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    O Fallon, MO
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    O Fallon, MO Medical Office Space for Lease

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    Weldon Spring, MO Dardenne Prairie, MO Cottleville, MO
    8 results
    Winghaven Medical Office Space Available
    $31 SF/Yr
    2,181 SF
    Winghaven Medical Office Space Available

    O Fallon, MO 63368

    Class A medical office space for lease in O'Fallon.
    • Class “A” medical office building
    • Ample parking with a ratio of 4/1,000 SF
    • On‑site diagnostic imaging including MRI, CT, digital mammography & QTC
    • Cardiology testing available
    • Features an endoscopy suite
    Updated: Mar 7
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    Medical Office Space Available
    $22 SF/Yr
    6,849 SF
    Medical Office Space Available

    Saint Peters, MO

    Medical office space for lease with abundant parking.
    • 1,636 – 6,849 SF Medical Office space available
    • Abundant parking with a ratio of 5.17 per 1,000 SF
    • Located just 1.7 miles from BJC Progress West Hospital
    • Great area with numerous amenities nearby
    • Monument signage on Hwy. K available
    Updated: Nov 24, 2025
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    Medical/Professional Office Suite For Rent
    $21 SF/Yr
    7,180 SF
    Medical/Professional Office Suite For Rent

    Medical/professional office suite available for lease with monument signage.

    114 Piper Hill Dr, St Peters, MO

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    Keaton Crossing Office/Medical Space
    Contact for pricing
    408 SF
    Keaton Crossing Office/Medical Space

    Premier office/medical space in O’Fallon's high-demand corridor.

    O Fallon, MO

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    Keaton Crossing Office/Medical Space
    Contact for pricing
    1,400 SF
    Keaton Crossing Office/Medical Space

    Premier office/medical space in O'Fallon's high-demand corridor.

    4132 Keaton Crossing Blvd, O Fallon, MO

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    Keaton Crossing Office/Medical Space
    Contact for pricing
    2,492 SF
    Keaton Crossing Office/Medical Space

    Premier office/medical space in O'Fallon's high-demand corridor.

    4142 Keaton Crossing Blvd, O Fallon, MO

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    Updated Surgery Center For Rent
    $26 SF/Yr
    5,676 SF
    Updated Surgery Center For Rent

    Updated surgery center with operating and procedure rooms available for rent.

    St Peters, MO

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    Medical/Professional Office Space For Rent
    $20 SF/Yr
    3,265 SF
    Medical/Professional Office Space For Rent

    Medical and professional office space with prominent signage and ample parking.

    5650 Mexico Rd, St Peters, MO

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    Based on your search, we've compiled 21 Potential Opportunities for your consideration. Besides 8 Active listings in O Fallon, MO, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 5 Properties for Sales.

    Medical Office Space for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Medical Office Space Available
    $30 SF/Yr
    6,445 SF
    Medical Office Space Available

    6,445 SF medical office space in Chesterfield, Missouri.

    17300 N Outer 40 Rd A, Chesterfield, MO

    View details
    Office or Medical Space Available
    Contact for pricing
    Office or Medical Space Available

    Full 2nd floor available for office or medical use.

    17253 Chesterfield Airport Road, Chesterfield, MO 63005

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    Medical Office Space on Campus
    $28 SF/Yr
    2,241 SF
    Medical Office Space on Campus

    Medical office connected to SSM DePaul Hospital with amenities.

    12277 De Paul Dr, Bridgeton, MO

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    Medical Office Space for Rent
    Contact for pricing
    3,528 SF
    Medical Office Space for Rent

    Medical office space available on SSM DePaul Hospital campus.

    3440 De Paul Lane, Bridgeton, MO

    View details

    Similar Spaces for Sale in O Fallon, MO

    Consider Similar Space for Sale. We found 5 Spaces matching your search parameters.

    Standalone Office Building
    $560,000
    0.38 Acres
    Standalone Office Building

    Move-in-ready office building suited for medical, therapy, dental, or professional uses with onsite parking and easy access.

    410 Jungermann Road, St Peters, MO 63376

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    St. Peters Commercial Property For Sale
    $560,000
    3,000 SF
    St. Peters Commercial Property For Sale

    3,000 SF commercial property in high-growth St. Peters, Missouri.

    410 Jungermann Road, St Peters, MO 63376

    View details
    O'Fallon Medical Office Space
    $1,200,000
    2,600 SF
    O'Fallon Medical Office Space

    2,700 SF medical office space in O'Fallon, Missouri.

    1002 Peruque Crossing Ct, O Fallon, MO

    View details
    Leased Office Condo For Sale
    $155,000
    1,800 SF
    Leased Office Condo For Sale

    Leased office condo for sale with a strong cap rate.

    4131-4139 Mexico Rd, Saint Peters, MO

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    Medical Office Building Near Hospital
    $2,378,000
    12,512 SF
    Medical Office Building Near Hospital

    12,512 SF medical office building near Barnes-Jewish St. Peters Hospital.

    St Peters, MO

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    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Office Development Land For Lease
    Contact for pricing
    4,000 SF
    Office Development Land For Lease

    2.43 acres for office development with build-to-suit opportunity.

    1323 Strawfloor Drive, Jonesboro, AR 72401

    View details
    Kingery Highway Commercial Development Opportunity
    $85,000 SF/Yr
    Kingery Highway Commercial Development Opportunity

    High-visibility land for retail, car wash, or medical development.

    8501 & 8511 Kingery Highway, Willowbrook, IL 60527

    View details
    Beaumont Centre Outparcel Opportunity
    Contact for pricing
    Beaumont Centre Outparcel Opportunity

    Outparcel opportunity in established shopping center for ground lease.

    3199 Beaumont Centre Circle, Lexington, KY 40513

    View details
    Prime Lexington Outlot Opportunity
    Contact for pricing
    Prime Lexington Outlot Opportunity

    Outlot for ground lease or build-to-suit in South Lexington.

    3330 Partner Place, Lexington, KY 40503

    View details

    O Fallon, MO Medical Office Space Leasing Opportunities Market Analysis

    Explore Medical Office Space leasing options in O Fallon, MO with 8 listings featured on our commercial real estate exchange. The current inventory includes 25,151 square feet of properties with an estimated lease value of $121 SF/Yr.

    Estimated lease rates for Medical Office Space in O Fallon, MO begin at $20 SF/Yr, with an average of $24 SF/Yr and extend to $31 SF/Yr.
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