North Syracuse, NY Office Buildings for Lease

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21 properties

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Updated: Mar 25

Iconic Mixed-Use State Tower

109 South Warren Street, Syracuse, NY 13202

$18.50 SF/Yr

23,201 sqft

Iconic 22‑story mixed‑use building in Hanover Square.
Multiple office spaces available, ranging from 529 to ±15,176 SF contiguous.
61 high‑end residential units on floors 8‑21.
Convenient location near major employers and highway access.
Amenities include 24/7 lobby attendant, attached parking garage, and on‑site restaurant.

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Updated: Sep 25, 2025

Class A Office Park Space

301 Plainfield Road, Syracuse, NY

$18 SF/Yr

96,084 sqft

Class A suburban office park
Common conference/gathering center with audio visual equipment
Get fit in the fitness center
Full service cafe/deli
Various leasing opportunities available from 1,681 SF to 13,920 SF

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Downtown Syracuse Office Building

716 James Street, Syracuse, NY 13203

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15,000 sqft

15,163 SF office building in downtown Syracuse for lease.

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Office Building with Large Yard

6331 E Molloy Rd, Dewitt, NY 13057

$3,376/Mo

1.10 AC lot

5,064 SF office building with yard for rent.

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Renovated Office Building with Parking

506 E Washington St, Syracuse, NY 13202

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6,300 sqft

Downtown office building with on-site parking and renovated interior.

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Class A Office Building Suite

5794 Widewaters Pkwy, Syracuse, NY 13214

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19,707 sqft

Class A office building offers ample on-site parking and approximately 20,000 SF available in Widewaters Office Park.

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Class A Office Space Available

500 Plum Street, Syracuse, NY 13204

$20 SF/Yr

7,054 sqft

Prestigious office building in historic Franklin Square, Syracuse.

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Prime Retail Office Suite

726 University Ave, Syracuse, NY 13210

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6,200 sqft

Two-floor retail space offers approximately 3,100 SF per level and can be subdivided, with two handicap-accessible bathrooms.

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Restored Office Building in Syracuse

358 W Jefferson St, Syracuse, NY

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15,000 sqft 0.84 AC lot

Restored office building with parking near Armory Square.

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Freestanding Office Building

2401 - 2425 James Street, Syracuse, NY 13206

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Office building for rent on James Street in Syracuse’s Eastwood neighborhood, with access to regional transportation corridors.

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Corner Retail or Office Space

4001 South Salina Street, Syracuse, NY 13205

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Corner commercial space on South Salina Street with CM zoning supporting multiple retail, office, and restaurant uses.

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Office Building with New Lobbies

125 Elwood Davis Rd, Syracuse, NY 13212

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2,644 sqft

Office building with newly updated lobbies and tenant spaces, conveniently near restaurants, hotels, shopping, banks.

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Office Building with Updated Lobby

125 Elwood Davis Rd, Syracuse, NY 13212

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2,601 sqft

Office building featuring newly updated first-class lobbies and renovated tenant spaces for modern occupancy.

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Landmark Mixed-Use Tower for Lease

109 S Warren St, Syracuse, NY 13202

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200,000 sqft

Historic building with office, retail, and luxury apartment spaces.

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Office Building Near Major Amenities

300-324 Spencer St, Syracuse, NY 13204

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150,000 sqft

Office building available for rent in Syracuse with easy access to Franklin Square, Destiny USA, Creekwalk, and I-81.

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Office Building with Free On-Site Parking

716 James St, Syracuse, NY 13203

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1,070 sqft

ADA-compliant office suites are available, with options to combine or subdivide and free on-site parking.

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Prestige Office Building

6712 Brooklawn Pkwy, Syracuse, NY 13211

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Office building with excellent parking, first-class interior finishes, and full-height mahogany doors throughout.

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Medical Office Building with Parking

5232 Witz Dr, N Syracuse, NY 13212

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22,867 sqft

Two-story office building with basement and elevator, ADA accessible, with excellent onsite parking.

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Renovated Office Space Available

300 S State St, Syracuse, NY 13202

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Recently renovated office building with fitness center and on-site amenities.

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Class A Office Building Space

620 Erie Blvd W, Syracuse, NY 13204

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120,000 sqft

Class A office building with on-site parking near Downtown.

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Downtown Syracuse Mixed-Use Facility

441 S Salina St, Syracuse, NY 13202

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440,000 sqft

440,000 SF mixed-use facility in downtown Syracuse.

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Based on your search, we've compiled 56 Potential Opportunities for your consideration. Besides 21 Active listings in North Syracuse, NY, we suggest exploring alternatives. Similar 35 Properties for Sales.

Similar Spaces for Sale in North Syracuse, NY

Consider Similar Space for Sale. We found 35 Spaces matching your search parameters.

Two-Side Office Building

430 S Main Street, Syracuse, NY 13212

$549,900

5,000 sqft 0.34 AC lot

Flexible commercial layout combines a finished professional suite with adjacent shell space for a customized build-out.

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Multi-Floor Office Building

105 Stanton Avenue, Syracuse, NY 13209

$795,000

17,776 sqft 1.38 AC lot

Brick-and-block office property with central air, forced-air heating, and a basement.

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Freestanding Office Building with Drive-Through

6555 Ridings Rd, Dewitt, NY 13206

$480,000

4,076 sqft 1.30 AC lot

Single-tenant property includes private offices, conference areas, and customer-service space.

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North Syracuse, NY Office buildings Lease Rates & Market Statistics

Browse 21 Office buildings for lease in North Syracuse, NY on Realmo, a commercial real estate marketplace serving the North Syracuse area. The current inventory totals 1,127,728 square feet of properties — an average of ~53,700 SF per listing.

Office buildings lease rates in North Syracuse range from $18 SF/Yr at the entry level to $20 SF/Yr at the top of the market, averaging $18.83 SF/Yr. Pricing across the market is relatively uniform, which simplifies like-for-like comparison between listings. The local average of $18.83 SF/Yr is 49% below the New York state average of $37.28 SF/Yr.

Office buildings make up 27% of the 79 Office Spaces currently for lease in North Syracuse, with asking rates averaging $18.83 SF/Yr — 26% above the citywide Office Spaces average of $14.97 SF/Yr. Also worth a look for tenants weighing alternatives: Office Units (57 listings) and Medical Office Space (8 listings) elsewhere in the North Syracuse market.

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