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    Picayune, MS Office Properties & Spaces for Sale

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    Gulfport, MS Jackson, MS Hattiesburg, MS
    8 results
    Prime Commercial Building in Picayune
    $399,900
    3,915 SF

    Prime Commercial Building in Picayune

    707 Memorial Blvd., Picayune, MS 39466

    Spacious commercial building with multiple suites in prime location.

    • Prime location in Picayune offering high visibility and accessibility.
    • Excellent investment opportunity for new or established businesses.
    • Located right off I‑59 and surrounded by other businesses.
    • Four possible rental suites in one building.
    • Three suites include bathrooms and kitchens.
    Updated: Dec 1, 2025
    View details
    Picayune Commercial Building For Sale
    $2,100,000
    12,160 SF

    Picayune Commercial Building For Sale

    16 Merrill Road, Picayune, MS 39466

    Commercial building in high-traffic area near interstate and major retailers.

    • Extensive recent interior renovation.
    • Excellent commercial location near Home Depot, Keesler Credit, RaceTrac, Walmart, and Banks.
    • Seconds from the interstate with easy access.
    • Flexible design due to non‑weight‑bearing walls, suitable for various commercial uses.
    • Currently equipped as a medical office with a lead‑proof room for an x‑ray unit.
    Updated: Apr 6
    View details
    Picayune Commercial Building For Sale
    $450,000
    3,064 SF

    Picayune Commercial Building For Sale

    3,010 sq ft building on 1.02 acres near I-59.

    2508 Hwy 43 S, Picayune, MS 39466
    View details
    Picayune Commercial Space For Sale
    Contact for pricing
    3,000 SF

    Picayune Commercial Space For Sale

    3000 sq ft retail or office space available.

    421A memorial blvd, Picayune, MS 39466
    View details
    Picayune Commercial Building For Sale
    $379,000
    2,300 SF

    Picayune Commercial Building For Sale

    Versatile commercial building with drive-thru, excellent visibility, and ample parking.

    249 Frontage Rd, Picayune, MS 39466
    View details
    Historical Downtown Picayune Land Parcel
    $110,000

    Historical Downtown Picayune Land Parcel

    Prime commercial land in thriving downtown Picayune, Mississippi.

    510 West Canal Street, Picayune, MS 39466
    View details
    Historical Downtown Picayune Land
    $55,000

    Historical Downtown Picayune Land

    Prime commercial land in thriving downtown Picayune.

    510 West Canal Street - Lot 10, Picayune, MS 39466
    View details
    Historical Downtown Picayune Land
    $55,000

    Historical Downtown Picayune Land

    Prime commercial lot in thriving downtown Picayune.

    510 West Canal Street - Lot 9, Picayune, MS 39466
    View details
    Based on your search, we've compiled 256 Potential Opportunities for your consideration. Besides 8 Active listings in Picayune, MS, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 240 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

    Explore Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Bogalusa Commercial Property with Expansion
    $400,000
    5,200 SF

    Bogalusa Commercial Property with Expansion

    Well-maintained medical/office building on 1.7 acres with expansion potential.

    15126 LA-21, Bogalusa, LA 70427
    View details
    Two-Story Office Building For Sale
    $425,000
    4,030 SF

    Two-Story Office Building For Sale

    Spacious 4,030 SF office building, 75% leased, great investment.

    102 VILLAGE Street, Slidell, LA 70458
    View details
    Renovated Commercial Building For Sale
    $65,000
    800 SF

    Renovated Commercial Building For Sale

    Renovated commercial building suitable for office, retail, or medical use.

    315 AUSTIN Street, Bogalusa, LA 70427
    View details
    Two-Story Office Building For Sale
    Contact for pricing
    4,030 SF

    Two-Story Office Building For Sale

    Two-story office building with multiple suites, ideal for investors.

    102 Village St, Slidell, LA 70458
    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Highway Frontage Commercial Lot
    $110,000

    Highway Frontage Commercial Lot

    1.097-acre commercial lot with highway frontage and B2 zoning.

    64659 Highway 41, Pearl River, LA 70452
    View details
    Bogalusa Commercial Lots For Sale
    $80,000
    0.32 Acres

    Bogalusa Commercial Lots For Sale

    Two commercial lots near Our Lady of Angels Hospital.

