N Charleston, SC Office properties & Spaces for Rent & Lease

Charleston Historic District Office Space

$22 SF/Yr

4,204 SF

Charleston Historic District Office Space

2 Cumberland St, Charleston, SC 29401

Renovated office suites with harbor views in historic Charleston.

Rare views of Charleston Harbor, Ravenel Bridge, US Customs House, and USS Yorktown.
Newly renovated suites with modern finishes ready for immediate occupancy.
Located in the historic district of Charleston's peninsula.
Open floorplans provide functional versatility.
Suites available on the 2nd and 3rd floors, each with 4,204 RSF.

Updated: Mar 6

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Downtown Charleston Freestanding Building

$29 SF/Yr

14,518 SF

Downtown Charleston Freestanding Building

276 East Bay Street, Charleston, SC 29401

Freestanding building in historic downtown Charleston with on-site parking.

Prime location in historic downtown Charleston, walking distance to restaurants and shopping.
Rare on‑site parking with 38 spaces.
High traffic volume (28,300 VPD) and excellent walkability (83%).
Flexible space options: lease entire building or subdivide by floor.
Close proximity to Union Pier development and future College of Charleston Business School.

Updated: Nov 21, 2025

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$20 SF/Yr

2,944 SF

Wappoo Creek Office Space Available

Office space for lease in a convenient Charleston location.

125 Wappoo Creek Dr, Charleston, SC 29412

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$32 SF/Yr

3,975 SF

Daniel Island Office Space Available

Second-floor office suite in Daniel Island's Town Center.

115 Riverlanding Dr, Charleston, SC

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$20 SF/Yr

2,200 SF

James Island Office Space Available

Office space for lease in a convenient Charleston location.

125 Wappoo Creek Dr, Charleston, SC 29412

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$43 SF/Yr

9,675 SF

Class A Office Space

Multi-tenant office building in Charleston's Historic District.

100 Calhoun Street, Charleston, SC 29401

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$42 SF/Yr

2,625 SF

Office Suite with Direct Elevator

Third-floor office suite with open workspace and outdoor patio.

121 Calhoun St, Charleston, SC 29401

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$22 SF/Yr

16,816 SF

Charleston Historic District Office Space

Renovated office suites with harbor views in Charleston's historic district.

2 Cumberland St, Charleston, SC 29401

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$23 SF/Yr

2,631 SF

Renovated Office Space on King

Renovated office space in Charleston's 'Dine & Design' district.

579 King Street, Charleston, SC 29403

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$22 SF/Yr

20,028 SF

Class A Office Space Available

Class A office suite for lease in growing Daniel Island/Cainhoy.

1951 Clements Ferry, Charleston, SC 29492

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$35 SF/Yr

10,673 SF

Historic Mixed-Use Building on King

Renovated mixed-use building in Charleston's Upper King Street corridor.

438 King St, Charleston, SC 29403

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$24 SF/Yr

9,275 SF

Office Complex Near Citadel Mall

Three-building office complex on 10.82 acres with ample parking.

1 South Park Circle, Charleston, SC 29407

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$44 SF/Yr

Move-in Ready Office/Retail Space

Office or retail space with on-site parking on Shem Creek.

103 Church Street, Charleston, SC 29464

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$30 SF/Yr

4,168 SF

Savannah Highway Retail/Office Space

Freestanding building with excellent visibility and ample parking.

422 Savannah Hwy, Charleston, SC

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Furnished Office Building Sublease Opportunity

$24 SF/Yr

78,394 SF

Furnished Office Building Sublease Opportunity

Well-appointed, fully furnished office building available for sublease.

125 Fairchild Street, Charleston, SC, USA, Charleston, SC 29492

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$49 SF/Yr

3,851 SF

Class A Office Space Available

Up to 3,851 SF of fully up-fitted Class A office space.

651 Meeting St, Charleston, SC

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$22 SF/Yr

3,000 SF

West Ashley Medical Office Space

3,000 SF office space in the heart of West Ashley.

1027 Physicians Dr, Charleston, SC

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$29 SF/Yr

Downtown Charleston Office Space

Office space for rent in Charleston's growing Upper Peninsula.

11 Isabella St Suite A, Charleston, SC 29403

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$16 SF/Yr

2,800 SF

Savannah Highway Retail/Office Building

Free-standing 2,800 SF retail or office building for lease.

2413 Savannah Hwy, Charleston, SC

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$36 SF/Yr

7,390 SF

Charleston Peninsula Office Space

Cool office space in pioneering mixed-use redevelopment on Charleston Peninsula.

1501 King Street Extension, Charleston, SC 29405

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Renovated Office/Retail Building on East Bay

$30 SF/Yr

3,789 SF

Renovated Office/Retail Building on East Bay

Modern, flexible office/retail space in prime downtown location.

341 East Bay St, Charleston, SC

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$20 SF/Yr

1,500 SF

Office Space on Jessen Lane

Highly visible office space in a rapidly growing commercial corridor.

405 Jessen Ln, Charleston, SC

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Downtown Charleston

Discover many ways to work your way in Downtown Charleston

170 Floors, Charleston, SC 29401

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1,627 SF

New Development with Waterfront Views

Office and retail spaces in Charleston's Upper Peninsula.

850 Morrison Dr, Charleston, SC 29403

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N Charleston, SC Office Properties & Spaces for Lease

Charleston Historic District Office Space

Renovated office suites with harbor views in historic Charleston.