Mt Pleasant, SC Office Spaces for Lease

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Isle Of Palms, SC Charleston, SC Sullivans Island, SC Wando, SC North Charleston, SC Hanahan, SC Johns Island, SC Goose Creek, SC

65 properties

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Updated: Jul 24

Class A Medical Office Building

1280 Hospital Dr, Mt Pleasant, SC 29464

$2,582/Mo

2,582 sqft

37,000 SF Class A medical office building with 2,582 SF available
Covered portico at the main entrance for patient drop‑off and pick‑up
Adjacent to the Hwy 17 / I‑526 intersection
Abundant surface parking on site
State‑of‑the‑art building systems

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Updated: Aug 8

First-Floor Office Suite

497 Bramson Court, Mount Pleasant, SC 29464

$32 SF/Yr

2,395 sqft

Approximately 2,395 SF of first‑floor office space
Suite 104 at 497 Bramson Court
Full‑service sublease through September 2027
Longer lease term may be considered based on subtenant credit
Located within Moultrie Office Park at Belle Hall

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Medical Office Suites with Ample Parking

1300 Hospital Dr, Mt Pleasant, SC 29464

$1,757/Mo

3,425 sqft

Three-story medical office building offers suites for lease with ample on-site paved parking.

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Turn a Listing Into an Investment Snapshot Cap Rate, Potential NOI, Demand score for every listing. Go To Analytics Center

Mount Pleasant Retail/Office/Medical Space

1123 Queensborough Boulevard, Mount Pleasant, SC 29464

$30 SF/Yr

3,949 sqft

3,949 SF space ideal for retail, office, or medical.

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Class A Medical Office Building

1200 Innovation Way, Mount Pleasant, SC 29466

$28 SF/Yr

14,084 sqft

Renovated medical/office building with ample parking in Mt. Pleasant.

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Mount Pleasant Office Space Available

1671 Belle Isle Avenue, Mount Pleasant, SC 29464

$26 SF/Yr

2,227 sqft

Office space available for lease in Mount Pleasant, SC.

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Flexible Offices and Coworking at Gregorie Ferry Landing. Contact us today to book a tour!

1240 Winnowing Way, Unit 100, Mount Pleasant, SC 29466

16 available spaces from 11 to 2,149 sqft

$129-$23,661/Mo per office

(972) 764-8885

Flexible workspace in Gregorie Ferry Landing. Book a tour & get info

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Medical Office in Mt. Pleasant

1300 Hospital Dr, Mount Pleasant, SC 29464

$34 SF/Yr

60,809 sqft

Medical office space available for sublease in Mt. Pleasant.

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Professional Office Building with Parking

845 Lowcountry Boulevard # A, Mount Pleasant, SC 29464

Contact for pricing

4,238 sqft

Office suites with windows, shared conference space, and free on-site parking in a high-visibility corridor.

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Class A Medical Office Building

1280 Hospital Drive Unit 100, Mount Pleasant, SC 29464

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2,582 sqft

Class A medical office building with covered main entrance and abundant surface parking.

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Retail Suite with Vanilla Box Condition

1110 Park West Blvd, Mount Pleasant, SC 29466

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2,805 sqft

Upfit-ready retail/office space with substantial electrical capacity opposite a Publix-anchored shopping center.

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Courtyard Retail Space

217 Lucas St, Mount Pleasant, SC 29464

$30 SF/Yr

Flexible layouts, mature shade trees, and ample surface parking support professional, retail, and creative commercial uses.

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Renovated Office Suite in Mt. Pleasant

1004 Anna Knapp Boulevard, Suite 3, Mount Pleasant, SC 29464

$1,300/Mo

Executive office suite available for sublease, renovated in 2024.

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Furnished Executive Office Suite

10 Shem Drive #100-E, Mount Pleasant, SC 29464

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110 sqft

Corner office E features multiple windows and furnished executive finishes with all utilities included.

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Second-Floor Office Unit

1501 Belle Isle Avenue, Mt Pleasant, SC 29464

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6,008 sqft

Configured workspace includes private offices, conference rooms, reception, and open bullpen areas for professional or corporate users.

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First-Floor Office Unit

497 Bramson Court Unit 104, Mount Pleasant, SC 29464

Contact for pricing

2,395 sqft

Office workspace includes on-site parking and full-service sublease terms in suburban Mount Pleasant.

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Multi-Tenant Office Building with Shared Parking

1124 Park West Boulevard, Mount Pleasant, SC 29466

$26 SF/Yr

Multi-tenant office building with first- and second-floor options, zoning PD, and convenient on-site shared parking.

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Second-Floor Office Suite

268 W Coleman Blvd, Mount Pleasant, SC 29464

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3,166 sqft

Move-in ready second-floor office suite with open bullpen, perimeter offices, conference room, and eat-in kitchen.

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Flex Space with Mezzanine Storage

2612 Larch Lane, Suite 110, Mount Pleasant, SC 29466

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1,900 sqft

Modern commercial suite pairs finished office areas with warehouse space, rear loading, and additional storage above.

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Flex Warehouse Office Suite

2612 Larch Lane, Suite 103, Mount Pleasant, SC 29466

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1,500 sqft

Suite 103 offers two private offices, reception, restroom, and warehouse space with a rear roll-up door.

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Brick Office Suite with Six Offices

3301 Salterbeck St, Mount Pleasant, SC 29466

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1,652 sqft

Freestanding professional suite offers private offices, reception, support rooms, and dedicated building parking.

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Flex Suite with Rear Roll-Up Door

2612 Larch Lane, Suite 107, Mount Pleasant, SC 29466

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1,900 sqft

Modern flex space includes private offices, reception, restroom, and a rear roll-up door.

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Dental-To-Medical Office Suite

1065-C Johnnie Dodds Blvd, Mount Pleasant, SC 29464

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1,500 sqft

Turn-key office currently set up for dental use, positioned across from a major hospital with convenient highway access.

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Two-Story Office Building

1501 Belle Isle Avenue Suite 240, Mount Pleasant, SC 29464

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40,000 sqft

Newly constructed two-story office building with modern interior and exterior finishes near I-526 access.

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Mt Pleasant, SC Office Spaces Lease Rates & Market Statistics

Explore 65 Office Spaces for lease in Mt Pleasant, SC on Realmo, a commercial real estate exchange covering the Mt Pleasant area. The current inventory totals 271,975 square feet of properties — an average of ~4,200 SF per listing.

Asking lease rates for Office Spaces in Mt Pleasant start at $6.16 SF/Yr, average $24.91 SF/Yr, and reach $34 SF/Yr at the top of the market. That's a 6x spread between entry-level and premium space, making side-by-side comparison of asking rents and lease terms essential. The local average of $24.91 SF/Yr is 7% above the South Carolina state average of $23.38 SF/Yr.

Within Charleston County, most Mt Pleasant office spaces listings are located in and around Mount Pleasant, with additional options across the city. By space type, the market includes 44 office units, 13 medical office space listings and 9 office buildings — medical office space options typically offer the lowest entry point, while office units command the highest rates.

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