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    Saint Charles, MO Mixed-use Properties for Sale

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    St Peters, MO Old Monroe, MO Dardenne Prairie, MO
    Historic Mixed-Use Building in Frenchtown
    $980,000
    8,218 SF

    Historic Mixed-Use Building in Frenchtown

    900 N 2nd St, Saint Charles, MO

    Mixed-use building with retail and apartments in historic Frenchtown.

    • Prime location in booming Historic Frenchtown, St. Charles, next to the proposed new City Hall.
    • 8,218 sf building with retail space on the main level and five apartments on the upper floors.
    • Three‑story building with historical significance, built in 1880.
    • Second floor features four units (800 sf - 900 sf +/-), with three finished.
    • All units have individual utility services.
    Updated: Aug 21, 2025
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    Based on your search, we've compiled 253 Potential Opportunities for your consideration. Besides 1 Active listings in Saint Charles, MO, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 244 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

    Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Move-In Ready Mixed-Use Building
    $238,500
    0.10 Acres

    Move-In Ready Mixed-Use Building

    Commercial building in the heart of Old Town Florissant.

    560 N Jefferson Street, Florissant, MO 63031
    View details
    Mixed-Use Property Near Lambert Airport
    $825,000
    5,500 SF

    Mixed-Use Property Near Lambert Airport

    Mixed-use property with retail and warehouse space, investment opportunity.

    Saint Ann, MO 63074
    View details
    Mixed-Use Property Near Lambert Airport
    $814,900
    5,500 SF

    Mixed-Use Property Near Lambert Airport

    Mixed-use property with retail and warehouse space, great investment opportunity.

    3444 N Lindbergh Blvd, Saint Ann, MO 63074
    View details
    Mixed-Use Building with Renovated Spaces
    Contact for pricing
    2,200 SF

    Mixed-Use Building with Renovated Spaces

    Income-producing mixed-use building with renovated office and residential spaces.

    699 Rue Saint Francois, Florissant, MO
    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    St Charles Development Opportunity
    $1,168,100
    9.09 Acres

    St Charles Development Opportunity

    9.09 acres of land in prime location for development.

    Saint Charles, MO 63303
    View details
    St Charles Development Opportunity
    $1,168,100
    9.09 Acres

    St Charles Development Opportunity

    9.09 acres of land in a prime location.

    Saint Charles, MO 63303
    View details
    St. Charles Development Opportunity
    $2,965,020
    14.33 Acres

    St. Charles Development Opportunity

    14.33 acres suitable for residential or mixed-use development.

    Saint Charles, MO 63303
    View details
    St. Charles Development Opportunity
    $2,965,020
    14.33 Acres

    St. Charles Development Opportunity

    14.33 acres of land in a prime St. Charles location.

    Saint Charles, MO 63303
    View details

    Off-Market Properties in Saint Charles, MO

    Consider similar Off-Market properties in Saint Charles, MO. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    Hayford Rd

    Hayford Rd

    OFFICE/RESIDENTIAL (MIXED USE) • 23.16 Acres
    Value Estimation by Request
    Hayford Rd, Saint Charles, MO 63301
    View details
    4125 Elm Pt Rd

    4125 Elm Pt Rd

    OFFICE/RESIDENTIAL (MIXED USE) • 2,343 SF
    Value Estimation by Request
    4125 Elm Pt Rd, Saint Charles, MO 63301-7308
    View details
    910 2nd St

    910 2nd St

    OFFICE/RESIDENTIAL (MIXED USE) • 8,710 SF
    Value Estimation
    $845,000
    910 2nd St, Saint Charles, MO 63301-2041
    View details
    1417 2nd St

    1417 2nd St

    OFFICE/RESIDENTIAL (MIXED USE) • 2,032 SF
    Value Estimation by Request
    1417 2nd St, Saint Charles, MO 63301-2107
    View details
    1055 1st Capitol Dr

    1055 1st Capitol Dr

    STORE/OFFICE (MIXED USE) • 2,124 SF
    Value Estimation by Request
    1055 1st Capitol Dr, Saint Charles, MO 63301-2735
    View details
    416 Main St

    416 Main St

    OFFICE/RESIDENTIAL (MIXED USE) • 4,161 SF
    Value Estimation
    $995,000
    416 Main St, Saint Charles, MO 63301-3302
    View details
    3241 Domain St

    3241 Domain St

    OFFICE/RESIDENTIAL (MIXED USE) • 3,512 SF
    Value Estimation by Request
    3241 Domain St, Saint Charles, MO 63301-8273
    View details
    2021 Hwy C C

