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    Saint Charles, MO
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    Saint Charles, MO Commercial Real Estate for Sale

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    St Peters, MO Old Monroe, MO Wentzville, MO
    45 results
    St Charles Industrial/Retail Building
    $595,000
    2,640 SF
    St Charles Industrial/Retail Building

    Saint Charles, MO 63304

    Freestanding building with highway visibility and multiple drive-in doors.
    • Excellent location with great highway visibility and easy access to Hwy 364.
    • Free‑standing building suitable for Commercial, Retail, or Light Industrial use.
    • Over 2,500 SF building on nearly an acre of land.
    • Features 4 drive‑in doors, ideal for various business operations.
    • Approximately 40 parking spaces available.
    Updated: May 6
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    St Charles Medical Office Building
    $2,450,000
    6,676 SF
    St Charles Medical Office Building

    Saint Charles, MO 63303

    Freestanding, fully occupied medical office building near highways.
    • 100% Occupied with Long‑Term Lease (Expires 2035)
    • Excellent Investment Opportunity / 1031 Exchange Potential
    • Free Standing Brick Building
    • Medical Use Tenant
    • Built in 2005
    Updated: May 4
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    Commercial Lots in High-Traffic Area
    $349,000
    2.37 Acres
    Commercial Lots in High-Traffic Area

    Two commercial lots totaling 2.37 acres in St Charles.

    Saint Charles, MO 63301

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    St Charles Office Investment Opportunity
    $80,000
    900 SF
    St Charles Office Investment Opportunity

    Duplex-style office building with renovation potential in high-visibility location.

    Saint Charles, MO 63301

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    St Charles Development Opportunity
    $1,168,100
    9.09 Acres
    St Charles Development Opportunity

    9.09 acres of land in prime location for development.

    Saint Charles, MO 63303

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    Commercial Lot on Harry Truman
    $440,000
    0.84 Acres
    Commercial Lot on Harry Truman

    Highly visible commercial lot suitable for various business ventures.

    Saint Charles, MO 63301

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    St Charles Development Opportunity
    $1,168,100
    9.09 Acres
    St Charles Development Opportunity

    9.09 acres of land in a prime location.

    Saint Charles, MO 63303

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    Freestanding NNN Restaurant For Sale
    $1,302,731
    0.48 Acres
    Freestanding NNN Restaurant For Sale

    Single tenant Captain D's with drive-thru in retail corridor.

    2951 Veterans Memorial Pky, Saint Charles, MO 63303

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    High-Visibility Parcel Near Lindenwood University
    $350,000
    1,146 SF
    High-Visibility Parcel Near Lindenwood University

    Rare opportunity: 1,146 SF building near a signalized corner.

    Saint Charles, MO 63301

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    St Charles Unimproved Industrial Land
    $3,103,800
    110.80 Acres
    St Charles Unimproved Industrial Land

    110.8 acres of land suitable for industrial development.

    Saint Charles, MO 63301

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    Saint Charles Adaptable Commercial Building
    $3,160,000
    8,128 SF
    Saint Charles Adaptable Commercial Building

    8,128 SF building suited for various uses in Saint Charles.

    1821 S River Rd, Saint Charles, MO

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    Medical Office Building For Sale
    $2,450,000
    6,676 SF
    Medical Office Building For Sale

    Freestanding, fully occupied medical building near highways.

    11 Garvey Pkwy, Saint Charles, MO 63303

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    Saint Charles Office/Flex Building
    Contact for pricing
    53,932 SF
    Saint Charles Office/Flex Building

    Class A office/flex building in a prime Saint Charles location.

    500 Fountain Lakes Blvd, Saint Charles, MO 63301

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    St Charles Industrial Development Land
    $3,103,800
    110.80 Acres
    St Charles Industrial Development Land

    110.8 acre industrial land with excellent development potential.

    Saint Charles, MO 63301

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    Prime Land Near Convention Center
    $3,000,000
    4.71 Acres
    Prime Land Near Convention Center

    4.71 acres ideal for hotel or residential development.

    1201 Veterans Memorial, Saint Charles, MO 63303

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    Restaurant Space Near Interstate I-70
    $2,200,000
    4,926 SF
    Restaurant Space Near Interstate I-70

    Former restaurant space with high visibility near I-70.

    1423 S 5TH ST, Saint Charles, MO

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    High-Visibility Corner Parcel For Sale
    $450,000
    1,350 SF
    High-Visibility Corner Parcel For Sale

    Corner parcel suitable for redevelopment, retail, or auto sales.

    212 S Kingshighway, Saint Charles, MO 63301

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    Redevelopment Opportunity Near Government Center
    $950,000
    4,545 SF
    Redevelopment Opportunity Near Government Center

    Retail building on corner lot near proposed City Hall.

    512 Clark St, Saint Charles, MO

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    Industrial Land Ready For Development
    $499,000
    2.50 Acres
    Industrial Land Ready For Development

    2.5 acres of industrial land with high visibility.

    400 Fountain Lakes Boulevard, Saint Charles, MO 63301

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    Historic Mixed-Use Building in Frenchtown
    $980,000
    8,218 SF
    Historic Mixed-Use Building in Frenchtown

    Mixed-use building with retail and apartments in historic Frenchtown.

    900 N 2nd St, Saint Charles, MO

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    Former QSR on Large Site
    $795,000
    2,300 SF
    Former QSR on Large Site

    High-visibility property suitable for retail, service, or office users.

    2525 West Clay Street, Saint Charles, MO

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    High-Visibility Commercial Parcel Available
    $200,000
    1,506 SF
    High-Visibility Commercial Parcel Available

    Commercial parcel suitable for redevelopment, office, or retail.

    Saint Charles, MO 63301

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    Industrial Property with Outdoor Storage
    $1,300,000
    14,470 SF
    Industrial Property with Outdoor Storage

    14,470 SF building with fenced and covered outdoor storage.

    2715 Veterans Memorial Pkwy, Saint Charles, MO

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    Restaurant, Bar & Patio on Main
    $1,395,000
    1,900 SF
    Restaurant, Bar & Patio on Main

    Fully operational restaurant, bar, and patio on Historic Main Street.

    515 South main Street, Saint Charles, MO 63301

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    Saint Charles, MO Commercial Real Estate Investment Opportunities Market Analysis

    Explore 72 commercial real estate for sale in Saint Charles, MO, showcased through 45 active listings on our real estate platform. These investment opportunities span a total of 224,067 square feet of properties for sale, with an estimated market value of $31,609,565.

    Sale prices for business properties in Saint Charles, MO start at $80,000, averaging $1,436,798, and reaching up to $3,894,135 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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    Demographics Overview

    Population 142K
    Population Growth (5Y) +1.4%
    Median Household Income $97,683
    College Educated 47.2%

    High-Yield Neighborhoods for Investment

    Identify Saint Charles submarkets with the highest inventory density on the market and evaluate the median listing prices of real estate assets

    Neighborhood Average Price
    63304 $595K
    63301 $1M
    63303 $1.8M

    Listings Trend

    Total CRE Area on Market Trend

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