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    Saint Charles, MO

    Saint Charles, MO Commercial Real Estate for Sale

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    Historic Mixed-Use Building in Frenchtown
    Updated: Aug 21, 2025
    Historic Mixed-Use Building in Frenchtown

    900 N 2nd St, Saint Charles, MO

    $980,000
    8,218 sqft 0.20 AC lot
    Prime location in booming Historic Frenchtown, St. Charles, next to the proposed new City Hall.
    8,218 sf building with retail space on the main level and five apartments on the upper floors.
    Three‑story building with historical significance, built in 1880.
    Second floor features four units (800 sf - 900 sf +/-), with three finished.
    All units have individual utility services.
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    This listing looks promising.

    Here's a quick look at some key insights for

    900 N 2nd St, Saint Charles, MO

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    • Est. Cap Rate

      8.4%
      Above avg (5.9%)

    • Est. NOI

      $82K
      Annual

    • Mortgage

      $60K
      Dec 2022

    • Property Type

      Commercial Office/Residential (Mixed Use)
      Built 1880
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    Industrial Facility with Office and Mezzanine
    Updated: Jul 21
    Industrial Facility with Office and Mezzanine

    Saint Charles, MO 63301

    $650,000
    1.33 AC lot
    4,800 SF industrial facility on a fully fenced, gated 1.33‑acre site in St. Charles County’s established industrial corridor
    Main building features office, warehouse, and shop space with five private offices, break room/kitchen, and ADA‑accessible restroom
    Two 18‑ft electric overhead drive‑in doors plus approx. 400‑amp electrical service for industrial/fleet functionality
    Includes approx. 1,500 SF mezzanine and two warehouse bays for additional storage, inventory, or workspace
    Detached approx. 30' x 40' accessory building (~1,200 SF) plus covered storage area
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    Freestanding Brick Medical Building
    Freestanding Brick Medical Building

    Saint Charles, MO 63303

    $2,450,000
    0.77 AC lot

    Freestanding brick medical building built in 2005 with 32 parking spaces and a lease scheduled to expire in 2035.

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    Commercial Land with Major Frontage
    Commercial Land with Major Frontage

    Saint Charles, MO 63301

    $349,000
    2.37 AC lot

    Two lots totaling 2.37 acres with approximately 210 feet of frontage on W. Clay in a high-traffic area.

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    Medical Office Building For Sale
    Medical Office Building For Sale

    11 Garvey Pkwy, Saint Charles, MO 63303

    $2,450,000
    6,676 sqft

    Freestanding, fully occupied medical building near highways.

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    Light Industrial Land with I-370 Access
    Light Industrial Land with I-370 Access

    Saint Charles, MO 63301

    $3,103,800
    110.80 AC lot

    110.8-acre industrial-zoned parcel offers direct access to I-370 with utilities available at nearby intersections.

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    Freestanding Light Industrial Building with Drive-In Doors
    Freestanding Light Industrial Building with Drive-In Doors

    Saint Charles, MO 63304

    $595,000
    0.91 AC lot

    Free-standing building with four drive-in doors, about 40 parking spaces, and leased billboard on nearly an acre.

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    C-2 Zoned Retail Development Lot
    C-2 Zoned Retail Development Lot

    Saint Charles, MO 63301

    $500,000
    42,689 sqft 0.98 AC lot

    Commercial land in Regency Plaza, zoned C-2, with no known deed restrictions beyond standard City approvals.

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    High-Visibility Parcel Near Lindenwood University
    High-Visibility Parcel Near Lindenwood University

    Saint Charles, MO 63301

    $350,000
    1,146 sqft 0.10 AC lot

    Rare opportunity: 1,146 SF building near a signalized corner.

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    High-Visibility Corner Parcel For Sale
    High-Visibility Corner Parcel For Sale

    212 S Kingshighway, Saint Charles, MO 63301

    $450,000
    1,350 sqft 0.15 AC lot

    Corner parcel suitable for redevelopment, retail, or auto sales.

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    Industrial Property with Outdoor Storage
    Industrial Property with Outdoor Storage

    2715 Veterans Memorial Pkwy, Saint Charles, MO

    $1,300,000
    14,470 sqft 0.98 AC lot

    14,470 SF building with fenced and covered outdoor storage.

