Des Moines, IA Mixed-use properties for Rent & Lease

Updated: Mar 25

East Village Mixed-Use Development

201 Southeast 6th Street, Des Moines, IA 50309

$14 SF/Yr

2,639 sqft

New Construction: Modern, upscale apartments in a desirable location.
Prime Location in East Village Market District: Close to restaurants, cafes, and shopping.
Mixed‑Use Development: Upscale apartments above commercial space.
Located in a Growing Area: Near new breweries, restaurants, and entertainment.
213 Upscale Apartments: Significant residential capacity.

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Updated: Nov 22, 2025

New Mixed-Use Building on Ingersoll

2701 Ingersoll Avenue, Des Moines, IA 50312

$30 SF/Yr

2,609 sqft

First zero carbon certified building in Iowa.
Constructed from mass timber, providing exceptional strength and stability.
Located on busy Ingersoll Avenue.
High traffic count of over 14,000 vehicles per day.
New construction.

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Mixed-Use Development in Downtown

1301 Mulberry Street, Des Moines, IA 50309

$20 SF/Yr

7,066 sqft

Five-story mixed-use development offering urban living and commercial space.

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Seven-Story Mixed-Use Property

603 E 3rd Street, Des Moines, IA 50309

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5,915 sqft

Apartment residences and street-level retail create an integrated live-work setting with contemporary amenities.

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Downtown Des Moines Retail Space

1301 Mulberry St, Des Moines, IA 50309

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5,738 sqft

Prime retail space in a new mixed-use development.

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Historic Des Moines Mixed-Use Building

405 6th Ave, Des Moines, IA 50309

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Renovated mixed-use building with apartments and commercial space.

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Based on your search, we've compiled 16 Potential Opportunities for your consideration. Besides 6 Active listings in Des Moines, IA, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 6 Properties for Sales.

Mixed-use properties for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

New Mixed-Use Development Retail Space

950 Jordan Creek Pkwy, West Des Moines, IA 50266

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2,810 sqft

Retail space available in West Des Moines mixed-use development.

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Class B Office Suite

350 3RD Avenue SW, Unit 101, Cedar Rapids, IA 52404

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2,400 sqft

Redeveloped workspace with dedicated entry, private restrooms, and access to multiple parking options.

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Ground-Floor Retail Suite in Mixed-Use

800-900 3rd St Se, Cedar Rapids, IA 52401

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252,815 sqft

First-floor retail suites are available in Loftus, with prominent 3rd St. SE frontage and a south end-cap patio.

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Mixed-Use Lifestyle Center

5465 Mills Civic Pkwy, West Des Moines, IA 50266

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13,101 sqft 27.00 AC lot

Retail, office, entertainment, and residential uses are integrated within a single mixed-use center.

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Similar Spaces for Sale in Des Moines, IA

Consider Similar Space for Sale. We found 6 Spaces matching your search parameters.

Flex Space with Warehouse

2401 Hickman Road, Des Moines, IA 50310

$1,335,000

1.86 AC lot

Mixed-use commercial facility combining warehouse, office, training, breakroom, garage, and restroom areas.

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Brick Mixed-Use Building

4000-4002 11th Pl, Des Moines, IA 50313

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1,425 sqft

Combines a neighborhood retail suite with a one-bedroom apartment, kitchen, fenced yard, and covered patio.

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Historic Court Avenue Building For Sale

216 Court Ave, Des Moines, IA 50309

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36,000 sqft

Historic building in the Court Avenue district available for sale.

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Mixed-Use Property with Redevelopment Potential

3138 SW 9th St, Des Moines, IA 50315

$210,000

MX1 zoning supports retail and office uses alongside an existing building and adjacent parcel.

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Mixed-Use Property Near Grandview University

3001 E 14th St, Des Moines, IA 50316

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3,683 sqft

High-visibility mixed-use property in a primary commercial corridor.

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Mixed-Use Property with In-Unit Laundry

1729 Grand Ave, Des Moines, IA 50309

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26,816 sqft

The property pairs original architectural details with updated systems, kitchens, and in-unit laundry.

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Des Moines, IA Mixed-use properties Lease Rates & Market Statistics

Browse 6 Mixed-use properties for lease in Des Moines, IA on Realmo, a commercial real estate marketplace serving the Des Moines area. The current inventory totals 23,967 square feet of properties.

Mixed-use properties lease rates in Des Moines range from $14 SF/Yr at the entry level to $30 SF/Yr at the top of the market, averaging $21.33 SF/Yr. Pricing across the market is relatively uniform, which simplifies like-for-like comparison between listings. At $21.33 SF/Yr, the local average runs 25% above Iowa's state average of $17.02 SF/Yr.

Des Moines accounts for 55% of the 11 mixed-use properties currently available across Polk County, where nearby markets include West Des Moines and Altoona.