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    Portsmouth, NH Office Spaces for Lease

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    Economical Office and Warehouse Space
    Economical Office and Warehouse Space

    200 International Drive, Portsmouth, NH

    Contact for pricing
    2,539 sqft 20.38 AC lot

    Flexible office and warehouse space near major routes.

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    Third-Floor Office Suite
    Third-Floor Office Suite

    15 Rye St, Portsmouth, NH 03801

    Contact for pricing
    10,829 sqft

    Third-floor office space with prominent windowlines in a three-story, ENERGY STAR-certified office building.

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    First-Class Office Space Available
    First-Class Office Space Available

    15 Rye St, Portsmouth, NH

    Contact for pricing
    5,257 sqft 10.39 AC lot

    First-class office space with panoramic views and central location.

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    Office or Medical Office Space
    Office or Medical Office Space

    14 Manchester Square, Portsmouth, NH

    Contact for pricing
    2,027 sqft 11.06 AC lot

    Office or medical space in Portsmouth's Pease Tradeport.

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    Remodeled Colonial Office Building
    Remodeled Colonial Office Building

    110 Chapel St, Portsmouth, NH 03801

    Contact for pricing
    4,928 sqft

    Recently remodeled office building with potential for additional office space.

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    Class A Office Space Sublease
    Class A Office Space Sublease

    90 Aboretum Dr, Portsmouth, NH 03801

    $22 SF/Yr

    Class A office space for sublease in Portsmouth, NH.

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    Ground-Floor Office Space in Portsmouth
    Ground-Floor Office Space in Portsmouth

    126 Daniel St, Portsmouth, NH 03801

    Contact for pricing
    1,600 sqft

    1,600 SF office suite in historic Old City Hall.

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    First Floor Office Space Available
    First Floor Office Space Available

    755 Banfield Rd, Portsmouth, NH 03801

    Contact for pricing
    2,875 sqft

    Office space for lease with conference room and collaborative area.

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    Energy Efficient Office Space
    Energy Efficient Office Space

    100 International Dr, Portsmouth, NH

    Contact for pricing
    5,249 sqft 13.83 AC lot

    Three-story office building in Pease International Tradeport.

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    Downtown Portsmouth Office Space Available
    Downtown Portsmouth Office Space Available

    10 Vaughan Mall, Portsmouth, NH 03801

    Contact for pricing

    Office spaces for lease in downtown Portsmouth, accessible by elevator.

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    Medical Office Suites For Lease
    Medical Office Suites For Lease

    330 Borthwick Ave, Portsmouth, NH 03801

    Contact for pricing

    Prime medical office suites available near Portsmouth Regional Hospital.

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    Office Units with On-Site Parking
    Office Units with On-Site Parking

    4 Greenleaf Woods Drive, Portsmouth, NH 03801

    $595/Mo
    6,414 sqft

    Updated professional offices support healthcare and therapy practices in a campus-style setting near downtown.

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    Medical Office Suite with Private Bath
    Medical Office Suite with Private Bath

    301-4 Greenleaf Woods Dr, Portsmouth, NH 03801

    $595/Mo

    Office suite includes a private bath with shower, kitchenette, and natural light from windows on three sides.

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    Class A Office Spaces Available
    Class A Office Spaces Available

    300 Constitution Ave, Portsmouth, NH 03801

    Contact for pricing
    10,275 sqft

    Class A office spaces for lease with modern designer furniture.

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    Based on your search, we've compiled 123 Potential Opportunities for your consideration. Besides 86 Active listings in Portsmouth, NH, we suggest exploring alternatives. Consider Similar 33 Spaces for Sales.

    Office Spaces for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Office Unit With Treatment Rooms
    Office Unit With Treatment Rooms

    1 Bayside Rd 101, Greenland, NH 03840

    $2,150/Mo
    1,519 sqft

    Renovated commercial suite with multiple enclosed rooms, private bath facilities, and access to a shared parking area.

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    Renovated Medical Office Suite
    Renovated Medical Office Suite

    101-1 Bayside Rd, Greenland, NH 03840

    $2,150/Mo
    1,519 sqft

    Renovated in 2025 with treatment rooms, private bathrooms, and laundry hookups.

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    Office Units with Common Entry
    Office Units with Common Entry

    19 Bridge Street, Kittery, ME 03904

    $600-$900/Mo
    0.09 AC lot

    Five leasable office suites share kitchen and bathroom facilities in a compact commercial property.

    View details
    Office Suites with Shared Entry
    Office Suites with Shared Entry

    19 Bridge St Unit 9, Kittery, ME 03904

    $600-$900/Mo

    Five office suites offer flexible leasing with shared kitchen and bathroom facilities.

    View details

    Similar Spaces for Sale in Portsmouth, NH

    Consider Similar Space for Sale. We found 33 Spaces matching your search parameters.

    Ground-Floor Retail Condominium
    Ground-Floor Retail Condominium

    53 Green St, Portsmouth, NH 03801

    $1,195,000
    2,828 sqft

    Cold, dark shell offers flexibility for a custom commercial build-out.

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    Recently Built Office Units
    Recently Built Office Units

    1-54 Maplewood Ave, Portsmouth, NH 03801

    $3,440,000
    4,862 sqft

    Downtown commercial space includes on-site parking and access to nearby public parking options.

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    Downtown Office Condominium Suite
    Downtown Office Condominium Suite

    118 Maplewood Avenue, #C1, Portsmouth, NH 03801

    $450,000
    951 sqft

    Versatile office condo with three private offices, conference room, restroom, kitchenette, and two dedicated parking spaces.

    View details
    Historic Downtown Office Building
    Historic Downtown Office Building

    40 Congress Street, Portsmouth, NH 03801

    $12,500,000
    22,601 sqft 0.09 AC lot

    CD5 zoning supports office, commercial, and mixed-use applications.

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    Downtown Office Condominium Suite
    Downtown Office Condominium Suite

    118 Maplewood Avenue, Unit C-1, Portsmouth, NH 03801

    $450,000
    951 sqft

    Own a functional office condominium with private offices, a conference room, and dedicated on-site parking.

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    Office Condominium with Private Offices
    Office Condominium with Private Offices

    C1-118 Maplewood Ave, Portsmouth, NH 03801

    $450,000
    951 sqft

    Professional suite includes three enclosed offices, a flexible conference room, kitchenette, storage, and a private restroom.

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    Two-Building Flex Industrial Site
    Two-Building Flex Industrial Site

    3601 Lafayette Road, Portsmouth, NH 03801

    $1,300,000
    2,615 sqft 4.50 AC lot

    Two commercial buildings on 4.5 acres include offices and a rear workshop/warehouse with four drive-in doors.

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    Historic Portsmouth Office Building For Sale
    Historic Portsmouth Office Building For Sale

    144 Washington Street, Portsmouth, NH 03801

    $3,300,000
    3,034 sqft

    Landmark Federal-style building in Portsmouth's historic Puddle Dock area.

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    Compact Medical Office Condo
    Compact Medical Office Condo

    230 Lafayette Rd Unit 11D, Portsmouth, NH 03801

    $94,160
    428 sqft

    A private, in-suite restroom medical office suite with ample on-site parking and easy access to major routes.

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    Freestanding Flex Building
    Freestanding Flex Building

    359 Corporate Dr, Portsmouth, NH 03801

    Contact for pricing
    24,750 sqft 10.00 AC lot

    Office, warehouse, solar panels, and multi-level space create a versatile commercial configuration.

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