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    Clayton, MO
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    Clayton, MO Office Spaces for Sale

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    Richmond Heights, MO Saint Louis, MO Maplewood, MO
    Clayton CBD Freestanding Building
    $1,499,000
    5,573 SF
    Clayton CBD Freestanding Building

    7530 Maryland Ave, Clayton, MO

    Architecturally significant building in Clayton CBD, suitable for various uses.
    • Prime Clayton CBD location offering potential for luxury single‑family home or duplex conversion.
    • Architecturally significant building designed by William B. Ittner with historic details.
    • Boasts substantial square footage: Nearly 6,400 SF across 1st & 2nd floors, plus a 3,300 SF basement.
    • Flexible R‑2 zoning allows for residential, office, educational, or mixed‑use development without zoning variance.
    • Unique features include a terrazzo staircase, 3 fireplaces, and a boardroom.
    Updated: Jul 14, 2025
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    Clayton Road Retail Opportunity
    $5,995,000
    8,500 SF
    Clayton Road Retail Opportunity

    8211-8221 Clayton Rd, Clayton, MO

    Retail and office spaces available in prime Clayton location.
    • Prime location across from the St. Louis Galleria
    • Superb access to prime St. Louis demographics: Ladue, Richmond Heights, Clayton, and University City
    • Great visibility on Clayton Rd. just west of Brentwood
    • 8211 Clayton: 8,500± sq. ft. retail building, could be demised
    • 8221 Clayton: 7,000± sq. ft. 1st floor office or retail, 3,300± sq. ft. second floor updated office
    Updated: Jul 19, 2024
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    Clayton Office Building For Sale
    $2,295,000
    19,330 SF
    Clayton Office Building For Sale

    Prime location with highway access and parking.

    889 S Brentwood Blvd, Clayton, MO

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    Clayton Office Building For Sale
    $2,295,000
    19,330 SF
    Clayton Office Building For Sale

    19,330 SqFt office building in Clayton, Missouri.

    889 S Brentwood Blvd, Clayton, MO 63105

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    26,400 SF Clayton Office Building
    Contact for pricing
    26,400 SF
    26,400 SF Clayton Office Building

    Free-standing building in downtown Clayton with covered parking.

    10 N Hanley Rd, Clayton, MO

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    Based on your search, we've compiled 18 Potential Opportunities for your consideration. Besides 5 Active listings in Clayton, MO, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 5 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

    Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Prime Richmond Heights Office Space
    Contact for pricing
    1,000 SF
    Prime Richmond Heights Office Space

    Spacious office suites in a high-visibility Richmond Heights location.

    1047 S Big Bend Boulevard, Richmond Heights, MO 63117

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    Office Building in Clayton, MO
    Contact for pricing
    10,535 SF
    Office Building in Clayton, MO

    Office building in a bustling downtown area.

    8077 Maryland Ave, Saint Louis, MO

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    Richmond Heights Office Building For Sale
    Contact for pricing
    58,249 SF
    Richmond Heights Office Building For Sale

    Office building in Richmond Heights, Missouri, with value-add opportunity.

    7700-7750 Clayton Rd, Richmond Heights, MO

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    St. Louis Office Building For Sale
    $1,595,000
    5,380 SF
    St. Louis Office Building For Sale

    Office building with 5380 square feet available for sale.

    Saint Louis, MO 63117

    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Vacant Lot in St. Louis
    Contact for pricing
    Vacant Lot in St. Louis

    Residential lot in established St. Louis neighborhood, close to amenities.

    5089 Raymond Avenue, St, Louis, MO 63113

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    Commercial Land in St Louis
    $100,000
    0.07 Acres
    Commercial Land in St Louis

    Level commercial land in the Forest Park Southeast Neighborhood.

    4481 Hunt Avenue, St, Louis, MO 63110

    View details
    Prime Development Land in St. Louis
    $130,000
    Prime Development Land in St. Louis

    Development opportunity in a coveted urban neighborhood near Grand Center.

    3912 Olive Street, St, Louis, MO 63108

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    Prime Development Land in Central West
    $130,000
    0.95 Acres
    Prime Development Land in Central West

    Development opportunity in coveted urban neighborhood near Grand Center Arts.

    3910 Olive Street, St, Louis, MO 63108

    View details

    Off-Market Properties in Clayton, MO

    Consider similar Off-Market properties in Clayton, MO. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    212 Central Ave

    212 Central Ave

    Office Spaces • 56,000 SF
    Value Estimation by Request
    212 Central Ave, Clayton, MO 63105
    View details
    7733 Forsyth Blvd

    7733 Forsyth Blvd

    Coworking space • 15,190 SF
    Value Estimation by Request
    7733 Forsyth Blvd, Clayton, MO 63105
    View details
    225-235 Meramec Ave

    225-235 Meramec Ave

    Medical Office Space • 102,600 SF
    Value Estimation by Request
    225-235 Meramec Ave, Clayton, MO 63105
    View details
    8001 Forsyth Blvd

    8001 Forsyth Blvd

    Office Spaces • 282,000 SF
    Value Estimation by Request
    8001 Forsyth Blvd, Clayton, MO 63105
    View details
    34 Brentwood Blvd

    34 Brentwood Blvd

    Office Spaces • 34,200 SF
    Value Estimation by Request
    34 Brentwood Blvd, Clayton, MO 63105
    View details

    Clayton, MO Office Spaces Investment Opportunities Market Analysis

    Explore 10 office spaces for sale in Clayton, MO, showcased through 5 active listings on our real estate platform. These investment opportunities span a total of 52,733 square feet of properties for sale, with an estimated market value of $12,084,000.

    Sale prices for office spaces in Clayton, MO start at $1,499,000, averaging $3,021,000, and reaching up to $5,995,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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    Top Commercial Asset Segments

    Office Units 31
    Office buildings 10
    Coworking space 3
    Medical Office Space 1

    Demographics Overview

    Population 39K
    Population Growth (5Y) +2.3%
    Median Household Income $131,270

    High-Yield Neighborhoods for Strategic Investment

    Identify Clayton submarkets with the highest inventory density on the market and evaluate the median listing prices of real estate assets

    Neighborhood Average Price
    Saint Louis - 63117 $1.9M
    Saint Louis - 63105 $2.3M

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