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    Sikeston, MO Office Properties & Spaces for Sale

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    Downtown Sikeston Commercial Office Building
    $279,000
    4,273 SF

    Downtown Sikeston Commercial Office Building

    202 S Kingshighway St, Sikeston, MO 63801

    Commercial property with endless business opportunities in downtown Sikeston.

    • Large 7,638 sq ft building suitable for diverse business opportunities.
    • Prime downtown Sikeston location on a corner lot.
    • Includes 15 parking spaces with handicap accessibility (2 spaces and ramp).
    • Functional layout with reception area, open workspace, private offices, conference room, and break room.
    • Equipped with both stairs and an elevator for basement access.
    Updated: Dec 10, 2025
    View details
    Based on your search, we've compiled 151 Potential Opportunities for your consideration. Besides 2 Active listings in Sikeston, MO, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 142 Off-Market properties to explore as potential leads, plus 3 Land Listings that present a potential for development.

    Explore Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Remodeled Commercial Building in Downtown
    $259,900
    4,000 SF

    Remodeled Commercial Building in Downtown

    Turn-key restaurant or flexible commercial space in downtown Dexter.

    117 S Locust St, Dexter, MO 63841
    View details
    Warehouse with Farmland in Dexter
    $1,595,000
    43.80 Acres

    Warehouse with Farmland in Dexter

    15,000 sq ft warehouse on 43.8 acres near Dexter.

    1405 Arvin Rd, Dexter, MO 63841
    View details
    Versatile Commercial Building in Cape
    $225,000
    0.57 Acres

    Versatile Commercial Building in Cape

    Adaptable 1800 sq ft commercial building in thriving Cape Girardeau.

    2357 Rust Ave, Cape Girardeau, MO 63703
    View details
    Cape Girardeau Commercial Property
    Pending
    $825,000
    7,000 SF

    Cape Girardeau Commercial Property

    Well-maintained commercial property with over 7,000 square feet.

    340 S Broadview St, Cape Girardeau, MO 63703
    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Commercial Land on Highway 61
    $144,000
    1.01 Acres

    Commercial Land on Highway 61

    Commercial land on high-traffic route near Sikeston Industrial Park.

    103 Grove St, Sikeston, MO 63801
    View details
    Commercial Land in Sikeston, MO
    $195,000
    0.72 Acres

    Commercial Land in Sikeston, MO

    Vacant, level commercial lot available in Sikeston, Missouri.

    116 Hospitality Dr, Sikeston, MO 63801
    View details
    Commercial Land Ready For Development
    $199,000
    2.00 Acres

    Commercial Land Ready For Development

    Two-acre commercial lot available for development in Sikeston, Missouri.

    224 S Interstate Dr, Sikeston, MO 63801
    View details

    Explore Off-Market Properties in Sikeston, MO

    Consider similar Off-Market properties in Sikeston, MO. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    2863 Malone Ave

    2863 Malone Ave

    OFFICE BUILDING • 2,400 SF
    Value Estimation by Request
    2863 Malone Ave, Sikeston, MO 63801-8616
    View details
    106 Plz Dr

    106 Plz Dr

    OFFICE BUILDING • 2,780 SF
    Value Estimation by Request
    106 Plz Dr, Sikeston, MO 63801-5137
    View details
    2400 Rose Pkwy

    2400 Rose Pkwy

    OFFICE BUILDING • 188,562 SF
    Value Estimation by Request
    2400 Rose Pkwy, Sikeston, MO 63801-7192
    View details
    217 Tanner St

    217 Tanner St

    OFFICE BUILDING • 1,796 SF
    Value Estimation by Request
    217 Tanner St, Sikeston, MO 63801-4268
    View details
    Tanner St

    Tanner St

    OFFICE BUILDING • 2,925 SF
    Value Estimation by Request
    Tanner St, Sikeston, MO 63801
    View details
    713 Tanner St

    713 Tanner St

    OFFICE BUILDING • 2,782 SF
    Value Estimation by Request
    713 Tanner St, Sikeston, MO 63801-2160
    View details
    Sikeston, MO 63801

    Sikeston, MO 63801

    OFFICE BUILDING • 2,940 SF
    Value Estimation by Request
    Sikeston, MO 63801
    View details
    Rodgers Ave

    Rodgers Ave

    OFFICE BUILDING • 1,550 SF
    Value Estimation by Request
    Rodgers Ave, Sikeston, MO 63801
    View details
    300 Wn St

    300 Wn St

    OFFICE BUILDING • 1,232 SF
    Value Estimation by Request
    300 Wn St, Sikeston, MO 63801-4134
    View details
    218 Ctr St

    218 Ctr St

    OFFICE BUILDING • 10,604 SF
    Value Estimation by Request
    218 Ctr St, Sikeston, MO 63801-4229
    View details
    602 Compress Rd

    602 Compress Rd

    OFFICE BUILDING • 6,060 SF
    Value Estimation by Request
    602 Compress Rd, Sikeston, MO 63801-5403
    View details
    615 Greer Ave

    615 Greer Ave

    OFFICE BUILDING • 1,074 SF
    Value Estimation by Request
    615 Greer Ave, Sikeston, MO 63801-3233
    View details
    501 Interstate Dr

    501 Interstate Dr

    OFFICE BUILDING • 4,500 SF
    Value Estimation by Request
    501 Interstate Dr, Sikeston, MO 63801-8608
    View details
    Interstate N Dr

    Interstate N Dr

    OFFICE BUILDING • 4,860 SF
    Value Estimation by Request
    Interstate N Dr, Sikeston, MO 63801
    View details
    105 Kathleen St

    105 Kathleen St

    OFFICE BUILDING • 1,008 SF
    Value Estimation by Request
    105 Kathleen St, Sikeston, MO 63801-2941
    View details
    504 Kendall St

    504 Kendall St

    OFFICE BUILDING • 2,400 SF
    Value Estimation by Request
    504 Kendall St, Sikeston, MO 63801-2742
    View details
    240 Kingshighway St

    240 Kingshighway St

    OFFICE BUILDING • 4,060 SF
    Value Estimation by Request
    240 Kingshighway St, Sikeston, MO 63801-4102
    View details
    710 Lk St

    710 Lk St

    MEDICAL BUILDING • 990 SF
    Value Estimation by Request
    710 Lk St, Sikeston, MO 63801-2165
    View details
    811 Main St

    811 Main St

    OFFICE BUILDING • 2,170 SF
    Value Estimation by Request
    811 Main St, Sikeston, MO 63801-2171
    View details
    805 Main St

    805 Main St

    OFFICE BUILDING • 3,000 SF
    Value Estimation by Request
    805 Main St, Sikeston, MO 63801-2171
    View details
    801 Main St

    801 Main St

    OFFICE BUILDING • 5,560 SF
    Value Estimation by Request
    801 Main St, Sikeston, MO 63801-5806
    View details
    106 Arthur

    106 Arthur

    OFFICE BUILDING • 25,000 SF
    Value Estimation by Request
    106 Arthur, Sikeston, MO 63801-5453
    View details
    315 Kingshighway St

    315 Kingshighway St

    OFFICE BUILDING • 1,822 SF
    Value Estimation by Request
    315 Kingshighway St, Sikeston, MO 63801-2947
    View details

    Sikeston, MO Office Properties & Spaces Investment Opportunities Market Analysis

    Explore 144 office properties & spaces for sale in Sikeston, MO on our real estate platform. These investment opportunities span a total of 585,719 square feet of properties for sale, with an estimated market value of $5,114,000.

    Sale prices for office spaces in Sikeston, MO start at $279,000, averaging $568,222, and reaching up to $775,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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