Mount Pleasant, SC Office Spaces for Lease

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Charleston, SC Wando, SC North Charleston, SC Hanahan, SC Goose Creek, SC Johns Island, SC Summerville, SC Ladson, SC

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Flexible Offices and Coworking at Gregorie Ferry Landing. Contact us today to book a tour!

1240 Winnowing Way, Unit 100, Mount Pleasant, SC 29466

16 available spaces from 11 to 2,149 sqft

$129-$23,661/Mo per office

(972) 764-8885

Flexible workspace in Gregorie Ferry Landing. Book a tour & get info

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Updated: Aug 8

First-Floor Office Suite

497 Bramson Court, Mount Pleasant, SC 29464

$32 SF/Yr

2,395 sqft

Approximately 2,395 SF of first‑floor office space
Suite 104 at 497 Bramson Court
Full‑service sublease through September 2027
Longer lease term may be considered based on subtenant credit
Located within Moultrie Office Park at Belle Hall

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Updated: Mar 27

Medical Office Suites with Ample Parking

1300 Hospital Dr, Mt Pleasant, SC 29464

$1,757/Mo

3,425 sqft

Three‑story medical office building totaling 60,809 SF at 1300 Hospital Drive in Mount Pleasant, SC
Three suites for lease ranging from ±1,757 to ±3,425 SF
Ample on‑site paved parking with a large parking lot
Located in Mount Pleasant’s medical corridor near I‑526 and Highway 17
Close to Novant Health East Cooper Medical Center (130‑bed acute care hospital)

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Mount Pleasant Retail/Office/Medical Space

1123 Queensborough Boulevard, Mount Pleasant, SC 29464

$30 SF/Yr

3,949 sqft

3,949 SF space ideal for retail, office, or medical.

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Class A Medical Office Building

1200 Innovation Way, Mount Pleasant, SC 29466

$28 SF/Yr

14,084 sqft

Renovated medical/office building with ample parking in Mt. Pleasant.

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Medical Office in Mt. Pleasant

1300 Hospital Dr, Mount Pleasant, SC 29464

$34 SF/Yr

60,809 sqft

Medical office space available for sublease in Mt. Pleasant.

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Retail Suite with Vanilla Box Condition

1110 Park West Blvd, Mount Pleasant, SC 29466

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2,805 sqft

Upfit-ready retail/office space with substantial electrical capacity opposite a Publix-anchored shopping center.

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Courtyard Retail Space

217 Lucas St, Mount Pleasant, SC 29464

$30 SF/Yr

Flexible layouts, mature shade trees, and ample surface parking support professional, retail, and creative commercial uses.

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Renovated Office Suite in Mt. Pleasant

1004 Anna Knapp Boulevard, Suite 3, Mount Pleasant, SC 29464

$1,300/Mo

Executive office suite available for sublease, renovated in 2024.

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Multi-Tenant Office Building

1124 Park West Boulevard, Mount Pleasant, SC 29466

$26 SF/Yr

Move-in-ready suites in a modern, multi-tenant office building with first- and second-floor options.

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Second-Floor Office Suite

268 W Coleman Blvd, Mount Pleasant, SC 29464

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3,166 sqft

Move-in ready second-floor office suite with open bullpen, perimeter offices, conference room, and eat-in kitchen.

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Flex Space with Mezzanine Storage

2612 Larch Lane, Suite 110, Mount Pleasant, SC 29466

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1,900 sqft

Modern commercial suite pairs finished office areas with warehouse space, rear loading, and additional storage above.

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Flex Warehouse Office Suite

2612 Larch Lane, Suite 103, Mount Pleasant, SC 29466

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1,500 sqft

Suite 103 offers two private offices, reception, restroom, and warehouse space with a rear roll-up door.

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Brick Office Suite with Six Offices

3301 Salterbeck St, Mount Pleasant, SC 29466

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1,652 sqft

Freestanding professional suite offers private offices, reception, support rooms, and dedicated building parking.

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Flex Suite with Rear Roll-Up Door

2612 Larch Lane, Suite 107, Mount Pleasant, SC 29466

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1,900 sqft

Modern flex space includes private offices, reception, restroom, and a rear roll-up door.

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Dental-To-Medical Office Suite

1065-C Johnnie Dodds Blvd, Mount Pleasant, SC 29464

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1,500 sqft

Turn-key office currently set up for dental use, positioned across from a major hospital with convenient highway access.

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Office Suite with Parking

845 Lowcountry Blvd, Mount Pleasant, SC 29464

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215 sqft

Office suite includes free on-site parking, a kitchenette, and shared conference room access.

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Two-Office First-Floor Suite

825 Lowcountry Boulevard, Mount Pleasant, SC 29464

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150 sqft

Suite 103 provides a compact office configuration within a business center setting.

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Office Space in Oak Grove

710 Johnnie Dodds Blvd, Mount Pleasant, SC 29464

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5,370 sqft

Office units for rent in Mt. Pleasant, SC.

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Mount Pleasant Office Space

1671 Belle Isle Ave, Mt Pleasant, SC 29464

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2,227 sqft

Office space available for lease in Mount Pleasant, SC.

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Mount Pleasant Office Condo For Lease

856 Lowcountry Boulevard, Mount Pleasant, SC 29464

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2,880 sqft

Well-appointed office condo in central Mount Pleasant location.

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Waterfront Office Suite

75 Port City Lndg, Mt Pleasant, SC 29464

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Class A office space with private offices, conference rooms, a bullpen, break room, and waterfront views.

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Class A Office Suite with Elevator

880 Whipple Road, Suite 200, Mount Pleasant, SC 29464

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Move-in ready suite with private offices, a conference room, and flexible open work area in a central Mount Pleasant location.

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Mount Pleasant Office Space Available

1041 Johnnie Dodds Blvd, Mount Pleasant, SC

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1,600 sqft 0.50 AC lot

Office space featuring private offices, conference area, and kitchen.

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First-Floor Retail/Office Suites

1233 Ben Sawyer Boulevard # 800, Mount Pleasant, SC 29464

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Move-in ready first-floor suites with parking and prominent visibility along Ben Sawyer Boulevard.

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Mount Pleasant, SC Office Spaces Lease Rates & Market Statistics

Browse 35 Office Spaces for lease in Mount Pleasant, SC on Realmo, a commercial real estate marketplace serving the Mount Pleasant area. The current inventory totals 202,615 square feet of properties — an average of ~5,800 SF per listing.

Office Spaces lease rates in Mount Pleasant range from $6.16 SF/Yr at the entry level to $34 SF/Yr at the top of the market, averaging $26.59 SF/Yr. That's a 6x spread between entry-level and premium space, making side-by-side comparison of asking rents and lease terms essential. The local average of $26.59 SF/Yr is 9% above the South Carolina state average of $24.34 SF/Yr.

Mount Pleasant accounts for 21% of the 169 office spaces currently available across Charleston County, where nearby markets include Charleston and North Charleston. By space type, the market includes 25 office units and 8 medical office space listings.

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