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    Picayune, MS
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    Picayune, MS Office Spaces for Sale

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    Carriere, MS Ozona, MS Pearl River, LA Talisheek, LA Bush, LA Perkinston, MS Slidell, LA Kiln, MS
    13 properties
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    Medical Office Building with Exam Rooms
    Updated: Sep 10
    Medical Office Building with Exam Rooms

    906 Sixth Ave., Picayune, MS 39466

    $575,000
    4,455 sqft 0.50 AC lot
    4455‑square‑foot medical office property on 0.5 acres
    No less than 8 exam rooms
    Two waiting areas for patient reception
    Kitchen and file room included
    Office Professional zoning
    View details
    Renovated Medical Office Space
    Updated: Apr 6
    Renovated Medical Office Space

    16 Merrill Road, Picayune, MS 39466

    $2,100,000
    12,160 sqft 2.00 AC lot
    12,160 square feet on 2 acres
    C3 zoning supports the existing commercial property classification
    Recently renovated medical office interior
    Non‑weight‑bearing walls allow interior reconfiguration
    Lead‑proof room can accommodate an X‑ray unit
    View details
    Retail Building with Hardwood Floors
    Retail Building with Hardwood Floors

    521 W Canal, Picayune, MS 39466

    $270,000
    1,696 sqft 0.43 AC lot

    C-2 zoning and a flexible interior support salon, office, boutique, and other small-business uses.

    View details
    Realmo Analytics Monitor Off-market properties and contact owners who are ready to sell. Many signals applied to make quality leads for you. Get Leads
    Medical Office with Exam Rooms
    Medical Office with Exam Rooms

    906 6th Ave, Picayune, MS 39466

    $575,000
    4,455 sqft

    Office Professional zoning and a previously established clinical layout support a range of medical office configurations.

    View details
    Multi-Suite Storefront Property
    Multi-Suite Storefront Property

    707 Memorial Blvd., Picayune, MS 39466

    $392,900
    3,915 sqft 0.39 AC lot

    Commercially zoned building with multiple suites, private bathrooms, kitchen areas, and office space for occupancy or rental.

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    Renovated Commercial Building For Sale
    Renovated Commercial Building For Sale

    16 Merrill Rd, Picayune, MS 39466

    $2,100,000
    12,160 sqft

    Commercial building suitable for medical or general office use.

    View details
    Four-Suite Office Building
    Four-Suite Office Building

    707 Memorial Blvd., Picayune, MS 39466

    $392,900
    3,915 sqft

    Flexible office configuration with kitchens, bathrooms, and separate suites for occupancy or rental use.

    View details
    Two-Story Remodeled Office Building
    Two-Story Remodeled Office Building

    118 E Canal St, Picayune, MS 39466

    $399,900
    5,696 sqft

    Two-story office building with recently remodeled features and fully leased space near Highway 11 access.

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    Flex Space with Fenced Yard
    Flex Space with Fenced Yard

    202 Harris Street, Picayune, MS 39466

    Contact for pricing
    4,500 sqft

    Office and shop areas are paired with secured outdoor storage and three-phase electrical service.

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    Medical Office Suite
    Medical Office Suite

    6351 Highway 11, Picayune, MS 39466

    Contact for pricing
    2,124 sqft

    An established clinical layout includes patient check-in, several rooms with sinks and cabinets, and accessible parking.

    View details
    Renovated Coworking Space
    Renovated Coworking Space

    A-111 Highway 11 S, Picayune, MS 39466

    Contact for pricing
    100 sqft

    Flexible workspace with private or shared desks, client-facing amenities, and bundled utilities, internet, and security.

    View details
    Fully Leased Retail Office Building
    Fully Leased Retail Office Building

    801 Hwy 11 S, Picayune, MS 39466

    Contact for pricing
    6,300 sqft

    Fully leased building with retail and office space occupied by two medical clinics and a sporting goods retailer.

    View details
    Flex Space with Industrial Power
    Flex Space with Industrial Power

    1307 S Hwy. 11, Picayune, MS 39466

    $250,000

    Remodeled commercial building with office, kitchenette, storage, fenced grounds, and enhanced electrical capacity.

    View details
    Based on your search, we've compiled 80 Potential Opportunities for your consideration. Besides 13 Active listings in Picayune, MS, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 59 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

    Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Corner-Lot Mixed-Use Property
    Corner-Lot Mixed-Use Property

    39400 PINE Street, Pearl River, LA 70452

    $158,000
    1,630 sqft

    The layout supports commercial or residential use, with office areas and a kitchenette already in place.

    View details
    Mixed-Use Building with Office Layout
    Mixed-Use Building with Office Layout

    39400 Pine St, Pearl River, LA 70452

    $158,000
    1,630 sqft

    Corner-lot property with office space, a kitchenette, and a separate area for reception or conferencing.

