Picayune, MS Office Spaces for Sale

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Carriere, MS Pearl River, LA Talisheek, LA Kiln, MS Perkinston, MS Bush, LA Slidell, LA Poplarville, MS

10 properties

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Updated: Apr 6

Medical Office Building with X-Ray Room

16 Merrill Road, Picayune, MS 39466

$2,100,000

12,160 sqft 2.00 AC lot

Easily adaptable layout due to non‑weight‑bearing walls, suitable for various commercial uses.
Recently underwent extensive interior renovation.
Excellent commercial location surrounded by established businesses (Home Depot, Keesler Credit, RaceTrac, Walmart, Banks).
Seconds from the interstate, providing convenient access.
Equipped with a lead‑proof room, ideal for medical use (e.g., X‑ray unit).

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Updated: Dec 31, 2025

Light Industrial Warehouse with Office

1817 Palestine Rd, Picayune, MS 39466

$199,000

7,500 sqft 2.00 AC lot

7,500 SF warehouse on approx. 2 acres
Includes built‑in office space
Expansive lot for parking, outdoor storage, or future expansion
Warehouse layout is suited for light industrial, storage, or business operations
Property is overgrown and in need of TLC

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Corner Brick Retail/Office Building

141 Kirkwood Street, Picayune, MS 39466

$159,700

1,325 sqft 0.05 AC lot

Brick commercial building on a downtown corner with recorded restrictive covenants and a shared wall agreement.

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Leased Retail/Office Building For Sale

801 Highway 11 South, Picayune, MS 39466

$1,300,000

6,300 sqft

Fully leased retail/office building in Picayune, Mississippi.

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Prime Commercial Building in Picayune

707 Memorial Blvd., Picayune, MS 39466

$399,900

3,915 sqft 0.39 AC lot

Spacious commercial building with multiple suites in prime location.

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Remodeled Flex and Office Building

1307 Hwy. 11 S, Picayune, MS 39466

$250,000

952 sqft 2.50 AC lot

Remodeled flex/office property in I-1 zoning with fenced site, circle driveway, and offices plus half baths.

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Drive-Through Restaurant Building

249 Frontage Rd, Picayune, MS 39466

$379,000

2,300 sqft 0.64 AC lot

Metal building with two drive-thru windows, commercial hood vent, and more than 25 parking spaces near I-59 North visibility.

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Renovated Commercial Building For Sale

16 Merrill Rd, Picayune, MS 39466

$2,100,000

12,160 sqft

Commercial building suitable for medical or general office use.

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Versatile Commercial Space For Sale

1707 East Canal, Picayune, MS 39466

$299,000

4,000 sqft

4000 sqft commercial property with high visibility and versatile space.

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Flex Warehouse with Two Bay Doors

320 S Curran Ave, Picayune, MS 39466

$225,000

1,920 sqft

Move-in-ready flex warehouse with front office setup, break room, and two large bay garage doors.

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Based on your search, we've compiled 80 Potential Opportunities for your consideration. Besides 10 Active listings in Picayune, MS, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 62 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

Opportunities in Nearby Cities

Here are 4 Similar properties we found in Nearby Locations for your consideration.

Medical Office and Therapy Facility

15126 LA-21, Bogalusa, LA 70427

$400,000

5,200 sqft 1.65 AC lot

Well-maintained medical office building with exam rooms, therapy space, and gated parking for patient and staff use.

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Multi-Specialty Medical Facility

2750 Gause Boulevard East, Slidell, LA 70461

$5,000,000

25,000 sqft 3.90 AC lot

Large medical facility with about 49 exam rooms, multiple physician offices, and dedicated lab, dental, and optometry space.

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Two-Story Office Building For Sale

102 VILLAGE Street, Slidell, LA 70458

$425,000

4,030 sqft

Spacious 4,030 SF office building, 75% leased, great investment.

View details

Renovated Commercial Building For Sale

315 AUSTIN Street, Bogalusa, LA 70427

$65,000

800 sqft

Renovated commercial building suitable for office, retail, or medical use.

View details

Potential Development Sites for Consideration

Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

Historic Commercial/Residential Corner Lot

522 E Canal Street, Picayune, MS 39466

$189,900

1,889 sqft

117-year-old property in Picayune's Downtown Golf Cart District.

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Prime Commercial Land in Picayune

NHN Corner S Main and Elizabeth Street, Picayune, MS 39466

$600,000

2.80 AC lot

High-traffic commercial land in Picayune's business district.

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Picayune Commercial Land For Sale

Carroll Street, Picayune, MS 39466

$75,000

5.05 AC lot

Two lots totaling 5.05 acres in Picayune, Mississippi.

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High Visibility Commercial Lot

105 Highland Parkway, Picayune, MS 39466

$549,000

1.04 AC lot

Commercial lot near hospital and post office in Picayune, MS.