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    St. Charles Retail Space Available
    St. Charles Retail Space Available

    Saint Charles, MO 63301

    $1,900,000
    7,712 sqft

    Retail space for sale in St. Charles, Missouri.

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    Restaurant, Bar & Patio on Main
    Restaurant, Bar & Patio on Main

    515 South main Street, Saint Charles, MO 63301

    $1,345,000
    1,900 sqft

    Fully operational restaurant, bar, and patio on Historic Main Street.

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    Redevelopment Opportunity Near Government Center
    Redevelopment Opportunity Near Government Center

    512 Clark St, Saint Charles, MO

    $950,000
    4,545 sqft 0.78 AC lot

    Retail building on corner lot near proposed City Hall.

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    Prime Land Near Convention Center
    Prime Land Near Convention Center

    1201 Veterans Memorial, Saint Charles, MO 63303

    $3,000,000
    4.71 AC lot

    4.71 acres ideal for hotel or residential development.

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    Saint Charles Office/Flex Building
    Saint Charles Office/Flex Building

    500 Fountain Lakes Blvd, Saint Charles, MO 63301

    Contact for pricing
    53,932 sqft

    Class A office/flex building in a prime Saint Charles location.

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    Historic Main Street Storefront Opportunity
    Historic Main Street Storefront Opportunity

    Saint Charles, MO 63301

    $270,000
    864 sqft 0.03 AC lot

    Charming brick storefront in vibrant, high-traffic historic district.

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    Triple-Net Office Headquarters with Data Center
    Triple-Net Office Headquarters with Data Center

    Saint Charles, MO 63301

    Contact for pricing
    42,528 sqft 5.06 AC lot

    42,528-SF office headquarters includes a call center and data center, leased on an absolute triple-net basis.

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    Retail Property in St Charles
    Retail Property in St Charles

    Saint Charles, MO 63303

    $2,800,000
    7,158 sqft

    Retail property available for sale in St Charles, Missouri.

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    Open-Plan Retail Storefront
    Open-Plan Retail Storefront

    Saint Charles, MO 63303

    $279,000

    Former gun shop with an open floor plan and C-3 general commercial zoning.

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    Class A Office/Flex Building
    Class A Office/Flex Building

    500 Fountain Lakes Blvd, Saint Charles, MO

    Contact for pricing
    53,932 sqft 5.74 AC lot

    Office/flex building with heavy power and potential for warehouse conversion.

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    Retail Space For Sale
    Retail Space For Sale

    1125 N 2nd St, Saint Charles, MO 63301

    $800,000
    1,426 sqft

    Retail space available for purchase.

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    Commercial Lot on Harry Truman
    Commercial Lot on Harry Truman

    Saint Charles, MO 63301

    $440,000
    0.84 AC lot

    Highly visible commercial lot ideal for retail or restaurant.

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    Commercial Land Near Highway
    Commercial Land Near Highway

    936 Hemsath Rd, Saint Charles, MO

    $485,000
    1.96 AC lot

    Commercial land available near major highways.

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    Saint Charles, MO Commercial Real Estate Market Trends and Statistics

    Explore 72 commercial real estate for sale in Saint Charles, MO, showcased through 43 active listings on our real estate platform. These investment opportunities span a total of 222,068 square feet of properties for sale, with an estimated market value of $18,680,430.

    Sale prices for business properties in Saint Charles, MO start at $270,000, averaging $1,245,362, and reaching up to $2,800,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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    Demographics Overview

    Population 142K
    Population Growth (5Y) +1.4%
    Median Household Income $97,683
    College Educated 47.2%

    High-Yield Neighborhoods for Investment

    Identify Saint Charles submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

    Neighborhood Average Price
    63304 $595K
    63301 $949K
    63303 $2.1M

    Listings Trend

    New vs delisted commercial listings in St. Charles County

    New Delisted

    Total CRE Inventory on Market (SF)

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    Most Searched ZIP Codes in Saint Charles, MO

    • 63301
    • 63303
    • 63304

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