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    Saint Charles, MO

    Saint Charles, MO Commercial Real Estate for Sale

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    Temperature-Controlled Flex Space
    Updated: Jun 2
    Temperature-Controlled Flex Space

    Saint Charles, MO 63303

    $950,000
    0.79 AC lot
    7,150 SF office/warehouse on 0.79 acres
    I‑1 Light Industrial zoning
    11' to 12' 6" clear height in warehouse
    One 10x12 loading dock and 1 drive‑in door
    600Amp 3 Phase Electric
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    Historic Main Street Mixed-Use Property
    Updated: Aug 24
    Historic Main Street Mixed-Use Property

    Saint Charles, MO 63301

    $725,000
    0.16 AC lot
    Circa‑1890 brick mixed‑use building on a 0.16‑acre parcel
    28 feet of Main Street frontage in St. Charles' Historic Main Street District
    Ground‑floor restaurant tenant has operated at the property for 10 years
    Second and third floors identified for renovation into apartment units
    Central Business District (AA4) zoning supports commercial and residential uses
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    Historic Office Building
    Historic Office Building

    Saint Charles, MO 63301

    $850,000
    0.17 AC lot

    Designated historic office property with flexible rooms, multiple entrances, and dedicated parking near the County Courthouse.

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    Scored against comparables nationwide. These are worth a look.

    Scored against comparables nationwide. These are worth a look.

    Cap Rate available after sign in
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    Local Demand available after sign in
    Freestanding Flex Space with Loading Dock
    Freestanding Flex Space with Loading Dock

    1565 Kisker Rd, Saint Charles, MO 63304

    $650,000
    3,950 sqft

    Flexible office and warehouse configuration with reception, private office, restroom, and open work area.

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    Freestanding Brick Medical Office
    Freestanding Brick Medical Office

    Saint Charles, MO 63303

    $2,450,000
    0.77 AC lot

    Occupied medical office property with a durable brick exterior, dedicated parking, and access to regional highways.

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    Commercial Land with Parking
    Commercial Land with Parking

    Saint Charles, MO 63301

    $440,000
    0.84 AC lot

    C-3 zoning, public water, and an existing asphalt parking area support commercial site planning.

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    Historic Mixed-Use Brick Building
    Historic Mixed-Use Brick Building

    Saint Charles, MO 63301

    $1,550,000
    0.09 AC lot

    The property combines ground-floor retail with upper-level apartment and Airbnb rentals.

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    Walgreens Pharmacy with Drive Thru
    Walgreens Pharmacy with Drive Thru

    2329 W Clay St, Saint Charles, MO 63301

    $3,836,444
    17,612 sqft 2.60 AC lot

    17,612 SF Walgreens on 2.6 acres in Saint Charles.

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    Historic Mixed-Use Building
    Historic Mixed-Use Building

    Saint Charles, MO 63301

    $950,000
    0.09 AC lot

    Brick commercial property combines short-term apartment units with a ready-to-use fitness facility and lower-level locker rooms.

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    Two-Lot Commercial Land
    Two-Lot Commercial Land

    Saint Charles, MO 63301

    $349,000
    2.37 AC lot

    Two commercial parcels are offered together with public water available.

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    Flex Space with Clear-Span Warehouse
    Flex Space with Clear-Span Warehouse

    Saint Charles, MO 63303

    Contact for pricing
    5,000 sqft

    Two connected commercial suites combine refurbished offices with climate-controlled warehouse areas and rear storage space.

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    Industrial Land with Highway Access
    Industrial Land with Highway Access

    Saint Charles, MO 63301

    $2,160,600
    110.80 AC lot

    Light Industrial-zoned land with visibility, convenient I-370 access, and public water service.

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    Lewis & Clark's Restaurant
    Lewis & Clark's Restaurant

    Saint Charles, MO 63301

    Contact for pricing
    6,379 sqft

    Established restaurant property on South Main Street in St. Charles.

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    Drive-Through Restaurant Building
    Drive-Through Restaurant Building

    3784 Elm St, Saint Charles, MO 63301

    Contact for pricing
    1,587 sqft 0.86 AC lot

    Existing retail and fast-food property with vehicle service access, surface parking, and Improved Commercial zoning.

