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    Saint Charles, MO Office Spaces for Sale

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    St Peters, MO Old Monroe, MO Wentzville, MO
    12 results
    St Charles Medical Office Building
    $2,450,000
    6,676 SF
    St Charles Medical Office Building

    Saint Charles, MO 63303

    Freestanding, fully occupied medical office building near highways.
    • 100% Occupied with Long‑Term Lease (Expires 2035)
    • Excellent Investment Opportunity / 1031 Exchange Potential
    • Free Standing Brick Building
    • Medical Use Tenant
    • Built in 2005
    Updated: May 4
    View details
    St Charles Office Investment Opportunity
    $80,000
    900 SF
    St Charles Office Investment Opportunity

    Saint Charles, MO 63301

    Duplex-style office building with renovation potential in high-visibility location.
    • High visibility location on First Capitol Drive frontage.
    • Duplex‑style office building with two separate suites, each with private entrance and restroom.
    • Strong potential for various business uses: office, retail, medical, salon, etc.
    • Value‑add opportunity through full renovation to increase rental income.
    • Solid brick construction.
    Updated: May 28
    View details
    High-Visibility Parcel Near Lindenwood University
    $350,000
    1,146 SF
    High-Visibility Parcel Near Lindenwood University

    Rare opportunity: 1,146 SF building near a signalized corner.

    Saint Charles, MO 63301

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    Saint Charles Adaptable Commercial Building
    $3,160,000
    8,128 SF
    Saint Charles Adaptable Commercial Building

    8,128 SF building suited for various uses in Saint Charles.

    1821 S River Rd, Saint Charles, MO

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    Medical Office Building For Sale
    $2,450,000
    6,676 SF
    Medical Office Building For Sale

    Freestanding, fully occupied medical building near highways.

    11 Garvey Pkwy, Saint Charles, MO 63303

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    Saint Charles Office/Flex Building
    Contact for pricing
    53,932 SF
    Saint Charles Office/Flex Building

    Class A office/flex building in a prime Saint Charles location.

    500 Fountain Lakes Blvd, Saint Charles, MO 63301

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    High-Visibility Corner Parcel For Sale
    $450,000
    1,350 SF
    High-Visibility Corner Parcel For Sale

    Corner parcel suitable for redevelopment, retail, or auto sales.

    212 S Kingshighway, Saint Charles, MO 63301

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    High-Visibility Commercial Parcel Available
    $200,000
    1,506 SF
    High-Visibility Commercial Parcel Available

    Commercial parcel suitable for redevelopment, office, or retail.

    Saint Charles, MO 63301

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    Historic Main Street Storefront Opportunity
    $275,000
    864 SF
    Historic Main Street Storefront Opportunity

    Charming brick storefront in vibrant, high-traffic historic district.

    Saint Charles, MO 63301

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    Main Street Mixed-Use Building
    $750,000
    0.16 Acres
    Main Street Mixed-Use Building

    Multi-story building with restaurant, retail, office, and residential potential.

    138 N Main St, Saint Charles, MO

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    Class A Office/Flex Building
    Contact for pricing
    53,932 SF
    Class A Office/Flex Building

    Office/flex building with heavy power and potential for warehouse conversion.

    500 Fountain Lakes Blvd, Saint Charles, MO

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    Multi-Tenant Office Building For Sale
    $1,800,000
    14,100 SF
    Multi-Tenant Office Building For Sale

    Well-maintained office building with highway visibility and updated suites.

    2085 Bluestone Dr, Saint Charles, MO 63303

    View details
    Based on your search, we've compiled 80 Potential Opportunities for your consideration. Besides 12 Active listings in Saint Charles, MO, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 60 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

    Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Renovated Office Building For Rent
    $5,210,000
    27,560 SF
    Renovated Office Building For Rent

    Office building with renovated lobby and signage opportunities available for lease.

    3301-3303 Rider Trl S, Earth City, MO

    View details
    Renovated Office Building For Lease
    Contact for pricing
    Renovated Office Building For Lease

    Three-story office building with flexible floor plates and renovated interiors.

    13900 Riverport Drive, Maryland Heights, MO 63043

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    Earth City Redevelopment Opportunity
    Contact for pricing
    6,489 SF
    Earth City Redevelopment Opportunity

    6,489 SF property on 1.62 acres in Earth City.

    3330 Rider Trl, Earth City, MO

    View details
    Class A Office Space
    Contact for pricing
    22,124 SF
    Class A Office Space

    High-end office space with potential for customization.

