Office Building

Des Moines, IA Office Buildings for Lease

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Urbandale, IA Windsor Heights, IA Pleasant Hill, IA West Des Moines, IA Ankeny, IA Clive, IA Johnston, IA Elkhart, IA
33 properties
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Medical Office Building
Updated: Jul 17
Medical Office Building

2459 East Euclid Avenue, Des Moines, IA 50317

$20 SF/Yr
6,240 sqft 0.53 AC lot
Well‑maintained medical office building with up to 6,240 SF of total space
0.53‑acre lot with on‑site parking
Space offers versatile options for medical use or standard office use
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Two-Story Office Building For Sale
Updated: Mar 25
Two-Story Office Building For Sale

3161 Southeast 22nd Street, Des Moines, IA 50320

$16 SF/Yr
1,872 sqft
Unique opportunity to own an office building in SE Des Moines with limited office inventory.
Remodeled in 2013 with new windows, siding, and quality interior remodel.
New furnace/air conditioning/water heater in 2025.
1,224 SF partially finished basement ideal for storage.
24’ x 24’ detached garage/storage shed.
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Downtown Des Moines Office Space
Downtown Des Moines Office Space

500 Southwest 7th Street, Des Moines, IA 50309

$19.25 SF/Yr
14,360 sqft

Three-story office building in vibrant Riverpoint district with parking.

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Historic Office Building in Des Moines
Historic Office Building in Des Moines

1420 Locust Street, Des Moines, IA 50309

$17 SF/Yr
7,689 sqft

Two-story office building with unique architecture and high-end finishes.

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Office Building Near Recreation
Office Building Near Recreation

3161 SE 22nd St, Des Moines, IA 50320

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3,096 sqft

Office property with RX1 zoning and recently replaced furnace, air conditioning, and water heater systems.

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Office Building with Historic-Modern Interiors
Office Building with Historic-Modern Interiors

801 Grand Ave, Des Moines, IA 50309

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1,702 sqft

Available for lease at 801 Grand Ave, featuring a historic-inspired facade and office spaces that blend heritage and contemporary design.

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Office Building with Auditorium
Office Building with Auditorium

3300 Grand Avenue, Des Moines, IA 50312

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152,854 sqft

Office building within a health and business complex, featuring commons areas, coffee bar, cafeteria with grease interceptor, and an auditorium.

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Grand Avenue Office Building
Grand Avenue Office Building

3440 Grand Avenue, Des Moines, IA 50312

$20 SF/Yr
90,223 sqft

Five-story office building in DMU32 Health and Business Complex.

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Class A Office Retail Building
Class A Office Retail Building

400 Locust St, Des Moines, IA 50309

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1,609 sqft

Eight-story Class A office and retail building in downtown Des Moines.

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Renovated Market District Office Building
Renovated Market District Office Building

118 Southeast 4th Street, Des Moines, IA 50309

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33,792 sqft

Creative office space in the heart of the Market District.

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Modern Office Building in East Village
Modern Office Building in East Village

300 E Locust St, Des Moines, IA 50309

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1,000 sqft

Three-story office building with on-site parking in the East Village.

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Historic Office Building with 14-Foot Ceilings
Historic Office Building with 14-Foot Ceilings

108 3rd St, Des Moines, IA 50309

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31,833 sqft

Historic office building with 14-foot ceilings, natural light, and space sizes ranging up to 31,833 SF.

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Office Building with Auditorium Seating
Office Building with Auditorium Seating

3300 Grand Ave, Des Moines, IA 50312

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38,247 sqft

Large office building within the DMU32 Health and Business Complex with modern common areas, cafeteria, and auditorium seating.

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Flexible Office Building with Auditorium
Flexible Office Building with Auditorium

3300 Grand Ave, Des Moines, IA 50312

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46,669 sqft

A modern office facility at 3300 Grand Avenue with lounge, bookstore, library, commons, and a 383-seat multi-level auditorium.

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Modern Space in DMU32 Complex
Modern Space in DMU32 Complex

3300 Grand Avenue, Des Moines, IA 50312

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152,854 sqft

152,854 SF building with flexible space and amenities.

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Class A Office Building
Class A Office Building

1150 Locust Street, Des Moines, IA 50391

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22,262 sqft

Seven-story Class A office building in Downtown Des Moines.

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Historic-Modern Office Building
Historic-Modern Office Building

801 Grand Ave, Des Moines, IA 50309

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3,500 sqft

Office building featuring historic interior accents blended with contemporary elements and state-of-the-art amenities.

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Impressive Skyview Building for Lease
Impressive Skyview Building for Lease

800 Walnut St, Des Moines, IA

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35,000 sqft 0.96 AC lot

Nine-story building with large floor plans and ample parking.

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Class A Office and Retail Building
Class A Office and Retail Building

400 Locust St, Des Moines, IA 50309

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49,279 sqft

Eight-story Class A building with an open atrium, skywalk access, and office/retail space available in contiguous suites.

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Modern Office Space Available
Modern Office Space Available

1459 Grand Ave, Des Moines, IA

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31,199 sqft 2.99 AC lot

Six-story office building with modern design and collaborative spaces.

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Platinum LEED Office Building with Rooftop Patio
Platinum LEED Office Building with Rooftop Patio

130 E 3rd St, Des Moines, IA 50309

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4,493 sqft

Platinum LEED office building with rooftop patio and bar, solar panels, shared conference space, and parking available.

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Office Building with Rooftop Patio Potential
Office Building with Rooftop Patio Potential

118 SE 4th St, Des Moines, IA 50309

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439 sqft

Complete renovation underway; flexible floorplates allow multiple tenants and rooftop patio potential.

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Renovated Multi-Tenant Office Building
Renovated Multi-Tenant Office Building

118 SE 4th St, Des Moines, IA 50309

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647 sqft

Up to 33,792 SF with flexible suite sizes and on-site parking for lease, including a 100% vacant second floor.

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Office Building with Demisable Space
Office Building with Demisable Space

118 SE 4th St, Des Moines, IA 50309

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200 sqft

Renovation-planned office building offering 4,000 SF to full size, plus up to 55 on-site parking stalls available.

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Des Moines, IA Office buildings Lease Rates & Market Statistics

Browse 33 Office buildings for lease in Des Moines, IA on Realmo, a commercial real estate marketplace serving the Des Moines area. The current inventory totals 889,375 square feet of properties — an average of ~26,950 SF per listing.

Office buildings lease rates in Des Moines range from $16 SF/Yr at the entry level to $20 SF/Yr at the top of the market, averaging $18.45 SF/Yr. Pricing across the market is relatively uniform, which simplifies like-for-like comparison between listings. At $18.45 SF/Yr, the local average runs 65% above Iowa's state average of $11.21 SF/Yr.

Des Moines accounts for 63% of the 52 office buildings currently available across Polk County, where nearby markets include West Des Moines and Urbandale. Office buildings make up 37% of the 89 Office Spaces currently for lease in Des Moines, with asking rates averaging $18.45 SF/Yr — 22% above the citywide Office Spaces average of $15.08 SF/Yr. Tenants comparing options may also consider Office Units (48 listings) and Creative space (9 listings) elsewhere in the Des Moines market.

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