Add Listing
    For Lease
    • For Sale
    • For Lease
    • Recently Sold
    • Property Lookup
    • Brokers
    Space Uses
    • Retail
    • Restaurant
    • Office
    • Coworking
    • Medical Space
    • Automotive
    • Industrial
    • Warehouse
    • Flex
    • Hospitality
    • Sports & Entertainment
    • Specialty
    Price
    Price range
    $
    $
    Size
    Property size / sq.ft.
    AI Search

    Meet Realmo: The Largest Hub
    of Commercial Real     Estate in the US

    Over 1 million active listings and over 150 million property profiles

    Clayton, MO Commercial Real Estate for Lease

    List
    Map
    Saint Louis, MO Louis, MO Kansas City, MO
    50 results
    Sevens Building
    Contact for pricing

    Sevens Building

    Discover many ways to work your way in Sevens Building

    7777 Bonhomme Ave, Unit 1800, Clayton, MO 63105
    View details
    Pierre Laclede
    Contact for pricing

    Pierre Laclede

    7733 Forsyth Blvd, Unit 11TH, Clayton, MO 63105

    Discover many ways to work your way in Pierre Laclede

    • Be part of a vibrant coworking community with dedicated desk or hot desking options in thousands of idyllic locations across the globe
    • Grow in a modern workplace with the added advantage of a benefits program offering exclusive discounts and bespoke procurement support
    • Access Regus' network of workspaces and business lounges as often as you need and take advantage of their exclusive benefits
    • Impress clients, hold memorable workshops, and deliver a winning pitch in Regus' meeting spaces, fully equipped for gatherings of any size
    • Collaborate with like‑minded professionals and enjoy regular networking and community events with a Regus membership
    Updated: Feb 19
    View details
    Downtown Clayton Office Building
    $21 SF/Yr
    102,600 SF

    Downtown Clayton Office Building

    225-235 S Meramec Ave, Clayton, MO 63105

    Two interconnected office buildings in downtown Clayton with on-site amenities.

    • Prime Downtown Clayton location with high visibility and close proximity to the Courthouse.
    • Enjoy on‑site amenities including management, post office, cafe, and common space.
    • Abundant parking with a 1,200‑space garage and street parking.
    • Newly built‑out spaces with high‑end finishes.
    • Brand new lobby and updated common areas.
    Updated: Nov 25, 2025
    View details
    Class A Office Tower Clayton
    $35 SF/Yr
    2,610 SF

    Class A Office Tower Clayton

    Class A office tower in downtown Clayton for lease.

    8235 Forsyth Blvd, Clayton, MO
    View details
    Class A Office Tower Clayton
    $35 SF/Yr
    4,086 SF

    Class A Office Tower Clayton

    Class A office tower in downtown Clayton for lease.

    8182 Maryland Ave, Clayton, MO
    View details
    Clayton Office Space Available Now
    $30 SF/Yr
    4,288 SF

    Clayton Office Space Available Now

    Former law firm space with elevator exposure and tenant amenities.

    231 S Bemiston Ave, Clayton, MO
    View details
    Professionally Managed Office Space Available
    $25 SF/Yr
    2,709 SF

    Professionally Managed Office Space Available

    Office space for lease with covered parking and convenient location.

    8151 Clayton Rd, Clayton, MO
    View details
    Clayton Office Space For Rent
    $26 SF/Yr
    3,346 SF

    Clayton Office Space For Rent

    Eleven-story office building in Clayton with recent renovations.

    222 S Central Ave, Clayton, MO
    View details
    Downtown Clayton Office Space Available
    $29 SF/Yr
    1,737 SF

    Downtown Clayton Office Space Available

    Office space for lease in downtown Clayton with amenities.

    150 N Meramec Ave, Clayton, MO
    View details
    Clayton Office Space For Rent
    $14 SF/Yr
    350 SF

    Clayton Office Space For Rent

    Office spaces in the heart of Clayton near I-170 & I-64/40.

