Lancaster, PA Office Spaces for Sale

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42 properties

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Updated: Jun 18, 2025

Victorian Mixed-Use Townhouse

626 North Duke Street, Lancaster, PA 17602

$529,900

2,774 sqft

Mixed‑use building with first‑floor office and three‑bedroom apartment above
2774 SF brick townhouse built in 1878
Office includes conference room, private office, work area, and two powder rooms
Apartment spans the 2nd and 3rd floors with kitchen, laundry, and period‑style bathroom
Paved rear parking area with access from North Christian Street and egress easement to East New Street

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626 North Duke Street, Lancaster, PA 17602

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Est. Cap Rate

8.7%
Above avg (5.9%)
Est. NOI

$46K
Annual
Price @ 7% Cap

$656K
Above asking
Property Type

Religious, Church, Worship
Built 1974

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Updated: Aug 24

Turnkey Medical Office Facility

60 W WALNUT Street, Lancaster, PA 17603

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0.72 AC lot

Multiple clinical suites with dental equipment, fixtures, and furnishings in place
Flexible configuration for one multispecialty practice or multiple dental and medical users
On‑site parking at 60 W Walnut Street, Lancaster, PA 17603
0.72‑acre parcel
Central Air cooling

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Multi-Suite Medical Office Building

2445 Marietta Ave, Lancaster, PA 17601

$1,500,000

5,000 sqft 2.80 AC lot

Two suites combine a dedicated medical layout with flexible professional office space.

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Mixed-Use Property with Separate Entrances

112 W CHESTNUT STREET, Lancaster, PA 17603

$594,900

1,864 sqft

First-floor retail and office space pairs with a two-bedroom apartment above.

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Clear-Span Open Office Suite

313 W LIBERTY STREET #335, Lancaster, PA 17603

$156,135

10,409 sqft

Office suite with reception, mailroom, private restroom, server room, and large windows in a wheelchair-accessible office building.

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Medical Office Condo with Treatment Rooms

231 N Shippen St Unit 30, Lancaster, PA 17602

$199,900

2,500 sqft

Dental office configuration includes reception, treatment rooms, and dedicated storage within a professional commercial condo.

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Leased Office Condominium Units

1525 Oregon Pike, Lancaster, PA 17601

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5,000 sqft

Five office condominium units within Oregon Commons, totaling approximately 5,000 square feet, are fully leased to two tenants.

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Professional Condo in Downtown Lancaster

128 East Grant Street, Lancaster, PA 17602

$115,000

1,242 sqft

Upscale condo with offices and conference room in downtown Lancaster.

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Industrial Building with Office

216 Wohlsen Way, Lancaster, PA 17603

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29,011 sqft

Industrial building includes well-appointed office space, two dock doors, three drive-in doors, and 36 on-site parking spaces.

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Corner Office Unit with Parking

222 E ORANGE STREET #100, Lancaster, PA 17602

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1,320 sqft

Historic suite offers a glass entry, private restroom, built-in storage, and dedicated signage.

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Mixed-Use Storefront and Residence

305 N QUEEN ST, Lancaster, PA 17603

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3,316 sqft

First-floor storefront with flexible space plus an upscale 2nd- and 3rd-floor residence, suited for live-work operations.

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Office Unit With Elevator Access

415 N PRINCE STREET, Lancaster, PA 17603

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1,810 sqft

Condominium-style professional space in a restored building with parking garage access and a central Lancaster City business address.

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Office Suite with Open Floor Plan

425 N PRINCE STREET #001, Lancaster, PA 17603

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3,252 sqft

A mostly open 3,252 SF office suite with original wood beams, exposed stone walls, and natural light.

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Second-Floor Office Suite

3002 HEMPLAND ROAD #2, Lancaster, PA 17601

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882 sqft

Professional office layout with private rooms, reception space, and a conference room in a business park setting.

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Historic Building Retail/Office Suite

325 N QUEEN STREET #101, Lancaster, PA 17603

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1,420 sqft

Bright suite with large street-facing windows, private restroom, and a treatment/storage room in the Keppel Building.

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Bi-Level Office Suite with Staircase

325 N QUEEN STREET #G-03, Lancaster, PA 17603

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1,065 sqft

Bi-level suite in the historic Keppel Building with two open work areas connected by a spiral staircase.

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Downtown Lancaster Assemblage For Sale

37-45 North Duke Street, Lancaster, PA 17603

$2,295,000

30,008 sqft

Three-parcel assemblage in downtown Lancaster with single tenant net lease.

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Three-Story Brick Building For Sale

100 North Queen Street, Lancaster, PA 17603

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77,294 sqft

Three-story brick building with finished lower level and outside space.

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Mixed-Use Warehouse and Retail Building

548-550 New Holland Ave, Lancaster, PA 17602

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10,938 sqft 0.68 AC lot

Free-standing C-2 building combines retail, office, warehouse space with dock and grade-level doors, plus a second-floor apartment.

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Second-Floor Office Unit

2938 Columbia Avenue Unit 902, Lancaster, PA 17603

$151,000

1,000 sqft

Windowed suite includes private rooms, meeting space, a reception area, and a private restroom.

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Equipped Dental Medical Office

60 W WALNUT STREET, Lancaster, PA 17603

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17,150 sqft

Multiple equipped clinical suites support a dental or medical practice configuration.

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Five-Unit Mixed-Use Property

205 E King St, Lancaster, PA 17602

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3,322 sqft

First-floor commercial space supports a combination of residential and business uses in downtown Lancaster.

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Private Outdoor Viewing Deck Office Building

311 HARRISBURG AVENUE, Lancaster, PA 17603

$4,250,000

Office building converted from a tobacco warehouse with a private outdoor viewing deck into Penn Medicine Stadium.

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Historic Office Building with Carriage House

802 N Duke St, Lancaster, PA 17602

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11,680 sqft 0.50 AC lot

Renovated commercial setting with ornate architectural details, flexible interior areas, and a separate residential-style carriage house.

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Lancaster, PA Office Spaces Market Trends and Statistics

Explore 72 office spaces for sale in Lancaster, PA, showcased through 42 active listings on our real estate platform. These investment opportunities span a total of 463,103 square feet of properties for sale, with an estimated market value of $13,285,828.

Sale prices for office spaces in Lancaster, PA start at $115,000, averaging $1,207,802, and reaching up to $4,250,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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Top Commercial Asset Segments

Commercial property segments ranked by active listings on the market

Demographics Overview

Population 175K

Population Growth (5Y) +4.0%

Median Household Income $81,785

College Educated 18.8%

High-Yield Neighborhoods for Investment

Identify Lancaster submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

Neighborhood	Average Price
17602	$175K
17603	$836.6K

Taxes & Financing

Tax Rate (average for all types) 2.75%

Property Tax per SF $25.11 per SF

Tax Rate vs County Average 0.37 pp above county avg

Average Loan-to-Value 65.0%

Listings Trend

New vs delisted commercial listings in Lancaster County

New Delisted

Total CRE Inventory on Market (SF)

Property Size Breakdown

The majority of commercial real estate listings in Lancaster fall within the 100,000+ square foot range.

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