Monroe County, FL Commercial Real Estate for Lease

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78 properties
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Mixed-Use Live-Work Unit
Updated: Jun 26
Mixed-Use Live-Work Unit

88100 Overseas Highway, Plantation Key, FL 33036

$3,200/Mo
1,008 sqft $38 SF/Yr
1980‑built mixed‑use unit for lease at 88100 Overseas Hwy, Unit 1 in Islamorada
1 bedroom, 1 bathroom unit with full‑size refrigerator and stove/oven
Private patio plus side yard for outdoor seating, displays, or additional work/storage
$3,200/month rent with water, electric, and yard maintenance included
Annual lease preferred, with possible 6‑month lease for qualified tenants
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Retail Office Space at Galleon Square
Updated: Jul 10
Retail Office Space at Galleon Square

218 Whitehead Street, Key West, FL 33040

$5,250/Mo
950 sqft $66 SF/Yr
950 SF retail/office space in Galleon Square in Old Town Key West
Metal roof and off‑street parking
Year built: 1942
NNN charges are in addition to the quoted base rent
Public space positioning: next door to Mel Fisher Maritime Museum, across from Custom House Museum and Mallory Square
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Key Largo Commercial Building For Rent
Key Largo Commercial Building For Rent

110 Ocean Drive, Key Largo, FL 33037

$3,600/Mo
1,883 sqft $22 SF/Yr

Freestanding commercial building in central Key Largo with flexible zoning.

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Retail Storefront in Cruise District
Retail Storefront in Cruise District

419 Duval Street, Key West, FL 33040

$8,900/Mo
900 sqft $118 SF/Yr

Street-facing retail space positioned in Key West’s Old Town cruise-ship area with rear employee parking.

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Key West Office/Medical Space
Key West Office/Medical Space

1111 12th Street, Key West, FL 33040

$26,276 SF/Yr
7,007 sqft $15,342,994/Mo

7,007 SF office/medical space in desirable New Town location.

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Prime Duval Street Commercial Building
Prime Duval Street Commercial Building

132 Duval Street, Key West, FL 33040

$35,000 SF/Yr
6,230 sqft $18,170,833/Mo

Two-story building on Duval Street, ideal for retail or restaurant.

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Stock Island Commercial Space Available
Stock Island Commercial Space Available

5300 Overseas Highway, Stock Island, FL 33040

$5,000/Mo
789 sqft $76 SF/Yr

High-visibility commercial property on Overseas Highway, minutes from Key West.

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Stock Island Commercial Property For Lease
Stock Island Commercial Property For Lease

5300 Overseas Highway, Stock Island, FL 33040

$3,000/Mo
1,110 sqft $32 SF/Yr

High-visibility commercial property on Overseas Highway, minutes from Key West.

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Marathon, FL Commercial Space
Marathon, FL Commercial Space

10045 Overseas Highway, Marathon, FL 33050

$1,514/Mo
1,009 sqft $18 SF/Yr

Upstairs unit available for rent in Marathon, Florida.

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Key West Office/Medical Space
Key West Office/Medical Space

1111 12th Street, Key West, FL 33040

$4,635/Mo
1,235 sqft $45 SF/Yr

Move-in ready office or medical suite in central Key West.

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Old Town Endcap Retail Suite
Old Town Endcap Retail Suite

1206 White Street, Key West, FL 33040

$4,250/Mo
1,100 sqft $46 SF/Yr

End unit retail space with an assigned parking spot and hurricane-rated windows and doors in Old Town.

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High-Visibility Retail Space on Highway
High-Visibility Retail Space on Highway

5300 Overseas Highway, Key West, FL 33040

$8,000/Mo
1,913 sqft $50 SF/Yr

Prime commercial property on Overseas Highway with high visibility.

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Class A Office Center Lease
Class A Office Center Lease

94500 Overseas Highway, Key Largo, FL 33037

$10,900/Mo
3,591 sqft $36 SF/Yr

Class A office space for lease in Key Largo, FL.

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Key Largo Free Standing Office
Key Largo Free Standing Office

101875 Overseas Highway, Key Largo, FL 33037

$3,500/Mo
768 sqft $54 SF/Yr

Free standing office building in the heart of Key Largo.

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Key Largo Office Building Opportunity
Key Largo Office Building Opportunity

100150 Overseas Highway, Key Largo, FL 33037

$9,900/Mo
2,436 sqft $48 SF/Yr

Modern, fully equipped office building in a high-visibility Key Largo location.

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New Retail Space in Key West
New Retail Space in Key West

3201 Flagler Avenue, Key West, FL 33040

$6,000/Mo
1,491 sqft $48 SF/Yr

New retail space for lease in a mixed-use development.

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Updated Office Space in Key West
Updated Office Space in Key West

524 Eaton Street, Key West, FL 33040

$1,400/Mo
160 sqft $105 SF/Yr

Small, updated office space in Old Town Key West.

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Key West Retail Space For Rent
Key West Retail Space For Rent

431 Front Street, Key West, FL 33040

$5,828/Mo
657 sqft $106 SF/Yr

Retail space in high-traffic Key West location.

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Duval Street Retail Opportunity
Duval Street Retail Opportunity

210-216 Duval Street, Key West, FL 33040

$44,677 SF/Yr
5,901 sqft $21,969,914/Mo

Prime retail or restaurant space on Key West's Duval Street.

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Islamorada Office Spaces For Rent
Islamorada Office Spaces For Rent

88101 Old Highway, Plantation Key, FL 33036

$600/Mo
163 sqft $44 SF/Yr

Charming office spaces available in Islamorada, Florida.

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Turnkey Office Space on U.S.-1
Turnkey Office Space on U.S.-1

31031 Avenue A, Big Pine Key, FL 33043

$4,500/Mo
2,436 sqft $22 SF/Yr

Finished office building for lease with high visibility.

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Updated Office Space in Key West
Updated Office Space in Key West

524 Eaton Street, Key West, FL 33040

$1,250/Mo
232 sqft $64 SF/Yr

Small, updated office space in Old Town Key West.

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Key Vaca Center: Marathon Office Space
Key Vaca Center: Marathon Office Space

10045 Overseas Hwy, Marathon, FL 33050

$7 SF/Yr
10,288 sqft $6,172/Mo

14,000 SF Office Building, Multiple Suites Available

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Key West Corner Retail/Office
Key West Corner Retail/Office

1110 Truman Avenue, Key West, FL 33040

$3,850/Mo
773 sqft $59 SF/Yr

Renovated corner space in Old Town Key West.

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Monroe County, FL Commercial real estate Market Trends and Statistics

Explore Commercial real estate leasing options in Monroe County, FL with 78 listings featured on our commercial real estate exchange. The current inventory includes 170,602 square feet of properties with an estimated lease value of $203,355.

Estimated lease rates for Commercial real estate in Monroe County, FL begin at $1.87 SF/Yr, with an average of $3,506 /Mo and extend to $44,677.
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