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    Clayton, MO
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    Clayton, MO Office Spaces for Lease

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    University City, MO Saint Louis, MO Richmond Heights, MO
    39 results
    Sevens Building
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    Pierre Laclede
    $129-$4,786/Mo
    Pierre Laclede

    7733 Forsyth Blvd, Unit 11TH, Clayton, MO 63105

    Discover many ways to work your way in Pierre Laclede
    • Be part of a vibrant coworking community with dedicated desk or hot desking options in thousands of idyllic locations across the globe
    • Grow in a modern workplace with the added advantage of a benefits program offering exclusive discounts and bespoke procurement support
    • Access Regus' network of workspaces and business lounges as often as you need and take advantage of their exclusive benefits
    • Impress clients, hold memorable workshops, and deliver a winning pitch in Regus' meeting spaces, fully equipped for gatherings of any size
    • Collaborate with like‑minded professionals and enjoy regular networking and community events with a Regus membership
    Updated: Feb 19
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    Downtown Clayton Office Building
    $21 SF/Yr
    102,600 SF
    Downtown Clayton Office Building

    225-235 S Meramec Ave, Clayton, MO 63105

    Two interconnected office buildings in downtown Clayton with on-site amenities.
    • Prime Downtown Clayton location with high visibility and close proximity to the Courthouse.
    • Enjoy on‑site amenities including management, post office, cafe, and common space.
    • Abundant parking with a 1,200‑space garage and street parking.
    • Newly built‑out spaces with high‑end finishes.
    • Brand new lobby and updated common areas.
    Updated: Nov 25, 2025
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    Class A Office Tower Clayton
    $35 SF/Yr
    2,610 SF
    Class A Office Tower Clayton

    Class A office tower in downtown Clayton for lease.

    8235 Forsyth Blvd, Clayton, MO

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    Downtown Clayton Office Space Available
    $29 SF/Yr
    1,737 SF
    Downtown Clayton Office Space Available

    Office space for lease in downtown Clayton with amenities.

    150 N Meramec Ave, Clayton, MO

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    Class A Office Tower Clayton
    $35 SF/Yr
    4,086 SF
    Class A Office Tower Clayton

    Class A office tower in downtown Clayton for lease.

    8182 Maryland Ave, Clayton, MO

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    Clayton Office Space For Rent
    $14 SF/Yr
    350 SF
    Clayton Office Space For Rent

    Office spaces in the heart of Clayton near I-170 & I-64/40.

    30-44 N Brentwood Blvd, Clayton, MO

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    Downtown Clayton Office Space Available
    $29 SF/Yr
    2,372 SF
    Downtown Clayton Office Space Available

    Office space for rent in downtown Clayton, Missouri.

    165 N Meramec Ave, Clayton, MO

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    Clayton Office Space Available Now
    $30 SF/Yr
    4,288 SF
    Clayton Office Space Available Now

    Former law firm space with elevator exposure and tenant amenities.

    231 S Bemiston Ave, Clayton, MO

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    Professionally Managed Office Space Available
    $25 SF/Yr
    2,709 SF
    Professionally Managed Office Space Available

    Office space for lease with covered parking and convenient location.

    8151 Clayton Rd, Clayton, MO

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    Clayton Office Space For Rent
    $26 SF/Yr
    3,346 SF
    Clayton Office Space For Rent

    Eleven-story office building in Clayton with recent renovations.

    222 S Central Ave, Clayton, MO

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    Class A Office Space Available
    $45 SF/Yr
    27,666 SF
    Class A Office Space Available

    High-end office space with many amenities and ample parking.

    7700 Forsyth Blvd, Clayton, MO

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    Downtown Clayton Office Space Available
    $28 SF/Yr
    10,007 SF
    Downtown Clayton Office Space Available

    Office space in downtown Clayton with convenient access and amenities.

    168 N Meramec Ave, Clayton, MO

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    Clayton CBD Office Space
    $31 SF/Yr
    1,464 SF
    Clayton CBD Office Space

    Move-in ready office suites in central Clayton location.

    7777 Bonhomme Ave, Clayton, MO

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    Renovated Office Space in Clayton
    $26 SF/Yr
    1,993 SF
    Renovated Office Space in Clayton

    Multiple suites available in a recently renovated building.

    7711 Bonhomme Ave, Clayton, MO

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    Clayton Office Space For Rent
    $24 SF/Yr
    3,305 SF
    Clayton Office Space For Rent

    3,305 SF office space available in Clayton, Missouri.

    8301 Maryland Ave, Clayton, MO

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    Clayton Office Space Available
    $24 SF/Yr
    3,270 SF
    Clayton Office Space Available

    Office space available for lease in Clayton, Missouri.

    8251 Maryland Ave, Clayton, MO

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    Global Network of Flexible Workspaces
    $84 SF/Yr
    Global Network of Flexible Workspaces

    Tailored office spaces with coworking and virtual office options.

    7777 Bonhomme Ave Suite 1800, Clayton, MO 63105

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    Clayton Office Space For Rent
    $31 SF/Yr
    7,441 SF
    Clayton Office Space For Rent

    7,441 square foot office space available for lease.

    135 N Meramec Ave, Clayton, MO

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    Clayton Office Space For Rent
    $31 SF/Yr
    45,777 SF
    Clayton Office Space For Rent

    Office space available in Clayton, Missouri with multiple amenities.

    7701 Forsyth Blvd, Clayton, MO

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    Clayton Office Space For Rent
    $31 SF/Yr
    39,547 SF
    Clayton Office Space For Rent

    Office space available with conferencing center and fitness center.

    7733 Forsyth Blvd, Clayton, MO

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    Clayton Office Space For Rent
    $32 SF/Yr
    4,494 SF
    Clayton Office Space For Rent

    Office space for rent in Clayton, Missouri.

    120 S Central Ave, Clayton, MO

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    Energy Efficient Clayton Office Space
    Contact for pricing
    Energy Efficient Clayton Office Space

    Sophisticated office space in a central Clayton location.

    7733 Forsyth Boulevard Suite 1100, Clayton, MO 63105

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    Upscale Office Space Available
    $30 SF/Yr
    6,125 SF
    Upscale Office Space Available

    Premium office space with amenities in Clayton, Missouri.

    8000 Maryland Ave, Clayton, MO

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    Clayton, MO Office Spaces Leasing Opportunities Market Analysis

    Explore Office Spaces leasing options in Clayton, MO with 39 listings featured on our commercial real estate exchange. The current inventory includes 342,788 square feet of properties with an estimated lease value of $808 /Mo.

    Estimated lease rates for Office Spaces in Clayton, MO begin at $14 SF/Yr, with an average of $28 SF/Yr and extend to $45 SF/Yr.
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    Most Searched ZIP Codes in Clayton, MO

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