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    Saint Charles, MO Mixed-use Properties for Sale

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    St Peters, MO Old Monroe, MO Wentzville, MO
    Historic Mixed-Use Building in Frenchtown
    $980,000
    8,218 SF
    Historic Mixed-Use Building in Frenchtown

    900 N 2nd St, Saint Charles, MO

    Mixed-use building with retail and apartments in historic Frenchtown.
    • Prime location in booming Historic Frenchtown, St. Charles, next to the proposed new City Hall.
    • 8,218 sf building with retail space on the main level and five apartments on the upper floors.
    • Three‑story building with historical significance, built in 1880.
    • Second floor features four units (800 sf - 900 sf +/-), with three finished.
    • All units have individual utility services.
    Updated: Aug 21, 2025
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    Based on your search, we've compiled 80 Potential Opportunities for your consideration. Besides 1 Active listings in Saint Charles, MO, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 71 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

    Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    St Peters Mixed-Use Building
    $1,600,000
    15,250 SF
    St Peters Mixed-Use Building

    Mixed-use building with highway visibility and warehouse space.

    4524 S Saint Peters Parkway, St Peters, MO 63304

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    Mixed-Use Building Near Cave Springs
    $750,000
    7,890 SF
    Mixed-Use Building Near Cave Springs

    7890 SF mixed-use building on 1.73 acres for sale.

    3960 Mexico Road, St Peters, MO 63376

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    Move-In Ready Mixed-Use Building
    $238,500
    0.10 Acres
    Move-In Ready Mixed-Use Building

    Commercial building in the heart of Old Town Florissant.

    560 N Jefferson Street, Florissant, MO 63031

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    Mixed-Use Building with Renovated Spaces
    Contact for pricing
    2,200 SF
    Mixed-Use Building with Renovated Spaces

    Income-producing mixed-use building with renovated office and residential spaces.

    699 Rue Saint Francois, Florissant, MO

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    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    St Charles Development Opportunity
    $1,168,100
    9.09 Acres
    St Charles Development Opportunity

    9.09 acres of land in prime location for development.

    Saint Charles, MO 63303

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    St Charles Development Opportunity
    $1,168,100
    9.09 Acres
    St Charles Development Opportunity

    9.09 acres of land in a prime location.

    Saint Charles, MO 63303

    View details
    St. Charles Development Opportunity
    $2,965,020
    14.33 Acres
    St. Charles Development Opportunity

    14.33 acres suitable for residential or mixed-use development.

    Saint Charles, MO 63303

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    St. Charles Development Opportunity
    $2,965,020
    14.33 Acres
    St. Charles Development Opportunity

    14.33 acres of land in a prime St. Charles location.

    Saint Charles, MO 63303

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    Off-Market Properties in Saint Charles, MO

    Consider similar Off-Market properties in Saint Charles, MO. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    Hayford Rd
    OFFICE/RESIDENTIAL (MIXED USE)
    Lot: 23.16 Acres
    Value Estimation by Request

    Hayford Rd, Saint Charles, MO 63301

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    4125 Elm Pt Rd
    OFFICE/RESIDENTIAL (MIXED USE)
    2,343 SF Lot: 6.45 Acres
    Value Estimation by Request

    4125 Elm Pt Rd, Saint Charles, MO 63301-7308

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    910 2nd St
    OFFICE/RESIDENTIAL (MIXED USE)
    8,710 SF Lot: 0.22 Acres
    Estimated value
    $845,000

    910 2nd St, Saint Charles, MO 63301-2041

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    1417 2nd St
    OFFICE/RESIDENTIAL (MIXED USE)
    2,032 SF Lot: 0.14 Acres
    Value Estimation by Request

    1417 2nd St, Saint Charles, MO 63301-2107

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    1055 1st Capitol Dr
    STORE/OFFICE (MIXED USE)
    2,124 SF Lot: 0.17 Acres
    Value Estimation by Request

    1055 1st Capitol Dr, Saint Charles, MO 63301-2735

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    416 Main St
    OFFICE/RESIDENTIAL (MIXED USE)
    4,161 SF Lot: 0.12 Acres

    416 Main St, Saint Charles, MO 63301-3302

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    3241 Domain St
    OFFICE/RESIDENTIAL (MIXED USE)
    3,512 SF Lot: 0.03 Acres
    Value Estimation by Request

