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Mount Pleasant, SC Office Spaces for Lease

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Isle Of Palms, SC Charleston, SC Wando, SC North Charleston, SC Hanahan, SC Johns Island, SC Goose Creek, SC Awendaw, SC
51 properties
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Class A Medical Office Building
Updated: Jul 24
Class A Medical Office Building

1280 Hospital Dr, Mt Pleasant, SC 29464

$2,582/Mo
2,582 sqft
37,000 SF Class A medical office building with 2,582 SF available
Covered portico at the main entrance for patient drop‑off and pick‑up
Adjacent to the Hwy 17 / I‑526 intersection
Abundant surface parking on site
State‑of‑the‑art building systems
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First-Floor Office Suite
Updated: Aug 8
First-Floor Office Suite

497 Bramson Court, Mount Pleasant, SC 29464

$32 SF/Yr
2,395 sqft
Approximately 2,395 SF of first‑floor office space
Suite 104 at 497 Bramson Court
Full‑service sublease through September 2027
Longer lease term may be considered based on subtenant credit
Located within Moultrie Office Park at Belle Hall
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Medical Office Suites with Ample Parking
Medical Office Suites with Ample Parking

1300 Hospital Dr, Mt Pleasant, SC 29464

$1,757/Mo
3,425 sqft

Three-story medical office building offers suites for lease with ample on-site paved parking.

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Turn a Listing Into an Investment Snapshot Cap Rate, Potential NOI, Demand score for every listing. Go To Analytics Center
Mount Pleasant Retail/Office/Medical Space
Mount Pleasant Retail/Office/Medical Space

1123 Queensborough Boulevard, Mount Pleasant, SC 29464

$30 SF/Yr
3,949 sqft

3,949 SF space ideal for retail, office, or medical.

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Class A Medical Office Building
Class A Medical Office Building

1200 Innovation Way, Mount Pleasant, SC 29466

$28 SF/Yr
14,084 sqft

Renovated medical/office building with ample parking in Mt. Pleasant.

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Mount Pleasant Office Space Available
Mount Pleasant Office Space Available

1671 Belle Isle Avenue, Mount Pleasant, SC 29464

$26 SF/Yr
2,227 sqft

Office space available for lease in Mount Pleasant, SC.

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Flexible Offices and Coworking at Gregorie Ferry Landing. Contact us today to book a tour!
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Medical Office in Mt. Pleasant
Medical Office in Mt. Pleasant

1300 Hospital Dr, Mount Pleasant, SC 29464

$34 SF/Yr
60,809 sqft

Medical office space available for sublease in Mt. Pleasant.

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Professional Office Building with Parking
Professional Office Building with Parking

845 Lowcountry Boulevard # A, Mount Pleasant, SC 29464

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4,238 sqft

Office suites with windows, shared conference space, and free on-site parking in a high-visibility corridor.

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Class A Medical Office Building
Class A Medical Office Building

1280 Hospital Drive Unit 100, Mount Pleasant, SC 29464

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2,582 sqft

Class A medical office building with covered main entrance and abundant surface parking.

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Renovated Office Suite in Mt. Pleasant
Renovated Office Suite in Mt. Pleasant

1004 Anna Knapp Boulevard, Suite 3, Mount Pleasant, SC 29464

$1,300/Mo

Executive office suite available for sublease, renovated in 2024.

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Furnished Executive Office Suite
Furnished Executive Office Suite

10 Shem Drive #100-E, Mount Pleasant, SC 29464

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110 sqft

Corner office E features multiple windows and furnished executive finishes with all utilities included.

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Multi-Tenant Office Building with Shared Parking
Multi-Tenant Office Building with Shared Parking

1124 Park West Boulevard, Mount Pleasant, SC 29466

$26 SF/Yr

Multi-tenant office building with first- and second-floor options, zoning PD, and convenient on-site shared parking.

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Second-Floor Office Suite
Second-Floor Office Suite

268 W Coleman Blvd, Mount Pleasant, SC 29464

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3,166 sqft

Move-in ready second-floor office suite with open bullpen, perimeter offices, conference room, and eat-in kitchen.

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Flex Warehouse Office Suite
Flex Warehouse Office Suite

2612 Larch Lane, Suite 103, Mount Pleasant, SC 29466

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1,500 sqft

Suite 103 offers two private offices, reception, restroom, and warehouse space with a rear roll-up door.

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Dental-To-Medical Office Suite
Dental-To-Medical Office Suite

1065-C Johnnie Dodds Blvd, Mount Pleasant, SC 29464

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1,500 sqft

Turn-key office currently set up for dental use, positioned across from a major hospital with convenient highway access.

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Two-Story Office Building
Two-Story Office Building

1501 Belle Isle Avenue Suite 240, Mount Pleasant, SC 29464

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40,000 sqft

Newly constructed two-story office building with modern interior and exterior finishes near I-526 access.

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Office Suite with Parking
Office Suite with Parking

845 Lowcountry Blvd, Mount Pleasant, SC 29464

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215 sqft

Office suite includes free on-site parking, a kitchenette, and shared conference room access.

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Medical Office Suite
Medical Office Suite

1300 Hospital Drive Suite 310, Mount Pleasant, SC 29464

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1,757 sqft

Suite 310 is available within a three-story medical office building with ample free parking.

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Class A Office Building
Class A Office Building

710 Johnnie Dodds Blvd, Mount Pleasant, SC 29464

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5,370 sqft

5,370 SF Class A office space with convenient access to Ravenel Bridge and I-526.

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Courtyard Retail Space
Courtyard Retail Space

217 Lucas St, Mount Pleasant, SC 29464

$30 SF/Yr

Flexible layouts, mature shade trees, and ample surface parking support professional, retail, and creative commercial uses.

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Mount Pleasant Office Condo For Lease
Mount Pleasant Office Condo For Lease

856 Lowcountry Boulevard, Mount Pleasant, SC 29464

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2,880 sqft

Well-appointed office condo in central Mount Pleasant location.

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Second-Floor Office Suite
Second-Floor Office Suite

242 Mathis Ferry Road # 201, Mount Pleasant, SC 29464

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Professional office suite with private rooms, collaborative workspace, break area, storage, and adjacent common restrooms.

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Waterfront Office Suite
Waterfront Office Suite

75 Port City Landing Ste 1320, Mount Pleasant, SC 29464

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Class A office space with private offices, conference rooms, a bullpen, break room, and waterfront views.

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Mount Pleasant, SC Office Spaces Lease Rates & Market Statistics

Browse 51 Office Spaces for lease in Mount Pleasant, SC on Realmo, a commercial real estate marketplace serving the Mount Pleasant area. The current inventory totals 250,457 square feet of properties — an average of ~4,900 SF per listing.

Office Spaces lease rates in Mount Pleasant range from $6.16 SF/Yr at the entry level to $34 SF/Yr at the top of the market, averaging $24.91 SF/Yr. That's a 6x spread between entry-level and premium space, making side-by-side comparison of asking rents and lease terms essential. The local average of $24.91 SF/Yr is 6% above the South Carolina state average of $23.45 SF/Yr.

Mount Pleasant accounts for 22% of the 233 office spaces currently available across Charleston County, where nearby markets include Charleston and North Charleston. By space type, the market includes 31 office units, 13 medical office space listings and 8 office buildings — medical office space options typically offer the lowest entry point, while office units command the highest rates.

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