Picayune, MS Commercial Real Estate for Sale

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Carriere, MS Pearl River, LA Talisheek, LA Kiln, MS Perkinston, MS Bush, LA Slidell, LA Abita Springs, LA

87 properties

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Updated: Apr 6

Medical Office Building with X-Ray Room

16 Merrill Road, Picayune, MS 39466

$2,100,000

12,160 sqft 2.00 AC lot

Easily adaptable layout due to non‑weight‑bearing walls, suitable for various commercial uses.
Recently underwent extensive interior renovation.
Excellent commercial location surrounded by established businesses (Home Depot, Keesler Credit, RaceTrac, Walmart, Banks).
Seconds from the interstate, providing convenient access.
Equipped with a lead‑proof room, ideal for medical use (e.g., X‑ray unit).

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Updated: Jun 23

Fenced Flex Building with Workshop

1306 S Haugh, Picayune, MS 39466

$355,000

7,201 sqft 1.05 AC lot

7,201 SF metal flex building on 1.05 acres
Two roll‑up doors serve the showroom
Workshop includes three roll‑up doors
Interior features office, retail counter, showroom, and stock rooms
Fenced outdoor storage area

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Historic Retail Landmark with Wraparound Porch

319 W Canal, Picayune, MS 39466

$279,000

2,120 sqft 0.40 AC lot

C-2 zoned retail landmark with original wood floors, high ceilings, oversized rooms, and a wraparound porch.

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Renovated Commercial Building For Sale

16 Merrill Rd, Picayune, MS 39466

$2,100,000

12,160 sqft

Commercial building suitable for medical or general office use.

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Retail Building with Hardwood Floors

521 W Canal, Picayune, MS 39466

$273,000

1,696 sqft 0.43 AC lot

C-2 zoning and a flexible interior support salon, office, boutique, and other small-business uses.

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Two-Story Retail Storefront

118 E Canal Street, Picayune, MS 39466

$399,900

5,696 sqft 0.10 AC lot

Recently remodeled, fully leased commercial space near downtown Picayune with access to Highway 11.

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Drive-Through Restaurant Property

711 Memorial Blvd., Picayune, MS 39466

$199,900

1,211 sqft 0.23 AC lot

Vacant drive-through restaurant site with service window on a high-visibility retail corridor.

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Historic Mixed-Use Property

319 W Canal St, Picayune, MS 39466

$279,000

2,120 sqft

C-2 zoning and a flexible interior support retail, office, and other commercial concepts.

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Commercial Land Assemblage Near Interstate Access

Highland Parkway lot: 3-7, Picayune, MS 39466

$749,999

418,176 sqft 9.60 AC lot

Five contiguous parcels offer a substantial commercial site near Interstate 59 and State Highway 11.

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Food-Processing Flex Building

106 Hayden Oaks Drive, Picayune, MS 39466

$495,000

2,500 sqft 0.40 AC lot

Newly built commercial space combines specialized food-preparation improvements with office, retail, and covered exterior areas.

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Storefront with Drive-Through

711 Memorial Blvd, Picayune, MS 39466

$199,900

1,211 sqft

Vacant commercial space includes a drive-through lane and service window for retail or food-service operations.

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Profitable Cinema on 1.9 Acres

997 Cooper Road, Picayune, MS 39466

$1,150,000

10,800 sqft 1.90 AC lot

Operating cinema with redevelopment potential in growing suburban market.

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Brick Corner Storefront

141 Kirkwood Street, Picayune, MS 39466

$149,700

1,325 sqft 0.05 AC lot

OP-1 zoning and prior pharmacy-retail use support office, medical, service, or boutique retail applications.

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Picayune Cinema on 1.9 Acres

997 Cooper Rd, Picayune, MS 39466

$1,150,000

10,800 sqft 1.90 AC lot

Profitable, fully functional cinema with redevelopment potential in growing suburban market.

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C-3 Commercial Land

714 N Curran Ave, Picayune, MS 39466

$124,000

10,454 sqft 0.24 AC lot

C-3 Highway Commercial zoning and public utilities support commercial development near Highway 11.

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Flex Warehouse with Multiple Bays

1707 E Canal, Picayune, MS 39466

$299,000

4,000 sqft 0.63 AC lot

Brand-new flex warehouse offers office space, multiple storage areas, several bays, and a digital sign.

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Downtown Picayune Commercial Building

141 Kirkwood St, Picayune, MS 39466

$149,700

1,325 sqft

Versatile commercial building in downtown Picayune, suitable for various businesses.

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Versatile Corner Commercial Building

815 WILLIAMS Avenue, Picayune, MS 39466

$165,000

1,413 sqft

Corner lot commercial building with three private rooms/offices, two baths, kitchen, laundry, and enclosed sunroom.

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High-Visibility Highway Commercial Lot

714 N Curran Ave, Picayune, MS 39466

$124,000

10,454 sqft

Zoned C-3 Highway Commercial, this ready-to-build lot with public utilities sits just off Highway 11.

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Warehouse With Built-In Offices

1817 Palestine Rd, Picayune, MS 39466

$199,000

7,500 sqft 2.00 AC lot

I2-zoned warehouse with office space and a two-acre site supporting parking, outdoor storage, or light industrial operations.

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Day Care Center with Enclosed Sunroom

815 Williams Ave, Picayune, MS 39466

$165,000

15,422 sqft

Flexible layout includes private rooms, bathrooms, kitchen, laundry, and a climate-controlled enclosed sunroom.

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Mixed-Use Property with Dual Frontage

2467 Highway 43 S, Picayune, MS 39466

$619,900

6,755 sqft 2.34 AC lot

C4-zoned commercial property with road access, rear quarters, and a layout suited to several stated uses.

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Versatile Commercial Space For Sale

1707 E Canal St, Picayune, MS 39466

$299,000

4,000 sqft

4000 sqft commercial property with high visibility and versatile space.

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Picayune Church Property For Sale

1700 GOODYEAR BLVD, Picayune, MS 39466

$425,000

4,410 sqft 0.61 AC lot

Community church with sanctuary, meeting rooms, and kitchen.

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Picayune, MS Commercial Real Estate Market Trends and Statistics

Explore 87 commercial real estate for sale in Picayune, MS, showcased through 87 active listings on our real estate platform. These investment opportunities span a total of 2,207,900 square feet of properties for sale, with an estimated market value of $26,861,562.

Sale prices for business properties in Picayune, MS start at $53,000, averaging $433,251, and reaching up to $2,100,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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Demographics Overview

Population 28K

Population Growth (5Y) +8.6%

Median Household Income $50,926

College Educated 15.2%

High-Yield Neighborhoods for Investment

Identify Picayune submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

Neighborhood	Average Price
39466	$413.7K

Taxes & Financing

Average Loan-to-Value 65.0%

Listings Trend

New vs delisted commercial listings in Pearl River County

New Delisted

Total CRE Inventory on Market (SF)

Average Property Price per SF

For-sale pricing trends across core commercial property types in Pearl River County

Office

Property Size Breakdown

The majority of commercial real estate listings in Picayune fall within the 25,000 to 50,000 square foot range.

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