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    Picayune, MS Office Spaces for Sale

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    Carriere, MS Poplarville, MS Pearl River, LA Talisheek, LA Kiln, MS Bush, LA Perkinston, MS Slidell, LA
    13 properties
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    Medical Office Building with X-Ray Room
    Updated: Apr 6
    Medical Office Building with X-Ray Room

    16 Merrill Road, Picayune, MS 39466

    $2,100,000
    12,160 sqft 2.00 AC lot
    Easily adaptable layout due to non‑weight‑bearing walls, suitable for various commercial uses.
    Recently underwent extensive interior renovation.
    Excellent commercial location surrounded by established businesses (Home Depot, Keesler Credit, RaceTrac, Walmart, Banks).
    Seconds from the interstate, providing convenient access.
    Equipped with a lead‑proof room, ideal for medical use (e.g., X‑ray unit).
    View details
    Retail Building with Hardwood Floors
    Updated: Aug 21
    Retail Building with Hardwood Floors

    521 W Canal, Picayune, MS 39466

    $273,000
    1,696 sqft 0.43 AC lot
    1,696‑square‑foot retail building on 0.43 acres
    Currently configured as a hair studio
    Original hardwood floors paired with vinyl plank flooring
    C‑2 zoning
    Located at 521 W Canal in Picayune, MS 39466
    View details
    Multi-Suite Storefront Property
    Multi-Suite Storefront Property

    707 Memorial Blvd., Picayune, MS 39466

    $392,900
    3,915 sqft 0.39 AC lot

    Commercially zoned building with multiple suites, private bathrooms, kitchen areas, and office space for occupancy or rental.

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    Renovated Commercial Building For Sale
    Renovated Commercial Building For Sale

    16 Merrill Rd, Picayune, MS 39466

    $2,100,000
    12,160 sqft

    Commercial building suitable for medical or general office use.

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    Remodeled Flex and Office Building
    Remodeled Flex and Office Building

    1307 Hwy. 11 S, Picayune, MS 39466

    $250,000
    952 sqft 2.50 AC lot

    Remodeled flex/office property in I-1 zoning with fenced site, circle driveway, and offices plus half baths.

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    Four-Suite Office Building
    Four-Suite Office Building

    707 Memorial Blvd., Picayune, MS 39466

    $399,900
    3,915 sqft

    Flexible office configuration with kitchens, bathrooms, and separate suites for occupancy or rental use.

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    Two-Story Remodeled Office Building
    Two-Story Remodeled Office Building

    118 E Canal Street, Picayune, MS 39466

    Contact for pricing
    5,086 sqft

    Two-story office building with recently remodeled features and fully leased space near Highway 11 access.

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    Flex Space with Fenced Yard
    Flex Space with Fenced Yard

    202 Harris Street, Picayune, MS 39466

    Contact for pricing
    4,500 sqft

    Office and shop areas are paired with secured outdoor storage and three-phase electrical service.

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    Flex Space with Industrial Power
    Flex Space with Industrial Power

    1307 S Hwy. 11, Picayune, MS 39466

    $280,000

    Remodeled commercial building with office, kitchenette, storage, fenced grounds, and enhanced electrical capacity.

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    Renovated Coworking Space
    Renovated Coworking Space

    A-111 Highway 11 S, Picayune, MS 39466

    Contact for pricing
    100 sqft

    Flexible workspace with private or shared desks, client-facing amenities, and bundled utilities, internet, and security.

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    Two-Unit Commercial Office/Retail Building
    Two-Unit Commercial Office/Retail Building

    220 S Curran Avenue, Picayune, MS 39466

    Contact for pricing
    3,700 sqft

    Two-unit commercial building with ample parking, including office and currently rented beauty shop space.

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    Office Building with Conference Room
    Office Building with Conference Room

    104 Street A, Picayune, MS 39466

    Contact for pricing
    12,000 sqft 3.11 AC lot

    Office property with multiple offices, conference space, kitchen, IT room, and outdoor pavilion.

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    Historical Downtown Picayune Land
    Historical Downtown Picayune Land

    510 West Canal Street - Lot 10, Picayune, MS 39466

    Contact for pricing
    0.15 AC lot

    Prime commercial land in thriving downtown Picayune.

    View details
    Based on your search, we've compiled 80 Potential Opportunities for your consideration. Besides 13 Active listings in Picayune, MS, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 59 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

    Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Industrial Warehouse with Fenced Yard
    Industrial Warehouse with Fenced Yard

    70239 CALEB Lane, Abita Springs, LA 70420

    $1,990,000
    3,000 sqft 2.89 AC lot

    Metal warehouse with dedicated office space, multiple entrances, heavy-duty flooring, and an enclosed outdoor storage area.

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    Industrial Warehouse with Office
    Industrial Warehouse with Office

    70239 CALEB Lane, Abita Springs, LA 70420

    $1,990,000

    Up-to-date warehouse with office space, roll-up doors, and fenced yard storage on industrial-zoned land.

