Picayune, MS Commercial Real Estate for Sale

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Carriere, MS Ozona, MS Pearl River, LA Talisheek, LA Bush, LA Perkinston, MS Slidell, LA Kiln, MS

96 properties

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Updated: Sep 10

Medical Office Building with Exam Rooms

906 Sixth Ave., Picayune, MS 39466

$575,000

4,455 sqft 0.50 AC lot

4455‑square‑foot medical office property on 0.5 acres
No less than 8 exam rooms
Two waiting areas for patient reception
Kitchen and file room included
Office Professional zoning

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Updated: Sep 4

Grocery Store Building

916 Palestine Road, Picayune, MS 39466

$1,200,000

6,878 sqft 1.22 AC lot

6,878‑square‑foot commercial building
Approximately 1.22‑acre property
C‑1 zoning
On‑site parking included
Located at 916 Palestine Road in Picayune, MS 39466

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Manufacturing Facility with Sign Equipment

313 E Canal St., Picayune, MS 39466

$2,500,000

9,656 sqft 0.56 AC lot

C2-zoned facility with maintained production equipment, off-road parking, and rear drive-in access.

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Grocery Store Building on Acreage

916 Palestine Rd, Picayune, MS 39466

$1,200,000

6,878 sqft 1.22 AC lot

The sale covers the building and land, while the existing grocery business is excluded.

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Renovated Medical Office Space

16 Merrill Road, Picayune, MS 39466

$2,100,000

12,160 sqft 2.00 AC lot

C3-zoned facility with adaptable partitions and a lead-proof room suitable for X-ray equipment.

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Two-Story Storefront Building

118 E Canal Street, Picayune, MS 39466

$399,900

5,696 sqft 0.10 AC lot

The property is fully occupied and was recently remodeled, with C-3 zoning.

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Retail Building with Hardwood Floors

521 W Canal, Picayune, MS 39466

$273,000

1,696 sqft 0.43 AC lot

C-2 zoning and a flexible interior support salon, office, boutique, and other small-business uses.

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Manufacturing Facility with Sign Equipment

313 E Canal St, Picayune, MS 39466

$2,500,000

9,656 sqft

Manufacturing facility with sign-production equipment, transferable client accounts, parking, and rear drive-in access.

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Historic Mixed-Use Property

319 W Canal, Picayune, MS 39466

$269,000

2,120 sqft 0.40 AC lot

C-2 commercial zoning, adaptable interior space, and a wraparound porch support varied business concepts in downtown Picayune.

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Commercial Land Assemblage Near Interstate Access

Highland Parkway lot: 3-7, Picayune, MS 39466

$749,999

418,176 sqft 9.60 AC lot

Five contiguous parcels offer a substantial commercial site near Interstate 59 and State Highway 11.

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Medical Office with Exam Rooms

906 6th Ave, Picayune, MS 39466

$575,000

4,455 sqft

Office Professional zoning and a previously established clinical layout support a range of medical office configurations.

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Drive-Through Restaurant Property

711 Memorial Blvd., Picayune, MS 39466

$199,900

1,211 sqft 0.23 AC lot

Vacant commercial space with a dedicated drive-through lane and service window for restaurant-oriented occupancy.

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Mixed-Use Property with Ponds

119 Ceasar Rd, Picayune, MS 39466

$429,000

1,200 sqft 5.10 AC lot

COMM/RES zoning, water features, a greenhouse, and established recreational improvements create a flexible property setting.

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Three-Building Warehouse and Retail Site

1007 Highway 11 South, Picayune, MS 39466

$640,000

21,350 sqft 3.40 AC lot

Three buildings on 3.40 acres include a 10,000 SF warehouse separate from the main building.

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Commercial Land

714 N Curran Ave, Picayune, MS 39466

$124,000

10,454 sqft 0.24 AC lot

C-3 Highway Commercial zoning and public utilities support commercial site planning.

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Four-Screen Cinema Property

997 Cooper Road, Picayune, MS 39466

$1,150,000

10,800 sqft 1.90 AC lot

Freestanding theater facility near I-59 Exit 6 with C-3 zoning and a substantial on-site parking area.

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Renovated Commercial Building For Sale

16 Merrill Rd, Picayune, MS 39466

$2,100,000

12,160 sqft

Commercial building suitable for medical or general office use.

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Brick Corner Storefront

141 Kirkwood Street, Picayune, MS 39466

$139,700

1,325 sqft 0.05 AC lot

Downtown commercial building with OP-1 (Office Prof.) zoning and a prior pharmacy and retail history.

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Storefront Property with Freight Elevator

213 Highway 11 South, Picayune, MS 39466

$245,000

10,000 sqft

Multi-level commercial space includes a freight elevator and access from Highway 11 and South Curran Avenue.

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Day Care Property on Corner Lot

815 WILLIAMS Avenue, Picayune, MS 39466

$165,000

1,413 sqft

Commercial building with flexible room layout, off-street parking, and public water service.

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Picayune Cinema on 1.9 Acres

997 Cooper Rd, Picayune, MS 39466

$1,150,000

10,800 sqft 1.90 AC lot

Profitable, fully functional cinema with redevelopment potential in growing suburban market.

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Three-Building Warehouse Property

1007 Highway 11 S, Picayune, MS 39466

$640,000

21,350 sqft 3.40 AC lot

C-2-zoned commercial property with multiple buildings and substantial warehouse capacity.

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Historic Mixed-Use Property

319 W Canal, Picayune, MS 39466

$269,000

2,120 sqft

C-2 zoning and a flexible interior support retail, office, and other commercial concepts.

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Highway Commercial Land

Highland Parkway, Picayune, MS 39466

$1,445,000

5.78 AC lot

Public water service and cable availability are listed for the parcel.

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Picayune, MS Commercial Real Estate Market Trends and Statistics

Explore 96 commercial real estate for sale in Picayune, MS, showcased through 96 active listings on our real estate platform. These investment opportunities span a total of 10,974,089 square feet of properties for sale, with an estimated market value of $54,133,963.

Sale prices for business properties in Picayune, MS start at $47,000, averaging $741,561, and reaching up to $14,445,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

Picayune, MS CRE market trends — vacancy, lease rates and price per SF, updated monthly

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Demographics Overview

Population 28K

Population Growth (5Y) +8.6%

Median Household Income $50,926

College Educated 15.2%

High-Yield Neighborhoods for Investment

Identify Picayune submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

Neighborhood	Average Price
39466	$480.6K

Taxes & Financing

Average Loan-to-Value 65.0%

Listings Trend

New vs delisted commercial listings in Pearl River County

New Delisted

Total CRE Inventory on Market (SF)

Average Property Price per SF

For-sale Residential Income pricing trends in Pearl River County

Residential Income

Property Size Breakdown

The majority of commercial real estate listings in Picayune fall within the 25,000 to 50,000 square foot range.

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