    2021 Hwy C C

    OFFICE/RESIDENTIAL (MIXED USE) • 1,540 SF
    Value Estimation by Request
    2021 Hwy C C, Saint Charles, MO 63301-6624
    View details
    91 Skyline Dr

    91 Skyline Dr

    OFFICE/RESIDENTIAL (MIXED USE) • 1,798 SF
    Value Estimation by Request
    91 Skyline Dr, Saint Charles, MO 63304-2624
    View details
    901 2nd St

    901 2nd St

    OFFICE/RESIDENTIAL (MIXED USE) • 4,410 SF
    Value Estimation by Request
    901 2nd St, Saint Charles, MO 63301-2040
    View details
    2195 1st Capitol Dr

    2195 1st Capitol Dr

    OFFICE/RESIDENTIAL (MIXED USE) • 4,608 SF
    Value Estimation
    $835,000
    2195 1st Capitol Dr, Saint Charles, MO 63301-5803
    View details
    3222 Rue Royale St

    3222 Rue Royale St

    OFFICE/RESIDENTIAL (MIXED USE) • 2,160 SF
    Value Estimation by Request
    3222 Rue Royale St, Saint Charles, MO 63301-8348
    View details
    950 Hemsath Rd

    950 Hemsath Rd

    OFFICE/RESIDENTIAL (MIXED USE) • 8,100 SF
    Value Estimation
    $730,000
    950 Hemsath Rd, Saint Charles, MO 63303
    View details
    708 Main St

    708 Main St

    OFFICE/RESIDENTIAL (MIXED USE) • 3,156 SF
    Value Estimation
    $575,000
    708 Main St, Saint Charles, MO 63301-3443
    View details
    5209 Hwy N Hwy

    5209 Hwy N Hwy

    OFFICE/RESIDENTIAL (MIXED USE) • 4,487 SF
    Value Estimation by Request
    5209 Hwy N Hwy, Saint Charles, MO 63304-8300
    View details
    1042 David Mdws Ln

    1042 David Mdws Ln

    OFFICE/RESIDENTIAL (MIXED USE) • 7,455 SF
    Value Estimation
    $675,000
    1042 David Mdws Ln, Saint Charles, MO 63304-7622
    View details
    3253 Domain St

    3253 Domain St

    OFFICE/RESIDENTIAL (MIXED USE) • 2,076 SF
    Value Estimation by Request
    3253 Domain St, Saint Charles, MO 63301-8248
    View details
    3257 Domain St

    3257 Domain St

    OFFICE/RESIDENTIAL (MIXED USE) • 3,353 SF
    Value Estimation by Request
    3257 Domain St, Saint Charles, MO 63301-8245
    View details
    3275 Hawning Rd

    3275 Hawning Rd

    OFFICE/RESIDENTIAL (MIXED USE) • 1,410 SF
    Value Estimation by Request
    3275 Hawning Rd, Saint Charles, MO 63301-0271
    View details
    915 Main St

    915 Main St

    OFFICE/RESIDENTIAL (MIXED USE) • 4,764 SF
    Value Estimation
    $775,000
    915 Main St, Saint Charles, MO 63301-3445
    View details
    1700 Randolph St

    1700 Randolph St

    OFFICE/RESIDENTIAL (MIXED USE) • 3,600 SF
    Value Estimation by Request
    1700 Randolph St, Saint Charles, MO 63301-0827
    View details
    700 Main St

    700 Main St

    OFFICE/RESIDENTIAL (MIXED USE) • 4,101 SF
    Value Estimation
    $835,000
    700 Main St, Saint Charles, MO 63301-3443
    View details
    3640 Hwy 94

    3640 Hwy 94

    OFFICE/RESIDENTIAL (MIXED USE) • 2,520 SF
    Value Estimation by Request
    3640 Hwy 94, Saint Charles, MO 63301-5333
    View details

    Saint Charles, MO Mixed-Use Properties Investment Opportunities Market Analysis

    Explore 245 mixed-use properties for sale in Saint Charles, MO on our real estate platform. These investment opportunities span a total of 8,218 square feet of properties for sale, with an estimated market value of $980,000.

    Sale prices for multi use buildings in Saint Charles, MO start at $980,000, averaging $980,000, and reaching up to $980,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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    Saint Charles Demographics Overview

    Population 142K
    Population Growth (5Y) +1.4%
    Median Household Income $97,683
    College Educated 47.2%

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