720
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Versatile Commercial Space For Sale
Contact for pricing

Versatile Commercial Space For Sale

Functional office space with recent renovations and convenient location.

309 N Main St, Lancaster, SC 29720
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Fort Mill Industrial Property
$12,900,000
92,926 SF

Fort Mill Industrial Property

92,926 SF Flex/Warehouse, $12.9M

11632 Harrisburg Rd, Fort Mill, SC 29707
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The Point: Indian Land Retail
Contact for pricing
1.00 Acre

The Point: Indian Land Retail

High-traffic retail & commercial development.

9425 Charlotte Hwy, Fort Mill, SC 29707
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Versatile Flex, Office, Warehouse Space
Contact for pricing
92,926 SF

Versatile Flex, Office, Warehouse Space

92,926 SF flex, office, and warehouse space for sale.

11632 Harrisburg Rd, Indian Land, SC 29707
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Lancaster Medical/Office Space Available
Contact for pricing
10,861 SF

Lancaster Medical/Office Space Available

Versatile space near MUSC Health Lancaster Medical Center.

980 N Woodland Dr, Lancaster, SC 29720
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Based on your search, we've compiled 265 Potential Opportunities for your consideration. Besides 11 Active listings in Lancaster County, SC, we suggest exploring several alternatives: similar 250 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

Potential Development Sites for Consideration

Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

Prime Commercial Land on Charlotte Highway
$2,200,000
15.55 Acres

Prime Commercial Land on Charlotte Highway

15.55 acres with high traffic and development potential.

2383 Charlotte Hwy, Lancaster, SC 29720
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Prime Development Land on Charlotte Highway
$2,200,000
15.55 Acres

Prime Development Land on Charlotte Highway

Development opportunity on a high-traffic corridor near residential developments.

2383 Charlotte Hwy, Lancaster, SC 29720
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Commercial Land in Lancaster, SC
$75,000
0.28 Acres

Commercial Land in Lancaster, SC

Prime commercial land with high visibility and easy access.

E Arch St, Lancaster, SC 29720
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Lancaster Land For Sale
$115,000
11.66 Acres

Lancaster Land For Sale

11.66 acres of wooded property in downtown Lancaster, SC.

Woodland Dr, Lancaster, SC 29720
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Explore Off-Market Properties in Lancaster County, SC

Consider similar Off-Market properties in Lancaster County, SC. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

9571 Charlotte Hwy

9571 Charlotte Hwy

Coworking space • 28,000 SF
Value Estimation by Request
9571 Charlotte Hwy, Indian Land, SC 29707
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905-933 Highway 9 Byp

905-933 Highway 9 Byp

Restaurants • 14,400 SF
Value Estimation by Request
905-933 Highway 9 Byp, Lancaster, SC 29720
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113th N Main St

113th N Main St

OFFICE (GENERAL) • 1,604 SF
Value Estimation by Request
113th N Main St, Heath Springs, SC 29058
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1830 Macmillan Park Dr

1830 Macmillan Park Dr

OFFICE (GENERAL) • 94,220 SF
Value Estimation
$15,840,000
1830 Macmillan Park Dr, Indian Land, SC 29707-7712
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9680 Old Bailes Rd

9680 Old Bailes Rd

OFFICE (GENERAL) • 60,000 SF
Value Estimation
$10,085,000
9680 Old Bailes Rd, Indian Land, SC 29707-7539
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9794 Charlotte Hwy

9794 Charlotte Hwy

OFFICE (GENERAL) • 5,200 SF
Value Estimation by Request
9794 Charlotte Hwy, Indian Land, SC 29707-8113
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8123 Charlotte Hwy

8123 Charlotte Hwy

OFFICE (GENERAL) • 5,252 SF
Value Estimation by Request
8123 Charlotte Hwy, Indian Land, SC 29707-9601
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Catawba St

Catawba St

OFFICE (GENERAL) • 2,268 SF
Value Estimation by Request
Catawba St, Lancaster, SC 29720
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Colonial Ave

Colonial Ave

OFFICE (GENERAL) • 5,148 SF
Value Estimation by Request
Colonial Ave, Lancaster, SC 29720
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122 Market St

122 Market St

OFFICE (GENERAL) • 266 SF
Value Estimation by Request
122 Market St, Lancaster, SC 29720-2552
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1003 Meeting St

1003 Meeting St

MEDICAL BUILDING • 6,041 SF
Value Estimation by Request
1003 Meeting St, Lancaster, SC 29720-2205
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1001 Meeting St

1001 Meeting St

OFFICE (GENERAL) • 11,390 SF
Value Estimation
$635,000
1001 Meeting St, Lancaster, SC 29720-2205
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201 Meeting St Ste A

201 Meeting St Ste A

MEDICAL BUILDING • 11,301 SF
Value Estimation
$505,000
201 Meeting St Ste A, Lancaster, SC 29720-2380
View details

Lancaster County, SC Office Properties & Spaces Investment Opportunities Market Analysis

Explore 261 office properties & spaces for sale in Lancaster County, SC, showcased through 11 active listings on our real estate platform. These investment opportunities span a total of 378,587,028 square feet of properties for sale, with an estimated market value of $78,410,000.

Sale prices for office spaces in Lancaster County, SC start at $55,000, averaging $580,814, and reaching up to $12,900,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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