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    Monroe County, FL Office Spaces for Lease

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    Miami, FL Jacksonville, FL Orlando, FL
    32 results
    Key Largo Commercial Building For Rent
    $3,600/Mo
    1,883 SF
    Key Largo Commercial Building For Rent

    110 Ocean Drive, Key Largo, FL 33037

    Freestanding commercial building in central Key Largo with flexible zoning.
    • Prime Central Key Largo location directly across from the Courtyard Marriott and Marina.
    • Zoned Urban Commercial, offering exceptional flexibility for various business uses.
    • Expansive front parking area plus a fully fenced equipment and storage yard.
    • Updated freestanding commercial building with high visibility.
    • Features include a welcoming waiting area, receptionist office, two private executive offices, full ADA‑compliant bathroom, shower/dressing area, and company kitchen/breakroom.
    Updated: May 17
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    Key West Office/Medical Space
    $26,276 SF/Yr
    7,007 SF
    Key West Office/Medical Space

    1111 12th Street, Key West, FL 33040

    7,007 SF office/medical space in desirable New Town location.
    • Rare large space (7,007 SF, approximately half a floor) in a desirable professional hub.
    • Ideal for office or medical use, currently configured with over 25 private offices and a conference room.
    • Central location in Key West with high visibility.
    • Ample off‑street parking and elevator access.
    • Professionally managed building with a welcoming common lobby and shared restrooms.
    Updated: Mar 30
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    Prime Duval Street Commercial Building
    $35,000 SF/Yr
    6,230 SF
    Prime Duval Street Commercial Building

    Two-story building on Duval Street, ideal for retail or restaurant.

    132 Duval Street, Key West, FL 33040

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    Key West Office/Medical Space
    $4,635/Mo
    1,235 SF
    Key West Office/Medical Space

    Move-in ready office or medical suite in central Key West.

    1111 12th Street, Key West, FL 33040

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    Stock Island Commercial Property For Lease
    $3,000/Mo
    1,110 SF
    Stock Island Commercial Property For Lease

    High-visibility commercial property on Overseas Highway, minutes from Key West.

    5300 Overseas Highway, Stock Island, FL 33040

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    Marathon, FL Commercial Space
    $1,514/Mo
    1,009 SF
    Marathon, FL Commercial Space

    Upstairs unit available for rent in Marathon, Florida.

    10045 Overseas Highway, Marathon, FL 33050

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    Class A Office Center Lease
    $10,900/Mo
    3,591 SF
    Class A Office Center Lease

    Class A office space for lease in Key Largo, FL.

    94500 Overseas Highway, Key Largo, FL 33037

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    Key Largo Free Standing Office
    $3,500/Mo
    768 SF
    Key Largo Free Standing Office

    Free standing office building in the heart of Key Largo.

    101875 Overseas Highway, Key Largo, FL 33037

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    Key West Office Space Available
    $1,100/Mo
    Key West Office Space Available

    190 sq ft office space for rent in Key West.

    3706 N Roosevelt Boulevard, Key West, FL 33040

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    Key Largo Office Building Opportunity
    $9,900/Mo
    2,436 SF
    Key Largo Office Building Opportunity

    Modern, fully equipped office building in a high-visibility Key Largo location.

    100150 Overseas Highway, Key Largo, FL 33037

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    Updated Office Space in Key West
    $1,400/Mo
    Updated Office Space in Key West

    Small, updated office space in Old Town Key West.

    524 Eaton Street, Key West, FL 33040

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    Islamorada Office Spaces For Rent
    $600/Mo
    Islamorada Office Spaces For Rent

    Charming office spaces available in Islamorada, Florida.

    88101 Old Highway, Plantation Key, FL 33036

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    Turnkey Office Space on U.S.-1
    $4,500/Mo
    2,436 SF
    Turnkey Office Space on U.S.-1

    Finished office building for lease with high visibility.

    31031 Avenue A, Big Pine Key, FL 33043

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    Updated Office Space in Key West
    $1,250/Mo
    Updated Office Space in Key West

    Small, updated office space in Old Town Key West.

    524 Eaton Street, Key West, FL 33040

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    Key Vaca Center: Marathon Office Space
    $7 SF/Yr
    Key Vaca Center: Marathon Office Space

    14,000 SF Office Building, Multiple Suites Available

    10045 Overseas Hwy, Marathon, FL 33050

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    Stock Island Commercial Space Available
    $4,000/Mo
    2,060 SF
    Stock Island Commercial Space Available

    Commercial space with office and outdoor yard in Stock Island.

    5600 3Rd Avenue, Stock Island, FL 33040

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    Key West Retail/Office Opportunity
    $4,750/Mo
    1,496 SF
    Key West Retail/Office Opportunity

    Mixed-use building in Old Town Key West, near Duval Street.

    607 Fleming Street, Key West, FL 33040

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    Key Largo Commercial Office Space
    $5,457/Mo
    5,457 SF
    Key Largo Commercial Office Space

    5,457 sqft Key Largo office space for lease.

    99451 Overseas Highway, Key Largo, FL 33037

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    Conch Harbor Retail Center Space
    $3,600/Mo
    1,200 SF
    Conch Harbor Retail Center Space

    Office or retail space available in Key West, Florida.

    951 Caroline Street, Key West, FL 33040

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    Prime Office Space on Eaton
    $2,450/Mo
    385 SF
    Prime Office Space on Eaton

    385 sq ft office space in Old Town Key West.

    425 Eaton Street, Key West, FL 33040

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    KEY VACA CENTER
    $1.87 SF/Yr
    KEY VACA CENTER

    Office / Retail / Medical Offices - 3 spaces available | 1,000 SqFt - 4,020 SqFt

    10095 Overseas Hwy, Marathon, FL 33050

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    Key Largo Office For Rent
    $1,250/Mo
    Key Largo Office For Rent

    Office space available for rent in Key Largo, Florida.

    103301 Overseas Hwy, Key Largo, FL 33037

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    Islamorada Warehouse-Style Space Available
    $14,166/Mo
    10,000 SF
    Islamorada Warehouse-Style Space Available

    Open warehouse space with flexible layout in central Islamorada.

    210 Industrial Dr, Islamorada, FL 33036

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    Big Pine Key Office Space
    $3,500/Mo
    1,440 SF
    Big Pine Key Office Space

    Renovated office space on Overseas Highway in Big Pine Key.

    29872 Overseas Highway, Big Pine Key, FL 33043

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    Monroe County, FL Office Spaces Leasing Opportunities Market Analysis

    Explore Office Spaces leasing options in Monroe County, FL with 32 listings featured on our commercial real estate exchange. The current inventory includes 51,152 square feet of properties with an estimated lease value of $26 SF/Yr.

    Estimated lease rates for Office Spaces in Monroe County, FL begin at $1.87 SF/Yr, with an average of $8 SF/Yr and extend to $17 SF/Yr.
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