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Location, type, price

Office

Perryville, MO Office Spaces for Sale

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Oak Ridge, MO Sedgewickville, MO Millersville, MO Jackson, MO Altenburg, MO Marble Hill, MO Whitewater, MO Marquand, MO

6 properties

Office Building with Attached Garage

Updated: May 17

Office Building with Attached Garage

875 PCR 500, Perryville, MO 63775

$745,000

5.16 AC lot

5.16+/- acres outside Perryville city limits
Main building includes 8 offices, reception, conference room, 2 vaults, kitchen, storage, and product showcase space
48x52 attached garage with overhead doors, half bath, electric, and furnace
88x24 outbuilding with gravel floors, electric, 2 enclosed bays, and an open lean‑to
Solar panels installed on site; two parking areas and multiple entrances

Multi-Tenant Office Building

Updated: Sep 1

Multi-Tenant Office Building

519 N Main Street, Perryville, MO 63775

$405,000

4,099 sqft

4,099‑square‑foot brick office building, constructed in 1983
Originally designed for three units; currently configured as two with secured interior access
Lobby, reception and bill collection areas, private offices, open work areas, conference room, and kitchenette
Four half baths
New roof installed in 2026; three HVAC systems, each approximately eight years old or newer

Office Building with Garage

Office Building with Garage

875 PCR 500, Perryville, MO 63775

$745,000

5.16 AC lot

Solar panels, multiple entrances and two parking areas are among the property's operational features.

Realmo Analytics Monitor Off-market properties and contact owners who are ready to sell. Many signals applied to make quality leads for you. Get Leads

Flex Space with Separate Office

Flex Space with Separate Office

1205 N Kingshighway St, Perryville, MO 63775

Contact for pricing

13,134 sqft

Flex property combines a large shop with a separate office building for operational and administrative functions.

Turnkey Historic Brick Office Building

Turnkey Historic Brick Office Building

23/25/27 W Saint Joseph St, Perryville, MO 63775

$1,150,000

Fully restored 1859 brick building with updated HVAC including central air and mini-splits, plus multiple income-producing spaces.

Class A Professional Office Plaza

Class A Professional Office Plaza

1304-1310 Brenda Ave., Perryville, MO 63775

Contact for pricing

Professional office units in a Class A plaza with off-street parking and backlit monument signage.

Based on your search, we've compiled 78 Potential Opportunities for your consideration. Besides 6 Active listings in Perryville, MO, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 66 Off-Market properties to explore as potential leads, plus 2 Land Listings that present a potential for development.

Opportunities in Nearby Cities

Here are 4 Similar properties we found in Nearby Locations for your consideration.

Renovated Historic Mixed-Use Property

Renovated Historic Mixed-Use Property

305 N Main Street, Ste Genevieve, MO 63670

$540,000

2.83 AC lot

Stone residence and detached commercial building support a flexible live-work arrangement in a historic district.

Commercial Sale, Chester, IL

Commercial Sale, Chester, IL

1205 Swanwick St, Chester, IL 62233

$105,000

0.10 AC lot

Multiple office areas include rear storage and a partial basement for additional functional space.

Updated Office Building

Updated Office Building

1205 Swanwick Street, Chester, IL 62233

$105,000

0.10 AC lot

Multiple office areas include rear storage and a partial basement for additional functional space.

Four-Office Building

Four-Office Building

205 Sainte Genevieve Dr, Ste Genevieve, MO 63670

$150,000

Interior includes a larger room, a utility room, one and a half baths, and a single-car carport.

Potential Development Sites for Consideration

Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

C-2 Commercial Land with Frontage

C-2 Commercial Land with Frontage

1324 W Saint Joseph Street, Perryville, MO 63775

$972,000

1,092 sqft 0.94 AC lot

C-2 commercial land with public water, public sewer, and completed site improvements.

Commercial Land with Highway Frontage

Commercial Land with Highway Frontage

540 East Broadway, Sparta, IL 62286

Contact for pricing

Commercial parcel between two medical facilities with state highway frontage, public water, and public sewer.