    View details
    Renovated Multi-Unit Office Building
    Renovated Multi-Unit Office Building

    59118 N PEARL Street, Slidell, LA 70461

    Contact for pricing
    3,200 sqft

    Completely renovated, fully leased office building with four 800 SF units and 15 parking spaces.

    View details
    Office Building with Warehouse
    Office Building with Warehouse

    516 J F Smith Ave, Slidell, LA 70460

    Contact for pricing
    23,000 sqft 3.24 AC lot

    Office and warehouse property with dedicated work areas, support rooms, a generator, and an outdoor freight elevator.

    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Historic Commercial/Residential Corner Lot
    Historic Commercial/Residential Corner Lot

    522 E Canal Street, Picayune, MS 39466

    Contact for pricing
    1,889 sqft

    117-year-old property in Picayune's Downtown Golf Cart District.

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    Picayune Commercial Land For Sale
    Picayune Commercial Land For Sale

    Hwy. 11 N, Picayune, MS 39466

    $219,000
    3.33 AC lot

    3.329 acre commercial land with high visibility.

    View details
    B2-Zoned Commercial Land
    B2-Zoned Commercial Land

    64659 HWY 41 Highway, Pearl River, LA 70452

    $110,000

    Highway 41 frontage and B2 commercial zoning define this development parcel near the interstate.

    View details
    C-2 Commercial Land with Dual Frontage
    C-2 Commercial Land with Dual Frontage

    950 ROBERT Boulevard, Slidell, LA 70458

    $739,000
    2.46 AC lot

    Wooded commercial tract with access from two roads and utility service subject to annexation and zoning requirements.

    View details

    Off-Market Properties in Picayune, MS

    Consider similar Off-Market properties in Picayune, MS. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    405 Memorial Blvd
    OFFICE BUILDING

    405 Memorial Blvd, Picayune, MS 39466-5545

    $590,000
    Estimated value
    1,000 sqft 0.57 AC lot
    View details
    105 St A A
    OFFICE BUILDING

    105 St A A, Picayune, MS 39466-5467

    $845,000
    Estimated value
    12,000 sqft 3.11 AC lot
    View details
    323 Main St
    OFFICE BUILDING

    323 Main St, Picayune, MS 39466-3313

    Value Estimation by Request
    1,225 sqft 0.18 AC lot
    View details
    722 Canal St
    OFFICE BUILDING

    722 Canal St, Picayune, MS 39466-3900

    Value Estimation by Request
    1,124 sqft 0.30 AC lot
    View details
    500 Canal St
    OFFICE BUILDING

    500 Canal St, Picayune, MS 39466-3915

    Value Estimation by Request
    1,487 sqft 30.30 AC lot
    View details
    6482 Hwy 11th N
    OFFICE BUILDING

    6482 Hwy 11th N, Picayune, MS 39466

    $740,000
    Estimated value
    5,347 sqft 1.18 AC lot
    View details
    311 Acorn Ln
    OFFICE BUILDING

    311 Acorn Ln, Picayune, MS 39466-2047

    $655,000
    Estimated value
    4,416 sqft 0.96 AC lot
    View details
    503 Canal St
    PROFESSIONAL BUILDING

    503 Canal St, Picayune, MS 39466-3914

    Value Estimation by Request
    1,528 sqft 0.17 AC lot
    View details
    119 Ceasar Rd
    OFFICE BUILDING

    119 Ceasar Rd, Picayune, MS 39466-8898

    Value Estimation by Request
    480 sqft 5.10 AC lot
    View details
    1403 Hwy 43rd N
    MEDICAL BUILDING

    1403 Hwy 43rd N, Picayune, MS 39466-2833

    Value Estimation by Request
    1,510 sqft 0.46 AC lot
    View details
    115 Canal St
    OFFICE BUILDING

    115 Canal St, Picayune, MS 39466-3906

    Value Estimation by Request
    2,298 sqft 0.06 AC lot
    View details

    Picayune, MS Office Spaces Market Trends and Statistics

    Explore 72 office spaces for sale in Picayune, MS, showcased through 13 active listings on our real estate platform. These investment opportunities span a total of 60,184 square feet of properties for sale, with an estimated market value of $5,795,800.

    Sale prices for office spaces in Picayune, MS start at $250,000, averaging $827,971, and reaching up to $2,100,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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    Top Commercial Asset Segments

    Commercial property segments ranked by active listings on the market

    Office Units 14
    Coworking space 3
    Medical Office Space 3
    Office buildings 2

    Demographics Overview

    Population 28K
    Population Growth (5Y) +8.6%
    Median Household Income $50,926
    College Educated 15.2%

    High-Yield Neighborhoods for Investment

    Identify Picayune submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

    Neighborhood Average Price
    39466 $676.8K

    Taxes & Financing

    Average Loan-to-Value 65.0%

    Listings Trend

    New vs delisted commercial listings in Pearl River County

    New Delisted

    Total CRE Inventory on Market (SF)

    Average Property Price per SF

    For-sale pricing trends across core commercial property types in Pearl River County

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