    30-44 N Brentwood Blvd, Clayton, MO
    View details
    Class A Office Space Available
    $45 SF/Yr
    27,666 SF

    Class A Office Space Available

    High-end office space with many amenities and ample parking.

    7700 Forsyth Blvd, Clayton, MO
    View details
    Downtown Clayton Office Space Available
    $29 SF/Yr
    2,372 SF

    Downtown Clayton Office Space Available

    Office space for rent in downtown Clayton, Missouri.

    165 N Meramec Ave, Clayton, MO
    View details
    Former Bank Building For Sale
    Contact for pricing
    7,200 SF

    Former Bank Building For Sale

    7,200 SF building on 0.64 acre in Clayton, MO.

    6369 Clayton Rd, Clayton, MO
    View details
    New Retail Space in Clayton
    Contact for pricing
    2,126 SF

    New Retail Space in Clayton

    New retail space in mixed-use development with high foot traffic.

    33 N Central Ave, Clayton, MO
    View details
    Versatile Retail Space Available
    $23 SF/Yr
    6,774 SF

    Versatile Retail Space Available

    Adaptable space suitable for various business ventures.

    8-16 N Meramec Ave, Clayton, MO
    View details
    Downtown Clayton Office Space Available
    $28 SF/Yr
    10,007 SF

    Downtown Clayton Office Space Available

    Office space in downtown Clayton with convenient access and amenities.

    168 N Meramec Ave, Clayton, MO
    View details
    Global Network of Flexible Workspaces
    $84 SF/Yr

    Global Network of Flexible Workspaces

    Tailored office spaces with coworking and virtual office options.

    7777 Bonhomme Ave Suite 1800, Clayton, MO 63105
    View details
    Clayton CBD Office Space
    $31 SF/Yr
    1,464 SF

    Clayton CBD Office Space

    Move-in ready office suites in central Clayton location.

    7777 Bonhomme Ave, Clayton, MO
    View details
    Clayton Office Space Available
    $24 SF/Yr
    3,270 SF

    Clayton Office Space Available

    Office space available for lease in Clayton, Missouri.

    8251 Maryland Ave, Clayton, MO
    View details
    Clayton Office Space For Rent
    $24 SF/Yr
    3,305 SF

    Clayton Office Space For Rent

    3,305 SF office space available in Clayton, Missouri.

    8301 Maryland Ave, Clayton, MO
    View details
    Clayton Office Space For Rent
    $31 SF/Yr
    7,441 SF

    Clayton Office Space For Rent

    7,441 square foot office space available for lease.

    135 N Meramec Ave, Clayton, MO
    View details
    Energy Efficient Clayton Office Space
    Contact for pricing

    Energy Efficient Clayton Office Space

    Sophisticated office space in a central Clayton location.

    7733 Forsyth Boulevard Suite 1100, Clayton, MO 63105
    View details
    Downtown Clayton Retail/Restaurant Space
    Contact for pricing
    2,400 SF

    Downtown Clayton Retail/Restaurant Space

    Prime location with open ceilings and polished concrete floors.

    16 N Central Ave, Clayton, MO
    View details
    Renovated Office Space in Clayton
    $26 SF/Yr
    1,993 SF

    Renovated Office Space in Clayton

    Multiple suites available in a recently renovated building.

    7711 Bonhomme Ave, Clayton, MO
    View details

    Clayton, MO Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in Clayton, MO with 50 listings featured on our commercial real estate exchange. The current inventory includes 3,580,893,360 square feet of properties with an estimated lease value of $388 /Mo.

    Estimated lease rates for Commercial real estate in Clayton, MO begin at $14 SF/Yr, with an average of $29 SF/Yr and extend to $45 SF/Yr.
    List
    Map

    Browse Commercial real estate for Lease Near Clayton, MO

    Popular Searches in Clayton, MO

    Popular Categories

    Most Searched ZIP Codes in Clayton, MO

    • 63105
    • 63117

    Select Neighborhood

    Google sign-in failed. Please try again or use another login method.
    Sign Up Successful!
    You now have access to more from Realmo!