    W 5TH Street, Bogalusa, LA 70427
    View details
    Slidell Commercial Land For Sale
    $739,000
    2.46 Acres

    Slidell Commercial Land For Sale

    2.46 acre commercial property with high visibility in Slidell.

    950 ROBERT Boulevard lot: --, Slidell, LA 70458
    View details
    Camellia Square Out Parcel Land
    $550,000

    Camellia Square Out Parcel Land

    0.94 acre commercial land in demand location.

    1736 Gause Boulevard East, Slidell, LA 70461
    View details

    Explore Off-Market Properties in Picayune, MS

    Consider similar Off-Market properties in Picayune, MS. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    405 Memorial Blvd

    405 Memorial Blvd

    OFFICE BUILDING • 1,000 SF
    Value Estimation by Request
    405 Memorial Blvd, Picayune, MS 39466-5545
    View details
    105 St A A

    105 St A A

    OFFICE BUILDING • 12,000 SF
    Value Estimation by Request
    105 St A A, Picayune, MS 39466-5467
    View details
    323 Main St

    323 Main St

    OFFICE BUILDING • 1,225 SF
    Value Estimation by Request
    323 Main St, Picayune, MS 39466-3313
    View details
    722 Canal St

    722 Canal St

    OFFICE BUILDING • 1,124 SF
    Value Estimation by Request
    722 Canal St, Picayune, MS 39466-3900
    View details
    500 Canal St

    500 Canal St

    OFFICE BUILDING • 1,487 SF
    Value Estimation by Request
    500 Canal St, Picayune, MS 39466-3915
    View details
    6482 Hwy 11th N

    6482 Hwy 11th N

    OFFICE BUILDING • 5,347 SF
    Value Estimation by Request
    6482 Hwy 11th N, Picayune, MS 39466
    View details
    311 Acorn Ln

    311 Acorn Ln

    OFFICE BUILDING • 4,416 SF
    Value Estimation by Request
    311 Acorn Ln, Picayune, MS 39466-2047
    View details
    503 Canal St

    503 Canal St

    PROFESSIONAL BUILDING • 1,528 SF
    Value Estimation by Request
    503 Canal St, Picayune, MS 39466-3914
    View details
    119 Ceasar Rd

    119 Ceasar Rd

    OFFICE BUILDING • 480 SF
    Value Estimation by Request
    119 Ceasar Rd, Picayune, MS 39466-8898
    View details
    1403 Hwy 43rd N

    1403 Hwy 43rd N

    MEDICAL BUILDING • 1,510 SF
    Value Estimation by Request
    1403 Hwy 43rd N, Picayune, MS 39466-2833
    View details
    115 Canal St

    115 Canal St

    OFFICE BUILDING • 2,298 SF
    Value Estimation by Request
    115 Canal St, Picayune, MS 39466-3906
    View details
    2007 Wildwood Dr

    2007 Wildwood Dr

    MEDICAL BUILDING • 2,313 SF
    Value Estimation by Request
    2007 Wildwood Dr, Picayune, MS 39466-2178
    View details
    210 Mitchell St

    210 Mitchell St

    OFFICE BUILDING • 3,040 SF
    Value Estimation by Request
    210 Mitchell St, Picayune, MS 39466-4540
    View details
    111 Hwy 11th S

    111 Hwy 11th S

    OFFICE BUILDING • 2,858 SF
    Value Estimation by Request
    111 Hwy 11th S, Picayune, MS 39466-4501
    View details
    1527 Hwy 11th N

    1527 Hwy 11th N

    OFFICE BUILDING • 1,200 SF
    Value Estimation by Request
    1527 Hwy 11th N, Picayune, MS 39466-2027
    View details
    1107 Memorial Blvd

    1107 Memorial Blvd

    PROFESSIONAL BUILDING • 1,885 SF
    Value Estimation by Request
    1107 Memorial Blvd, Picayune, MS 39466-4715
    View details

    Picayune, MS Office Properties & Spaces Investment Opportunities Market Analysis

    Explore 248 office properties & spaces for sale in Picayune, MS, showcased through 8 active listings on our real estate platform. These investment opportunities span a total of 49,678,851 square feet of properties for sale, with an estimated market value of $59,248,900.

    Sale prices for office spaces in Picayune, MS start at $65,000, averaging $543,567, and reaching up to $2,100,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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