Add Listing
    Key West, FL
    For Lease
    • For Sale
    • For Lease
    • Recently Sold
    • Property Lookup
    • Brokers
    Space Uses
    1
    • Retail
    • Restaurant
    • Office
    • Coworking
    • Medical Space
    • Automotive
    • Industrial
    • Warehouse
    • Flex
    • Hospitality
    • Sports & Entertainment
    • Specialty
    Rent
    Rent
    $
    $
    Size
    Property Size / SF

    Key West, FL Office Spaces for Lease

    Notify Me
    List
    Map
    13 results
    Key West Office/Medical Space
    $26,276 SF/Yr
    7,007 SF
    Key West Office/Medical Space

    1111 12th Street, Key West, FL 33040

    7,007 SF office/medical space in desirable New Town location.
    • Rare large space (7,007 SF, approximately half a floor) in a desirable professional hub.
    • Ideal for office or medical use, currently configured with over 25 private offices and a conference room.
    • Central location in Key West with high visibility.
    • Ample off‑street parking and elevator access.
    • Professionally managed building with a welcoming common lobby and shared restrooms.
    Updated: Mar 30
    View details
    Prime Duval Street Commercial Building
    $35,000 SF/Yr
    6,230 SF
    Prime Duval Street Commercial Building

    132 Duval Street, Key West, FL 33040

    Two-story building on Duval Street, ideal for retail or restaurant.
    • Prime Duval Street location in the heart of Old Town Key West with high tourist foot traffic.
    • Totally renovated building with new plumbing, electric, foundation, central AC, impact doors and windows.
    • Large open floor plan with 3,200 sq ft of retail space on the ground floor and 3,000 sq ft of storage/office space on the second floor.
    • 35' of Duval St. visibility & frontage with large impact display windows.
    • Two valuable off‑street parking spaces included.
    Updated: Feb 9
    View details
    Key West Office/Medical Space
    $4,635/Mo
    1,235 SF
    Key West Office/Medical Space

    Move-in ready office or medical suite in central Key West.

    1111 12th Street, Key West, FL 33040

    View details
    Key West Office Space Available
    $1,100/Mo
    Key West Office Space Available

    190 sq ft office space for rent in Key West.

    3706 N Roosevelt Boulevard, Key West, FL 33040

    View details
    Updated Office Space in Key West
    $1,400/Mo
    Updated Office Space in Key West

    Small, updated office space in Old Town Key West.

    524 Eaton Street, Key West, FL 33040

    View details
    Updated Office Space in Key West
    $1,250/Mo
    Updated Office Space in Key West

    Small, updated office space in Old Town Key West.

    524 Eaton Street, Key West, FL 33040

    View details
    Key West Retail/Office Opportunity
    $4,750/Mo
    1,496 SF
    Key West Retail/Office Opportunity

    Mixed-use building in Old Town Key West, near Duval Street.

    607 Fleming Street, Key West, FL 33040

    View details
    Conch Harbor Retail Center Space
    $3,600/Mo
    1,200 SF
    Conch Harbor Retail Center Space

    Office or retail space available in Key West, Florida.

    951 Caroline Street, Key West, FL 33040

    View details
    Prime Office Space on Eaton
    $2,450/Mo
    385 SF
    Prime Office Space on Eaton

    385 sq ft office space in Old Town Key West.

    425 Eaton Street, Key West, FL 33040

    View details
    Flagler Avenue Professional Office Space
    $11,300/Mo
    3,877 SF
    Flagler Avenue Professional Office Space

    Commercial space for rent in Key West, Florida.

    3216 Flagler Avenue, Key West, FL 33040

    View details
    Key West Office Condo Rental
    $4,300/Mo
    1,475 SF
    Key West Office Condo Rental

    Centrally located office condo in Key West, Florida.

    1010 Kennedy Drive, Key West, FL 33040

    View details
    Key West Office Condo Rental
    $6,000/Mo
    2,058 SF
    Key West Office Condo Rental

    Centrally located office condo for lease in Key West, Florida.

    1010 Kennedy Drive, Key West, FL 33040

    View details
    Retail Space Available For Rent
    Contact for pricing
    1,491 SF
    Retail Space Available For Rent

    Single tenant retail space available, approximately 1,491 square feet.

    3201 Flagler Ave, Key West, FL 33040

    View details
    Based on your search, we've compiled 39 Potential Opportunities for your consideration. Besides 13 Active listings in Key West, FL, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 18 Properties for Sales.

    Office Spaces for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Class A Office Center Lease
    $10,900/Mo
    3,591 SF
    Class A Office Center Lease

    Class A office space for lease in Key Largo, FL.

    94500 Overseas Highway, Key Largo, FL 33037

    View details
    Key Vaca Center: Marathon Office Space
    $7 SF/Yr
    Key Vaca Center: Marathon Office Space

    14,000 SF Office Building, Multiple Suites Available

    10045 Overseas Hwy, Marathon, FL 33050

    View details
    Key Largo Commercial Office Space
    $5,457/Mo
    5,457 SF
    Key Largo Commercial Office Space

    5,457 sqft Key Largo office space for lease.

