N Charleston, SC Medical Office Space for Lease

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Wando, SC Mount Pleasant, SC North Charleston, SC Hanahan, SC Goose Creek, SC Isle Of Palms, SC Awendaw, SC Sullivans Island, SC

12 properties

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Updated: Jun 1

Renovating Office Park Suites

15 Gamecock Ave, Charleston, SC 29407

$2,500/Mo

3,625 sqft

Two office suites available in Orange Grove Office Park: Unit 1A (+/-720 SF) and Unit B (+/-3,625 SF).
Unit 1A listed at $2,500/month; Unit B listed at $28/SF on a NNN basis.
Ongoing renovations at the office park.
Located in Charleston’s West Ashley submarket within Orange Grove Office Park, just off Sam Rittenberg.
Immediate access to I‑26; minutes to Downtown Charleston and Charleston International Airport.

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Updated: Jun 2

Single-Story Office Building

255 East Bay Street, Charleston, SC 29401

$35 SF/Yr

4,730 sqft

4,730 SF single‑story office building in City of Charleston’s GB (General Business) zoning
Currently leased to Roper Physician Partners; tenant will vacate with notice
6 parking spaces included with the lease; 19 marked spaces in front, 2 marked spaces on Pinckney St, and 2 unmarked spaces in the rear
Landlord will consider leasing “as is,” long‑term ground lease, and redevelopment
Lease rate listed at $35/SF NNN

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Flexible Office Suite

29 Leinbach Drive # D5, Charleston, SC 29407

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1,664 sqft

Flexible suite configuration supports professional, medical, and specialized service operations.

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Freestanding Medical Office Space

159 Wentworth Street, Charleston, SC 29401

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First-floor layout includes reception, private offices, and exam rooms.

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West Ashley Medical Office Sublease

2270 Ashley Crossing Ln, Charleston, SC

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3,746 sqft 8.99 AC lot

3,746 SF medical office space available for immediate sublease.

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Fitness and Chiropractic Sublease Space

1291 Folly Rd, Charleston, SC 29412

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5,650 sqft

Sublease 1,130± SF within Gold’s Gym, with a former cafe space and a chiropractic suite offering private offices.

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Two-Story Freestanding Office Building

2125 Charlie Hall Boulevard #First Floor, Charleston, SC 29414

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Entire first floor is available in a centrally located, medically oriented freestanding office building with ample parking.

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Private Treatment Room Medical Office

29 Leinbach Dr, Charleston, SC 29407

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Sublease space includes shared waiting-area access within an established chiropractic clinic.

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Remodeled Office Space Available

1483 Tobias Gadson Blvd, Charleston, SC

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1,312 sqft 6.17 AC lot

Centrally located office suites near St. Francis Hospital.

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Retail and Medical Suites

2048 Sam Rittenberg Blvd, Charleston, SC 29407

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1,320 sqft

Existing tenants include a salon and spa, general dentistry, hearing provider, and nail spa, with an option for a paid ATM site.

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Medical Office Space Available

2287 Henry Tecklenburg Dr, Charleston, SC 29414

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Medical office space for lease near Bon Secours Hospital.

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Retail and Medical Office Space

State Rd S-8-33, Charleston, SC 29492

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Retail and medical office space at Point Hope community.

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Based on your search, we've compiled 21 Potential Opportunities for your consideration. Besides 12 Active listings in N Charleston, SC, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 5 Properties for Sales.

Medical Office Space for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Medical Office and Wellness Space

2409 Mall Dr, North Charleston, SC 29406

$8,333/Mo

8,333 sqft 1.21 AC lot

Reconfigurable interior with high-ceiling open area and ample free surface parking on a major North Charleston corridor.

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Mount Pleasant Retail/Office/Medical Space

1123 Queensborough Boulevard, Mount Pleasant, SC 29464

$30 SF/Yr

3,949 sqft

3,949 SF space ideal for retail, office, or medical.

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Updated Freestanding Office Building

2132 Dorchester Road, North Charleston, SC 29405

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Updated commercial space includes private offices, a kitchen, restroom, and surface parking.

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Medical Office Suite

1123 Queensborough Boulevard # 102, Mount Pleasant, SC 29464

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This suite is leased to a medical practice and is in excellent condition for medical or general office use.

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Similar Spaces for Sale in N Charleston, SC

Consider Similar Space for Sale. We found 5 Spaces matching your search parameters.

Day Care Center with Office Potential

1910 McMillan Avenue North, Charleston, SC 29405

$2,300,000

12,895 sqft

Former childcare facility with adaptability for medical, professional, religious, or financial service operations.

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Two-Story Medical Office Space

1845 Savage Rd, Charleston, SC 29407

$1,300,000

3,383 sqft

Standalone clinical facility with a durable exterior and an existing medical layout.

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Medical Office Suite with Exam Rooms

1470 Tobias Gadson Boulevard Suite 201, Charleston, SC 29407

Contact for pricing

3,622 sqft

Second-floor medical condominium with a ready-made clinical layout, private offices, patient areas, and on-site parking.

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Medical Office Condo with Parking

198 Rutledge Avenue Ste 1, Charleston, SC 29403

Contact for pricing

3,243 sqft

Renovated medical office condominium with exam rooms, dedicated parking, and Limited Business zoning near Charleston’s hospital district.

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Downtown Medical Office Condo

198 Rutledge Avenue, Charleston, SC 29403

$1,740,000

First-floor office condo with dedicated parking near Charleston’s hospital district.

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N Charleston, SC Medical Office Space Lease Rates & Market Statistics

Browse 12 Medical Office Space listings for lease in N Charleston, SC on Realmo, a commercial real estate marketplace serving the N Charleston area. The current inventory totals 22,047 square feet of properties — an average of ~1,850 SF per listing.

Medical Office Space lease rates in N Charleston range from $8.28 SF/Yr at the entry level to $35 SF/Yr at the top of the market, averaging $21.64 SF/Yr. That's a 4x spread between entry-level and premium space, making side-by-side comparison of asking rents and lease terms essential. The local average of $21.64 SF/Yr is in line with the South Carolina state average.

Medical Office Space listings make up 7% of the 181 Office Spaces currently for lease in N Charleston, with asking rates averaging $21.64 SF/Yr — 30% below the citywide Office Spaces average of $30.76 SF/Yr. Also worth a look for tenants weighing alternatives: Office Units (138 listings) and Office buildings (37 listings) elsewhere in the N Charleston market.

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