Off-Market Properties in Perryville, MO

Consider similar Off-Market properties in Perryville, MO. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

123 Spg St

OFFICE (GENERAL)

123 Spg St, Perryville, MO 63775-2040

Estimated value:

$255,000

2,341 sqft 0.30 AC lot

11 Saint Joseph St

OFFICE (GENERAL)

11 Saint Joseph St, Perryville, MO 63775-1344

Estimated value:

$195,000

1,776 sqft

102 St

RADIO OR TV STATION

102 St, Perryville, MO 63775-2002

Estimated value: by Request

103 Saint Joseph St

OFFICE (GENERAL)

103 Saint Joseph St, Perryville, MO 63775-1345

Estimated value:

$265,000

7,912 sqft 0.10 AC lot

1508 Edgemont Blvd

DENTAL BUILDING

1508 Edgemont Blvd, Perryville, MO 63775-1231

Estimated value:

$420,000

6,408 sqft 1.00 AC lot

121 Main St

DENTAL BUILDING

121 Main St, Perryville, MO 63775-2524

Estimated value:

$265,000

1,960 sqft

624 Old Saint Marys Rd

OFFICE (GENERAL)

624 Old Saint Marys Rd, Perryville, MO 63775-1832

Estimated value:

$270,000

4,700 sqft 0.30 AC lot

4200 Pcr 806

OFFICE (GENERAL)

4200 Pcr 806, Perryville, MO 63775-9187

Estimated value:

$245,000

720 sqft 5.00 AC lot

334 Main St

DENTAL BUILDING

334 Main St, Perryville, MO 63775-1362

Estimated value:

$250,000

1,470 sqft

8 Sainte Marie St

OFFICE (GENERAL)

8 Sainte Marie St, Perryville, MO 63775-1347

Estimated value:

$265,000

4,420 sqft

108 En St

OFFICE (GENERAL)

108 En St, Perryville, MO 63775-2005

Estimated value:

$145,000

600 sqft 0.10 AC lot

3146 Hwy 51

OFFICE (GENERAL)

3146 Hwy 51, Perryville, MO 63775-7153

Estimated value:

$150,000

144 sqft 1.60 AC lot

1426 Kingshighway St

OFFICE (GENERAL)

1426 Kingshighway St, Perryville, MO 63775

Estimated value:

$260,000

336 sqft

875 Pcr 500

Office Spaces

875 Pcr 500, Perryville, MO 63775

Estimated value: by Request

6,854 sqft 8.66 AC lot

181 Whippoorwill Ln

RADIO OR TV STATION

181 Whippoorwill Ln, Perryville, MO 63775-8635

Estimated value: by Request

111 Walnut St

OFFICE (GENERAL)

111 Walnut St, Perryville, MO 63775-2000

Estimated value:

$250,000

2,400 sqft

315 Smith St

OFFICE (GENERAL)

315 Smith St, Perryville, MO 63775-1928

Estimated value:

$150,000

736 sqft

Shannie Rd

RADIO OR TV STATION

Shannie Rd, Perryville, MO 63775

Estimated value:

$245,000

0.10 AC lot

Perryville, MO Office Spaces Market Trends and Statistics

Explore 72 office spaces for sale in Perryville, MO, showcased through 6 active listings on our real estate platform. These investment opportunities span a total of 17,233 square feet of properties for sale, with an estimated market value of $3,045,000.

Sale prices for office properties in Perryville, MO start at $405,000, averaging $761,250, and reaching up to $1,150,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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Top Commercial Asset Segments

Commercial property segments ranked by active listings on the market

Demographics Overview

Population 17K

Population Growth (5Y) +21.1%

Median Household Income $65,171

College Educated 18.7%

High-Yield Neighborhoods for Investment

Identify Perryville submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

Neighborhood	Average Price
63775	$631.7K

Taxes & Financing

Average Loan-to-Value 65.0%

Listings Trend

New vs delisted commercial listings in Cape Girardeau County

New Delisted

Total CRE Inventory on Market (SF)

How Realmo verifies these figures

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