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    Key Largo, FL Office Spaces for Lease

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    Tavernier, FL Plantation Key, FL Islamorada, FL Florida City, FL Homestead, FL
    Key Largo Office Building Opportunity
    Updated: Jan 14
    Key Largo Office Building Opportunity

    100150 Overseas Highway, Key Largo, FL 33037

    $9,900/Mo
    2,436 sqft
    Fully equipped Key Largo office building built in 1999
    Metal roof
    Ground‑level access with a flexible floor plan for office, medical, or professional use
    Secure fenced area with ample parking and a covered rear drive‑thru
    US‑1 back‑lit signage plus existing drive‑thru for customer convenience
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    Key Largo Commercial Opportunity
    Updated: Nov 27, 2025
    Key Largo Commercial Opportunity

    106600 Overseas Highway, Key Largo, FL 33037

    $3,000/Mo
    2,400 sqft
    Highway frontage building
    2,400' of upstairs space for lease
    Downstairs is leased to FDOT contractor
    Adjacent property has storage space available for additional rental starting at $295 per space per month
    Adjacent property has 400' of water dockage for boats, sailboats, etc.
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    Office Space for Lease
    Office Space for Lease

    103301 Overseas Hwy, Key Largo, FL 33037

    $1,250/Mo

    Office space available for lease in Key Largo, suited for professional service tenants needing a straightforward commercial location.

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    Class A Multi-Story Office Center
    Class A Multi-Story Office Center

    94500 Overseas Highway, Key Largo, FL 33037

    $10,900/Mo

    Multi-story office suite with a ground-level reception and private offices, plus an upper level with open space and a sun deck.

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    Based on your search, we've compiled 23 Potential Opportunities for your consideration. Besides 4 Active listings in Key Largo, FL, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 11 Properties for Sales.

    Office Spaces for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Medical Office Suite in Professional Center
    Medical Office Suite in Professional Center

    312-925 Ne 30th Ter, Homestead, FL 33033

    $6,000/Mo
    2,122 sqft

    Office suite ready for new build out with tenant-controlled HVAC and high-speed internet in a Class B professional center.

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    Second-Floor Office Suite with Restrooms
    Second-Floor Office Suite with Restrooms

    33004 S Dixie Hwy, Florida City, FL 33034

    $29 SF/Yr

    Entire second-floor office suite with polished cement floors, high ceilings, and private restrooms on US 1 frontage.

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    Medical Office Suite in Professional Center
    Medical Office Suite in Professional Center

    212-925 Ne 30th Ter, Homestead, FL 33033

    $6,000/Mo

    Modern office suite in a Class B professional center with tenant-controlled HVAC and 24-hour keypad access.

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    Flex Warehouse with Street-Level Loading
    Flex Warehouse with Street-Level Loading

    12 NE 3rd Street, Florida City, FL 33034

    $18 SF/Yr

    Vacant flex space with office areas under AC, two street-level loading doors, and strong Turnpike signage exposure.

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    Similar Spaces for Sale in Key Largo, FL

    Consider Similar Space for Sale. We found 11 Spaces matching your search parameters.

    Mixed-Use Building with Six Suites
    Mixed-Use Building with Six Suites

    92295 Old State Road, Key Largo, FL 33070

    $2,895,000
    6,241 sqft 0.86 AC lot

    Solid concrete mixed-use building with six exterior-access suites and multiple restrooms on a fenced lot.

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    High-Frontage Mixed-Use Building with Suites
    High-Frontage Mixed-Use Building with Suites

    92295 Old State Road, #4A, Key Largo, FL 33070

    $2,895,000
    6,214 sqft 0.86 AC lot

    Concrete mixed-use building with six exterior-access suites and extensive US-1 frontage for flexible retail, office, and medical use.

