Des Moines, IA Office buildings for Rent & Lease

Updated: Mar 25

Downtown Des Moines Office Space

500 Southwest 7th Street, Des Moines, IA 50309

$19.25 SF/Yr

14,360 sqft

Lowest fully serviced lease rate available for comparable downtown properties.
Free on‑site surface parking available.
Up to 14,360 SF of Contiguous Space.
Centrally located South of Des Moines’ Central Business District, adjacent to new living and retail amenities.
Attractive open foyer providing an abundance of natural light.

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Updated: Jun 23

Medical Office Building with Parking

1530 East Euclid Avenue, Des Moines, IA 50313

$15 SF/Yr

9,608 sqft

Well‑maintained medical office building with up to 9,608 SF total space
1.074‑acre lot with on‑site parking for office and medical use
Includes private exam rooms and offices
Dedicated lab space plus storage areas
Available monument signage

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Premier Riverfront Office and Retail

110 E Court Ave, Des Moines, IA 50309

$24.95 SF/Yr

1,643 sqft

Class A+ office and retail space in Des Moines' East Village.

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Medical Office Building

6601 SW 9th St, Des Moines, IA 50315

$23 SF/Yr

22,572 sqft

Medical office space with built-out examination rooms, multiple waiting areas, and ample on-site parking.

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Historic Office Building in Des Moines

1420 Locust Street, Des Moines, IA 50309

$17 SF/Yr

7,689 sqft

Two-story office building with unique architecture and high-end finishes.

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Class A Office Retail Building

400 Locust Street, Des Moines, IA 50309

$9 SF/Yr

158,557 sqft

Eight-story Class A office and retail building in downtown Des Moines.

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Traditional Office Suite

541-545 31st St, Des Moines, IA 50312

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3,200 sqft

Up to 3,200 SF of perimeter offices and a conference room are available in an office building on 31st St.

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Des Moines Office Space Available

1500 Northwest 118th Street, Des Moines, IA 50325

$9.75 SF/Yr

86,892 sqft

Office building with high visibility and convenient highway access.

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Downtown Des Moines Office Space

777 3rd Street, Des Moines, IA 50309

$4,500,000 SF/Yr

30,210 sqft

Office space with downtown views and interstate access.

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Grand Avenue Office and Clinic

3200 Grand Avenue, Des Moines, IA 50312

$22 SF/Yr

152,854 sqft

First-class office and clinic space with parking ramp.

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Grand Avenue Office Building

3440 Grand Avenue, Des Moines, IA 50312

$20 SF/Yr

90,223 sqft

Five-story office building in DMU32 Health and Business Complex.

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Two-Story Building on Corner Lot

2120 Ingersoll Ave, Des Moines, IA

$33 SF/Yr

5,496 sqft

5,496 SF building suitable for office, retail, or restaurant.

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Class A Office Building

1150 Locust Street, Des Moines, IA 50391

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22,262 sqft

Seven-story Class A office building in Downtown Des Moines.

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Renovated Market District Office Building

118 Southeast 4th Street, Des Moines, IA 50309

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33,792 sqft

Creative office space in the heart of the Market District.

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Downtown Des Moines Office Space

1440 Locust St, Des Moines, IA 50309

$17 SF/Yr

Historic three-story office building with high-end finishes and parking.

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Modern Space in DMU32 Complex

3300 Grand Avenue, Des Moines, IA 50312

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152,854 sqft

152,854 SF building with flexible space and amenities.

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Modern Office Space Available

1459 Grand Ave, Des Moines, IA

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31,199 sqft

Six-story office building with modern design and collaborative spaces.

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Class A Office Space Available

1100-1150 Locust St, Des Moines, IA

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22,262 sqft

Class A office space for rent in downtown Des Moines.

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Class A Office Building

699 Walnut St, Des Moines, IA 50309

$20 SF/Yr

15,518 sqft

Class A office building with skywalk access and on-site security.

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Renovated Market District Office Building

118 SE 4th St, Des Moines, IA 50309

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33,792 sqft

33,792 SF renovated office building in the Market District.

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Class A Office Building

2700 Grand Ave, Des Moines, IA 50312

$11.95 SF/Yr

Attractive office building with professional management and convenient location.

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Renovated Office Building with Parking

213 13th St, Des Moines, IA

$15 SF/Yr

14,856 sqft

Historically renovated office building in the heart of Des Moines.

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Des Moines Ruan Center Space

666 Grand Ave, Des Moines, IA 50309

$17.50 SF/Yr

460,000 sqft

460,000 SF of office and retail space available for lease.

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Class A Office Building

2600 Grand Avenue, Des Moines, IA 50312

$11.95 SF/Yr

Attractive office building with professional management and ample parking.

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Des Moines, IA Office buildings Market Trends and Statistics

Explore Office buildings leasing options in Des Moines, IA with 25 listings featured on our commercial real estate exchange. The current inventory includes 1,070,478 square feet of properties with an estimated lease value of $4,500,245.

Estimated lease rates for Office buildings in Des Moines, IA begin at $9 SF/Yr, with an average of $321,446 and extend to $4,500,000.