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    Picayune, MS Retail Properties & Spaces for Sale

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    Gulfport, MS Jackson, MS Hattiesburg, MS
    20 results
    Downtown Picayune Commercial Investment Opportunity
    $425,000
    5,696 SF

    Downtown Picayune Commercial Investment Opportunity

    118 E Canal Street, Picayune, MS 39466

    Two-story, fully leased commercial building in downtown Picayune.

    • Fully leased 5,086 sq ft commercial building providing immediate income.
    • Prime location in the heart of Downtown Picayune.
    • Excellent visibility and easy accessibility, one block off Highway 11.
    • Recently remodeled with updated features and strong curb appeal.
    • Turnkey investment with established occupancy.
    Updated: Apr 1
    View details
    Versatile Commercial Property on Highway
    $650,000
    6,755 SF

    Versatile Commercial Property on Highway

    2467 Highway 43 South, Picayune, MS 39466

    6,755 sq ft commercial property on 1.32 acres.

    • High‑visibility location: Situated on Highway 43 South with 8,900+ vehicles passing daily.
    • Large commercial space: 6,755 sq. ft. on 1.32 acres provides ample room for various business ventures.
    • Versatile potential: Suitable for event venue, restaurant revival, short‑term rentals (Airbnb), or other commercial uses.
    • Strategic location: Only 5 minutes south of I‑59 in Picayune, offering easy access.
    • Rear quarters ideal for Airbnb or guest accommodations.
    Updated: Oct 29, 2025
    View details
    Prime Commercial Building in Picayune
    $399,900
    3,915 SF

    Prime Commercial Building in Picayune

    Spacious commercial building with multiple suites in prime location.

    707 Memorial Blvd., Picayune, MS 39466
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    Turnkey Auto Repair Business
    $325,000
    4,912 SF

    Turnkey Auto Repair Business

    Established auto repair business on 1.82 acres.

    1747 Hwy.11 South, Picayune, MS 39466
    View details
    Profitable Cinema on High-Traffic Location
    $1,150,000
    10,800 SF

    Profitable Cinema on High-Traffic Location

    10,800 sq. ft. cinema on 1.9 acres near I-59.

    997 Cooper Road, Picayune, MS 39466
    View details
    Turn-Key Commercial Building in Picayune
    $225,000
    1,920 SF

    Turn-Key Commercial Building in Picayune

    Move-in ready commercial building in the heart of Picayune, MS.

    320 S Curran, Picayune, MS 39466
    View details
    Picayune Commercial Building For Sale
    $450,000
    3,064 SF

    Picayune Commercial Building For Sale

    3,010 sq ft building on 1.02 acres near I-59.

    2508 Hwy 43 S, Picayune, MS 39466
    View details
    Picayune Commercial Space For Sale
    Contact for pricing
    3,000 SF

    Picayune Commercial Space For Sale

    3000 sq ft retail or office space available.

    421A memorial blvd, Picayune, MS 39466
    View details
    Picayune Commercial Retail Space Available
    $245,000
    10,000 SF

    Picayune Commercial Retail Space Available

    Retail property with highway access in Picayune, Mississippi.

    213 Highway 11 South, Picayune, MS 39466
    View details
    Picayune Commercial Building For Sale
    $379,000
    2,300 SF

    Picayune Commercial Building For Sale

    Versatile commercial building with drive-thru, excellent visibility, and ample parking.

    249 Frontage Rd, Picayune, MS 39466
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    Retail Space Near Walmart
    Contact for pricing
    1,500 SF

    Retail Space Near Walmart

    Commercial retail space available, 1500 sq ft, near Hwy 43.

    1407 Armand Dr, Picayune, MS 39466
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    Restaurant Ready Commercial Property
    $149,500
    1,727 SF

    Restaurant Ready Commercial Property

    Commercial property with restaurant equipment included, ready for operation.

    728 West Canal Street, Picayune, MS 39466
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    Commercial Corner Unit in Picayune
    Contact for pricing
    900 SF

    Commercial Corner Unit in Picayune

    Corner unit suitable for small business in high-traffic area.

    421 D Memorial Blvd, Picayune, MS 39466
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    Picayune Cinema on 1.9 Acres
    $1,150,000
    10,800 SF

    Picayune Cinema on 1.9 Acres

    Profitable, fully functional cinema with redevelopment potential in growing suburban market.

    997 Cooper Road, Picayune, MS 39466
    View details
    Dollar General NNN Investment Opportunity
    $1,677,285
    10,566 SF

    Dollar General NNN Investment Opportunity

    NNN Dollar General with corporate guarantee and rent escalations.

    6352 Highway 11 N, Picayune, MS
    View details
    Freestanding Retail Property For Sale
    Contact for pricing
    6,718 SF

    Freestanding Retail Property For Sale

    Retail property in a high-visibility location with ease of access.

    230 Memorial Blvd, Picayune, MS
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    Historical Downtown Picayune Land Parcel
    $110,000

    Historical Downtown Picayune Land Parcel

    Prime commercial land in thriving downtown Picayune, Mississippi.

    510 West Canal Street, Picayune, MS 39466
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    Historical Downtown Picayune Land
    $55,000

    Historical Downtown Picayune Land

    Prime commercial land in thriving downtown Picayune.

    510 West Canal Street - Lot 10, Picayune, MS 39466
    View details
    Historical Downtown Picayune Land
    $55,000

    Historical Downtown Picayune Land

    Prime commercial lot in thriving downtown Picayune.

    510 West Canal Street - Lot 9, Picayune, MS 39466
    View details
    Vacant Land Ready For Development
    $149,000

    Vacant Land Ready For Development

    Vacant land suitable for various commercial developments.

    000 SE Corner of Hwy 43 South and Donald Mitchell Rd, Picayune, MS 39466
    View details
    Based on your search, we've compiled Potential Opportunities for your consideration. Besides 20 Active Listings in Picayune, MS, we suggest to view alternatives - similar 324 Off-Market properties to explore as potential leads.

    Explore Off-Market Properties in Picayune, MS

    Consider similar Off-Market properties in Picayune, MS. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    706 Memorial Blvd

    706 Memorial Blvd

    RESTAURANT • 2,064 SF
    Value Estimation by Request
    706 Memorial Blvd, Picayune, MS 39466-4632
    View details
    201 Memorial Blvd

    201 Memorial Blvd

    RESTAURANT • 2,048 SF
    Value Estimation by Request
    201 Memorial Blvd, Picayune, MS 39466-5539
    View details
    109 3rd St

    109 3rd St

    RETAIL STORES (PERSONAL SERVICES) • 4,000 SF
    Value Estimation by Request
    109 3rd St, Picayune, MS 39466-3319
    View details
    214 Telly Rd

    214 Telly Rd

    RETAIL STORES (PERSONAL SERVICES) • 1,872 SF
    Value Estimation by Request
    214 Telly Rd, Picayune, MS 39466-5364
    View details

    Picayune, MS Retail Properties & Spaces Investment Opportunities Market Analysis

    Explore 344 retail properties & spaces for sale in Picayune, MS, showcased through 20 active listings on our real estate platform. These investment opportunities span a total of 36,707,524 square feet of properties for sale, with an estimated market value of $90,828,400.

    Sale prices for stores in Picayune, MS start at $50,000, averaging $550,475, and reaching up to $1,640,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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