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    Two-Story Office Building
    Two-Story Office Building

    Saint Charles, MO 63303

    Contact for pricing
    9,200 sqft

    Updated multi-level office property with highway exposure, monument signage, and flexible floor-by-floor configuration.

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    Grocery-Anchored Two-Tenant Building
    Grocery-Anchored Two-Tenant Building

    Saint Charles, MO 63303

    Contact for pricing
    11,597 sqft

    Two-tenant retail property with a planned ALDI grocery store and pylon signage along Interstate 70.

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    Two-Story Office Building
    Two-Story Office Building

    Saint Charles, MO 63301

    Contact for pricing
    8,884 sqft

    Two-story office building with bullpens, multiple offices, and conference space, totaling 8,884 sf.

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    Tenant-Occupied Duplex
    Tenant-Occupied Duplex

    Saint Charles, MO 63301

    $300,000
    1,440 sqft

    Two occupied units provide an established residential income property configuration for an incoming owner.

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    Office Suite with Bullpen
    Office Suite with Bullpen

    918-924 Hemsath Rd, Saint Charles, MO 63303

    Contact for pricing
    1,560 sqft

    Flexible professional workspace includes a private office, kitchenette, restroom, and dedicated storage.

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    Flex Space with Data Center
    Flex Space with Data Center

    Saint Charles, MO 63301

    Contact for pricing
    64,000 sqft 4.51 AC lot

    Warehouse and office improvements with loading capacity and direct access from Hwy 370.

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    Flex Space with Heavy Power
    Flex Space with Heavy Power

    Saint Charles, MO 63303

    Contact for pricing
    23,660 sqft 1.70 AC lot

    Industrial flex property with remodeled offices, secured outdoor storage, dock access, and multiple drive-in doors.

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    Restaurant, Bar & Patio on Main
    Restaurant, Bar & Patio on Main

    515 South main Street, Saint Charles, MO 63301

    Contact for pricing
    1,900 sqft

    Fully operational restaurant, bar, and patio on Historic Main Street.

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    Educational Facility
    Educational Facility

    400 North Kingshighway Street, Saint Charles, MO 63301

    Contact for pricing
    39,189 sqft

    Existing school property with a substantial footprint for continued educational use.

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    Free-Standing Medical Office Building
    Free-Standing Medical Office Building

    11 Garvey Pkwy, Saint Charles, MO 63303

    Contact for pricing
    6,676 sqft

    Free-standing brick medical office building built in 2005 with 32 parking spaces and 100% occupied long-term medical lease.

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    Saint Charles, MO Commercial Real Estate Market Trends and Statistics

    Explore 72 commercial real estate for sale in Saint Charles, MO, showcased through 54 active listings on our real estate platform. These investment opportunities span a total of 317,464 square feet of properties for sale, with an estimated market value of $20,013,474.

    Sale prices for business properties in Saint Charles, MO start at $199,500, averaging $1,177,263, and reaching up to $3,836,444 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

    Saint Charles, MO CRE market trends — vacancy, lease rates and price per SF, updated monthly
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    Demographics Overview

    Population 142K
    Population Growth (5Y) +1.4%
    Median Household Income $97,683
    College Educated 47.2%

    High-Yield Neighborhoods for Investment

    Identify Saint Charles submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

    Neighborhood Average Price
    63304 $650K
    63301 $957.1K
    63303 $1.1M

    Listings Trend

    New vs delisted commercial listings in St. Charles County

    New Delisted

    Total CRE Inventory on Market (SF)

    How Realmo verifies these figures

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    Most Searched ZIP Codes in Saint Charles, MO

    • 63301
    • 63303
    • 63304

    Featured Saint Charles Real Estate Agencies

    Realmo connects you with licensed Saint Charles CRE brokers providing property specifications, local market pricing, and commercial transaction underwriting support.

    SHOW-ME REALTY ASSOCIATES, LLC
    208 COLE BLVD Saint Charles, MO 63301
    Phone: (314) 324-1897
    www.showmerealtyassociates.com
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