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    Perryville, MO
    Health Care

    Perryville, MO Healthcare Properties for Sale

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    Oak Ridge, MO Daisy, MO Sedgewickville, MO Jackson, MO Millersville, MO Hermann, MO Frohna, MO Marble Hill, MO
    Remodeled Flex Space
    Updated: Aug 31
    Remodeled Flex Space

    805 N Main Street, Perryville, MO 63775

    $235,000
    0.19 AC lot
    2023 remodel with updated plumbing, HVAC, and electrical wiring
    Full‑view storefront and 10' x 10' garage door
    30' x 47' paved parking area
    0.189‑acre parcel in Perryville, MO
    Finished bathroom with walk‑in shower and ceramic tile flooring
    View details
    Turnkey Historic Brick Office Building
    Updated: Oct 13, 2025
    Turnkey Historic Brick Office Building

    23/25/27 W Saint Joseph Street, Perryville, MO 63775

    $1,150,000
    1859 brick historic commercial building, built as the first brick building on the square
    Fully replumbed, rewired, and reroofed, with updated HVAC including central air and mini‑splits
    All new windows plus tuckpointing inside and out for long‑term durability
    Currently features three office spaces, an operating salon, and three Airbnb units on the upper level
    Interior includes reception/waiting areas, multiple private offices and break rooms, and a functional layout
    View details
    See what stands out in Cape Girardeau County

    We check every for-sale listing in the county against comparable properties across the country. Most price about where you would expect. A few are worth a second look.

    We check every listing here. A few are worth a second look.

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    Based on your search, we've compiled 18 Potential Opportunities for your consideration. Besides 2 Active listings in Perryville, MO, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 12 Off-Market properties to explore as potential leads

    Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Commercial Building with Abundant Parking
    Commercial Building with Abundant Parking

    1429 N Mount Auburn Rd, Cape Girardeau, MO 63701

    $2,500,000
    2,614 sqft 1.87 AC lot

    Versatile commercial building on 1.9 acres with ample parking.

    View details
    Nursing Facility with Historic Home
    Nursing Facility with Historic Home

    207 E Front St., Annapolis, MO 63620

    $379,500
    0.46 AC lot

    Two-story brick residence complements a purpose-built care wing with suites, common areas, accessibility features, and updated systems.

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    Single-Tenant Ambulatory Surgery Center
    Single-Tenant Ambulatory Surgery Center

    3241 Percy Dr, Cape Girardeau, MO 63701

    Contact for pricing
    13,650 sqft

    Single-tenant ambulatory surgery center across from St. Francis Medical Center with two years remaining on lease.

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    Daycare Facility with Historic Residence
    Daycare Facility with Historic Residence

    207 E. Front St., Annapolis, MO 63620

    $379,500

    Expanded childcare property with specialized rooms, common areas, secured outdoor space, and commercial kitchen infrastructure.

    View details

    Off-Market Properties in Perryville, MO

    Consider similar Off-Market properties in Perryville, MO. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    1508 Edgemont Blvd
    DENTAL BUILDING

    1508 Edgemont Blvd, Perryville, MO 63775-1231

    $420,000
    Estimated value
    6,408 sqft 1.00 AC lot
    View details
    121 Main St
    DENTAL BUILDING

    121 Main St, Perryville, MO 63775-2524

    $265,000
    Estimated value
    1,960 sqft
    View details
    334 Main St
    DENTAL BUILDING

    334 Main St, Perryville, MO 63775-1362

    $250,000
    Estimated value
    1,470 sqft
    View details
    202 Sainte Marie St
    DENTAL BUILDING

    202 Sainte Marie St, Perryville, MO 63775-2031

    $260,000
    Estimated value
    561 sqft
    View details
    203 Saint Joseph St
    DENTAL BUILDING

    203 Saint Joseph St, Perryville, MO 63775-1827

    $290,000
    Estimated value
    1,404 sqft
    View details
    908 Kingshighway St
    DENTAL BUILDING

    908 Kingshighway St, Perryville, MO 63775-2108

    $260,000
    Estimated value
    1,320 sqft 1.90 AC lot
    View details
    12 Jackson St
    DENTAL BUILDING

    12 Jackson St, Perryville, MO 63775-2515

    $285,000
    Estimated value
    3,070 sqft
    View details
    14 Jackson St
    DENTAL BUILDING

    14 Jackson St, Perryville, MO 63775-2515

    $280,000
    Estimated value
    1,104 sqft
    View details
    100 Jackson St
    DENTAL BUILDING

    100 Jackson St, Perryville, MO 63775-2517

    $285,000
    Estimated value
    2,576 sqft 0.30 AC lot
    View details
    1506 Saint Joseph St Ste, Unit 30
    DENTAL BUILDING

    1506 Saint Joseph St Ste, Perryville, MO 63775-1681

    Unit 30
    $350,000
    Estimated value
    9,920 sqft 1.00 AC lot
    View details
    22 St
    DENTAL BUILDING

    22 St, Perryville, MO 63775-2547

    $280,000
    Estimated value
    1,036 sqft 0.30 AC lot
    View details
    430 St
    HOMES (RETIRED, NURSING)

    430 St, Perryville, MO 63775-1359

    $545,000
    Estimated value
    38,876 sqft 5.30 AC lot
    View details

    Perryville, MO Healthcare Properties Market Trends and Statistics

    Explore 14 healthcare properties for sale in Perryville, MO on our real estate platform.

    Sale prices for medical real estate in Perryville, MO start at $235,000, averaging $692,500, and reaching up to $1,150,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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    Top Commercial Asset Segments

    Commercial property segments ranked by active listings on the market

    Spa & wellness properties 2

    Demographics Overview

    Population 17K
    Population Growth (5Y) +21.1%
    Median Household Income $65,171
    College Educated 18.7%

    High-Yield Neighborhoods for Investment

    Identify Perryville submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

    Neighborhood Average Price
    63775 $1.2M

    Taxes & Financing

    Average Loan-to-Value 65.0%

    Listings Trend

    New vs delisted commercial listings in Cape Girardeau County

    New Delisted

    Total CRE Inventory on Market (SF)

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