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    Picayune, MS Office Properties & Spaces for Sale

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    Prime Commercial Building in Picayune
    $399,900
    3,915 SF

    Prime Commercial Building in Picayune

    707 Memorial Blvd, Picayune, MS 39466

    Spacious commercial building with multiple suites in prime location.

    • Prime location in Picayune offering high visibility and accessibility.
    • Excellent investment opportunity for new or established businesses.
    • Located right off I‑59 and surrounded by other businesses.
    • Four possible rental suites in one building.
    • Three suites include bathrooms and kitchens.
    Updated: Dec 1, 2025
    View details
    Picayune Commercial Building For Sale
    $450,000
    3,064 SF

    Picayune Commercial Building For Sale

    2508 Highway 43 S, Picayune, MS 39466

    3,010 sq ft building on 1.02 acres near I-59.

    • High‑traffic location: Minutes from I‑59, offering excellent accessibility and visibility.
    • Versatile 3,010 sq ft building suitable for restaurant, office, or retail use.
    • Substantial 1.02‑acre lot providing ample space and potential.
    • Additional 624 sq ft storage/office building for added functionality.
    • Includes a 240 sq ft shed for extra storage.
    Updated: Nov 25, 2025
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    Picayune Commercial Building For Sale
    $379,000
    2,300 SF

    Picayune Commercial Building For Sale

    Versatile commercial building with drive-thru, excellent visibility, and ample parking.

    249 Frontage Rd, Picayune, MS 39466
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    Executive Office Space in Picayune
    Contact for pricing
    1,500 SF

    Executive Office Space in Picayune

    Private office space with conference room access in Picayune, MS.

    4100 Highway 11 North, Picayune, MS 39466
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    Renovated Office Space in Picayune
    Contact for pricing
    100 SF

    Renovated Office Space in Picayune

    Newly renovated office space in Picayune's Historic District.

    111 Highway 11 S, Picayune, MS 39466
    View details
    Based on your search, we've compiled 253 Potential Opportunities for your consideration. Besides 5 Active listings in Picayune, MS, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 240 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

    Explore Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Prime 2.29 Acre Commercial Land
    Contact for pricing
    2.29 Acres

    Prime 2.29 Acre Commercial Land

    High-traffic I-59 interchange site, ideal for development.

    0 Military Rd, Pearl River, LA 70452
    View details
    Bogalusa Commercial Property with Expansion
    $400,000
    5,200 SF

    Bogalusa Commercial Property with Expansion

    Well-maintained medical/office building on 1.7 acres with expansion potential.

    15126 La-21 None, Bogalusa, LA 70427
    View details
    Prime Bogalusa Office Building
    $199,000
    19,005 SF

    Prime Bogalusa Office Building

    19,005 SF Office, Owner/User Opportunity

    525 Avenue V, Bogalusa, LA 70427
    View details
    Prime Pearl River Agricultural Land
    $1,349,924
    3.10 Acres

    Prime Pearl River Agricultural Land

    3.1-acre tract, ideal for diverse uses. Excellent investment opportunity.

    1090 Aka Military Rd And Cleo Rd, Pearl River, LA 70452
    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Picayune Land Parcel For Sale
    $69,900
    2.05 Acres

    Picayune Land Parcel For Sale

    2.053 acre parcel in growing area, suitable for commercial uses.

    Nhn Golf Crse Dr, Picayune, MS 39466
    View details
    Picayune Vacant Commercial Lot
    $249,000
    1.74 Acres

    Picayune Vacant Commercial Lot

    Commercial lot in a desirable location near Highway 43.

    Parcel C Nhn Wildwood St, Picayune, MS 39466
    View details
    High Visibility Commercial Lot For Sale
    $549,000
    1.04 Acres

    High Visibility Commercial Lot For Sale

    Commercial lot for sale or lease in high-traffic location.

    105 Highland Pkwy, Picayune, MS 39466
    View details
    Highway Frontage Commercial Land
    $720,000
    21.16 Acres

    Highway Frontage Commercial Land

    Undeveloped commercial land with highway frontage in Picayune, MS.