    13640-13690 Riverport Dr, Maryland Heights, MO

    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Weldon Spring Development Opportunity
    $750,000
    2.01 Acres
    Weldon Spring Development Opportunity

    2.01 acre lot ready for development in Weldon Spring.

    6147 S Highway 94, Weldon Spring, MO 63304

    View details
    Highway Z Commercial Land
    $175,000
    Highway Z Commercial Land

    Highly visible, level lot in New Melle, Missouri.

    4578 Highway Z, Wentzville, MO 63385

    View details
    Weldon Spring Development Opportunity
    $405,545
    1.33 Acres
    Weldon Spring Development Opportunity

    1.33 acres for development in Weldon Spring, Missouri.

    1.33 acres Siedentop Road, Weldon Spring, MO 63304

    View details
    Weldon Spring Land For Sale
    $579,348
    1.90 Acres
    Weldon Spring Land For Sale

    1.9 acre lot with utilities and highway visibility.

    6219 S Highway 94, Weldon Spring, MO 63304

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    Off-Market Properties in Saint Charles, MO

    Consider similar Off-Market properties in Saint Charles, MO. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    609 1st Capitol Dr
    OFFICE BUILDING
    800 SF Lot: 0.06 Acres
    Value Estimation by Request

    609 1st Capitol Dr, Saint Charles, MO 63301-2727

    View details
    1112 1st Capitol Dr
    OFFICE BUILDING
    5,530 SF Lot: 0.28 Acres
    Estimated value
    $550,000

    1112 1st Capitol Dr, Saint Charles, MO 63301-2769

    View details
    3451 Harry S Truman Blvd
    OFFICE BUILDING
    42,528 SF Lot: 5.06 Acres
    Estimated value
    $5,065,000

    3451 Harry S Truman Blvd, Saint Charles, MO 63301-4047

    View details
    617 Main St
    OFFICE BUILDING
    2,646 SF Lot: 0.14 Acres
    Value Estimation by Request

    617 Main St, Saint Charles, MO 63301-3440

    View details
    Randolph St
    OFFICE BUILDING
    139,056 SF Lot: 12.13 Acres
    Estimated value
    $13,855,000

    Randolph St, Saint Charles, MO 63301

    View details
    1014 1st Capitol Dr
    OFFICE BUILDING
    900 SF Lot: 0.05 Acres

    1014 1st Capitol Dr, Saint Charles, MO 63301-2736

    View details
    2270 Bluestone Dr
    OFFICE BUILDING
    3,000 SF Lot: 0.48 Acres
    Value Estimation by Request

    2270 Bluestone Dr, Saint Charles, MO 63303-5981

    View details
    2111 Collier Corporate Pkwy
    OFFICE BUILDING
    2,000 SF Lot: 0.24 Acres
    Value Estimation by Request

    2111 Collier Corporate Pkwy, Saint Charles, MO 63303-6707

    View details
    2138 1st Capitol Dr
    MEDICAL BUILDING
    5,016 SF Lot: 0.48 Acres
    Estimated value
    $1,255,000

    2138 1st Capitol Dr, Saint Charles, MO 63301-5804

    View details
    2633 Clay St
    OFFICE BUILDING
    6,970 SF Lot: 1.28 Acres
    Estimated value
    $940,000

    2633 Clay St, Saint Charles, MO 63301-2525

    View details
    2085 Collier Corporate Pkwy
    OFFICE BUILDING
    2,000 SF Lot: 0.65 Acres
    Value Estimation by Request

    2085 Collier Corporate Pkwy, Saint Charles, MO 63303-6701

    View details
    3333 Rue Royale St
    OFFICE BUILDING
    9,204 SF Lot: 0.18 Acres
    Estimated value
    $935,000

    3333 Rue Royale St, Saint Charles, MO 63301-8237

    View details

    Saint Charles, MO Office Spaces Investment Opportunities Market Analysis

    Explore 72 office spaces for sale in Saint Charles, MO, showcased through 12 active listings on our real estate platform. These investment opportunities span a total of 41,346 square feet of properties for sale, with an estimated market value of $11,215,000.

    Sale prices for office spaces in Saint Charles, MO start at $80,000, averaging $1,246,111, and reaching up to $3,160,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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    Top Commercial Asset Segments

    Office Units 40
    Office buildings 12
    Medical Office Space 6
    Coworking space 1

    Demographics Overview

    Population 142K
    Population Growth (5Y) +1.4%
    Median Household Income $97,683
    College Educated 47.2%

    High-Yield Neighborhoods for Investment

    Identify Saint Charles submarkets with the highest inventory density on the market and evaluate the median listing prices of real estate assets

    Neighborhood Average Price
    63301 $271K
    63303 $2.2M

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