Des Moines, IA Medical Office Space for Rent & Lease

$15 SF/Yr

6,650 SF

High Visibility Retail/Office Space

6201 Southeast 14th Street, Des Moines, IA 50320

Retail or medical office space in a high-traffic location.

Highly visible retail space at a major intersection.
Ideal for retail, medical office, or service occupiers.
Convenient internal access to Olive Garden/Raising Cane’s/Dollar Tree.
Located on Des Moines’ Southside.
Pylon signage available along SE 14th Street.

Updated: Mar 25

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$18 SF/Yr

2,247 SF

Medical Suite in Des Moines

1215-1415 Pleasant St, Des Moines, IA

Medical suite for lease within Methodist Medical Center Campus.

Located on the Methodist Medical Center Campus
Onsite parking provided by an adjacent parking ramp
Ideal location for healthcare professionals
2,247 USF available in Suite 102
Suite 102 is on the first floor

Updated: Oct 22, 2025

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$22 SF/Yr

152,854 SF

Grand Avenue Office and Clinic

First-class office and clinic space with parking ramp.

3200 Grand Avenue, Des Moines, IA 50312

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$22 SF/Yr

7,572 SF

Des Moines Medical Office Space

Medical office space in Des Moines' major medical corridor.

330 Laurel Street, Des Moines, IA 50314

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$15 SF/Yr

2,275 SF

Fleur Drive Retail/Medical Space

Well-maintained retail or medical space in a high-traffic area.

4214 Fleur Dr, Des Moines, IA

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Renovated Office Building in Sherman Hills

$22 SF/Yr

2,217 SF

Renovated Office Building in Sherman Hills

Historically renovated office building suitable for office or medical use.

800 19th St, Des Moines, IA

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9,608 SF

Medical Office Space Available

Medical office building with on-site parking in high-traffic area.

1530 E Euclid Ave, Des Moines, IA 50313

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$12 SF/Yr

2,000 SF

Des Moines Office Space Available

Office space available for lease in Des Moines, Iowa.

4919 Douglas Ave, Des Moines, IA 50310

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24,000 SF

Medical Surgery Center For Lease

Class A medical surgery center adjacent to Mercy One Medical Center.

450 Laurel St, Des Moines, IA 50314

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Based on your search, we've compiled 20 Potential Opportunities for your consideration. Besides 9 Active listings in Des Moines, IA, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 3 Properties for Sales.

Medical Office Space for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

$22 SF/Yr

1,400 SF

Johnston Office or Retail Space

Office or retail space in Johnston near professional offices.

5705 Northwest 100th Street, Johnston, IA 50131

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4,259 SF

Johnston Office Space For Lease

Medical/Professional office space available in Johnston, Iowa.

6105 Northwest 86th Street, Johnston, IA 50131

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$15 SF/Yr

1,413 SF

Medical Office Space Available

Ready-to-use medical suite with ample parking and prime location.

1031 Office Park Rd, West Des Moines, IA 50265

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$15 SF/Yr

5,073 SF

Office/Medical Suites For Rent

Office and medical suites available in West Des Moines, Iowa.

1031 Office Park Rd, West Des Moines, IA 50265

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Similar Spaces for Sale in Des Moines, IA

Consider Similar Space for Sale. We found 3 Spaces matching your search parameters.

$460,000

Medical Office Near Mercy Campus

Medical office space for sale near Mercy Medical Campus.

303 University Avenue, Des Moines, IA 50314

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7,260 SF

Former Dentist Office with Space

First and second floor office spaces available for lease.

4919 Douglas Avenue, Des Moines, IA 50310

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Luxury Mixed-Use Community in Des Moines

Contact for pricing

16,901 SF

Luxury Mixed-Use Community in Des Moines

42-unit mixed-use property with apartments, townhomes, and medical office.

4362 Hickman Road, Des Moines, IA 50310

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Potential Development Sites for Consideration

Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

$85,000 SF/Yr

Kingery Highway Commercial Development Opportunity

High-visibility land for retail, car wash, or medical development.

8501 & 8511 Kingery Highway, Willowbrook, IL 60527

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4,000 SF

Office Development Land For Lease

2.43 acres for office development with build-to-suit opportunity.

1323 Strawfloor Drive, Jonesboro, AR 72401

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Beaumont Centre Outparcel Opportunity

Outparcel opportunity in established shopping center for ground lease.

3199 Beaumont Centre Circle, Lexington, KY 40513

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Contact for pricing

Prime Lexington Outlot Opportunity

Outlot for ground lease or build-to-suit in South Lexington.

3330 Partner Place, Lexington, KY 40503

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Des Moines, IA Medical Office Space Leasing Opportunities Market Analysis

Explore Medical Office Space leasing options in Des Moines, IA with 9 listings featured on our commercial real estate exchange. The current inventory includes 175,815 square feet of properties with an estimated lease value of $126 SF/Yr.

Estimated lease rates for Medical Office Space in Des Moines, IA begin at $12 SF/Yr, with an average of $18 SF/Yr and extend to $22 SF/Yr.