    Nhn Hwy 43 North, Picayune, MS 39466
    View details

    Explore Off-Market Properties in Picayune, MS

    Consider similar Off-Market properties in Picayune, MS. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    124 Kirkwood St

    124 Kirkwood St

    OFFICE BUILDING • 2,240 SF
    Value Estimation by Request
    124 Kirkwood St, Picayune, MS 39466-3866
    View details
    1230 Martin Luther King Blvd

    1230 Martin Luther King Blvd

    OFFICE BUILDING • 3,200 SF
    Value Estimation by Request
    1230 Martin Luther King Blvd, Picayune, MS 39466-5427
    View details
    100 Polymer Dr

    100 Polymer Dr

    OFFICE BUILDING • 2,607 SF
    Value Estimation by Request
    100 Polymer Dr, Picayune, MS 39466-5441
    View details
    6th Ave

    6th Ave

    OFFICE BUILDING • 1,200 SF
    Value Estimation by Request
    6th Ave, Picayune, MS 39466
    View details
    6th Ave

    6th Ave

    OFFICE BUILDING • 1,800 SF
    Value Estimation by Request
    6th Ave, Picayune, MS 39466
    View details
    6th Ave

    6th Ave

    OFFICE BUILDING • 1,854 SF
    Value Estimation by Request
    6th Ave, Picayune, MS 39466
    View details
    215 Telly Rd

    215 Telly Rd

    OFFICE BUILDING • 1,925 SF
    Value Estimation by Request
    215 Telly Rd, Picayune, MS 39466-5363
    View details
    Picayune, MS 39466

    Picayune, MS 39466

    OFFICE BUILDING • 997 SF
    Value Estimation by Request
    Picayune, MS 39466
    View details
    7 Bennett St

    7 Bennett St

    OFFICE BUILDING • 800 SF
    Value Estimation by Request
    7 Bennett St, Picayune, MS 39466-3030
    View details
    615 Canal St

    615 Canal St

    OFFICE BUILDING • 1,768 SF
    Value Estimation by Request
    615 Canal St, Picayune, MS 39466-3916
    View details
    510 Canal St

    510 Canal St

    OFFICE BUILDING • 822 SF
    Value Estimation by Request
    510 Canal St, Picayune, MS 39466-4514
    View details
    110 Canal St

    110 Canal St

    OFFICE BUILDING • 2,070 SF
    Value Estimation by Request
    110 Canal St, Picayune, MS 39466-4506
    View details
    722 Canal St

    722 Canal St

    OFFICE BUILDING • 1,124 SF
    Value Estimation by Request
    722 Canal St, Picayune, MS 39466-3900
    View details
    789 Ceasar Rd

    789 Ceasar Rd

    OFFICE BUILDING • 2,400 SF
    Value Estimation by Request
    789 Ceasar Rd, Picayune, MS 39466-8872
    View details
    114 Elizabeth St

    114 Elizabeth St

    OFFICE BUILDING • 2,700 SF
    Value Estimation by Request
    114 Elizabeth St, Picayune, MS 39466-4402
    View details
    241 Frontage Rd

    241 Frontage Rd

    OFFICE BUILDING • 7,952 SF
    Value Estimation by Request
    241 Frontage Rd, Picayune, MS 39466-7587
    View details
    29 Global Ln

    29 Global Ln

    OFFICE BUILDING • 880 SF
    Value Estimation by Request
    29 Global Ln, Picayune, MS 39466-9289
    View details
    923 Hwy 11th S

    923 Hwy 11th S

    OFFICE BUILDING • 3,000 SF
    Value Estimation by Request
    923 Hwy 11th S, Picayune, MS 39466-5313
    View details
    1747 Hwy 11th S

    1747 Hwy 11th S

    OFFICE BUILDING • 1,400 SF
    Value Estimation by Request
    1747 Hwy 11th S, Picayune, MS 39466-8056
    View details

    Picayune, MS Office Properties & Spaces Investment Opportunities Market Analysis

    Explore 245 office properties & spaces for sale in Picayune, MS, showcased through 5 active listings on our real estate platform. These investment opportunities span a total of 49,702,374 square feet of properties for sale, with an estimated market value of $57,378,900.

    Sale prices for office spaces in Picayune, MS start at $65,000, averaging $526,411, and reaching up to $1,060,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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    Browse Office Properties & Spaces for Sale Near Picayune, MS

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    Most Searched ZIP Codes in Picayune, MS

    • 39466

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