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    Freestanding Mixed-Use Concrete Building
    Freestanding Mixed-Use Concrete Building

    100636 Overseas Highway, Key Largo, FL 33037

    $1,790,000
    4,910 sqft 0.18 AC lot

    Free-standing concrete mixed-use building on Overseas Highway with ground-floor commercial space, upstairs 3BD/3BA residence, and 10 parking spaces.

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    Two-Story Medical Office Building
    Two-Story Medical Office Building

    91760 Overseas Highway, Key Largo, FL 33070

    $1,469,000
    2,562 sqft

    Two-story office building with mezzanine-level storage and impact-resistant windows and doors.

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    Two-Story Office Building with Covered Parking
    Two-Story Office Building with Covered Parking

    106240 Overseas Hwy, Key Largo, FL 33037

    $1,925,000
    3,936 sqft 0.50 AC lot

    Two-story office building with newly installed metal roof, leased ground floor space, and additional second-story area available.

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    Key Largo Commercial Property For Sale
    Key Largo Commercial Property For Sale

    91760 Overseas Highway, Key Largo, FL 33070

    $1,469,000
    2,562 sqft 0.16 AC lot

    Prime commercial property with US-1 frontage in the heart of Tavernier.

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    Marina-Licensed Storage Yard
    Marina-Licensed Storage Yard

    98468 Overseas Highway, #1, Key Largo, FL 33037

    $2,850,000

    For-sale storage yard with marina license, office and cottage on 125 feet of road frontage on the bay side.

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    Free-Standing Mixed-Use Retail Building
    Free-Standing Mixed-Use Retail Building

    100636 Overseas Highway, Key Largo, FL 33037

    $1,790,000

    Ground-floor storefront with office and storage, plus an upstairs 3BD/3BA renovated apartment and parking on US-1.

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    Fully Renovated Mixed-Use Property
    Fully Renovated Mixed-Use Property

    91865 Overseas Highway, Key Largo, FL 33070

    $6,495,000

    Renovated mixed-use income property with 10 residential units and 5 established commercial tenants.

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    Office Space Available
    Office Space Available

    103301 Overseas Hwy, Key Largo, FL 33037

    Contact for pricing

    Office space for rent in Key Largo, Florida.

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    Corner Lot Retail-Office Building
    Corner Lot Retail-Office Building

    91625 Overseas Highway, Key Largo, FL 33070

    $1,215,000
    2,540 sqft 0.32 AC lot

    Remodeled commercial building with impact windows and doors, open layout, and multiple offices on a corner lot.

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    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Vacant Commercial Parcel For Sale
    Vacant Commercial Parcel For Sale

    1508 Nw 1st Ave, Miami, FL 33136

    $2,000/Mo

    Vacant commercial land parcel available for sale.

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    Commercial Land with US-41 Frontage
    Commercial Land with US-41 Frontage

    14500 N CLEVELAND Avenue, North Fort Myers, FL 33903

    $10,416/Mo

    Two adjacent commercial parcels totaling about 1.85 acres along US-41 in North Fort Myers.

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    Zoned Commercial Land Parcel
    Zoned Commercial Land Parcel

    1701 N US 27 Highway, Sebring, FL 33870

    $8,900/Mo

    1.52-acre commercial land parcel zoned B3, located directly across from The Shops at Shelby Crossing.

    View details
    Zoned Commercial Development Land
    Zoned Commercial Development Land

    6012 LORRAINE Road, Bradenton, FL 34211

    $21,000/Mo

    Approximately 4.67-acre parcel zoned commercial and offered for rent near shopping.

    View details

    Key Largo, FL Office Spaces Market Trends and Statistics

    Explore Office Spaces leasing options in Key Largo, FL with 4 listings featured on our commercial real estate exchange. The current inventory includes 4,836 square feet of properties with an estimated lease value of $63.77 SF/Yr.

    Estimated lease rates for Office Spaces in Key Largo, FL begin at $15 SF/Yr, with an average of $31.89 SF/Yr and extend to $48.77 SF/Yr.
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