    3241 Domain St, Saint Charles, MO 63301-8273

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    2021 Hwy C C
    OFFICE/RESIDENTIAL (MIXED USE)
    1,540 SF Lot: 5.62 Acres
    Value Estimation by Request

    2021 Hwy C C, Saint Charles, MO 63301-6624

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    91 Skyline Dr
    OFFICE/RESIDENTIAL (MIXED USE)
    1,798 SF Lot: 0.10 Acres
    Value Estimation by Request

    91 Skyline Dr, Saint Charles, MO 63304-2624

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    901 2nd St
    OFFICE/RESIDENTIAL (MIXED USE)
    4,410 SF Lot: 0.08 Acres
    Value Estimation by Request

    901 2nd St, Saint Charles, MO 63301-2040

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    2195 1st Capitol Dr
    OFFICE/RESIDENTIAL (MIXED USE)
    4,608 SF Lot: 1.03 Acres
    Estimated value
    $835,000

    2195 1st Capitol Dr, Saint Charles, MO 63301-5803

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    3222 Rue Royale St
    OFFICE/RESIDENTIAL (MIXED USE)
    2,160 SF Lot: 0.04 Acres
    Value Estimation by Request

    3222 Rue Royale St, Saint Charles, MO 63301-8348

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    950 Hemsath Rd
    OFFICE/RESIDENTIAL (MIXED USE)
    8,100 SF Lot: 2.07 Acres
    Estimated value
    $730,000

    950 Hemsath Rd, Saint Charles, MO 63303

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    708 Main St
    OFFICE/RESIDENTIAL (MIXED USE)
    3,156 SF Lot: 0.10 Acres
    Estimated value
    $575,000

    708 Main St, Saint Charles, MO 63301-3443

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    5209 Hwy N Hwy
    OFFICE/RESIDENTIAL (MIXED USE)
    4,487 SF Lot: 0.16 Acres
    Value Estimation by Request

    5209 Hwy N Hwy, Saint Charles, MO 63304-8300

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    1042 David Mdws Ln
    OFFICE/RESIDENTIAL (MIXED USE)
    7,455 SF Lot: 3.69 Acres
    Estimated value
    $675,000

    1042 David Mdws Ln, Saint Charles, MO 63304-7622

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    3253 Domain St
    OFFICE/RESIDENTIAL (MIXED USE)
    2,076 SF Lot: 0.03 Acres
    Value Estimation by Request

    3253 Domain St, Saint Charles, MO 63301-8248

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    3257 Domain St
    OFFICE/RESIDENTIAL (MIXED USE)
    3,353 SF Lot: 0.05 Acres
    Value Estimation by Request

    3257 Domain St, Saint Charles, MO 63301-8245

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    3275 Hawning Rd
    OFFICE/RESIDENTIAL (MIXED USE)
    1,410 SF Lot: 3.89 Acres
    Value Estimation by Request

    3275 Hawning Rd, Saint Charles, MO 63301-0271

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    915 Main St
    OFFICE/RESIDENTIAL (MIXED USE)
    4,764 SF Lot: 0.62 Acres
    Estimated value
    $775,000

    915 Main St, Saint Charles, MO 63301-3445

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    1700 Randolph St
    OFFICE/RESIDENTIAL (MIXED USE)
    3,600 SF Lot: 0.19 Acres
    Value Estimation by Request

    1700 Randolph St, Saint Charles, MO 63301-0827

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    700 Main St
    OFFICE/RESIDENTIAL (MIXED USE)
    4,101 SF Lot: 0.15 Acres
    Estimated value
    $835,000

    700 Main St, Saint Charles, MO 63301-3443

    View details
    3640 Hwy 94
    OFFICE/RESIDENTIAL (MIXED USE)
    2,520 SF Lot: 30.80 Acres
    Value Estimation by Request

    3640 Hwy 94, Saint Charles, MO 63301-5333

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    Saint Charles, MO Mixed-Use Properties Market Trends and Statistics

    Explore 72 mixed-use properties for sale in Saint Charles, MO on our real estate platform. These investment opportunities span a total of 8,218 square feet of properties for sale, with an estimated market value of $980,000.

    Sale prices for multi use buildings in Saint Charles, MO start at $980,000, averaging $980,000, and reaching up to $980,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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    Demographics Overview

    Population 142K
    Population Growth (5Y) +1.4%
    Median Household Income $97,683
    College Educated 47.2%

    Listings Trend

    New vs delisted commercial listings in St. Charles County

    New Delisted

    Total CRE Inventory on Market (SF)

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