    99451 Overseas Highway, Key Largo, FL 33037

    View details
    KEY VACA CENTER
    $1.87 SF/Yr
    KEY VACA CENTER

    Office / Retail / Medical Offices - 3 spaces available | 1,000 SqFt - 4,020 SqFt

    10095 Overseas Hwy, Marathon, FL 33050

    View details

    Similar Spaces for Sale in Key West, FL

    Consider Similar Space for Sale. We found 18 Spaces matching your search parameters.

    New Mixed-Use Development in Key West
    $749,000
    1,491 SF
    New Mixed-Use Development in Key West

    Commercial space in new mixed-use development, completion end of 2026.

    3201 Flagler Avenue, Key West, FL 33040

    View details
    Key West Commercial Opportunity
    $1,500,000
    1,436 SF
    Key West Commercial Opportunity

    Standalone commercial building in Old Town Key West with parking.

    604 Whitehead Street, Key West, FL 33040

    View details
    Key West Commercial Condos
    $1,950,000
    Key West Commercial Condos

    Prime investment opportunity in Key West's Old Town.

    1200-1206 White Street, Key West, FL 33040

    View details
    Key West Office Condo Investment
    $599,000
    1,133 SF
    Key West Office Condo Investment

    Fully leased office condo with strong tenant and ocean view.

    3718 N Roosevelt Boulevard, Key West, FL 33040

    View details
    Renovated Office Building in Key West
    $1,200,000
    2,045 SF
    Renovated Office Building in Key West

    Income-producing, renovated two-story office building in Key West, Florida.

    3140 Northside Drive, Key West, FL 33040

    View details
    Historic Key West Residence
    $2,175,000
    2,150 SF
    Historic Key West Residence

    Old Town residence blending historic charm with modern refinement.

    1209 Packer Street, Key West, FL 33040

    View details
    Old Town Key West Office
    Contact for pricing
    0.29 Acres
    Old Town Key West Office

    Small, updated office space in a friendly business environment.

    524 Eaton Street, Key West, FL 33040

    View details
    Updated Commercial Condos in Key West
    $1,275,000
    2,061 SF
    Updated Commercial Condos in Key West

    Two updated commercial condos in Key West with parking.

    1200+1202 White Street, Key West, FL 33040

    View details
    Old Town Key West Office
    Contact for pricing
    1,020 SF
    Old Town Key West Office

    Professional office space in a prime Key West location.

    1213 Truman Avenue, Key West, FL 33040

    View details
    Downtown Key West Office Space
    Contact for pricing
    320 SF
    Downtown Key West Office Space

    Small, private corner office in downtown Key West.

    524 Eaton Street, Key West, FL 33040

    View details
    Key West Commercial Condo Opportunity
    $699,000
    1,389 SF
    Key West Commercial Condo Opportunity

    Commercial condo in Old Town Key West, available 2026.

    1206 White Street, Key West, FL 33040

    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Commercial Lot on Franklin Avenue
    Contact for pricing
    10,203 SF
    Commercial Lot on Franklin Avenue

    Commercial lot zoned CG, great location for various businesses.

    16220 Franklin Avenue, Port Charlotte, FL 33953

    View details
    Commercial Land Near Shopping
    $21,000 SF/Yr
    200,000 SF
    Commercial Land Near Shopping

    Commercial land for rent, conveniently located near shopping.

    6012 LORRAINE ROAD, Bradenton, FL 34211

    View details
    Lakeland Commercial Business Park Spaces
    Contact for pricing
    Lakeland Commercial Business Park Spaces

    Commercial spaces for lease in West Lakeland business park.

    2525 Drane Field Road, Lakeland, FL 33811

    View details
    Downtown Winter Haven Commercial Land
    $29,940 SF/Yr
    Downtown Winter Haven Commercial Land

    City-approved commercial land in a growing business district.

    511 AVENUE G NW, Winter Haven, FL 33881

    View details

    Key West, FL Office Spaces Leasing Opportunities Market Analysis

    Explore Office Spaces leasing options in Key West, FL with 13 listings featured on our commercial real estate exchange. The current inventory includes 25,545 square feet of properties with an estimated lease value of $61,815.

    Estimated lease rates for Office Spaces in Key West, FL begin at $34 SF/Yr, with an average of $5,151 /Mo and extend to $35,000.
    List
    Map

    Browse Office Spaces for Lease Near Key West, FL

    Popular Searches in Key West, FL

    Popular Categories

    Most Searched ZIP Codes in Key West, FL

    • 33040

    Select Neighborhood

    Google sign-in failed. Please try again or use another login method.
    Sign Up Successful!
    You now have access to more from Realmo!