Office Building

Des Moines, IA Office Buildings for Lease

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Urbandale, IA Windsor Heights, IA Clive, IA Pleasant Hill, IA West Des Moines, IA Ankeny, IA Johnston, IA Elkhart, IA
47 properties
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Medical Office Building
Updated: Jul 17
Medical Office Building

2459 East Euclid Avenue, Des Moines, IA 50317

$20 SF/Yr
6,240 sqft 0.53 AC lot
Well‑maintained medical office building with up to 6,240 SF of total space
0.53‑acre lot with on‑site parking
Space offers versatile options for medical use or standard office use
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Historic Office Building in Des Moines
Updated: Mar 25
Historic Office Building in Des Moines

1420 Locust Street, Des Moines, IA 50309

$17 SF/Yr
7,689 sqft
Prime Downtown Des Moines location adjacent to Pappajohn Sculpture Park and Western Gateway Park.
Unique architecture and high‑end finishes.
Historic, mixed‑use building with attractive glass and masonry storefront.
Onsite parking.
Tall, exposed ceilings and ample natural light.
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Downtown Des Moines Office Space
Downtown Des Moines Office Space

500 Southwest 7th Street, Des Moines, IA 50309

$19.25 SF/Yr
14,360 sqft

Three-story office building in vibrant Riverpoint district with parking.

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Class A Office Retail Building
Class A Office Retail Building

400 Locust Street, Des Moines, IA 50309

$9 SF/Yr
158,557 sqft

Eight-story Class A office and retail building in downtown Des Moines.

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Des Moines Office Space Available
Des Moines Office Space Available

1500 Northwest 118th Street, Des Moines, IA 50325

$9.75 SF/Yr
86,892 sqft

Office building with high visibility and convenient highway access.

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Office Building Near Recreation
Office Building Near Recreation

3161 SE 22nd St, Des Moines, IA 50320

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3,096 sqft

Office property with RX1 zoning and recently replaced furnace, air conditioning, and water heater systems.

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Office Building with Historic-Modern Interiors
Office Building with Historic-Modern Interiors

801 Grand Ave, Des Moines, IA 50309

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1,702 sqft

Available for lease at 801 Grand Ave, featuring a historic-inspired facade and office spaces that blend heritage and contemporary design.

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Office Building with Floor-to-Ceiling Glass
Office Building with Floor-to-Ceiling Glass

800 Walnut St, Des Moines, IA 50309

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14,432 sqft

Skywalk-connected parking and floor-to-ceiling glass add convenience and daylight to this high-rise office building.

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Grand Avenue Office and Clinic
Grand Avenue Office and Clinic

3200 Grand Avenue, Des Moines, IA 50312

$22 SF/Yr
152,854 sqft

First-class office and clinic space with parking ramp.

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Nine-Story Office Building
Nine-Story Office Building

800 Walnut St, Des Moines, IA 50309

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8,087 sqft

Nine-story office building offers large block suites with floor-to-ceiling glass and an on-site backup generator.

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Grand Avenue Office Building
Grand Avenue Office Building

3440 Grand Avenue, Des Moines, IA 50312

$20 SF/Yr
90,223 sqft

Five-story office building in DMU32 Health and Business Complex.

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Historic Office Building with 14-Foot Ceilings
Historic Office Building with 14-Foot Ceilings

108 3rd St, Des Moines, IA 50309

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31,833 sqft

Historic office building with 14-foot ceilings, natural light, and space sizes ranging up to 31,833 SF.

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Two-Story Office Building For Sale
Two-Story Office Building For Sale

3161 Southeast 22nd Street, Des Moines, IA 50320

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1,872 sqft

1,872 SF office building with partially finished basement.

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Renovated Market District Office Building
Renovated Market District Office Building

118 Southeast 4th Street, Des Moines, IA 50309

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33,792 sqft

Creative office space in the heart of the Market District.

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Downtown Des Moines Office Space
Downtown Des Moines Office Space

777 3rd St., Des Moines, IA 32250

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30,210 sqft

Office space with downtown views and interstate access.

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Office Building with Floor-to-Ceiling Glass
Office Building with Floor-to-Ceiling Glass

800 Walnut St, Des Moines, IA 50309

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13,270 sqft

Skyview offers large floorplates with floor-to-ceiling glass windows and building backup generation, plus structured parking via skywalk.

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Multi-Story Office Building with Skywalk Parking
Multi-Story Office Building with Skywalk Parking

800 Walnut St, Des Moines, IA 50309

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6,527 sqft

Multi-floor office building with floor-to-ceiling glass, backup generator, and skywalk-connected parking access.

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Class A Office Building
Class A Office Building

2700 Grand Ave, Des Moines, IA 50312

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3,826 sqft

Attractive office building with professional management and convenient location.

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Historic-Modern Office Building
Historic-Modern Office Building

801 Grand Ave, Des Moines, IA 50309

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3,500 sqft

Office building featuring historic interior accents blended with contemporary elements and state-of-the-art amenities.

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Impressive Skyview Building for Lease
Impressive Skyview Building for Lease

800 Walnut St, Des Moines, IA

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35,000 sqft 0.96 AC lot

Nine-story building with large floor plans and ample parking.

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Office Building with Auditorium Seating
Office Building with Auditorium Seating

3300 Grand Ave, Des Moines, IA 50312

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38,247 sqft

Large office building within the DMU32 Health and Business Complex with modern common areas, cafeteria, and auditorium seating.

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Flexible Office Building with Auditorium
Flexible Office Building with Auditorium

3300 Grand Ave, Des Moines, IA 50312

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46,669 sqft

A modern office facility at 3300 Grand Avenue with lounge, bookstore, library, commons, and a 383-seat multi-level auditorium.

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Modern Space in DMU32 Complex
Modern Space in DMU32 Complex

3300 Grand Avenue, Des Moines, IA 50312

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152,854 sqft

152,854 SF building with flexible space and amenities.

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Office Building with Auditorium
Office Building with Auditorium

3300 Grand Ave, Des Moines, IA 50312

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43,531 sqft

Office building within a health and business complex, featuring commons areas, coffee bar, cafeteria with grease interceptor, and an auditorium.

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Des Moines, IA Office buildings Lease Rates & Market Statistics

Browse 47 Office buildings for lease in Des Moines, IA on Realmo, a commercial real estate marketplace serving the Des Moines area. The current inventory totals 1,771,255 square feet of properties — an average of ~37,700 SF per listing.

Office buildings lease rates in Des Moines range from $9 SF/Yr at the entry level to $22 SF/Yr at the top of the market, averaging $16.71 SF/Yr. Pricing across the market is relatively uniform, which simplifies like-for-like comparison between listings. At $16.71 SF/Yr, the local average runs 35% above Iowa's state average of $12.35 SF/Yr.

Des Moines accounts for 61% of the 77 office buildings currently available across Polk County, where nearby markets include West Des Moines and Urbandale. Office buildings make up 43% of the 110 Office Spaces currently for lease in Des Moines, with asking rates averaging $16.71 SF/Yr — 11% above the citywide Office Spaces average of $15 SF/Yr. Tenants comparing options may also consider Office Units (52 listings) and Creative space (10 listings) elsewhere in the Des Moines market.

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