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    Saint Charles, MO Commercial Real Estate for Lease

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    Saint Louis, MO Louis, MO Kansas City, MO
    51 results
    Office Space in Historic Building
    $1,200 /Mo
    7,318 SF

    Office Space in Historic Building

    Saint Charles, MO 63301

    Move-in ready office suites with amenities in St. Charles.

    • Prime downtown St. Charles location with quick access to 5th Street, Main Street, Lindenwood University, and Highways 70 and 370.
    • Move‑in ready office suite (30' x 20') suitable for three desks and one private office.
    • Convenient accessible entry and parking right outside the door.
    • Included amenities: 24/7 digital keypad access, reception area, small conference room, Internet & Wi‑Fi, dedicated mailbox, cleaning service, water filtration system, and security cameras.
    • Historic building with renovated office spaces.
    Updated: Mar 10
    View details
    Move-in Ready Office Space
    $500 /Mo

    Move-in Ready Office Space

    Saint Charles, MO 63304

    Full service office space with modern amenities included in rent.

    • All‑inclusive rent: Includes heat, electricity, trash, Wi‑Fi, kitchenette, and conference room use.
    • Move‑in ready office with recent renovations: new carpet, paint, lighting, interior and exterior updates.
    • Convenient location: Ample parking and easy access to Hwy 364 and 94.
    • Corner unit on the 1st floor with large windows providing natural light.
    • Access to atrium space with tables and outdoor seating.
    Updated: Dec 16, 2025
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    Turnkey Dental Office in St Charles
    $20 SF/Yr

    Turnkey Dental Office in St Charles

    2880 SF turnkey dental office or medical space for lease.

    Saint Charles, MO 63303
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    St Charles Lower-Level Office Space
    $700 /Mo

    St Charles Lower-Level Office Space

    660 SF office space with utilities and Wi-Fi included.

    Saint Charles, MO 63304
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    St Charles Industrial/Retail Building
    $5,000 /Mo
    2,640 SF

    St Charles Industrial/Retail Building

    Freestanding building with highway visibility and multiple drive-in doors.

    Saint Charles, MO 63304
    View details
    Office/Flex Building in Saint Charles
    $16 SF/Yr
    53,932 SF

    Office/Flex Building in Saint Charles

    Class A office/flex building with high visibility and heavy power.

    500 Fountain Lakes Blvd, Saint Charles, MO 63301
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    Professional Office in Business Park
    $15 SF/Yr
    7,200 SF

    Professional Office in Business Park

    Office space for lease in a well-located business park.

    Saint Charles, MO 63303
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    Westgate 200 Available For Lease
    $5 SF/Yr
    86,800 SF

    Westgate 200 Available For Lease

    86,800 SF divisible space with office and showroom.

    3817-3841 Millstone Parkway, Saint Charles, MO 63301
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    St. Charles Retail/Office Space
    $22 SF/Yr
    31,716 SF

    St. Charles Retail/Office Space

    Retail and office spaces available in high-traffic St. Charles location.

    3910-3930 South Old Highway 94, Saint Charles, MO 63304
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    Retail Space in Saint Charles
    $15 SF/Yr
    1,400 SF

    Retail Space in Saint Charles

    1,400 SF retail space for lease in Saint Charles.

    3754-3780 Elm St, Saint Charles, MO
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    Office Space Near I-70
    Contact for pricing
    7,584 SF

    Office Space Near I-70

    7,584 SF office space with convenient highway access.

    190 Spring Drive, Saint Charles, MO 63303
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    Office/Warehouse Space with Showroom
    $2,613 /Mo
    2,240 SF

    Office/Warehouse Space with Showroom

    2,240 SF office/warehouse with showroom near Highway 70.

    1831 Scherer Pkwy, Saint Charles, MO
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    Professional Office Building For Lease
    $18 SF/Yr
    1,600 SF

    Professional Office Building For Lease

    Freestanding office building with private offices, reception, and breakroom.

    2260 Bluestone Dr, Saint Charles, MO
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    Historic Building Office Suites Available
    $14 SF/Yr
    1,961 SF

    Historic Building Office Suites Available

    Well-maintained office suites in historic building near courthouse.

    300 N Main St, Saint Charles, MO
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    Banquet Center and Restaurant Space
    Contact for pricing
    8,430 SF

    Banquet Center and Restaurant Space

    Banquet center and restaurant with bars and patios for lease.

    111 TRANSIT ST, Saint Charles, MO
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    Main Street Adaptable Retail Building
    Contact for pricing
    13,550 SF

    Main Street Adaptable Retail Building

    Adaptable retail building in historic Main Street, St. Charles.

    920 S Main St, Saint Charles, MO
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    Stand Alone Office For Rent
    $15 SF/Yr
    1,377 SF

    Stand Alone Office For Rent

    1,377 SF stand-alone office space remodeled in 2023.

    1518 Caulks Hill Rd, Saint Charles, MO
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    Industrial/Flex Space in Hughes Park
    $12 SF/Yr
    1,250 SF

    Industrial/Flex Space in Hughes Park

    1,250 SF industrial/flex space for lease in Saint Charles.

    231 Fox Hill Rd, Saint Charles, MO
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    Regional Center Retail Space Available
    Contact for pricing
    5,670 SF

    Regional Center Retail Space Available

    Retail space for lease in regional shopping center.

    1315-1381 Bass Pro Dr, Saint Charles, MO
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    Industrial Warehouse with Office Space
    $7 SF/Yr
    35,235 SF

    Industrial Warehouse with Office Space

    35,235 SF warehouse with office space available for lease.

    10 S Corporate Hills Dr, Saint Charles, MO
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    Industrial Space with Dock Access
    $14 SF/Yr
    2,300 SF

    Industrial Space with Dock Access

    2300 SF industrial space available October 1st with dock.

    540 Little Hills Industrial, Saint Charles, MO
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    Retail Space on 5th Street
    Contact for pricing
    3,331 SF

    Retail Space on 5th Street

    3,331 SF retail space with frontage on 5th Street.

    1205 S 5th St, Saint Charles, MO
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    Professional Office Space Available
    Contact for pricing
    598 SF

    Professional Office Space Available

    Office space with excellent highway exposure and convenient location.

    2480 Executive Dr, Saint Charles, MO
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    Retail Space in Saint Charles
    Contact for pricing
    1,200 SF

    Retail Space in Saint Charles

    Retail space available in a well-located shopping center.

    1981-1997 Zumbehl Rd, Saint Charles, MO
    View details

    Saint Charles, MO Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in Saint Charles, MO with 51 listings featured on our commercial real estate exchange. The current inventory includes 4,192,841,596 square feet of properties with an estimated lease value of $118 SF/Yr.

    Estimated lease rates for Commercial real estate in Saint Charles, MO begin at $1.97 SF/Yr, with an average of $14 SF/Yr and extend to $22 SF/Yr.
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    Most Searched ZIP Codes in Saint Charles, MO

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    • 63303
    • 63304

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