    View details
    Office Building with 10 Private Offices
    Office Building with 10 Private Offices

    103 Galeria Boulevard, Slidell, LA 70458

    $289,900
    3,274 sqft

    Reception, lobby, break rooms, and multiple restrooms support a flexible workplace layout.

    View details
    Two-Story Medical Office Space
    Two-Story Medical Office Space

    107 Galeria Boulevard, Slidell, LA 70458

    $125,000
    2,700 sqft

    Existing plumbing and a downstairs clinical layout support medical-office reuse.

    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Commercial Land with Public Utilities
    Commercial Land with Public Utilities

    Hwy. 11 N, Picayune, MS 39466

    $219,000
    3.33 AC lot

    C-3-zoned development tract within Picayune city limits with public water and sewer service.

    View details
    B2-Zoned Commercial Land
    B2-Zoned Commercial Land

    64659 HWY 41 Highway, Pearl River, LA 70452

    $110,000

    Highway 41 frontage and B2 commercial zoning define this development parcel near the interstate.

    View details
    C-2 Commercial Land with Dual Frontage
    C-2 Commercial Land with Dual Frontage

    950 ROBERT Boulevard, Slidell, LA 70458

    $739,000
    2.46 AC lot

    Wooded commercial tract with access from two roads and utility service subject to annexation and zoning requirements.

    View details
    Commercial Land Near Interstate Access
    Commercial Land Near Interstate Access

    Highway 603, Bay Saint Louis, MS 39520

    $239,575
    87,120 sqft 2.00 AC lot

    Commercial tract with stated potential for gas station, retail, and office uses.

    View details

    Off-Market Properties in Picayune, MS

    Consider similar Off-Market properties in Picayune, MS. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    405 Memorial Blvd
    OFFICE BUILDING

    405 Memorial Blvd, Picayune, MS 39466-5545

    Estimated value:
    $590,000
    1,000 sqft 0.57 AC lot
    View details
    105 St A A
    OFFICE BUILDING

    105 St A A, Picayune, MS 39466-5467

    Estimated value:
    $845,000
    12,000 sqft 3.11 AC lot
    View details
    323 Main St
    OFFICE BUILDING

    323 Main St, Picayune, MS 39466-3313

    Estimated value: by Request
    1,225 sqft 0.18 AC lot
    View details
    722 Canal St
    OFFICE BUILDING

    722 Canal St, Picayune, MS 39466-3900

    Estimated value: by Request
    1,124 sqft 0.30 AC lot
    View details
    500 Canal St
    OFFICE BUILDING

    500 Canal St, Picayune, MS 39466-3915

    Estimated value: by Request
    1,487 sqft 30.30 AC lot
    View details
    6482 Hwy 11th N
    OFFICE BUILDING

    6482 Hwy 11th N, Picayune, MS 39466

    Estimated value:
    $740,000
    5,347 sqft 1.18 AC lot
    View details
    311 Acorn Ln
    OFFICE BUILDING

    311 Acorn Ln, Picayune, MS 39466-2047

    Estimated value:
    $655,000
    4,416 sqft 0.96 AC lot
    View details
    503 Canal St
    PROFESSIONAL BUILDING

    503 Canal St, Picayune, MS 39466-3914

    Estimated value: by Request
    1,528 sqft 0.17 AC lot
    View details
    119 Ceasar Rd
    OFFICE BUILDING

    119 Ceasar Rd, Picayune, MS 39466-8898

    Estimated value: by Request
    480 sqft 5.10 AC lot
    View details
    1403 Hwy 43rd N
    MEDICAL BUILDING

    1403 Hwy 43rd N, Picayune, MS 39466-2833

    Estimated value: by Request
    1,510 sqft 0.46 AC lot
    View details
    115 Canal St
    OFFICE BUILDING

    115 Canal St, Picayune, MS 39466-3906

    Estimated value: by Request
    2,298 sqft 0.06 AC lot
    View details

    Picayune, MS Office Spaces Market Trends and Statistics

    Explore 72 office spaces for sale in Picayune, MS, showcased through 13 active listings on our real estate platform. These investment opportunities span a total of 61,476 square feet of properties for sale, with an estimated market value of $7,055,700.

    Sale prices for office properties in Picayune, MS start at $250,000, averaging $783,966, and reaching up to $2,100,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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    Top Commercial Asset Segments

    Commercial property segments ranked by active listings on the market

    Office Units 9
    Medical Office Space 7
    Office buildings 4
    Coworking space 3

    Demographics Overview

    Population 28K
    Population Growth (5Y) +8.6%
    Median Household Income $50,926
    College Educated 15.2%

    High-Yield Neighborhoods for Investment

    Identify Picayune submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

    Neighborhood Average Price
    39466 $784.3K

    Taxes & Financing

    Average Loan-to-Value 65.0%

    Listings Trend

    New vs delisted commercial listings in Pearl River County

    New Delisted

    Total CRE Inventory on Market (SF)

    How Realmo verifies these figures

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