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    Clayton, MO Commercial Real Estate for Sale

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    Saint Louis, MO Richmond Heights, MO Maplewood, MO
    Clayton CBD Freestanding Building
    $1,499,000
    5,573 SF
    Clayton CBD Freestanding Building

    7530 Maryland Ave, Clayton, MO

    Architecturally significant building in Clayton CBD, suitable for various uses.
    • Prime Clayton CBD location offering potential for luxury single‑family home or duplex conversion.
    • Architecturally significant building designed by William B. Ittner with historic details.
    • Boasts substantial square footage: Nearly 6,400 SF across 1st & 2nd floors, plus a 3,300 SF basement.
    • Flexible R‑2 zoning allows for residential, office, educational, or mixed‑use development without zoning variance.
    • Unique features include a terrazzo staircase, 3 fireplaces, and a boardroom.
    Updated: Jul 14, 2025
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    Clayton Road Retail Opportunity
    $6,495,000
    8,500 SF
    Clayton Road Retail Opportunity

    8211-8221 Clayton Rd, Clayton, MO

    Retail and office spaces available in prime Clayton location.
    • Prime location across from the St. Louis Galleria
    • Superb access to prime St. Louis demographics: Ladue, Richmond Heights, Clayton, and University City
    • Great visibility on Clayton Rd. just west of Brentwood
    • 8211 Clayton: 8,500± sq. ft. retail building, could be demised
    • 8221 Clayton: 7,000± sq. ft. 1st floor office or retail, 3,300± sq. ft. second floor updated office
    Updated: Jul 19, 2024
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    Clayton Office Building For Sale
    $2,295,000
    19,330 SF
    Clayton Office Building For Sale

    Prime location with highway access and parking.

    889 S Brentwood Blvd, Clayton, MO

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    26,400 SF Clayton Office Building
    Contact for pricing
    26,400 SF
    26,400 SF Clayton Office Building

    Free-standing building in downtown Clayton with covered parking.

    10 N Hanley Rd, Clayton, MO

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    Based on your search, we've compiled 22 Potential Opportunities for your consideration. Besides 4 Active listings in Clayton, MO, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 14 Off-Market properties to explore as potential leads

    Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Richmond Heights Retail Investment Opportunity
    $3,015,000
    5,250 SF
    Richmond Heights Retail Investment Opportunity

    NNN leased retail property with long-term tenant and annual increases.

    1026 S Brentwood Blvd, Richmond Heights, MO

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    Retail Showroom Building For Sale
    $3,000,000
    36,960 SF
    Retail Showroom Building For Sale

    36,960 SF retail showroom near Clayton Rd intersection.

    Saint Louis, MO

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    Prime Richmond Heights Office Space
    Contact for pricing
    1,000 SF
    Prime Richmond Heights Office Space

    Spacious office suites in a high-visibility Richmond Heights location.

    Saint Louis, MO 63117

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    Richmond Heights Office Building For Sale
    Contact for pricing
    58,249 SF
    Richmond Heights Office Building For Sale

    Office building in Richmond Heights, Missouri, with value-add opportunity.

    7700-7750 Clayton Rd, Richmond Heights, MO

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    Off-Market Properties in Clayton, MO

    Consider similar Off-Market properties in Clayton, MO. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    212 Central Ave
    Office Spaces
    56,000 SF Lot: 1.21 Acres
    Value Estimation by Request

    212 Central Ave, Clayton, MO 63105

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    187 Carondelet Plz
    Lifestyle centers
    26,637 SF
    Value Estimation by Request

    187 Carondelet Plz, Clayton, MO 63105

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    7733 Forsyth Blvd
    Coworking space
    15,190 SF
    Value Estimation by Request

    7733 Forsyth Blvd, Clayton, MO 63105

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    6609 Clayton Rd
    Multifamily properties
    4,864 SF
    Value Estimation by Request

    6609 Clayton Rd, Clayton, MO 63117

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    6300 Southwood Ave
    Residential income properties
    Lot: 0.20 Acres

    6300 Southwood Ave, Clayton, MO 63105

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    225-235 Meramec Ave
    Medical Office Space
    102,600 SF
    Value Estimation by Request

    225-235 Meramec Ave, Clayton, MO 63105

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    8001 Forsyth Blvd
    Office Spaces
    282,000 SF

    8001 Forsyth Blvd, Clayton, MO 63105

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    Shoppes On Central Ave
    Retail properties & Spaces
    10,300 SF
    Value Estimation by Request
    Shoppes On Central Ave

    0 Shoppes On Central Ave, Clayton, MO 63105

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    507 Hanley Rd
    Individual retail properties
    1,870 SF
    Value Estimation by Request

    507 Hanley Rd, Clayton, MO 63105

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    7927 Forsyth Blvd
    Restaurants
    Value Estimation by Request

    7927 Forsyth Blvd, Clayton, MO 63105

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    8008 Carondelet Ave
    Land
    Lot: 0.35 Acres
    Value Estimation by Request

    8008 Carondelet Ave, Clayton, MO 63105

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    14 Bemiston Ave
    Retail properties & Spaces
    1,330 SF
    Value Estimation by Request

    14 Bemiston Ave, Clayton, MO 63105

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    Clarendale Clayton
    Restaurants
    1,837 SF
    Value Estimation by Request
    Clarendale Clayton

    0 Clarendale Clayton, Clayton, MO 63117

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    34 Brentwood Blvd
    Office Spaces
    34,200 SF
    Value Estimation by Request

    34 Brentwood Blvd, Clayton, MO 63105

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    Clayton, MO Commercial Real Estate Investment Opportunities Market Analysis

    Explore 18 commercial real estate for sale in Clayton, MO, showcased through 4 active listings on our real estate platform. These investment opportunities span a total of 33,403 square feet of properties for sale, with an estimated market value of $10,289,000.

    Sale prices for business properties in Clayton, MO start at $1,499,000, averaging $3,429,666, and reaching up to $6,495,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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    Demographics Overview

    Population 39K
    Population Growth (5Y) +2.3%
    Median Household Income $131,270

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