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    Perryville, MO
    Mixed-Use

    Perryville, MO Mixed-use Properties for Sale

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    Oak Ridge, MO Sedgewickville, MO Millersville, MO Jackson, MO Marble Hill, MO Patton, MO Whitewater, MO Cape Girardeau, MO
    Two-Level Day Care Center
    Updated: Aug 20
    Two-Level Day Care Center

    4 Kiefner Street, Perryville, MO 63775

    $335,000
    0.36 AC lot
    Over 4,000 square feet across two levels
    0.359‑acre lot at 4 Kiefner Street, Perryville, MO 63775
    Main level configured for childcare operations
    Upper level offers additional childcare, office, or living flexibility, subject to approvals
    New windows, updated HVAC systems, and a new roof over the flat portion completed within the last five years
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    Multi-Tenant Mixed-Use Property
    Updated: Dec 17, 2025
    Multi-Tenant Mixed-Use Property

    104-110 N Jackson Street, Perryville, MO 63775

    $3,030,000
    0.09 AC lot
    Eight residential units with a mix of short‑term Airbnbs and long‑term leases
    Four commercial units, all fully leased
    Electrical and HVAC systems updated in the commercial spaces
    Brick building constructed in 1901
    Located on the downtown square at 104‑110 N Jackson Street
    View details
    Realmo Analytics Monitor Off-market properties and contact owners who are ready to sell. Many signals applied to make quality leads for you. Get Leads
    Based on your search, we've compiled 11 Potential Opportunities for your consideration. Besides 2 Active listings in Perryville, MO, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 5 Off-Market properties to explore as potential leads

    Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Historic Mixed-Use Property
    Historic Mixed-Use Property

    305 N Main St, Ste Genevieve, MO 63670

    $540,000
    7,100 sqft

    Renovated stone residence with detached salon building and on-site parking.

    View details
    Renovated Historic Mixed-Use Property
    Renovated Historic Mixed-Use Property

    305 N Main Street, Ste Genevieve, MO 63670

    $540,000
    2.83 AC lot

    Stone residence and detached commercial building support a flexible live-work arrangement in a historic district.

    View details
    Flex Property With Apartment
    Flex Property With Apartment

    541B Hillview Drive, Chester, IL 62233

    $895,000
    5.63 AC lot

    Two buildings combine business space, an upstairs apartment, and a loft on a multi-acre commercial parcel.

    View details
    Highway Flex Space
    Highway Flex Space

    000 State Route 3, Chester, IL 62233

    Contact for pricing
    17,138 sqft 2.76 AC lot

    Commercially zoned acreage with an industrial building and direct State Route 3 access.

    View details

    Off-Market Properties in Perryville, MO

    Consider similar Off-Market properties in Perryville, MO. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    875 Pcr 500
    Office Spaces

    875 Pcr 500, Perryville, MO 63775

    Estimated value: by Request
    6,854 sqft 8.66 AC lot
    View details
    1750 Perryville Blvd
    STORE/OFFICE (MIXED USE)

    1750 Perryville Blvd, Perryville, MO 63775-6156

    Estimated value:
    $840,000
    109,538 sqft 16.00 AC lot
    View details
    6 Perryville Blvd
    STORE/OFFICE (MIXED USE)

    6 Perryville Blvd, Perryville, MO 63775-1267

    Estimated value:
    $380,000
    10,416 sqft 2.70 AC lot
    View details
    1011 Perryville Blvd
    STORE/OFFICE (MIXED USE)

    1011 Perryville Blvd, Perryville, MO 63775-2868

    Estimated value:
    $950,000
    45,400 sqft 7.40 AC lot
    View details
    628 Old Saint Marys Rd
    STORE/OFFICE (MIXED USE)

    628 Old Saint Marys Rd, Perryville, MO 63775-1837

    Estimated value:
    $315,000
    13,952 sqft 1.60 AC lot
    View details

    Perryville, MO Mixed-Use Properties Market Trends and Statistics

    Explore 7 mixed-use properties for sale in Perryville, MO on our real estate platform.

    Sale prices for multi use buildings in Perryville, MO start at $335,000, averaging $1,682,500, and reaching up to $3,030,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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    Demographics Overview

    Population 17K
    Population Growth (5Y) +21.1%
    Median Household Income $65,171
    College Educated 18.7%

    High-Yield Neighborhoods for Investment

    Identify Perryville submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

    Neighborhood Average Price
    63775 $1.7M

    Taxes & Financing

    Average Loan-to-Value 65.0%

    Listings Trend

    New vs delisted commercial listings in Cape Girardeau County

    New Delisted

    Total CRE Inventory on Market (SF)

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