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    Oconee County, SC Office Properties & Spaces for Lease

    8 results
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    Office Space in Seneca, SC
    $2,500 / Mo
    26,136 SF

    Office Space in Seneca, SC

    865 Old Clemson Hwy, Seneca, SC 29678

    Commercial office space available for lease in Seneca, South Carolina.

    • Central heating for those chilly nights.
    • Electric heating available as well.
    • Central air to keep you cool and comfortable.
    • Enjoy electric cooling options.
    • Built in 1997.
    Updated: Nov 11, 2025
    View details
    Office Space Near Clemson
    $4,000 / Mo
    26,136 SF

    Office Space Near Clemson

    865 Old Clemson Hwy, Seneca, SC 29678

    Two-level office building suitable for various businesses, near Clemson.

    • Close proximity to Clemson and Seneca
    • Suitable for various business types and offices
    • Potential conversion to medical or dental office
    • Two levels with separate entrances
    • Multiple offices and restrooms on each level
    Updated: Aug 7, 2025
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    Seneca Office Space For Lease
    $1,500 / Mo
    26,136 SF

    Seneca Office Space For Lease

    Two-level office building suitable for various businesses, near Clemson.

    865 Old Clemson Hwy, Seneca, SC 29678
    View details
    Move-in Ready Office Space
    $2,200 / Mo
    15,246 SF

    Move-in Ready Office Space

    Well-maintained office space in established professional park, ready for occupancy.

    111 N Earle St, Walhalla, SC 29691
    View details
    Seneca Office/Retail Space Available
    $15 SF/Yr
    4,800 SF

    Seneca Office/Retail Space Available

    Office and retail spaces for lease in Seneca, South Carolina.

    12019 North Radio Station Rd, Seneca, SC 29678
    View details
    Seneca Office Space For Rent
    $15 SF/Yr
    2,900 SF

    Seneca Office Space For Rent

    Office space in the heart of Seneca, ample parking.

    735 N Townville St, Seneca, SC 29678
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    West Union Office Space Available
    Contact for pricing
    4,800 SF

    West Union Office Space Available

    Office space available for rent in West Union, SC.

    153 Scenic Plaza Dr, West Union, SC 29696
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    Applewood Shopping Center: Seneca, SC
    $22 SF/Yr
    245,000 SF

    Applewood Shopping Center: Seneca, SC

    Prime Seneca Retail Space Available

    285 Applewood Center Pl, Seneca, SC 29678
    View details
    Based on your search, we've compiled 29 Potential Opportunities for your consideration. Besides 8 Active listings in Oconee County, SC, we suggest exploring alternatives. Similar 20 Properties for Sales.

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Commercial Land on US Highway
    $72,000
    63,162 SF

    Commercial Land on US Highway

    1.45 acre commercial land for ground lease in Seneca, SC.

    994 Us 123 Hwy, Seneca, SC 29678
    View details

    Explore Similar Spaces for Sale in Oconee County, SC

    Consider Similar Space for Sale. We found 20 Spaces in Nearby Locations matching your search parameters.

    Renovated Commercial Space on Main
    $490,000
    0.06 Acres

    Renovated Commercial Space on Main

    Prime commercial space ideal for retail, office, or restaurant.

    212 E Main St, Walhalla, SC 29691
    View details
    Westminster Commercial Space For Sale
    $135,000
    1,148 SF

    Westminster Commercial Space For Sale

    Versatile commercial space in high-traffic location, ready for customization.

    111 Retreat St, Westminster, SC 29693
    View details
    Versatile Commercial Property on Highway 28
    $1,200,000
    17,500 SF

    Versatile Commercial Property on Highway 28

    Two warehouse buildings totaling 17,500 SF on 1.67 acres.

    2810 Blue Ridge Blvd, West Union, SC 29696
    View details
    Commercial Building on Highway 28
    $579,000
    0.77 Acres

    Commercial Building on Highway 28

    Meticulously maintained commercial building with high visibility and ample parking.

    3691 Blue Ridge Blvd, Walhalla, SC 29691
    View details
    Downtown Westminster Retail/Office Opportunity
    $79,000
    2,500 SF

    Downtown Westminster Retail/Office Opportunity

    Unfinished space in downtown Westminster, suitable for retail or office.

    210 E Main St, Westminster, SC 29693
    View details
    Commercial Property on Radio Station Rd
    $250,000
    0.63 Acres

    Commercial Property on Radio Station Rd

    Commercial property with road frontage, suitable for business location.

    11081 N Radio Station Rd, Seneca, SC 29678
    View details
    Westminster Commercial Building for Sale
    $395,000
    0.29 Acres

    Westminster Commercial Building for Sale

    Commercial building suitable for medical or business office use.

    104 W Oak Hwy, Westminster, SC 29693
    View details
    Move-in Ready Office Space
    $349,900
    0.35 Acres

    Move-in Ready Office Space

    Well-maintained office space in established park, ideal for professionals.

    111 N Earle St, Walhalla, SC 29691
    View details
    Seneca Office Space For Sale
    $599,000
    2,400 SF

    Seneca Office Space For Sale

    Office space conveniently located off Bypass 123 in Seneca, SC.

    631 By Pass 123, Seneca, SC 29678
    View details
    Move-in Ready Office Space
    $349,900

    Move-in Ready Office Space

    Well-maintained office space suitable for various professional uses.

    111 N Earle St, Walhalla, SC 29691
    View details
    Medical Office NNN Investment
    $2,283,233
    6,227 SF

    Medical Office NNN Investment

    Single tenant medical office building with long-term lease.

    10110 Clemson Blvd, Seneca, SC 29672
    View details
    Seneca Office Building For Sale
    $499,950
    0.15 Acres

    Seneca Office Building For Sale

    Modern Office Space, Turn-Key Ready

    8 Accountants Cir, Seneca, SC 29678
    View details
    Seneca Medical Office Building
    $2,283,233
    6,227 SF

    Seneca Medical Office Building

    High-yield, single-tenant medical office

    10110 Clemson Blvd, Seneca, SC 29672
    View details
    Walhalla Main Street Multi-Tenant
    $1,300,000
    6,130 SF

    Walhalla Main Street Multi-Tenant

    Prime Retail Investment, Downtown Walhalla

    212 Main St, Walhalla, SC 29691
    View details
    Seneca Office Building - High Traffic Area
    $250,000
    0.78 Acres

    Seneca Office Building - High Traffic Area

    Prime Seneca location, high visibility, multiple uses.

    108 Keowee School Rd, Seneca, SC 29672
    View details
    Walhalla Office Space - Main Street
    Contact for pricing

    Walhalla Office Space - Main Street

    Prime Office Space, Downtown Walhalla. Affordable and Convenient.

    112 Main St, Walhalla, SC 29691
    View details

    Oconee County, SC Office Properties & Spaces Leasing Opportunities Market Analysis

    Explore Office Properties & Spaces leasing options in Oconee County, SC with 28 listings featured on our commercial real estate exchange. The current inventory includes 15,296,268,240 square feet of properties with an estimated lease value of $68 SF/Yr.

    Estimated lease rates for Office Properties & Spaces in Oconee County, SC begin at $0.69 SF/Yr, with an average of $8 SF/Yr and extend to $22 SF/Yr.
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