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Off-Market Properties in Picayune, MS

Consider similar Off-Market properties in Picayune, MS. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

OFFICE BUILDING

405 Memorial Blvd, Picayune, MS 39466-5545

Value Estimation by Request

1,000 sqft 0.57 AC lot

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OFFICE BUILDING

105 St A A, Picayune, MS 39466-5467

Value Estimation by Request

12,000 sqft 3.11 AC lot

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OFFICE BUILDING

323 Main St, Picayune, MS 39466-3313

Value Estimation by Request

1,225 sqft 0.18 AC lot

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OFFICE BUILDING

722 Canal St, Picayune, MS 39466-3900

Value Estimation by Request

1,124 sqft 0.30 AC lot

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OFFICE BUILDING

500 Canal St, Picayune, MS 39466-3915

Value Estimation by Request

1,487 sqft 30.30 AC lot

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OFFICE BUILDING

6482 Hwy 11th N, Picayune, MS 39466

Value Estimation by Request

5,347 sqft 1.18 AC lot

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OFFICE BUILDING

311 Acorn Ln, Picayune, MS 39466-2047

Value Estimation by Request

4,416 sqft 0.96 AC lot

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PROFESSIONAL BUILDING

503 Canal St, Picayune, MS 39466-3914

Value Estimation by Request

1,528 sqft 0.17 AC lot

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OFFICE BUILDING

119 Ceasar Rd, Picayune, MS 39466-8898

Value Estimation by Request

480 sqft 5.10 AC lot

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MEDICAL BUILDING

1403 Hwy 43rd N, Picayune, MS 39466-2833

Value Estimation by Request

1,510 sqft 0.46 AC lot

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OFFICE BUILDING

115 Canal St, Picayune, MS 39466-3906

Value Estimation by Request

2,298 sqft 0.06 AC lot

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MEDICAL BUILDING

2007 Wildwood Dr, Picayune, MS 39466-2178

Value Estimation by Request

2,313 sqft 0.30 AC lot

View details

OFFICE BUILDING

210 Mitchell St, Picayune, MS 39466-4540

Value Estimation by Request

3,040 sqft 24.59 AC lot

View details

OFFICE BUILDING

111 Hwy 11th S, Picayune, MS 39466-4501

Value Estimation by Request

2,858 sqft 0.10 AC lot

View details

Picayune, MS Office Spaces Market Trends and Statistics

Explore 72 office spaces for sale in Picayune, MS, showcased through 10 active listings on our real estate platform. These investment opportunities span a total of 52,532 square feet of properties for sale, with an estimated market value of $7,411,600.

Sale prices for office spaces in Picayune, MS start at $159,700, averaging $741,160, and reaching up to $2,100,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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Top Commercial Asset Segments

Commercial property segments ranked by active listings on the market

Demographics Overview

Population 28K

Population Growth (5Y) +8.6%

Median Household Income $50,926

College Educated 15.2%

High-Yield Neighborhoods for Investment

Identify Picayune submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

Neighborhood	Average Price
39466	$583.9K

Taxes & Financing

Average Loan-to-Value 65.0%

Listings Trend

New vs delisted commercial listings in Pearl River County

New Delisted

Total CRE Inventory on Market (SF)

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Picayune, MS Office Spaces for Sale

16 Merrill Road, Picayune, MS 39466

1817 Palestine Rd, Picayune, MS 39466

141 Kirkwood Street, Picayune, MS 39466

801 Highway 11 South, Picayune, MS 39466

707 Memorial Blvd., Picayune, MS 39466

1307 Hwy. 11 S, Picayune, MS 39466

249 Frontage Rd, Picayune, MS 39466

16 Merrill Rd, Picayune, MS 39466

1707 East Canal, Picayune, MS 39466

320 S Curran Ave, Picayune, MS 39466

Opportunities in Nearby Cities

15126 LA-21, Bogalusa, LA 70427

2750 Gause Boulevard East, Slidell, LA 70461

102 VILLAGE Street, Slidell, LA 70458

315 AUSTIN Street, Bogalusa, LA 70427

Potential Development Sites for Consideration

522 E Canal Street, Picayune, MS 39466

NHN Corner S Main and Elizabeth Street, Picayune, MS 39466

Carroll Street, Picayune, MS 39466

105 Highland Parkway, Picayune, MS 39466

Off-Market Properties in Picayune, MS

405 Memorial Blvd, Picayune, MS 39466-5545

105 St A A, Picayune, MS 39466-5467

323 Main St, Picayune, MS 39466-3313

722 Canal St, Picayune, MS 39466-3900

500 Canal St, Picayune, MS 39466-3915

6482 Hwy 11th N, Picayune, MS 39466

311 Acorn Ln, Picayune, MS 39466-2047

503 Canal St, Picayune, MS 39466-3914

119 Ceasar Rd, Picayune, MS 39466-8898

1403 Hwy 43rd N, Picayune, MS 39466-2833

115 Canal St, Picayune, MS 39466-3906

2007 Wildwood Dr, Picayune, MS 39466-2178

210 Mitchell St, Picayune, MS 39466-4540

111 Hwy 11th S, Picayune, MS 39466-4501

Picayune, MS Office Spaces Market Trends and Statistics

Top Commercial Asset Segments

Demographics Overview

High-Yield Neighborhoods for Investment

Taxes & Financing

Listings Trend

Total CRE Inventory on Market (SF)

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