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    Saint Charles, MO

    Saint Charles, MO Commercial Real Estate for Sale

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    Historic Main Street Mixed-Use Property
    Updated: Jul 29
    Historic Main Street Mixed-Use Property

    Saint Charles, MO 63301

    $800,000
    0.16 AC lot
    Circa‑1890 brick mixed‑use building on a 0.16‑acre parcel
    28 feet of Main Street frontage in St. Charles' Historic Main Street District
    Ground‑floor restaurant tenant has operated at the property for 10 years
    Second and third floors identified for renovation into apartment units
    Central Business District (AA4) zoning supports commercial and residential uses
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    Temperature-Controlled Flex Space
    Updated: Jun 2
    Temperature-Controlled Flex Space

    Saint Charles, MO 63303

    $950,000
    0.79 AC lot
    7,150 SF office/warehouse on 0.79 acres
    I‑1 Light Industrial zoning
    11' to 12' 6" clear height in warehouse
    One 10x12 loading dock and 1 drive‑in door
    600Amp 3 Phase Electric
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    Freestanding Brick Medical Office
    Freestanding Brick Medical Office

    Saint Charles, MO 63303

    $2,450,000
    0.77 AC lot

    Occupied medical office property with a durable brick exterior, dedicated parking, and access to regional highways.

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    See what stands out in St. Charles County

    We check every for-sale listing in the county against comparable properties across the country. Most price about where you would expect. A few are worth a second look.

    We check every listing here. A few are worth a second look.

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    Updated Flex Space with Warehouse
    Updated Flex Space with Warehouse

    Saint Charles, MO 63303

    $950,000
    7,150 sqft

    Light industrial property with temperature-controlled space, offices, and loading access in an established industrial park.

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    Historic Mixed-Use Brick Building
    Historic Mixed-Use Brick Building

    Saint Charles, MO 63301

    $1,550,000
    0.09 AC lot

    The property combines ground-floor retail with upper-level apartment and Airbnb rentals.

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    Historic Mixed-Use Building
    Historic Mixed-Use Building

    Saint Charles, MO 63301

    $950,000
    0.09 AC lot

    Brick commercial property combines short-term apartment units with a ready-to-use fitness facility and lower-level locker rooms.

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    Commercial Land with Parking
    Commercial Land with Parking

    Saint Charles, MO 63301

    $440,000
    0.84 AC lot

    C-3 zoning, public water, and an existing asphalt parking area support commercial site planning.

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    Flex Space with Clear-Span Warehouse
    Flex Space with Clear-Span Warehouse

    Saint Charles, MO 63303

    Contact for pricing
    5,000 sqft

    Two connected commercial suites combine refurbished offices with climate-controlled warehouse areas and rear storage space.

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    Two-Lot Commercial Land
    Two-Lot Commercial Land

    Saint Charles, MO 63301

    $349,000
    2.37 AC lot

    Two commercial parcels are offered together with public water available.

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    Gated Flex Space with Outdoor Storage
    Gated Flex Space with Outdoor Storage

    Saint Charles, MO 63301

    $650,000
    1.33 AC lot

    Flexible office, warehouse, and shop configuration with secured outdoor areas and direct access for industrial operations.

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    Lewis & Clark's Restaurant
    Lewis & Clark's Restaurant

    Saint Charles, MO 63301

    Contact for pricing
    6,379 sqft

    Established restaurant property on South Main Street in St. Charles.

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    Industrial Land with Highway Access
    Industrial Land with Highway Access

    Saint Charles, MO 63301

    $2,160,600
    110.80 AC lot

    Light Industrial-zoned land with visibility, convenient I-370 access, and public water service.

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    Brick Mixed-Use Property
    Brick Mixed-Use Property

    Saint Charles, MO 63301

    $350,000

    Storefront configuration includes an upper-level apartment and prominent retail glazing.

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    Drive-Through Restaurant Building
    Drive-Through Restaurant Building

    3784 Elm St, Saint Charles, MO 63301

    Contact for pricing
    1,587 sqft 0.86 AC lot

    Existing retail and fast-food property with vehicle service access, surface parking, and Improved Commercial zoning.

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    Two-Story Office Building
    Two-Story Office Building

    Saint Charles, MO 63301

    Contact for pricing
    8,884 sqft

    Two-story office building with bullpens, multiple offices, and conference space, totaling 8,884 sf.

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    Grocery-Anchored Two-Tenant Building
    Grocery-Anchored Two-Tenant Building

    Saint Charles, MO 63303

    Contact for pricing
    11,597 sqft

    Two-tenant retail property with a planned ALDI grocery store and pylon signage along Interstate 70.

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    Flex Space with Data Center
    Flex Space with Data Center

    Saint Charles, MO 63301

    Contact for pricing
    64,000 sqft 4.51 AC lot

    Warehouse and office improvements with loading capacity and direct access from Hwy 370.

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    Flex Space with Heavy Power
    Flex Space with Heavy Power

    Saint Charles, MO 63303

    Contact for pricing
    23,660 sqft 1.70 AC lot

    Industrial flex property with remodeled offices, secured outdoor storage, dock access, and multiple drive-in doors.

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    Retail Space at Signalized Intersection
    Retail Space at Signalized Intersection

    Saint Charles, MO 63301

    Contact for pricing
    3,600 sqft 0.58 AC lot

    Retail property with direct intersection access and Fifth Street frontage.

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    Office Building with Power Backup
    Office Building with Power Backup

    2070 Little Hills Expy, Saint Charles, MO 63301

    Contact for pricing
    41,125 sqft 4.75 AC lot

    Office building offering a drive-in door, UPS and generator support, and extensive on-site parking.

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    Restaurant, Bar & Patio on Main
    Restaurant, Bar & Patio on Main

    515 South main Street, Saint Charles, MO 63301

    Contact for pricing
    1,900 sqft

    Fully operational restaurant, bar, and patio on Historic Main Street.

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    Free-Standing Medical Office Building
    Free-Standing Medical Office Building

    11 Garvey Pkwy, Saint Charles, MO 63303

    Contact for pricing
    6,676 sqft

    Free-standing brick medical office building built in 2005 with 32 parking spaces and 100% occupied long-term medical lease.

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    Jack in the Box QSR Building
    Jack in the Box QSR Building

    3710 Elm St, Saint Charles, MO 63301

    $1,417,500

    Quick-service restaurant property operated by Jack in the Box since the building was constructed in 1999.

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    St. Charles Retail Space Available
    St. Charles Retail Space Available

    Saint Charles, MO 63301

    Contact for pricing
    7,712 sqft

    Retail space for sale in St. Charles, Missouri.

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    Saint Charles, MO Commercial Real Estate Market Trends and Statistics

    Explore 72 commercial real estate for sale in Saint Charles, MO, showcased through 67 active listings on our real estate platform. These investment opportunities span a total of 562,029 square feet of properties for sale, with an estimated market value of $15,365,600.

    Sale prices for business properties in Saint Charles, MO start at $199,500, averaging $903,858, and reaching up to $2,450,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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    Demographics Overview

    Population 142K
    Population Growth (5Y) +1.4%
    Median Household Income $97,683
    College Educated 47.2%

    High-Yield Neighborhoods for Investment

    Identify Saint Charles submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

    Neighborhood Average Price
    63301 $801.2K
    63303 $909.9K

    Listings Trend

    New vs delisted commercial listings in St. Charles County

    New Delisted

    Total CRE Inventory on Market (SF)

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    Most Searched ZIP Codes in Saint Charles, MO

    • 63301
    • 63303
    • 43302

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