Office

Des Moines, IA Office Spaces for Lease

Notify Me
List
Map
Urbandale, IA Windsor Heights, IA Clive, IA Pleasant Hill, IA West Des Moines, IA Ankeny, IA Johnston, IA Elkhart, IA
108 properties
Sort:
Medical Office Building with Parking
Updated: Jun 23
Medical Office Building with Parking

1530 East Euclid Avenue, Des Moines, IA 50313

$15 SF/Yr
9,608 sqft 1.07 AC lot
Well‑maintained medical office building with up to 9,608 SF total space
1.074‑acre lot with on‑site parking for office and medical use
Includes private exam rooms and offices
Dedicated lab space plus storage areas
Available monument signage
View details
Medical Office Building
Updated: Jul 17
Medical Office Building

2459 East Euclid Avenue, Des Moines, IA 50317

$20 SF/Yr
6,240 sqft 0.53 AC lot
Well‑maintained medical office building with up to 6,240 SF of total space
0.53‑acre lot with on‑site parking
Space offers versatile options for medical use or standard office use
View details
West Mall Inline Retail Spaces
West Mall Inline Retail Spaces

1111 East Army Post Road, Des Moines, IA 50315

$17.50 SF/Yr
15,665 sqft

Flexible inline retail space in a redeveloped mixed-use center, including a 45,000 SF former theatre building.

View details
Turn a Listing Into an Investment Snapshot Cap Rate, Potential NOI, Demand score for every listing. Go To Analytics Center
Plug-and-Play Office Call Center
Plug-and-Play Office Call Center

3600 Army Post Road, Suite 200, Des Moines, IA 50321

$15 SF/Yr
20,000 sqft

Move-in ready office suite with a 150-seat call center, private offices, and a training conference space.

View details
Office Space Near Sculpture Park
Office Space Near Sculpture Park

1300 Walnut Street, Des Moines, IA 50309

$12 SF/Yr
6,401 sqft

Office space for rent near downtown Des Moines attractions.

View details
Industrial Space with Dock Doors
Industrial Space with Dock Doors

10400 Hickman Road, Des Moines, IA 50325

$6 SF/Yr
20,000 sqft

20,000 SF industrial space with office and dock doors.

View details
Medical Office Space Available
Medical Office Space Available

1530 East Euclid Avenue, Des Moines, IA 50313

$15 SF/Yr
9,608 sqft 1.07 AC lot

Medical office building with versatile opportunities for medical or standard office.

View details
Historic Office Building in Des Moines
Historic Office Building in Des Moines

1420 Locust Street, Des Moines, IA 50309

$17 SF/Yr
7,689 sqft

Two-story office building with unique architecture and high-end finishes.

View details
Office Space Near Krause Gateway
Office Space Near Krause Gateway

1533 Linden Street, Des Moines, IA 50309

$12 SF/Yr
2,700 sqft

Office space for lease in a convenient location.

View details
Downtown Des Moines Office Space
Downtown Des Moines Office Space

500 Southwest 7th Street, Des Moines, IA 50309

$19.25 SF/Yr
14,360 sqft

Three-story office building in vibrant Riverpoint district with parking.

View details
Class A Office Retail Building
Class A Office Retail Building

400 Locust Street, Des Moines, IA 50309

$9 SF/Yr
158,557 sqft

Eight-story Class A office and retail building in downtown Des Moines.

View details
Des Moines Office Space Available
Des Moines Office Space Available

601 East Locust Street, Des Moines, IA 50309

$22 SF/Yr
7,516 sqft

Office space for rent with convenient parking and highway access.

View details
Retail/Office Space in Mixed-Use Building
Retail/Office Space in Mixed-Use Building

210 Southwest 11th Street, Des Moines, IA 50309

$18 SF/Yr
4,539 sqft

Trendy retail or office space in a modern urban neighborhood.

View details
Des Moines Office Space Available
Des Moines Office Space Available

1500 Northwest 118th Street, Des Moines, IA 50325

$9.75 SF/Yr
86,892 sqft

Office building with high visibility and convenient highway access.

View details
Three-Story Office-Flex with Cold Storage
Three-Story Office-Flex with Cold Storage

1495 Keosauqua Way, Des Moines, IA 50314

$2,000/Mo

Three-story space includes office, open work areas, and cold storage served by a conveyor system.

View details
Fully Serviced Workspace Options at IA, Des Moines - Grand Ave. Contact us today to book a tour!
View details
Flexible Workspace Solutions at Hub Tower. Contact us today to book a tour!
Flexible Workspace Solutions at Hub Tower. Contact us today to book a tour!

699 Walnut St, Unit 400, Des Moines, IA 50309

16 available spaces from 11 to 2,087 sqft
$109-$7,950/Mo per office

Flexible workspace in Hub Tower. Book a tour & get info

View details
Office Building Near Recreation
Office Building Near Recreation

3161 SE 22nd St, Des Moines, IA 50320

Contact for pricing
3,096 sqft

Office property with RX1 zoning and recently replaced furnace, air conditioning, and water heater systems.

View details
Flex Space with Office and Warehouse
Flex Space with Office and Warehouse

1427 E Pleasant View Dr, Des Moines, IA 50320

Contact for pricing
7,300 sqft 1.52 AC lot

Commercial property offers a flexible office-and-warehouse configuration across five parcels.

View details
Stratford Commons Office Park Space
Stratford Commons Office Park Space

12035 University Ave., Des Moines, IA 50325

$20.50 SF/Yr
12,645 sqft

Office space with private entrance, granite floors, and cherry woodwork.

View details
Flexible Office-Warehouse Property
Flexible Office-Warehouse Property

1415 E Pleasant View Dr, Des Moines, IA 50320

Contact for pricing
3,525 sqft 1.52 AC lot

Commercial property spanning five parcels with office and warehouse components.

View details
Des Moines Medical Office Space
Des Moines Medical Office Space

330 Laurel Street, Des Moines, IA 50314

$22 SF/Yr
7,572 sqft

Medical office space in Des Moines' major medical corridor.

View details
Creative Loft Office Space
Creative Loft Office Space

301 Grand Ave, Des Moines, IA 50309

Contact for pricing
4,836 sqft

Third-floor office suite in a 1916 brick building with loft/creative design and on-site parking.

View details
Office Building with Historic-Modern Interiors
Office Building with Historic-Modern Interiors

801 Grand Ave, Des Moines, IA 50309

Contact for pricing
1,702 sqft

Available for lease at 801 Grand Ave, featuring a historic-inspired facade and office spaces that blend heritage and contemporary design.

View details

Des Moines, IA Office Spaces Lease Rates & Market Statistics

Browse 108 Office Spaces for lease in Des Moines, IA on Realmo, a commercial real estate marketplace serving the Des Moines area. The current inventory totals 2,171,168 square feet of properties — an average of ~20,100 SF per listing.

Office Spaces lease rates in Des Moines range from $6 SF/Yr at the entry level to $22 SF/Yr at the top of the market, averaging $16.12 SF/Yr. That's a 4x spread between entry-level and premium space, making side-by-side comparison of asking rents and lease terms essential. At $16.12 SF/Yr, the local average runs 15% below Iowa's state average of $18.97 SF/Yr.

Des Moines accounts for 40% of the 272 office spaces currently available across Polk County, where nearby markets include West Des Moines and Urbandale. By space type, the market includes 49 office units, 48 office buildings and 11 medical office space listings — office units typically offer the lowest entry point, while medical office space commands the highest rates.

List
Map