Add Listing
    For Lease
    • For Sale
    • For Lease
    • Recently Sold
    • Property Lookup
    • Brokers
    Office
    1
    • Retail
    • Restaurant
    • Office
    • Coworking
    • Medical Space
    • Automotive
    • Industrial
    • Warehouse
    • Flex
    • Hospitality
    • Sports & Entertainment
    • Specialty
    Price
    Price range
    $
    $
    Size
    Property size / sq.ft.
    AI Search

    Durham County, NC Office Properties & Spaces for Lease

    60 results
    List
    Map
    Versatile Office/Medical Space Available
    $3,000 / Mo
    2,400 SF

    Versatile Office/Medical Space Available

    3925 N Duke St, Durham, NC 27704

    2400 sq ft office/medical suite in prime Durham location.

    • Prime Durham location, minutes from downtown and Duke Regional Hospital.
    • Versatile 2400 sq ft space suitable for office, medical, or service‑based businesses.
    • Five private offices plus open central workspace.
    • Previously configured for dental and salon use.
    • Large reception area ideal for client‑facing businesses.
    Updated: Feb 18
    View details
    Durham Office Condo For Lease
    $1,500 / Mo
    478 SF

    Durham Office Condo For Lease

    3201 Yorktown Ave, Durham, NC 27713

    Recently remodeled office condo with easy access and great location.

    • Recently remodeled with new paint, flooring, ceilings, light fixtures, updated bathroom and kitchenette, and new HVAC system
    • Easy access from parking lot
    • Convenient location: Minutes to Hwy 40 and 885
    • Proximity to Amenities: 2 Miles to Lowes Shopping Plaza, 4 Miles to RTP, 5 Miles to Southpoint Mall and Downtown Durham
    • Includes a brand new refrigerator
    Updated: Feb 10
    View details
    Office Space Near Universities
    $1,995 / Mo
    1,000 SF

    Office Space Near Universities

    Office space in Durham, close to amenities and universities.

    1804 Martin Luther King Junior Pkwy, Durham, NC 27707
    View details
    Office Condo in Durham's Office Park
    $3,500 / Mo
    2,000 SF

    Office Condo in Durham's Office Park

    Office condominium with private entrance in a convenient location.

    6 Consultant Pl, Durham, NC 27707
    View details
    Durham Office Space For Lease
    $45,045
    2,145 SF

    Durham Office Space For Lease

    Flexible office unit with ample parking and recent upgrades.

    1906 A, Durham, NC 27713
    View details
    Office Suite with Private Offices
    $36,000
    1,760 SF

    Office Suite with Private Offices

    Office suite featuring multiple private office spaces for rent.

    5315 Highgate Dr, Durham, NC 27713
    View details
    Prime Medical Office Space Available
    Pending
    $18 SF/Yr
    2,312 SF

    Prime Medical Office Space Available

    Versatile medical/office space in Durham's thriving North Duke corridor.

    2609 N Duke St Unit Bldg 300, Durham, NC 27704
    View details
    Professional Office Condos For Lease
    $2,400 / Mo
    5,120 SF

    Professional Office Condos For Lease

    Office condos for lease near Duke University Medical Center.

    2741 Campus Walk Ave, Durham, NC 27705
    View details
    Roxboro Road Professional Office Space
    $20 SF/Yr
    2,408 SF

    Roxboro Road Professional Office Space

    Office space ideal for professional services and medical offices.

    4210 N Roxboro St, Durham, NC 27704
    View details
    Downtown Durham Office Space Available
    Contact for pricing
    16,692 SF

    Downtown Durham Office Space Available

    Office spaces for lease in the heart of downtown Durham.

    433 W Main St, Durham, NC 27701
    View details
    Downtown Durham Office Space Available
    $32 SF/Yr
    25,678 SF

    Downtown Durham Office Space Available

    Suites available in historic Art Deco building, downtown Durham.

    331 W Main St, Durham, NC 27707
    View details
    Plug and Play Lab Space
    $30 SF/Yr
    94,603 SF

    Plug and Play Lab Space

    Move-in ready lab and office space in Durham, NC.

    4025 Stirrup Creek Dr, Durham, NC 27703
    View details
    Durham Medical/Office Building for Lease
    $23 SF/Yr
    4,769 SF

    Durham Medical/Office Building for Lease

    Freestanding 4,769 SF building suitable for medical or office use.

    110 E Carver St, Durham, NC 27704
    View details
    Renovated Office Building Near University
    Contact for pricing
    58,249 SF

    Renovated Office Building Near University

    Three-story office building near mixed-use development with ongoing renovations.

    3710 University Dr, Durham, NC 27707
    View details
    Downtown Durham Office Space
    Contact for pricing
    41,000 SF

    Downtown Durham Office Space

    Full floor office space in downtown Durham's iconic tower.

    212 West Main St, Durham, NC 27701
    View details
    Durham Office Building Near University
    Contact for pricing
    59,650 SF

    Durham Office Building Near University

    59,650 SF office building near mixed-use development.

    3708 Mayfair St, Durham, NC 27707
    View details
    Class A Office Space
    $23 SF/Yr
    79,440 SF

    Class A Office Space

    Class A office space for lease in North Durham.

    4321 Medical Park Dr, Durham, NC 27704
    View details
    Office/Medical Building Near Southpoint Mall
    $26 SF/Yr
    18,395 SF

    Office/Medical Building Near Southpoint Mall

    Single-story office/medical building near Southpoint Mall available for lease.

    5501 Fortunes Ridge Dr, Durham, NC 27713
    View details
    Downtown Durham Office Space Available
    $29 SF/Yr
    32,522 SF

    Downtown Durham Office Space Available

    Move-in ready office space in downtown Durham with modern amenities.

    505 S Duke St, Durham, NC 27701
    View details
    Office Space Near University Hill
    Contact for pricing
    12,500 SF

    Office Space Near University Hill

    Office space with high visibility, convenience, and walkability.

    3917 University Dr, Durham, NC 27707
    View details
    Durham Flex Space Available
    $13 SF/Yr
    35,000 SF

    Durham Flex Space Available

    35,000 SF flex space for rent in Durham.

    4808 Chin Page Rd, Durham, NC 27703
    View details
    Downtown Durham Retail/Office Space
    Contact for pricing
    465,000 SF

    Downtown Durham Retail/Office Space

    Retail and office space available for lease in downtown Durham.

    110 Corcoran St, Durham, NC 27701
    View details
    Medical Office Space in Durham
    $23 SF/Yr
    5,986 SF

    Medical Office Space in Durham

    Dental specialist office space for lease near Duke University/Hospital.

    1212 Broad St, Durham, NC 27705
    View details
    Renovated Historic Building on Ninth
    Contact for pricing
    8,400 SF

    Renovated Historic Building on Ninth

    Fully renovated historic building in Durham's vibrant 9th Street district.

    706 Ninth St, Durham, NC 27705
    View details

    Durham County, NC Office Properties & Spaces Leasing Opportunities Market Analysis

    Explore Office Properties & Spaces leasing options in Durham County, NC with 99 listings featured on our commercial real estate exchange. The current inventory includes 61,365,193,560 square feet of properties with an estimated lease value of $983 /Mo.

    Estimated lease rates for Office Properties & Spaces in Durham County, NC begin at $5 SF/Yr, with an average of $25 SF/Yr and extend to $60 SF/Yr.
    List
    Map

    Office Properties & Spaces by market

    Browse Office Properties & Spaces for Lease Near Durham, NC

    Popular Categories

    Select Neighborhood

    Google sign-in failed. Please try again or use another login method.
    Sign Up Successful!
    You now have access to more from Realmo!